Plant_lipase_EDS1-like
Relationship
Comment
Enhanced Disease Susceptibility 1 (EDS1), an essential component of R gene-mediated disease resistance. The Arabidopsis EDS1 (arath-eds1) and (phytoalexin-deficient 4) PAD4 (arath-PAD4) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4. EDS1 (arath-eds1) and PAD4 (arath-PAD4) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). This family is extracted from the Lipase3 gene family. The C-terminal domain known as the EP domain and its interface consists of hydrophobic interactions, salt bridges, and an extensive hydrogen bonding network. Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1/EDS1/SAG101 and ADR1/EDS1/PAD4) mediate TNL receptor defence signalling. (In the seed alignment and the HMM alignement the EP domain (not alpha/beta hydrolase domain) is excluded)Database
Interpro : IPR000734 Lipase , IPR044214 EDS1-like , IPR041266 EDS1, EP domain EDS1_EP
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF01764 Lipase_3 , PF18117 EDS1_EP
Prints : PR00821
EC Number : No EC Number
References (14)
| Title : METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress - Bernacki_2024_Int.J.Mol.Sci_25_3195 |
| Author(s) : Bernacki MJ , Rusaczonek A , Golebiewska K , Majewska-Fala AB , Czarnocka W , Karpinski SM |
| Ref : Int J Mol Sci , 25 :3195 , 2024 |
| Abstract : Bernacki_2024_Int.J.Mol.Sci_25_3195 |
| ESTHER : Bernacki_2024_Int.J.Mol.Sci_25_3195 |
| PubMedSearch : Bernacki_2024_Int.J.Mol.Sci_25_3195 |
| PubMedID: 38542169 |
| Title : The NLR immune receptor ADR1 and lipase-like proteins EDS1 and PAD4 mediate stomatal immunity in Nicotiana benthamiana and Arabidopsis - Wang_2023_Plant.Cell__ |
| Author(s) : Wang H , Song S , Gao S , Yu Q , Zhang H , Cui X , Fan J , Xin X , Liu Y , Staskawicz B , Qi T |
| Ref : Plant Cell , : , 2023 |
| Abstract : Wang_2023_Plant.Cell__ |
| ESTHER : Wang_2023_Plant.Cell__ |
| PubMedSearch : Wang_2023_Plant.Cell__ |
| PubMedID: 37851863 |
| Title : Plant immune signaling network mediated by helper NLRs - Gong_2023_Curr.Opin.Plant.Biol_73_102354 |
| Author(s) : Gong Y , Tian L , Kontos I , Li J , Li X |
| Ref : Curr Opin Plant Biol , 73 :102354 , 2023 |
| Abstract : Gong_2023_Curr.Opin.Plant.Biol_73_102354 |
| ESTHER : Gong_2023_Curr.Opin.Plant.Biol_73_102354 |
| PubMedSearch : Gong_2023_Curr.Opin.Plant.Biol_73_102354 |
| PubMedID: 37003229 |
| Title : Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity - Dongus_2022_Plant.J__ |
| Author(s) : Dongus JA , Bhandari DD , Penner E , Lapin D , Stolze SC , Harzen A , Patel M , Archer L , Dijkgraaf L , Shah J , Nakagami H , Parker JE |
| Ref : Plant J , : , 2022 |
| Abstract : Dongus_2022_Plant.J__ |
| ESTHER : Dongus_2022_Plant.J__ |
| PubMedSearch : Dongus_2022_Plant.J__ |
| PubMedID: 35324052 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity - Sun_2021_Nat.Commun_12_3335 |
| Author(s) : Sun X , Lapin D , Feehan JM , Stolze SC , Kramer K , Dongus JA , Rzemieniewski J , Blanvillain-Baufume S , Harzen A , Bautor J , Derbyshire P , Menke FLH , Finkemeier I , Nakagami H , Jones JDG , Parker JE |
| Ref : Nat Commun , 12 :3335 , 2021 |
| Abstract : Sun_2021_Nat.Commun_12_3335 |
| ESTHER : Sun_2021_Nat.Commun_12_3335 |
| PubMedSearch : Sun_2021_Nat.Commun_12_3335 |
| PubMedID: 34099661 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : Origins and Immunity Networking Functions of EDS1 Family Proteins - Lapin_2020_Annu.Rev.Phytopathol__ |
| Author(s) : Lapin D , Bhandari DD , Parker JE |
| Ref : Annu Rev Phytopathol , : , 2020 |
| Abstract : Lapin_2020_Annu.Rev.Phytopathol__ |
| ESTHER : Lapin_2020_Annu.Rev.Phytopathol__ |
| PubMedSearch : Lapin_2020_Annu.Rev.Phytopathol__ |
| PubMedID: 32396762 |
| Title : A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors - Lapin_2019_Plant.Cell_31_2430 |
| Author(s) : Lapin D , Kovacova V , Sun X , Dongus JA , Bhandari D , von Born P , Bautor J , Guarneri N , Rzemieniewski J , Stuttmann J , Beyer A , Parker JE |
| Ref : Plant Cell , 31 :2430 , 2019 |
| Abstract : Lapin_2019_Plant.Cell_31_2430 |
| ESTHER : Lapin_2019_Plant.Cell_31_2430 |
| PubMedSearch : Lapin_2019_Plant.Cell_31_2430 |
| PubMedID: 31311833 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : Comparative genomic analysis of the Lipase3 gene family in five plant species reveals distinct evolutionary origins - Wang_2018_Genetica_146_179 |
| Author(s) : Wang D , Zhang L , Hu J , Gao D , Liu X , Sha Y |
| Ref : Genetica , 146 :179 , 2018 |
| Abstract : Wang_2018_Genetica_146_179 |
| ESTHER : Wang_2018_Genetica_146_179 |
| PubMedSearch : Wang_2018_Genetica_146_179 |
| PubMedID: 29468429 |
| Title : EDS1 contributes to nonhost resistance of Arabidopsis thaliana against Erwinia amylovora - Moreau_2012_Mol.Plant.Microbe.Interact_25_421 |
| Author(s) : Moreau M , Degrave A , Vedel R , Bitton F , Patrit O , Renou JP , Barny MA , Fagard M |
| Ref : Mol Plant Microbe Interact , 25 :421 , 2012 |
| Abstract : Moreau_2012_Mol.Plant.Microbe.Interact_25_421 |
| ESTHER : Moreau_2012_Mol.Plant.Microbe.Interact_25_421 |
| PubMedSearch : Moreau_2012_Mol.Plant.Microbe.Interact_25_421 |
| PubMedID: 22316300 |
| Gene_locus related to this paper: arath-eds1 |
| Title : Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101 - Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245 |
| Author(s) : Wagner S , Rietz S , Parker JE , Niefind K |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :245 , 2011 |
| Abstract : Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245 |
| ESTHER : Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245 |
| PubMedSearch : Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245 |
| PubMedID: 21301097 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : A functional EDS1 ortholog is differentially regulated in powdery mildew resistant and susceptible grapevines and complements an Arabidopsis eds1 mutant - Gao_2010_Planta_231_1037 |
| Author(s) : Gao F , Shu X , Ali MB , Howard S , Li N , Winterhagen P , Qiu W , Gassmann W |
| Ref : Planta , 231 :1037 , 2010 |
| Abstract : Gao_2010_Planta_231_1037 |
| ESTHER : Gao_2010_Planta_231_1037 |
| PubMedSearch : Gao_2010_Planta_231_1037 |
| PubMedID: 20145949 |
| Gene_locus related to this paper: arath-eds1 |
| Title : Balanced nuclear and cytoplasmic activities of EDS1 are required for a complete plant innate immune response - Garcia_2010_PLoS.Pathog_6_e1000970 |
| Author(s) : Garcia AV , Blanvillain-Baufume S , Huibers RP , Wiermer M , Li G , Gobbato E , Rietz S , Parker JE |
| Ref : PLoS Pathog , 6 :e1000970 , 2010 |
| Abstract : Garcia_2010_PLoS.Pathog_6_e1000970 |
| ESTHER : Garcia_2010_PLoS.Pathog_6_e1000970 |
| PubMedSearch : Garcia_2010_PLoS.Pathog_6_e1000970 |
| PubMedID: 20617163 |
| Gene_locus related to this paper: arath-eds1 |
| Title : Plant immunity: the EDS1 regulatory node - Wiermer_2005_Curr.Opin.Plant.Biol_8_383 |
| Author(s) : Wiermer M , Feys BJ , Parker JE |
| Ref : Curr Opin Plant Biol , 8 :383 , 2005 |
| Abstract : Wiermer_2005_Curr.Opin.Plant.Biol_8_383 |
| ESTHER : Wiermer_2005_Curr.Opin.Plant.Biol_8_383 |
| PubMedSearch : Wiermer_2005_Curr.Opin.Plant.Biol_8_383 |
| PubMedID: 15939664 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |
| Title : EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases - Falk_1999_Proc.Natl.Acad.Sci.U.S.A_96_3292 |
| Author(s) : Falk A , Feys BJ , Frost LN , Jones JDG , Daniels MJ , Parker JE |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 96 :3292 , 1999 |
| Abstract : Falk_1999_Proc.Natl.Acad.Sci.U.S.A_96_3292 |
| ESTHER : Falk_1999_Proc.Natl.Acad.Sci.U.S.A_96_3292 |
| PubMedSearch : Falk_1999_Proc.Natl.Acad.Sci.U.S.A_96_3292 |
| PubMedID: 10077677 |
| Gene_locus related to this paper: arath-eds1 |
Structures (10)
Genes Proteins in Plant_lipase_EDS1-like family (167)
Fragments of genes in Plant_lipase_EDS1-like family (15)
Structures in Plant_lipase_EDS1-like family (10)Substrates in Plant_lipase_EDS1-like family (3)
No Inhibitor