Gene_Locus Report

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Gene_locus Report for: human-NDRG3

Homo sapiens (Human) ndrg3 protein ndr1-related development protein ndr3 otthump00000030883 otthump00000030882

Comment
old human-ndr3 Q96SM2 alternative splicing


Relationship
Family|Ndr_family
Block| X
Position in NCBI Life Tree|Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E


Molecular evidence
Database
No mutation
3 structures: 6L4B, 6L4G, 6L4H
No kinetic





No Substrate
No inhibitor
>3 Genbank links 7 more: AL031662, AL132768, AF308609
>3 UniProt links 4 more: Q9UGV2, Q5TH29, Q5TH30
3 Structure : 6L4B, 6L4G, 6L4H
>3 UniProt links 4 more: Q9UGV2, Q5TH29, Q5TH30
>3 Interpro links 4 more: Q9UGV2, Q5TH29, Q5TH30
>3 Prodom links 4 more: Q9UGV2, Q5TH29, Q5TH30
>3 Pfam links 4 more: Q9UGV2, Q5TH29, Q5TH30
>3 PIRSF links 4 more: Q9UGV2, Q5TH29, Q5TH30
>3 SUPERFAM links 4 more: Q9UGV2, Q5TH29, Q5TH30
1 EntrezGene : 57446
1 SNP : 57446
1 UniGene : 437338
1 HUGO HGNC : 14462
1 OMIM : 605273
1 Ensembl : ENSG00000101079
Sequence
Graphical view for this peptide sequence: human-NDRG3
Colored MSA for Ndr_family (raw)
MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQGHDIETTHGVVHVTIRGLP
KGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEG
APSFPTGYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALN
HPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILAHHFGQEELQ
ANLDLIQTYRMHIAQDINQDNLQLFLNSYNGRRDLEIERPILGQNDNKSK
TLKCSTLLVVGDNSPAVEAVVECNSRLNPINTTLLKMADCGGLPQVVQPG
KLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSLGSGESPFSRSVTSN
QSDGTQESCESPDVLDRHQTMEVSC
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQGHDIETTHGVVHVTIRGLP
KGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEG
APSFPTGYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALN
HPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILAHHFGQEELQ
ANLDLIQTYRMHIAQDINQDNLQLFLNSYNGRRDLEIERPILGQNDNKSK
TLKCSTLLVVGDNSPAVEAVVECNSRLNPINTTLLKMADCGGLPQVVQPG
KLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSLGSGESPFSRSVTSN
QSDGTQESCESPDVLDRHQTMEVSC


References
8 more
    Title: High expression of NDRG3 correlates with poor prognosis in gastric cancer patients
    Liu Y, Xia J, Zhou Y, Shao S
    Ref: Rev Esp Enferm Dig, 113:524, 2021 : PubMed

            

    Title: Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein
    Kim KR, Kim KA, Park JS, Jang JY, Choi Y, Lee HH, Lee DC, Park KC, Yeom YI and Han BW <1 more author(s)>
    Ref: Biomolecules, 10:, 2020 : PubMed

            

    Title: SNHG20/miR-140-5p/NDRG3 axis contributes to 5-fluorouracil resistance in gastric cancer
    Yu J, Shen J, Qiao X, Cao L, Yang Z, Ye H, Xi C, Zhou Q, Wang P, Gong Z
    Ref: Oncol Lett, 18:1337, 2019 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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