2-tolylazo-1,3-aminoenketone-tacrine-7a
AChE, IC50 0.889 +/- 0.007 microM and butyrylcholinesterase BChE, IC50 0.0359 +/- 0.0020 microM
General
Type : Multitarget, Derivative of Tacrine, Alkyl linked bis-ligand, Antioxidant
Chemical_Nomenclature : (2Z)-2-[(E)-(4-Methylphenyl)diazenyl]-1-phenyl-3-({2-[(1,2,3,4-tetrahydroacridin-9-yl)amino]butyl}amino)but-2-en-1-one
Canonical SMILES : C1=C2C(=CC=C1)C(=C3C(=N2)CCCC3)NCCCCNC(=C(C(=O)C4=CC=CC=C4)N=NC5=CC=C(C=C5)C)C
InChI : InChI=1S\/C34H37N5O\/c1-24-18-20-27(21-19-24)38-39-32(34(40)26-12-4-3-5-13-26)25(2)35-22-10-11-23-36-33-28-14-6-8-16-30(28)37-31-17-9-7-15-29(31)33\/h3-6,8,12-14,16,18-21,35H,7,9-11,15,17,22-23H2,1-2H3,(H,36,37)
InChIKey : GAYUHXBNPCBEJJ-UHFFFAOYSA-N
Other name(s) : 7a
Target
References (1)
| Title : New Multifunctional Agents for Potential Alzheimer's Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones - Elkina_2022_Biomolecules_12_ |
| Author(s) : Elkina NA , Grishchenko MV , Shchegolkov EV , Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Radchenko EV , Palyulin VA , Zhilina EF , Perminova AN , Lapshin LS , Burgart YV , Saloutin VI , Richardson RJ |
| Ref : Biomolecules , 12 : , 2022 |
| Abstract : |
| PubMedSearch : Elkina_2022_Biomolecules_12_ |
| PubMedID: 36358901 |