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Inhibitor Report for: Methoctramine

General
Type Muscarinic antagonist, Not A/B H target, Alkyl linked bis-ligand
Chemical_Nomenclature N,N'-bis[6-[(2-methoxyphenyl)methylamino]hexyl]octane-1,8-diamine
Canonical SMILES COC1=CC=CC=C1CNCCCCCCNCCCCCCCCNCCCCCCNCC2=CC=CC=C2OC
InChI InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
InChIKey RPMBYDYUVKEZJA-UHFFFAOYSA-N
Other name(s) Methoctramine free base ; CHEBI:73339 ; UNII-NVJ76B897D ; CHEMBL27673
________________________________________________________________________________________________
MW|582.9
Formula|C36H62N4O2
CAS_number|
PubChem|4108, 107759, 44134815, 71464675
UniChem|RPMBYDYUVKEZJA-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: Methoctramine

56 more
    Title: Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure
    Bolognesi ML, Bixel MG, Marucci G, Bartolini M, Krauss M, Angeli P, Antonello A, Rosini M, Tumiatti V and Melchiorre C <1 more author(s)>
    Ref: Journal of Medicinal Chemistry, 45:3286, 2002 : PubMed

            

    Title: The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins
    Chahdi A, Daeffler L, Bueb JL, Gies JP, Landry Y
    Ref: Naunyn Schmiedebergs Arch Pharmacol, 357:357, 1998 : PubMed

            

    Title: The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists
    Melchiorre C, Minarini A, Budriesi R, Chiarini A, Spampinato S, Tumiatti V
    Ref: Life Sciences, 56(11-12):837, 1995 : PubMed