Family: Homoserine_transacetylase

Block: X

Parent Family: Abhydrolase_6


Homoserine acetyltransferase (homoserine transacetylase; EC: catalyses the first step unique to methionine biosynthesis, converting L-homoserine to O-acetyl-L-homoserine using acetyl-CoA as an acetyl group donor. This enzyme is unique to fungi and some bacteria. This enzyme regulates homoserine in a number of biosynthetic pathways, making it vital to cell growth and viability. The biosynthesis of methionine in particular has been shown to be susceptible to small-molecule inhibition in fungi and is consequently a good candidate for antifungal agents PIRSF000443. A subset of this family was shown by Toelzer et al. to be esterases and unable to bind acetyl-CoA and was extracted as a new family (Homoserine_transacetylase_like_est)


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (18)

Genes Proteins in Homoserine_transacetylase family (427)

Fragments of genes in Homoserine_transacetylase family (1)

Structures in Homoserine_transacetylase family (18)

Substrates in Homoserine_transacetylase family (4)

Inhibitors in Homoserine_transacetylase family (2)

References (4)

Title : Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha\/beta-hydrolases - Mirza_2005_Biochemistry_44_15768
Author(s) : Mirza IA , Nazi I , Korczynska M , Wright GD , Berghuis AM
Ref : Biochemistry , 44 :15768 , 2005
PubMedID: 16313180
Gene_locus related to this paper: haein-metx

Title : Catalytic mechanism of fungal homoserine transacetylase - Nazi_2005_Biochemistry_44_13560
Author(s) : Nazi I , Wright GD
Ref : Biochemistry , 44 :13560 , 2005
PubMedID: 16216079

Title : Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Haemophilus influenzae met2-encoded homoserine transacetylase - Born_2000_Biochemistry_39_8556
Author(s) : Born TL , Franklin M , Blanchard JS
Ref : Biochemistry , 39 :8556 , 2000
PubMedID: 10913262
Gene_locus related to this paper: haein-metx

Title : The MET2 gene of Saccharomyces cerevisiae: molecular cloning and nucleotide sequence - Langin_1986_Gene_49_283
Author(s) : Langin T , Faugeron G , Goyon C , Nicolas A , Rossignol JL
Ref : Gene , 49 :283 , 1986
PubMedID: 3552887
Gene_locus related to this paper: yeast-met2