Peptidase_S37

Relationship

Family: Peptidase_S37

Block: X

Parent Family: No family

Comment

This group of serine peptidases belong to MEROPS peptidase family S37 (clan SC). The members of this group of secreted peptidases are restricted to bacteria. In Streptomyces lividans the peptidase removes tripeptides from the N terminus of extracellular proteins (tripeptidyl aminopeptidase,Tap). The peptidase from Streptomyces mobaraensis has been shown to activate the transglutaminase precursor by removal of a leading tri- or tetrapeptide (Umezawa et al., 2004). Calcium ions enhance activity (Zotzel et al., 2003).

Database

Interpro : IPR008761 Peptidase_S37 tripeptidyl aminopeptidase

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF05576 Peptidase_S37

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in Peptidase_S37 family (802)

Fragments of genes in Peptidase_S37 family (44)

No fragment of genes

No substrate

Inhibitors in Peptidase_S37 family (1)

References (2)

Title : Novel prolyl tri\/tetra-peptidyl aminopeptidase from Streptomyces mobaraensis: substrate specificity and enzyme gene cloning - Umezawa_2004_J.Biochem_136_293
Author(s) : Umezawa Y , Yokoyama K , Kikuchi Y , Date M , Ito K , Yoshimoto T , Matsui H
Ref : J Biochem , 136 :293 , 2004
PubMedID: 15598885
Gene_locus related to this paper: strmb-tpap

Title : Activated transglutaminase from Streptomyces mobaraensis is processed by a tripeptidyl aminopeptidase in the final step - Zotzel_2003_Eur.J.Biochem_270_4149
Author(s) : Zotzel J , Pasternack R , Pelzer C , Ziegert D , Mainusch M , Fuchsbauer HL
Ref : European Journal of Biochemistry , 270 :4149 , 2003
PubMedID: 14519127
Gene_locus related to this paper: strmb-tpap