Diethyl-hydrogen-phosphate
adduct left on enzyme after elimination of leaving group. Same adduct for Paraoxon, DEUP, echothiophate || DEP Diethyl-phthalate and Diethyl-hydrogen-phosphate not to be confounded
General
Type : Covalent inhibitor adduct
Chemical_Nomenclature : diethyl hydrogen phosphate
Canonical SMILES : CCOP(=O)(O)OCC
InChI : InChI=1S\/C4H11O4P\/c1-3-7-9(5,6)8-4-2\/h3-4H2,1-2H3,(H,5,6)
InChIKey : UCQFCFPECQILOL-UHFFFAOYSA-N
Other name(s) : diethyl hydrogen phosphate || Diethyl phosphate || diethylphosphate || Diethyl acid phosphate || DEP
MW : 154.10
Formula : C4H11O4P
CAS_number : 598-02-7
PubChem : 654
UniChem : UCQFCFPECQILOL-UHFFFAOYSA-N
References (11)
| Title : Structure and function of an insect alpha-carboxylesterase (alphaEsterase7) associated with insecticide resistance - Jackson_2013_Proc.Natl.Acad.Sci.U.S.A_110_10177 |
| Author(s) : Jackson CJ , Liu JW , Carr PD , Younus F , Coppin C , Meirelles T , Lethier M , Pandey G , Ollis DL , Russell RJ , Weik M , Oakeshott JG |
| Ref : Proc Natl Acad Sci U S A , 110 :10177 , 2013 |
| Abstract : |
| PubMedSearch : Jackson_2013_Proc.Natl.Acad.Sci.U.S.A_110_10177 |
| PubMedID: 23733941 |
| Gene_locus related to this paper: luccu-E3aest7 |
| Title : Crystal Structure of Proteus mirabilis Lipase, a Novel Lipase from the Proteus\/Psychrophilic Subfamily of Lipase Family I.1 - Korman_2012_PLoS.One_7_e52890 |
| Author(s) : Korman TP , Bowie JU |
| Ref : PLoS ONE , 7 :e52890 , 2012 |
| Abstract : |
| PubMedSearch : Korman_2012_PLoS.One_7_e52890 |
| PubMedID: 23300806 |
| Gene_locus related to this paper: promi-c2lfd0 |
| Title : Structure and stability of a thermostable carboxylesterase from the thermoacidophilic archaeon Sulfolobus tokodaii. - Angkawidjaja_2012_Febs.J_279_3071 |
| Author(s) : Angkawidjaja C , Koga Y , Takano K , Kanaya S |
| Ref : Febs J , 279 :3071 , 2012 |
| Abstract : |
| PubMedSearch : Angkawidjaja_2012_Febs.J_279_3071 |
| PubMedID: 22748144 |
| Gene_locus related to this paper: sulto-ST0071 |
| Title : The crystal structure of the cephalosporin deacetylating enzyme acetyl xylan esterase bound to paraoxon explains the low sensitivity of this serine hydrolase to organophosphate inactivation - Montoro-Garcia_2011_Biochem.J_436_321 |
| Author(s) : Montoro-Garcia S , Gil-Ortiz F , Garcia-Carmona F , Polo LM , Rubio V , Sanchez-Ferrer A |
| Ref : Biochemical Journal , 436 :321 , 2011 |
| Abstract : |
| PubMedSearch : Montoro-Garcia_2011_Biochem.J_436_321 |
| PubMedID: 21382014 |
| Gene_locus related to this paper: bacpu-AXE |
| Title : X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger - Nachon_2011_Biochem.J_434_73 |
| Author(s) : Nachon F , Carletti E , Wandhammer M , Nicolet Y , Schopfer LM , Masson P , Lockridge O |
| Ref : Biochemical Journal , 434 :73 , 2011 |
| Abstract : |
| PubMedSearch : Nachon_2011_Biochem.J_434_73 |
| PubMedID: 21091433 |
| Gene_locus related to this paper: human-BCHE |
| Title : X-ray crystallographic and MD simulation studies on the mechanism of interfacial activation of a family I.3 lipase with two lids - Angkawidjaja_2010_J.Mol.Biol_400_82 |
| Author(s) : Angkawidjaja C , Matsumura H , Koga Y , Takano K , Kanaya S |
| Ref : Journal of Molecular Biology , 400 :82 , 2010 |
| Abstract : |
| PubMedSearch : Angkawidjaja_2010_J.Mol.Biol_400_82 |
| PubMedID: 20438738 |
| Gene_locus related to this paper: psesp-Q9RBY1 |
| Title : Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis - Samanta_2008_J.Biol.Chem_283_31617 |
| Author(s) : Samanta U , Bahnson BJ |
| Ref : Journal of Biological Chemistry , 283 :31617 , 2008 |
| Abstract : |
| PubMedSearch : Samanta_2008_J.Biol.Chem_283_31617 |
| PubMedID: 18784071 |
| Gene_locus related to this paper: human-PLA2G7 |
| Title : Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging - Nachon_2005_Biochemistry_44_1154 |
| Author(s) : Nachon F , Asojo OA , Borgstahl GE , Masson P , Lockridge O |
| Ref : Biochemistry , 44 :1154 , 2005 |
| Abstract : |
| PubMedSearch : Nachon_2005_Biochemistry_44_1154 |
| PubMedID: 15667209 |
| Gene_locus related to this paper: human-BCHE |
| Title : Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines - Ronning_2000_Nat.Struct.Biol_7_141 |
| Author(s) : Ronning DR , Klabunde T , Besra GS , Vissa VD , Belisle JT , Sacchettini JC |
| Ref : Nat Struct Biol , 7 :141 , 2000 |
| Abstract : |
| PubMedSearch : Ronning_2000_Nat.Struct.Biol_7_141 |
| PubMedID: 10655617 |
| Gene_locus related to this paper: myctu-a85c |
| Title : Cutinase, a lipolytic enzyme with a preformed oxyanion hole - Martinez_1994_Biochemistry_33_83 |
| Author(s) : Martinez C , Nicolas A , van Tilbeurgh H , Egloff MP , Cudrey C , Verger R , Cambillau C |
| Ref : Biochemistry , 33 :83 , 1994 |
| Abstract : |
| PubMedSearch : Martinez_1994_Biochemistry_33_83 |
| PubMedID: 8286366 |
| Gene_locus related to this paper: fusso-cutas , orysa-LPL1 |
| Title : The crystal and molecular structure of the Rhizomucor miehei triacylglyceride lipase at 1.9 A resolution - Derewenda_1992_J.Mol.Biol_227_818 |
| Author(s) : Derewenda ZS , Derewenda U , Dodson GG |
| Ref : Journal of Molecular Biology , 227 :818 , 1992 |
| Abstract : |
| PubMedSearch : Derewenda_1992_J.Mol.Biol_227_818 |
| PubMedID: 1404390 |
| Gene_locus related to this paper: rhimi-lipas |