Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Plant_lipase_EDS1-like

Plant_lipase_EDS1-like



Relationship
Block L
Comment
Enhanced Disease Susceptibility 1 (EDS1), an essential component of R gene-mediated disease resistance. The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4. EDS1 (arath-eds1) and PAD4 (arath-F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). This family is extracted from the Lipase3 gene family. The C-terminal domain known as the EP domain and its interface consists of hydrophobic interactions, salt bridges, and an extensive hydrogen bonding network. Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1/EDS1/SAG101 and ADR1/EDS1/PAD4) mediate TNL receptor defence signalling. (In the seed alignment and the HMM alignement the EP domain (not alpha/beta hydrolase domain) is excluded)

Database
Sequences
Interpro
|
IPR000734 (Lipase), IPR044214 (EDS1-like), IPR041266 (EDS1, EP domain EDS1_EP)
PIRSF
|
Pdoc
|
PFam
|
PF01764 (Lipase_3), PF18117 (EDS1_EP)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
10 more
    Title: Plant immune signaling network mediated by helper NLRs
    Gong Y, Tian L, Kontos I, Li J, Li X
    Ref: Curr Opin Plant Biol, 73:102354, 2023 : PubMed

            

    Title: The NLR immune receptor ADR1 and lipase-like proteins EDS1 and PAD4 mediate stomatal immunity in Nicotiana benthamiana and Arabidopsis
    Wang H, Song S, Gao S, Yu Q, Zhang H, Cui X, Fan J, Xin X, Liu Y and Qi T <1 more author(s)>
    Ref: Plant Cell, :, 2023 : PubMed

            

    Title: Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity
    Dongus JA, Bhandari DD, Penner E, Lapin D, Stolze SC, Harzen A, Patel M, Archer L, Dijkgraaf L and Parker JE <2 more author(s)>
    Ref: Plant J, :, 2022 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Plant_lipase_EDS1-like family (8)

Genes Proteins in Plant_lipase_EDS1-like family (167)

Fragments of genes in Plant_lipase_EDS1-like family (15)

Substrates of some enzymes in the Plant_lipase_EDS1-like family (3)

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer