| Title : Discovery of New Highly Potent Histamine H(3) Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors - Malek_2024_ACS.Chem.Neurosci__ |
| Author(s) : Malek R , Salat K , Totoson P , Karcz T , Refouvelet B , Skrzypczak-Wiercioch A , Maj M , Simakov A , Martin H , Siwek A , Szalaj N , Godyn J , Panek D , Wieckowska A , Jozwiak K , Demougeot C , Kiec-Kononowicz K , Chabchoub F , Iriepa I , Marco-Contelles J , Ismaili L |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : |
| PubMedSearch : Malek_2024_ACS.Chem.Neurosci__ |
| PubMedID: 39208251 |
| Title : Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment - Dakhlaoui_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Dakhlaoui I , Bernard PJ , Pietrzak D , Simakov A , Maj M , Refouvelet B , Beduneau A , Cornu R , Jozwiak K , Chabchoub F , Iriepa I , Martin H , Marco-Contelles J , Ismaili L |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Dakhlaoui_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37298693 |
| Title : Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca(2+) Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation - Malek_2022_Molecules_28_ |
| Author(s) : Malek R , Simakov A , Davis A , Maj M , Bernard PJ , Wnorowski A , Martin H , Marco-Contelles J , Chabchoub F , Dallemagne P , Rochais C , Jozwiak K , Ismaili L |
| Ref : Molecules , 28 : , 2022 |
| Abstract : |
| PubMedSearch : Malek_2022_Molecules_28_ |
| PubMedID: 36615267 |
| Title : Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments - Bautista-Aguilera_2021_Chem.Rec_21_162 |
| Author(s) : Bautista-Aguilera O M , Ismaili L , Iriepa I , Diez-Iriepa D , Chabchoub F , Marco-Contelles J , Perez M |
| Ref : Chem Rec , 21 :162 , 2021 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2021_Chem.Rec_21_162 |
| PubMedID: 33169934 |
| Title : Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy - Zribi_2020_Molecules_25_ |
| Author(s) : Zribi L , Pachon-Angona I , Bautista-Aguilera OM , Diez-Iriepa D , Marco-Contelles J , Ismaili L , Iriepa I , Chabchoub F |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : Zribi_2020_Molecules_25_ |
| PubMedID: 32668671 |
| Title : Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy - Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| Author(s) : Dgachi Y , Martin H , Malek R , Jun D , Janockova J , Sepsova V , Soukup O , Iriepa I , Moraleda I , Maalej E , Carreiras MC , Refouvelet B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : J Enzyme Inhib Med Chem , 34 :163 , 2019 |
| Abstract : |
| PubMedSearch : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| PubMedID: 30482062 |
| Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416 |
| Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 62 :11416 , 2019 |
| Abstract : |
| PubMedSearch : Malek_2019_J.Med.Chem_62_11416 |
| PubMedID: 31724859 |
| Title : Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy - Dgachi_2017_Future.Med.Chem_9_715 |
| Author(s) : Dgachi Y , Martin H , Bonet A , Chioua M , Iriepa I , Moraleda I , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Future Med Chem , 9 :715 , 2017 |
| Abstract : |
| PubMedSearch : Dgachi_2017_Future.Med.Chem_9_715 |
| PubMedID: 28504912 |
| Title : Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease - Dgachi_2016_Molecules_21_ |
| Author(s) : Dgachi Y , Bautista-Aguilera OM , Benchekroun M , Martin H , Bonet A , Knez D , Godyn J , Malawska B , Gobec S , Chioua M , Janockova J , Soukup O , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Dgachi_2016_Molecules_21_ |
| PubMedID: 27187348 |
| Title : Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy - Dgachi_2016_Eur.J.Med.Chem_126_576 |
| Author(s) : Dgachi Y , Sokolov O , Luzet V , Godyn J , Panek D , Bonet A , Martin H , Iriepa I , Moraleda I , Garcia-Iriepa C , Janockova J , Richert L , Soukup O , Malawska B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Eur Journal of Medicinal Chemistry , 126 :576 , 2016 |
| Abstract : |
| PubMedSearch : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| PubMedID: 27918993 |
| Title : Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy - Dgachi_2016_ChemMedChem_11_1318 |
| Author(s) : Dgachi Y , Ismaili L , Knez D , Benchekroun M , Martin H , Szalaj N , Wehle S , Bautista-Aguilera OM , Luzet V , Bonnet A , Malawska B , Gobec S , Chioua M , Decker M , Chabchoub F , Marco-Contelles J |
| Ref : ChemMedChem , 11 :1318 , 2016 |
| Abstract : |
| PubMedSearch : Dgachi_2016_ChemMedChem_11_1318 |
| PubMedID: 26804623 |
| Title : Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease - Cherif_2014_Future.Med.Chem_6_1883 |
| Author(s) : Cherif O , Allouche F , Chabchoub F , Chioua M , Soriano E , Yanez M , Cacabelos R , Romero A , Lopez MG , Marco-Contelles J |
| Ref : Future Med Chem , 6 :1883 , 2014 |
| Abstract : |
| PubMedSearch : Cherif_2014_Future.Med.Chem_6_1883 |
| PubMedID: 25495982 |
| Title : Nontoxic and neuroprotective beta-naphthotacrines for Alzheimer's disease - Esquivias-Perez_2013_Chem.Res.Toxicol_26_986 |
| Author(s) : Esquivias-Perez M , Maalej E , Romero A , Chabchoub F , Samadi A , Marco-Contelles J , Oset-Gasque MJ |
| Ref : Chemical Research in Toxicology , 26 :986 , 2013 |
| Abstract : |
| PubMedSearch : Esquivias-Perez_2013_Chem.Res.Toxicol_26_986 |
| PubMedID: 23676090 |
| Title : Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines - Maalej_2011_Bioorg.Med.Chem.Lett_21_2384 |
| Author(s) : Maalej E , Chabchoub F , Samadi A , de los Rios C , Perona A , Morreale A , Marco-Contelles J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2384 , 2011 |
| Abstract : |
| PubMedSearch : Maalej_2011_Bioorg.Med.Chem.Lett_21_2384 |
| PubMedID: 21411323 |