Berriman_2005_Science_309_416

Reference

Title : The genome of the African trypanosome Trypanosoma brucei - Berriman_2005_Science_309_416
Author(s) : Berriman M , Ghedin E , Hertz-Fowler C , Blandin G , Renauld H , Bartholomeu DC , Lennard NJ , Caler E , Hamlin NE , Haas B , Bohme U , Hannick L , Aslett MA , Shallom J , Marcello L , Hou L , Wickstead B , Alsmark UC , Arrowsmith C , Atkin RJ , Barron AJ , Bringaud F , Brooks K , Carrington M , Cherevach I , Chillingworth TJ , Churcher C , Clark LN , Corton CH , Cronin A , Davies RM , Doggett J , Djikeng A , Feldblyum T , Field MC , Fraser A , Goodhead I , Hance Z , Harper D , Harris BR , Hauser H , Hostetler J , Ivens A , Jagels K , Johnson D , Johnson J , Jones K , Kerhornou AX , Koo H , Larke N , Landfear S , Larkin C , Leech V , Line A , Lord A , MacLeod A , Mooney PJ , Moule S , Martin DM , Morgan GW , Mungall K , Norbertczak H , Ormond D , Pai G , Peacock CS , Peterson J , Quail MA , Rabbinowitsch E , Rajandream MA , Reitter C , Salzberg SL , Sanders M , Schobel S , Sharp S , Simmonds M , Simpson AJ , Tallon L , Turner CM , Tait A , Tivey AR , Van Aken S , Walker D , Wanless D , Wang S , White B , White O , Whitehead S , Woodward J , Wortman J , Adams MD , Embley TM , Gull K , Ullu E , Barry JD , Fairlamb AH , Opperdoes F , Barrell BG , Donelson JE , Hall N , Fraser CM , Melville SE , El-Sayed NM
Ref : Science , 309 :416 , 2005
Abstract :

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei. The 26-megabase genome contains 9068 predicted genes, including approximately 900 pseudogenes and approximately 1700 T. brucei-specific genes. Large subtelomeric arrays contain an archive of 806 variant surface glycoprotein (VSG) genes used by the parasite to evade the mammalian immune system. Most VSG genes are pseudogenes, which may be used to generate expressed mosaic genes by ectopic recombination. Comparisons of the cytoskeleton and endocytic trafficking systems with those of humans and other eukaryotic organisms reveal major differences. A comparison of metabolic pathways encoded by the genomes of T. brucei, T. cruzi, and Leishmania major reveals the least overall metabolic capability in T. brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.

PubMedSearch : Berriman_2005_Science_309_416
PubMedID: 16020726
Gene_locus related to this paper: tryb2-q6h9e3 , tryb2-q6ha27 , tryb2-q38cd5 , tryb2-q38cd6 , tryb2-q38cd7 , tryb2-q38dc1 , tryb2-q38de4 , tryb2-q38ds6 , tryb2-q38dx1 , tryb2-q380z6 , tryb2-q382c1 , tryb2-q382l4 , tryb2-q383a9 , tryb2-q386e3 , tryb2-q387r7 , tryb2-q388n1 , tryb2-q389w3 , trybr-PEPTB , trycr-q4cq28 , trycr-q4cq94 , trycr-q4cq95 , trycr-q4cq96 , trycr-q4csm0 , trycr-q4cwv3 , trycr-q4cx66 , trycr-q4cxr6 , trycr-q4cyc5 , trycr-q4cyf6 , trycr-q4d3a2 , trycr-q4d3x3 , trycr-q4d3y4 , trycr-q4d6h1 , trycr-q4d8h8 , trycr-q4d8h9 , trycr-q4d8i0 , trycr-q4d786 , trycr-q4d975 , trycr-q4da08 , trycr-q4dap6 , trycr-q4dbm2 , trycr-q4dbn1 , trycr-q4ddw7 , trycr-q4de42 , trycr-q4dhn8 , trycr-q4dkk8 , trycr-q4dkk9 , trycr-q4dm56 , trycr-q4dqa6 , trycr-q4dt91 , trycr-q4dvp2 , trycr-q4dw34 , trycr-q4dwm3 , trycr-q4dy49 , trycr-q4dy82 , trycr-q4dzp6 , trycr-q4e3m8 , trycr-q4e4t5 , trycr-q4e5d1 , trycr-q4e5z2

Related information

Gene_locus tryb2-q6h9e3    tryb2-q6ha27    tryb2-q38cd5    tryb2-q38cd6    tryb2-q38cd7    tryb2-q38dc1    tryb2-q38de4    tryb2-q38ds6    tryb2-q38dx1    tryb2-q380z6    tryb2-q382c1    tryb2-q382l4    tryb2-q383a9    tryb2-q386e3    tryb2-q387r7    tryb2-q388n1    tryb2-q389w3    trybr-PEPTB    trycr-q4cq28    trycr-q4cq94    trycr-q4cq95    trycr-q4cq96    trycr-q4csm0    trycr-q4cwv3    trycr-q4cx66    trycr-q4cxr6    trycr-q4cyc5    trycr-q4cyf6    trycr-q4d3a2    trycr-q4d3x3    trycr-q4d3y4    trycr-q4d6h1    trycr-q4d8h8    trycr-q4d8h9    trycr-q4d8i0    trycr-q4d786    trycr-q4d975    trycr-q4da08    trycr-q4dap6    trycr-q4dbm2    trycr-q4dbn1    trycr-q4ddw7    trycr-q4de42    trycr-q4dhn8    trycr-q4dkk8    trycr-q4dkk9    trycr-q4dm56    trycr-q4dqa6    trycr-q4dt91    trycr-q4dvp2    trycr-q4dw34    trycr-q4dwm3    trycr-q4dy49    trycr-q4dy82    trycr-q4dzp6    trycr-q4e3m8    trycr-q4e4t5    trycr-q4e5d1    trycr-q4e5z2
Gene_locus_frgt tryb2-q6h9e3    tryb2-q6ha27    tryb2-q38cd5    tryb2-q38cd6    tryb2-q38cd7    tryb2-q38dc1    tryb2-q38de4    tryb2-q38ds6    tryb2-q38dx1    tryb2-q380z6    tryb2-q382c1    tryb2-q382l4    tryb2-q383a9    tryb2-q386e3    tryb2-q387r7    tryb2-q388n1    tryb2-q389w3    trybr-PEPTB    trycr-q4cq28    trycr-q4cq94    trycr-q4cq95    trycr-q4cq96    trycr-q4csm0    trycr-q4cwv3    trycr-q4cx66    trycr-q4cxr6    trycr-q4cyc5    trycr-q4cyf6    trycr-q4d3a2    trycr-q4d3x3    trycr-q4d3y4    trycr-q4d6h1    trycr-q4d8h8    trycr-q4d8h9    trycr-q4d8i0    trycr-q4d786    trycr-q4d975    trycr-q4da08    trycr-q4dap6    trycr-q4dbm2    trycr-q4dbn1    trycr-q4ddw7    trycr-q4de42    trycr-q4dhn8    trycr-q4dkk8    trycr-q4dkk9    trycr-q4dm56    trycr-q4dqa6    trycr-q4dt91    trycr-q4dvp2    trycr-q4dw34    trycr-q4dwm3    trycr-q4dy49    trycr-q4dy82    trycr-q4dzp6    trycr-q4e3m8    trycr-q4e4t5    trycr-q4e5d1    trycr-q4e5z2    trycr-q4crk1    trycr-q4cw86    trycr-q4d995

Citations formats

Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Bohme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, MacLeod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM (2005)
The genome of the African trypanosome Trypanosoma brucei
Science 309 :416

Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Bohme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, MacLeod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM (2005)
Science 309 :416