Methylthiophen-tacrine-Amine-cpd5m
IC50 AChE 0.334 +/- 0.008 microM; BChE 0.165 +/- 0.004 microM cholinesterase inhibition, potent and voltage-independent NMDA receptor antagonism, blood-brain barrier permeability
General
Type : Multitarget, NMDA-Ligand, Derivative of Tacrine, Sulfure compound
Chemical_Nomenclature : 7-(4-methylthiophen-2-yl)-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
Canonical SMILES : C1(=CC=C2C(=C1)C(=C3C(=N2)CCCC3)N)C4=CC(=CS4)C
InChI : InChI=1S\/C18H18N2S\/c1-11-8-17(21-10-11)12-6-7-16-14(9-12)18(19)13-4-2-3-5-15(13)20-16\/h6-10H,2-5H2,1H3,(H2,19,20)
InChIKey : UUIMCDFDPAKGBU-UHFFFAOYSA-N
Other name(s) :
MW : 294.414
Formula : C18H18N2S || C18H19N2S+
CAS_number :
PubChem :
UniChem : UUIMCDFDPAKGBU-UHFFFAOYSA-N
Target
Families : Methylthiophen-tacrine-Amine-cpd5m ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment - Svobodova_2025_Eur.J.Med.Chem_292_117678 |
| Author(s) : Svobodova B , Moravcova Z , Misiachna A , Novakova G , Marek A , Finger V , Odvarkova J , Pejchal J , Karasova JZ , Netolicky J , Ladislav M , Hrabinova M , Sorf A , Muckova L , Fikejzlova L , Benkova M , Novak M , Prchal L , Capek J , Handl J , Rousar T , Greber KE , Ciura K , Horak M , Soukup O , Korabecny J |
| Ref : Eur Journal of Medicinal Chemistry , 292 :117678 , 2025 |
| Abstract : |
| PubMedSearch : Svobodova_2025_Eur.J.Med.Chem_292_117678 |
| PubMedID: 40288120 |