A-234-Nerve-agent
Novichok (newcomer/ newbie/ novice, beginner/) is a series of binary chemical weapons developed by the Soviet Union and Russia between 1971 and 1993. Mirzayanov provided the first description of these agents but are somewhat different from the structures identified later. The ligand in the structure ethyl (R)-N-[(1E)-1-(diethylamino)ethylidene]phosphonamidate C8H19N2O2P OJNAFPOCQGTUIK-CMDGGOBGSA-N. HuAChE IC50 0.101+/-0.003 microM and HuBChE IC50 0.036 +/- 0.002 microM
General
Type : Organophosphate, Novichok, Chemical Warfare Agent
Chemical_Nomenclature : ~{N}'-[ethoxy(fluoro)phosphoryl]-~{N},~{N}-diethylethanimidamide
Canonical SMILES : CCN(CC)C(=NP(=O)(OCC)F)C
InChI : InChI=1S\/C8H18FN2O2P\/c1-5-11(6-2)8(4)10-14(9,12)13-7-3\/h5-7H2,1-4H3\/b10-8+
InChIKey : SBPSVLLDDYOPDZ-CSKARUKUSA-N
Other name(s) : A-234 nerve agent, CHEBI:140425, A-234, A234, Ethyl N-[1-(diethylamino)ethylidene]phosphoramidofluoridate, L1M
MW : 224.21
Formula : C8H18FN2O2P
CAS_number :
PubChem : 132472361
UniChem : SBPSVLLDDYOPDZ-CSKARUKUSA-N
Wikipedia : Novichok_agent
Target
Families : A-234-Nerve-agent ligand of proteins in family
ACHE
Protein :
human-ACHE
References (15)
| Title : A-series agent A-234: initial in vitro and in vivo characterization - Hrabinova_2024_Arch.Toxicol__ |
| Author(s) : Hrabinova M , Pejchal J , Hepnarova V , Muckova L , Junova L , Opravil J , Zdarova Karasova J , Rozsypal T , Dlabkova A , Rehulkova H , Kucera T , Vecera Z , Caisberger F , Schmidt M , Soukup O , Jun D |
| Ref : Archives of Toxicology , : , 2024 |
| PubMedID: 38446233 |
| Title : Novichok Nerve Agents as Inhibitors of Acetylcholinesterase-In Silico Study of Their Non-Covalent Binding Affinity - Madaj_2024_Molecules_29_338 |
| Author(s) : Madaj R , Gostynski B , Chworos A , Cypryk M |
| Ref : Molecules , 29 :338 , 2024 |
| PubMedID: 38257251 |
| Title : Molecular modeling of Mannich phenols as reactivators of human acetylcholinesterase inhibited by A-series nerve agents - Vieira_2023_Chem.Biol.Interact_14ChEPon_110622 |
| Author(s) : Vieira LA , Almeida J , De Koning MC , LaPlante SR , Borges I , Franca TCC |
| Ref : Chemico-Biological Interactions , :110622 , 2023 |
| PubMedID: 37442286 |
| Title : Application of toxicology in silico methods for prediction of acute toxicity (LD(50)) for Novichoks - Noga_2023_Arch.Toxicol_97_1691 |
| Author(s) : Noga M , Michalska A , Jurowski K |
| Ref : Archives of Toxicology , 97 :1691 , 2023 |
| PubMedID: 37145338 |
| Title : Effective Degradation of Novichok Nerve Agents by the Zirconium Metal-Organic Framework MOF-808 - De Koning_2022_ACS.Appl.Mater.Interfaces_14_9222 |
| Author(s) : De Koning MC , Vieira Soares C , van Grol M , Bross RPT , Maurin G |
| Ref : ACS Appl Mater Interfaces , 14 :9222 , 2022 |
| PubMedID: 35138813 |
| Title : Unambiguous identification and determination of A234-Novichok nerve agent biomarkers in biological fluids using GC-MS\/MS and LC-MS\/MS - Mirbabaei_2022_Anal.Bioanal.Chem__ |
| Author(s) : Mirbabaei F , Mohammad-Khah A , Naseri MT , Babri M , Faraz SM , Hosseini SE , Ashrafi D |
| Ref : Anal Bioanal Chem , : , 2022 |
| PubMedID: 35190842 |
| Title : Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents - Jacquet_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Jacquet P , Remy B , Bross RPT , van Grol M , Gaucher F , Chabriere E , De Koning MC , Daude D |
| Ref : Int J Mol Sci , 22 : , 2021 |
| PubMedID: 34360916 |
| Title : Verification of Exposure to Novichok Nerve Agents Utilizing a Semitargeted Human Butyrylcholinesterase Nonapeptide Assay - Noort_2021_Chem.Res.Toxicol__ |
| Author(s) : Noort D , Fidder A , van der Riet-van Oeveren D , Busker R , van der Schans MJ |
| Ref : Chemical Research in Toxicology , : , 2021 |
| PubMedID: 34255498 |
| Title : Chemical Properties, Biological Activities and Poisoning Treatment of Novichok: A Review - Rahmania_2021_Pharm.Sci.Res_8_73 |
| Author(s) : Rahmania TA , Bantari Wisynu Kusuma Wardhani BWK , Renesteen E , Harahap Y |
| Ref : Pharmaceutical Sciences and Research (PSR) , 8 :73 , 2021 |
| PubMedID: |
| Title : Backbone Conformation Shifts in X-ray Structures of Human Acetylcholinesterase upon Covalent Organophosphate Inhibition - Luedtke_2021_Crystals_11_1270 |
| Author(s) : Luedtke S , Bojo C , Li Y , Luna E , Bianca Pomar , Radic Z |
| Ref : Crystals , 11 :1270 , 2021 |
| PubMedID: |
| Title : Novichoks: The Dangerous Fourth Generation of Chemical Weapons - Franca_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Franca TCC , Kitagawa DAS , Cavalcante SFA , da Silva JAV , Nepovimova E , Kuca K |
| Ref : Int J Mol Sci , 20 : , 2019 |
| PubMedID: 30862059 |
| Title : Novichok agents: a historical, current, and toxicological perspective - Chai_2018_Toxicol.Commun_2_45 |
| Author(s) : Chai PR , Hayes BD , Erickson TB , Boyer EW |
| Ref : Toxicol Commun , 2 :45 , 2018 |
| PubMedID: 30003185 |
| Title : Chemical warfare agent NOVICHOK - mini-review of available data - Nepovimova_2018_Food.Chem.Toxicol_121_343 |
| Author(s) : Nepovimova E , Kuca K |
| Ref : Food & Chemical Toxicology , 121 :343 , 2018 |
| PubMedID: 30213549 |