Inhibitor of DAGL but inhibits also ABHD6 HSL MGLL and CES1. However Baggelaar et al.2013 found no inhibition of DAGLA
Type : Carbamate
Chemical_Nomenclature : (cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate
Canonical SMILES : C1CCC(=NOC(=O)NCCCCCCNC(=O)ON=C2CCCCC2)CC1
InChI : InChI=1S\/C20H34N4O4\/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18\/h1-16H2,(H,21,25)(H,22,26)
InChIKey : RXSVYGIGWRDVQC-UHFFFAOYSA-N
Other name(s) : Rhc 80267, RHC-80267, U 57908, 83654-05-1, Rg 80267, 1,6-Bis(cyclohexyloximinocarbonyl)hexane
MW : 394.50
Formula : C20H34N4O4
CAS_number :
PubChem : 5063
UniChem : RXSVYGIGWRDVQC-UHFFFAOYSA-N
IUPHAR : 5255
Families : Rhc80267 ligand of proteins in family
Lipase_3
Carb_B_Chordata
ABHD6-Lip
Hormone-sensitive_lipase_like
Monoglyceridelipase_lysophospholip
Protein :
human-DAGLA
human-DAGLB
Title : Identification and Evaluation of Inhibitors of Lipase from Malassezia restricta using Virtual High-Throughput Screening and Molecular Dynamics Studies - Ali_2019_Int.J.Mol.Sci_20_ |
Author(s) : Ali S , Khan FI , Mohammad T , Lan D , Hassan MI , Wang Y |
Ref : Int J Mol Sci , 20 : , 2019 |
PubMedID: 30781686 |
Title : Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors - Iglesias_2016_J.Lipid.Res_57_131 |
Author(s) : Iglesias J , Lamontagne J , Erb H , Gezzar S , Zhao S , Joly E , Truong VL , Skorey K , Crane S , Madiraju SR , Prentki M |
Ref : J Lipid Res , 57 :131 , 2016 |
PubMedID: 26423520 |
Title : Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-alpha in brain - |
Author(s) : Baggelaar MP , Janssen FJ , van Esbroeck AC , den Dulk H , Allara M , Hoogendoorn S , McGuire R , Florea BI , Meeuwenoord N , van den Elst H , van der Marel GA , Brouwer J , Di Marzo V , Overkleeft HS , van der Stelt M |
Ref : Angew Chem Int Ed Engl , 52 :12081 , 2013 |
PubMedID: 24173880 |
Gene_locus related to this paper: human-DAGLA |
Title : Assay and inhibition of diacylglycerol lipase activity - Johnston_2012_Bioorg.Med.Chem.Lett_22_4585 |
Author(s) : Johnston M , Bhatt SR , Sikka S , Mercier RW , West JM , Makriyannis A , Gatley SJ , Duclos RI, Jr. |
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :4585 , 2012 |
PubMedID: 22738638 |
Title : Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling - Hoover_2008_Bioorg.Med.Chem.Lett_18_5838 |
Author(s) : Hoover HS , Blankman JL , Niessen S , Cravatt BF |
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5838 , 2008 |
PubMedID: 18657971 |
Title : L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity - Liu_2008_J.Cell.Physiol_216_91 |
Author(s) : Liu L , Heneghan JF , Michael GJ , Stanish LF , Egertova M , Rittenhouse AR |
Ref : Journal of Cellular Physiology , 216 :91 , 2008 |
PubMedID: 18247369 |
Title : Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils - Dale_1987_Br.J.Pharmacol_92_63 |
Author(s) : Dale MM , Penfield A |
Ref : British Journal of Pharmacology , 92 :63 , 1987 |
PubMedID: 2822195 |