Homoserine_transacetylase
Relationship
Comment
Homoserine acetyltransferase (homoserine transacetylase; EC: 2.3.1.31) catalyses the first step unique to methionine biosynthesis, converting L-homoserine to O-acetyl-L-homoserine using acetyl-CoA as an acetyl group donor. This enzyme is unique to fungi and some bacteria. This enzyme regulates homoserine in a number of biosynthetic pathways, making it vital to cell growth and viability. The biosynthesis of methionine in particular has been shown to be susceptible to small-molecule inhibition in fungi and is consequently a good candidate for antifungal agents PIRSF000443. A subset of this family was shown by Toelzer et al. to be esterases and unable to bind acetyl-CoA and was extracted as a new family (Homoserine_transacetylase_like_est)
Database
Interpro : IPR008220 Homoserine\/serine acetyltransferase MetX-like HAT_MetX-like , IPR000073 Alpha\/beta hydrolase fold-1
PIRSF : PIRSF000443 homoserine acetyltransferase
Pdoc : No Pdoc
Pfam : PF00561 Abhydrolase_1
Prints : No Print
EC Number : 2.3.1.31
Structures (18)
Genes Proteins in Homoserine_transacetylase family (427)
Fragments of genes in Homoserine_transacetylase family (1)
Structures in Homoserine_transacetylase family (18)Substrates in Homoserine_transacetylase family (4)
Inhibitors in Homoserine_transacetylase family (2)
References (4)
| Title : Catalytic mechanism of fungal homoserine transacetylase - Nazi_2005_Biochemistry_44_13560 |
| Author(s) : Nazi I , Wright GD |
| Ref : Biochemistry , 44 :13560 , 2005 |
| PubMedID: 16216079 |
| Title : Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha\/beta-hydrolases - Mirza_2005_Biochemistry_44_15768 |
| Author(s) : Mirza IA , Nazi I , Korczynska M , Wright GD , Berghuis AM |
| Ref : Biochemistry , 44 :15768 , 2005 |
| PubMedID: 16313180 |
| Gene_locus related to this paper: haein-metx |
| Title : Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Haemophilus influenzae met2-encoded homoserine transacetylase - Born_2000_Biochemistry_39_8556 |
| Author(s) : Born TL , Franklin M , Blanchard JS |
| Ref : Biochemistry , 39 :8556 , 2000 |
| PubMedID: 10913262 |
| Gene_locus related to this paper: haein-metx |
| Title : The MET2 gene of Saccharomyces cerevisiae: molecular cloning and nucleotide sequence - Langin_1986_Gene_49_283 |
| Author(s) : Langin T , Faugeron G , Goyon C , Nicolas A , Rossignol JL |
| Ref : Gene , 49 :283 , 1986 |
| PubMedID: 3552887 |
| Gene_locus related to this paper: yeast-met2 |