Russian-VX
Similar to VX
General
Type : Chemical Warfare Agent, Organophosphate, Nerve Agent V-series, Sulfur Compound
Chemical_Nomenclature : S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate
Canonical SMILES : CCN(CC)CCSP(=O)(C)OCC(C)C
InChI : InChI=1S\/C11H26NO2PS\/c1-6-12(7-2)8-9-16-15(5,13)14-10-11(3)4\/h11H,6-10H2,1-5H3
InChIKey : MNLAVFKVRUQAKW-UHFFFAOYSA-N
Other name(s) : S-[2-(diethylamino)ethyl] O-2-methylpropyl ester || VR nerve agent || Russian VX || R-VX || RVX || V-gas || S-(N,N-DEA)IMPT || VR || R 33 || R-33 || Substance-33 || Substance 33
MW : 267.368
Formula : C11H26NO2PS
CAS_number : 159939-87-4
PubChem : 178033
UniChem : MNLAVFKVRUQAKW-UHFFFAOYSA-N
Target
Families : Russian-VX ligand of proteins in family
ACHE
BCHE
Protein :
mouse-ACHE
human-BCHE
References (17)
| Title : The reactivation kinetic analysis, molecular docking, and dynamics of oximes against three V-type nerve agents inhibited four human cholinesterases - Li_2024_Chem.Biol.Interact__111061 |
| Author(s) : Li K , Liu Y , Li Q , Guo L , Xie J |
| Ref : Chemico-Biological Interactions , :111061 , 2024 |
| Abstract : |
| PubMedSearch : Li_2024_Chem.Biol.Interact__111061 |
| PubMedID: 38763347 |
| Title : The prediction of acute toxicity (LD(50)) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods - Noga_2023_Arch.Toxicol_98_267 |
| Author(s) : Noga M , Michalska A , Jurowski K |
| Ref : Archives of Toxicology , 98 :267 , 2023 |
| Abstract : |
| PubMedSearch : Noga_2023_Arch.Toxicol_98_267 |
| PubMedID: 38051368 |
| Title : The kinetic and molecular docking analysis of interactions between three V-type nerve agents and four human cholinesterases - Li_2023_Chem.Biol.Interact_372_110369 |
| Author(s) : Li K , Liu Y , Li Q , Guo L , Xie J |
| Ref : Chemico-Biological Interactions , 372 :110369 , 2023 |
| Abstract : |
| PubMedSearch : Li_2023_Chem.Biol.Interact_372_110369 |
| PubMedID: 36708975 |
| Title : Tracing and attribution of V-type nerve agents in human exposure by strategy of assessing the phosphonylated and disulfide adducts on ceruloplasmin - Fu_2019_Toxicology_430_152346 |
| Author(s) : Fu F , Chen J , Zhao P , Lu X , Gao R , Chen D , Liu H , Wang H , Pei C |
| Ref : Toxicology , 430 :152346 , 2019 |
| Abstract : |
| PubMedSearch : Fu_2019_Toxicology_430_152346 |
| PubMedID: 31857189 |
| Title : Novichok agents: a historical, current, and toxicological perspective - Chai_2018_Toxicol.Commun_2_45 |
| Author(s) : Chai PR , Hayes BD , Erickson TB , Boyer EW |
| Ref : Toxicol Commun , 2 :45 , 2018 |
| Abstract : |
| PubMedSearch : Chai_2018_Toxicol.Commun_2_45 |
| PubMedID: 30003185 |
| Title : Determination of the structural features of O-alkyl-S-2-(N,N-dialkylamino) ethyl alkylthiophosphonates from their electron ionization mass spectra - Terentyev_2016_J.Anal.Chem_71_1266 |
| Author(s) : Terentyev AG , Morozik YI , Rybal'chenko IV , Dudkin AV , Smirnov AO , Galyaev GV |
| Ref : Journal of Analytical Chemistry , 71 :1266 , 2016 |
| Abstract : |
| PubMedSearch : Terentyev_2016_J.Anal.Chem_71_1266 |
| PubMedID: |
| Title : Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity - Artursson_2013_Biochem.Pharmacol_85_1389 |
| Author(s) : Artursson E , Andersson PO , Akfur C , Linusson A , Borjegren S , Ekstrom F |
| Ref : Biochemical Pharmacology , 85 :1389 , 2013 |
| Abstract : |
| PubMedSearch : Artursson_2013_Biochem.Pharmacol_85_1389 |
| PubMedID: 23376121 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Microplate biochemical determination of Russian VX: influence of admixtures and avoidance of false negative results - Prokofieva_2012_Anal.Biochem_424_108 |
| Author(s) : Prokofieva DS , Jenkins RO , Goncharov NV |
| Ref : Analytical Biochemistry , 424 :108 , 2012 |
| Abstract : |
| PubMedSearch : Prokofieva_2012_Anal.Biochem_424_108 |
| PubMedID: 22381367 |
| Title : Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures - Mikler_2011_Toxicol.Lett_206_47 |
| Author(s) : Mikler J , Tenn C , Worek F , Reiter G , Thiermann H , Garrett M , Bohnert S , Sawyer TW |
| Ref : Toxicol Lett , 206 :47 , 2011 |
| Abstract : |
| PubMedSearch : Mikler_2011_Toxicol.Lett_206_47 |
| PubMedID: 21704135 |
| Title : Human serum butyrylcholinesterase as a prophylaxis against russian VX - Karasova_2011_Mil.Med.Sci.Lett_80_97 |
| Author(s) : Karasova JZ , Kuca K , Jun D , Bajgar J |
| Ref : Military Medical Science Letters , 80 :97 , 2011 |
| Abstract : |
| PubMedSearch : Karasova_2011_Mil.Med.Sci.Lett_80_97 |
| PubMedID: |
| Title : Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX - Hajek_2009_Drug.Chem.Toxicol_32_1 |
| Author(s) : Hajek P , Bajgar J , Slizova D , Krs O , Kuca K , Capek L , Fusek J |
| Ref : Drug & Chemical Toxicology , 32 :1 , 2009 |
| Abstract : |
| PubMedSearch : Hajek_2009_Drug.Chem.Toxicol_32_1 |
| PubMedID: 19514933 |
| Title : Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX - Karasova_2009_Neurotox.Res_16_356 |
| Author(s) : Karasova JZ , Bajgar J , Jun D , Pavlikova R , Kuca K |
| Ref : Neurotox Res , 16 :356 , 2009 |
| Abstract : |
| PubMedSearch : Karasova_2009_Neurotox.Res_16_356 |
| PubMedID: 19728005 |
| Title : Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX) - Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203 |
| Author(s) : Musilek K , Kuca K , Jun D |
| Ref : Acta Medica (Hradec Kralove) , 50 :203 , 2007 |
| Abstract : |
| PubMedSearch : Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203 |
| PubMedID: 18254274 |
| Title : The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings - Kassa_2006_Int.J.Toxicol_25_397 |
| Author(s) : Kassa J , Jun D , Kuca K |
| Ref : Int J Toxicol , 25 :397 , 2006 |
| Abstract : |
| PubMedSearch : Kassa_2006_Int.J.Toxicol_25_397 |
| PubMedID: 16940011 |
| Title : Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent - Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389 |
| Author(s) : Kuca K , Jun D , Cabal J , Hrabinova M , Bartosova L , Opletalova V |
| Ref : Basic Clin Pharmacol Toxicol , 98 :389 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389 |
| PubMedID: 16623863 |
| Title : Oxidative biodegradation of phosphorothiolates by fungal laccase - Amitai_1998_FEBS.Lett_438_195 |
| Author(s) : Amitai G , Adani R , Sod-Moriah G , Rabinovitz I , Vincze A , Leader H , Chefetz B , Leibovitz-Persky L , Friesem D , Hadar Y |
| Ref : FEBS Letters , 438 :195 , 1998 |
| Abstract : |
| PubMedSearch : Amitai_1998_FEBS.Lett_438_195 |
| PubMedID: 9827544 |
| Title : Enzymatic hydrolysis of Russian-VX by organophosphorus hydrolase - Rastogi_1997_Biochem.Biophys.Res.Commun_241_294 |
| Author(s) : Rastogi VK , DeFrank JJ , Cheng TC , Wild JR |
| Ref : Biochemical & Biophysical Research Communications , 241 :294 , 1997 |
| Abstract : |
| PubMedSearch : Rastogi_1997_Biochem.Biophys.Res.Commun_241_294 |
| PubMedID: 9425265 |