Nonafluoro-[(methylphenyl)hydrazinylidene]-oxoheptanoic-acid
Spcific for carboxylesterases no inhibition of AChE or BChE. Porcine carboxylesterase0.0421 +/- 0.0021. hCES1 with IC50 = 0.102 +/- 0.006 microM. hCES2, IC50 = 0.109 +/- 0.007 microM
General
Type : Trifluoro, Hydrazinylidene, Hydrazide
Chemical_Nomenclature : (2Z)-4,4,5,5,6,6,7,7,7-Nonafluoro-2-[2-(4-methylphenyl)hydrazinylidene]-3-oxoheptanoic acid
Canonical SMILES : O=C(C(=NNC1=CC=C(C=C1)C)C(=O)O)C(C(C(F)(F)C(F)(F)F)(F)F)(F)F
InChI : InChI=1S\/C14H9F9N2O3\/c1-6-2-4-7(5-3-6)24-25-8(10(27)28)9(26)11(15,16)12(17,18)13(19,20)14(21,22)23\/h2-5,24H,1H3,(H,27,28)
InChIKey : BPOKMWDYEYURFB-UHFFFAOYSA-N
Other name(s) :
hydrazinylidene]-oxoheptanoic-acid.gif)
Target
Families : Nonafluoro-[(methylphenyl)hydrazinylidene]-oxoheptanoic-acid ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES1
human-CES2
pig-EST1
References (3)
| Title : 2-Arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropanoic acids as selective and effective carboxylesterase inhibitors with powerful antioxidant potential - Burgart_2024_Bioorg.Med.Chem_115_117938 |
| Author(s) : Burgart YV , Makhaeva GF , Khudina OG , Krasnykh OP , Kovaleva NV , Elkina NA , Boltneva NP , Rudakova EV , Lushchekina SV , Shchegolkov EV , Triandafilova GA , Malysheva KO , Serebryakova OG , Borisevich SS , Ilyina MG , Zhilina EF , Saloutin VI , Charushin VN , Richardson RJ |
| Ref : Bioorganic & Medicinal Chemistry , 115 :117938 , 2024 |
| Abstract : |
| PubMedSearch : Burgart_2024_Bioorg.Med.Chem_115_117938 |
| PubMedID: 39504592 |
| Title : 2-Arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropanoic acids as selective and effective carboxylesterase inhibitors with powerful antioxidant potential - Burgart_2024_Bioorg.Med.Chem_115_117938 |
| Author(s) : Burgart YV , Makhaeva GF , Khudina OG , Krasnykh OP , Kovaleva NV , Elkina NA , Boltneva NP , Rudakova EV , Lushchekina SV , Shchegolkov EV , Triandafilova GA , Malysheva KO , Serebryakova OG , Borisevich SS , Ilyina MG , Zhilina EF , Saloutin VI , Charushin VN , Richardson RJ |
| Ref : Bioorganic & Medicinal Chemistry , 115 :117938 , 2024 |
| Abstract : |
| PubMedSearch : Burgart_2024_Bioorg.Med.Chem_115_117938 |
| PubMedID: 39504592 |
| Title : 2-Arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropanoic acids as selective and effective carboxylesterase inhibitors with powerful antioxidant potential - Burgart_2024_Bioorg.Med.Chem_115_117938 |
| Author(s) : Burgart YV , Makhaeva GF , Khudina OG , Krasnykh OP , Kovaleva NV , Elkina NA , Boltneva NP , Rudakova EV , Lushchekina SV , Shchegolkov EV , Triandafilova GA , Malysheva KO , Serebryakova OG , Borisevich SS , Ilyina MG , Zhilina EF , Saloutin VI , Charushin VN , Richardson RJ |
| Ref : Bioorganic & Medicinal Chemistry , 115 :117938 , 2024 |
| Abstract : |
| PubMedSearch : Burgart_2024_Bioorg.Med.Chem_115_117938 |
| PubMedID: 39504592 |