Gene_locus Report for: gibm7-w7muq1 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). N-formylkynurenine formamidase
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Pezizomycotina: N E > leotiomyceta: N E > sordariomyceta: N E > Sordariomycetes: N E > Hypocreomycetidae: N E > Hypocreales: N E > Nectriaceae: N E > Fusarium: N E > Fusarium fujikuroi species complex: N E > Fusarium verticillioides: N E ABHD11-Acetyl_transferase :
gibm7-w7mt52 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein .
ABHD13-BEM46 :
gibm7-w7mv30 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Hydrolase_4 domain-containing protein .
Canar_LipB :
gibm7-w7n1b5 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) Uncharacterized protein .
Carb_B_Bacteria :
gibm7-w7m4v2 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) (contaminant from bacteria?). Uncharacterized protein .
Dienelactone_hydrolase :
gibm7-dlh1 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Fusarium detoxification of benzoxazolinone cluster 1 protein DLH1 .
Fungal_carboxylesterase_lipase :
gibm7-w7mak5 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7mum7 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7maw6 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7msi0 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7luf0 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7msa3 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7mna8 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7n8b7 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7n564 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7ngc3 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7m4v6 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7lt61 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7mly6 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein ,
gibm7-w7ncn3 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein .
GTSAGmotif :
gibm7-w7n497 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) Uncharacterized protein .
HOD-cofactorfree-dioxygenase :
gibm7-w7mcf8 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Uncharacterized protein .
Hormone-sensitive_lipase_like :
gibm7-fdb39 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). Fusarium detoxification of benzoxazolinone cluster 2 protein FVEG_12639 .
Kynurenine-formamidase :
gibm7-w7n526 Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides). N-formylkynurenine formamidase .
Thioesterase :
gibmo-q6rkl1 Gibberella moniliformis polyketide synthase (fragment) .
Thiohydrolase :
gibm7-w7n4n0 Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium verticillioides); Gibberella nygamai (Bean root rot disease fungus) (Fusarium nygamai).; Fusarium oxysporum, Hydrolase_4 domain-containing protein Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: gibm7-w7muq1 Colored MSA for Kynurenine-formamidase (raw)
MADIAEDKSLGLTYASHQYGKHDRQKLGVWRFADRPAQKTGYWVVFIHGG
AWRDPRNNENDFTESIKRIVISGAVAILDIAGFVSIDYRLSPHPDFPQES
ATIKHPGHLEDIWSALNYLQGKYELSNNYILVGHSAGATLAFQLLMSGDI
LASHPKGPLPLAIVGVSGIFDLVGLNDRHNGGYAGFIEAAFGDDESAWEK
ASPARFGSSFRDNWASGKLAMLAWSTEDTLIDEPEIDNMASLLTEQGLKV
EVNKHLRGEHDFVWHDGSQIARLVITTLHHLNRI
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M A D I A E D K S L G L T Y A S H Q Y G K H D R Q K L G V W R F A D R P A Q K T G Y W V V F I H G G A W R D P R N N E N D F T E S I K R I V I S G A V A I L D I A G F V S I D Y R L S P H P D F P Q E S A T I K H P G H L E D I W S A L N Y L Q G K Y E L S N N Y I L V G H S A G A T L A F Q L L M S G D I L A S H P K G P L P L A I V G V S G I F D L V G L N D R H N G G Y A G F I E A A F G D D E S A W E K A S P A R F G S S F R D N W A S G K L A M L A W S T E D T L I D E P E I D N M A S L L T E Q G L K V E V N K H L R G E H D F V W H D G S Q I A R L V I T T L H H L N R I
Reference
Title: Comparative genomics reveals mobile pathogenicity chromosomes in FusariumMa LJ , van der Does HC , Borkovich KA , Coleman JJ , Daboussi MJ , Di Pietro A , Dufresne M , Freitag M , Grabherr M and Rep M <53 more author(s)> Ma LJ , van der Does HC , Borkovich KA , Coleman JJ , Daboussi MJ , Di Pietro A , Dufresne M , Freitag M , Grabherr M , Henrissat B , Houterman PM , Kang S , Shim WB , Woloshuk C , Xie X , Xu JR , Antoniw J , Baker SE , Bluhm BH , Breakspear A , Brown DW , Butchko RA , Chapman S , Coulson R , Coutinho PM , Danchin EG , Diener A , Gale LR , Gardiner DM , Goff S , Hammond-Kosack KE , Hilburn K , Hua-Van A , Jonkers W , Kazan K , Kodira CD , Koehrsen M , Kumar L , Lee YH , Li L , Manners JM , Miranda-Saavedra D , Mukherjee M , Park G , Park J , Park SY , Proctor RH , Regev A , Ruiz-Roldan MC , Sain D , Sakthikumar S , Sykes S , Schwartz DC , Turgeon BG , Wapinski I , Yoder O , Young S , Zeng Q , Zhou S , Galagan J , Cuomo CA , Kistler HC , Rep M (- 53) Ref: Nature, 464 :367, 2010 : PubMed Abstract ESTHER: Ma_2010_Nature_464_367 PubMedSearch: Ma 2010 Nature 464 367 PubMedID: 20237561 Gene_locus related to this paper: fusox-a0a1d3s5h0 ,
gibf5-fus2 ,
fusof-f9f2k2 ,
fusof-f9f3l6 ,
fusof-f9f6t8 ,
fusof-f9f6v2 ,
fusof-f9f132 ,
fusof-f9f781 ,
fusof-f9fd72 ,
fusof-f9fd90 ,
fusof-f9fem0 ,
fusof-f9fhk2 ,
fusof-f9fj19 ,
fusof-f9fj20 ,
fusof-f9fki8 ,
fusof-f9fmx2 ,
fusof-f9fnt4 ,
fusof-f9fpy4 ,
fusof-f9fvs6 ,
fusof-f9fwu0 ,
fusof-f9fxz4 ,
fusof-f9fzy5 ,
fusof-f9g2a2 ,
fusof-f9g3b1 ,
fusof-f9g5h7 ,
fusof-f9g6e6 ,
fusof-f9g6y7 ,
fusof-f9g7b0 ,
fusof-f9g797 ,
fusof-f9g972 ,
fusof-f9ga50 ,
fusof-f9gck4 ,
fusof-f9gd15 ,
gibze-a8w610 ,
gibze-b1pdn0 ,
gibze-i1r9e6 ,
gibze-i1rda9 ,
gibze-i1rdk7 ,
gibze-i1rec8 ,
gibze-i1rgs0 ,
gibze-i1rgy0 ,
gibze-i1rh52 ,
gibze-i1rhi8 ,
gibze-i1rig9 ,
gibze-i1rip5 ,
gibze-i1rpg6 ,
gibze-i1rsg2 ,
gibze-i1rv36 ,
gibze-i1rxm5 ,
gibze-i1rxp8 ,
gibze-i1rxv5 ,
gibze-i1s1u3 ,
gibze-i1s3j9 ,
gibze-i1s6l7 ,
gibze-i1s8i8 ,
gibze-i1s9x4 ,
gibze-q4huy1 ,
gibze-i1rg17 ,
fuso4-j9mvr9 ,
fuso4-j9ngs6 ,
fuso4-j9niq8 ,
fuso4-j9nqm2 ,
gibze-i1rb76 ,
gibze-i1s1m7 ,
gibze-i1s3z6 ,
gibze-i1rd78 ,
gibze-i1rgl9 ,
gibze-i1rjp7 ,
gibze-i1s1q6 ,
gibze-i1ri35 ,
gibze-i1rf76 ,
gibze-i1rhp3 ,
fusc1-n4uj11 ,
fusc4-n1s9p6 ,
gibf5-s0dqr2 ,
gibm7-w7n1b5 ,
fusof-f9g6q0 ,
gibm7-w7n497 ,
fusox-x0bme4 ,
gibm7-w7mcf8 ,
gibm7-w7mak5 ,
fusox-x0a2c5 ,
gibm7-w7mum7 ,
fusox-w9iyc7 ,
gibm7-w7maw6 ,
gibm7-w7msi0 ,
gibm7-w7luf0 ,
gibm7-w7msa3 ,
gibm7-w7mna8 ,
gibm7-w7n8b7 ,
gibm7-w7n564 ,
fusox-w9jpi0 ,
gibm7-w7ngc3 ,
gibm7-w7m4v6 ,
gibm7-w7m4v2 ,
gibm7-w7lt61 ,
gibm7-w7mly6 ,
gibm7-w7ncn3 ,
fusox-w9ibd7 ,
fusof-f9fnm6 ,
gibm7-w7n526 ,
gibza-a0a016pda4 ,
gibza-a0a016pl96 ,
gibm7-w7muq1 ,
fusof-f9gfd3 ,
gibm7-w7mt52 ,
gibze-i1rjb5 ,
gibf5-s0ehu3 ,
fusox-w9hvf0 ,
gibze-i1rkc4 ,
gibm7-w7mv30 ,
gibze-a0a1c3ylb1 ,
fuso4-a0a0c4diy4 ,
gibm7-w7n4n0 ,
gibze-gra11 ,
gibze-fsl2 ,
gibf5-fub4 ,
gibf5-fub5 ,
gibf5-fus5 ,
gibm7-dlh1 Abstract
Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species: Fusarium graminearum, Fusarium verticillioides and Fusarium oxysporum f. sp. lycopersici. Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective.
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