Salicylamide-8-Tacrine
Human RBC AChE, IC50 [microM] 0.224+/-0.017; Equine Serum BChE, IC50 [microM] 0.0104+/-0.0013; Porcine Liver CES, [%inhibition at 20microM] 29.5+/-2.5
General
Type : Multitarget, Derivative of Tacrine, Alkyl linked bis-ligand, Antioxidant, Salicylic
Chemical_Nomenclature : N-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl)salicylamide
Canonical SMILES : C1=CC=C2C(=C1)C(=C3C(=N2)CCCC3)NCCCCCCCCNC(=O)C4=C(C=CC=C4)O
InChI : InChI=1S\/C28H35N3O2\/c32-26-18-10-7-15-23(26)28(33)30-20-12-4-2-1-3-11-19-29-27-21-13-5-8-16-24(21)31-25-17-9-6-14-22(25)27\/h5,7-8,10,13,15-16,18,32H,1-4,6,9,11-12,14,17,19-20H2,(H,29,31)(H,30,33)
InChIKey : QTVMLHKUVQWJDT-UHFFFAOYSA-N
Other name(s) : 6d
Target
Families : Salicylamide-8-Tacrine ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease - Grishchenko_2022_ChemMedChem__e202200080 |
| Author(s) : Grishchenko MV , Makhaeva GF , Burgart YV , Rudakova EV , Boltneva NP , Kovaleva NV , Serebryakova OG , Lushchekina SV , Astakhova TY , Zhilina EF , Shchegolkov EV , Richardson RJ , Saloutin VI |
| Ref : ChemMedChem , :e202200080 , 2022 |
| Abstract : |
| PubMedSearch : Grishchenko_2022_ChemMedChem__e202200080 |
| PubMedID: 35322571 |