7-Methyloxyde-PhO-cpd-II52
II-52 Cytotoxicity CHOK1 43 +/- 0.5 microM; IC50 hACHE 0.84 +/- 0.02 microM; IC50 hBCHE 0.44 +/- 0.01 microM; hGluN1/hGluN2B RIa (1 microM) 25.7 +/- 2.2%
General
Type : Multitarget, NMDA-Ligand, Derivative of Tacrine, Acridine
Chemical_Nomenclature : 7-(2-methoxyphenoxy)-1,2,3,4-tetrahydroacridin-9-amine
Canonical SMILES : COC1=CC=CC=C1OC2=CC3=C(C=C2)N=C4CCCCC4=C3N
InChI : InChI=1S\/C20H20N2O2\/c1-23-18-8-4-5-9-19(18)24-13-10-11-17-15(12-13)20(21)14-6-2-3-7-16(14)22-17\/h4-5,8-12H,2-3,6-7H2,1H3,(H2,21,22)
InChIKey : UQBHJFYPFFUQPN-UHFFFAOYSA-N
Other name(s) : Compound II-52 || 7-(2-methoxyphenoxy)-1,2,3,4-tetrahydroacridine-9-amine hydrochloride || K1959
MW : 320.4
Formula : C20H20N2O2
CAS_number :
PubChem : 164597066
UniChem : UQBHJFYPFFUQPN-UHFFFAOYSA-N
Target
Families : 7-Methyloxyde-PhO-cpd-II52 ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (2)
| Title : Prophylaxis by a reversible cholinesterase inhibitor and the treatment NMDA receptor antagonists as combinatorial countermeasure against nerve agent poisoning in mice model - Kassa_2025_Chem.Biol.Interact_15ChEPon__111386 |
| Author(s) : Kassa J , Konecny J , Svobodova B , Horak M , Korabecny J , Soukup O |
| Ref : Chemico-Biological Interactions , :111386 , 2025 |
| Abstract : |
| PubMedSearch : Kassa_2025_Chem.Biol.Interact_15ChEPon__111386 |
| PubMedID: 39805415 |
| Title : Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition - Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| Author(s) : Misiachna A , Svobodova B , Netolicky J , Chvojkova M , Kleteckova L , Prchal L , Novak M , Hrabinova M , Kucera T , Muckova L , Moravcova Z , Karasova JZ , Pejchal J , Blazek F , Malinak D , Hakenova K , Krausova BH , Kolcheva M , Ladislav M , Korabecny J , Pahnke J , Vales K , Horak M , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 266 :116130 , 2024 |
| Abstract : |
| PubMedSearch : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| PubMedID: 38218127 |