Donnelly-roberts D

General

Full name : Donnelly-Roberts Diana L

First name : Diana L

Mail : Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6100

Zip Code :

City :

Country : USA

Email : diana.l.donnelly-roberts@abbvie.com

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References (74)

Title : Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with alpha7 nicotinic acetylcholine receptor agonists - Minami_2015_Biochem.Pharmacol_97(4)_454
Author(s) : Minami SS , Shen V , Le D , Krabbe G , Asgarov R , Perez-Celajes L , Lee CH , Li J , Donnelly-Roberts D , Gan L
Ref : Biochemical Pharmacology , 97 :454 , 2015
Abstract :
PubMedSearch : Minami_2015_Biochem.Pharmacol_97(4)_454
PubMedID: 26206194

Title : Nicotinic acetylcholine receptors as therapeutic targets: Emerging frontiers in basic research and clinical science--Editorial Comments -
Author(s) : Dani JA , Donnelly-Roberts D , Bertrand D
Ref : Biochemical Pharmacology , 97 :351 , 2015
PubMedID: 26074266

Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science--editorial comments -
Author(s) : Dani JA , Donnelly-Roberts D , Bertrand D
Ref : Biochemical Pharmacology , 86 :1041 , 2013
PubMedID: 23684691

Title : Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca(2)(+) channel blockers with analgesic activity - Beebe_2012_Bioorg.Med.Chem_20_4128
Author(s) : Beebe X , Darczak D , Henry RF , Vortherms T , Janis R , Namovic M , Donnelly-Roberts D , Kage KL , Surowy C , Milicic I , Niforatos W , Swensen A , Marsh KC , Wetter JM , Franklin P , Baker S , Zhong C , Simler G , Gomez E , Boyce-Rustay JM , Zhu CZ , Stewart AO , Jarvis MF , Scott VE
Ref : Bioorganic & Medicinal Chemistry , 20 :4128 , 2012
Abstract :
PubMedSearch : Beebe_2012_Bioorg.Med.Chem_20_4128
PubMedID: 22626552

Title : High throughput functional assays for P2X receptors - Namovic_2012_Curr.Protoc.Pharmacol_Chapter 9_Unit 9 15
Author(s) : Namovic MT , Jarvis MF , Donnelly-Roberts D
Ref : Curr Protoc Pharmacol , Chapter 9 :Unit 9 15 , 2012
Abstract :
PubMedSearch : Namovic_2012_Curr.Protoc.Pharmacol_Chapter 9_Unit 9 15
PubMedID: 22684723

Title : Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels - Vortherms_2011_Inflamm.Res_60_683
Author(s) : Vortherms TA , Swensen AM , Niforatos W , Limberis JT , Neelands TR , Janis RS , Thimmapaya R , Donnelly-Roberts D , Namovic MT , Zhang D , Brent Putman C , Martin RL , Surowy CS , Jarvis MF , Scott VE
Ref : Inflamm Res , 60 :683 , 2011
Abstract :
PubMedSearch : Vortherms_2011_Inflamm.Res_60_683
PubMedID: 21394563

Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science--Editorial Comments -
Author(s) : Donnelly-Roberts D , Bertrand D , Gopalakrishnan M
Ref : Biochemical Pharmacology , 82 :797 , 2011
PubMedID: 21600889

Title : Poster: A-582941, a pro-cognitive alpha7 nAChR agonist, differentially modulates mitochondrial membrane potential -
Author(s) : Namovic M , Hu M , Abraham V , Towne D , Lee C-H , Gopalakrishnan M , Esbenshade T , Donnelly-Roberts D
Ref : Biochemical Pharmacology , 82 :1027 , 2011
PubMedID:

Title : Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists - Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297
Author(s) : Perez-Medrano A , Donnelly-Roberts D , Florjancic AS , Nelson DW , Li T , Namovic MT , Peddi S , Faltynek CR , Jarvis MF , Carroll WA
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :3297 , 2011
Abstract :
PubMedSearch : Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297
PubMedID: 21536435

Title : The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice - Honore_2009_Behav.Brain.Res_204_77
Author(s) : Honore P , Donnelly-Roberts D , Namovic M , Zhong C , Wade C , Chandran P , Zhu C , Carroll W , Perez-Medrano A , Iwakura Y , Jarvis MF
Ref : Behavioural Brain Research , 204 :77 , 2009
Abstract :
PubMedSearch : Honore_2009_Behav.Brain.Res_204_77
PubMedID: 19464323

Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science--editorial perspective -
Author(s) : Bertrand D , Gopalakrishnan M , Donnelly-Roberts D
Ref : Biochemical Pharmacology , 78 :657 , 2009
PubMedID: 19576180

Title : Selective P2X(7) receptor antagonists for chronic inflammation and pain - Carroll_2009_Purinergic.Signal_5_63
Author(s) : Carroll WA , Donnelly-Roberts D , Jarvis MF
Ref : Purinergic Signal , 5 :63 , 2009
Abstract :
PubMedSearch : Carroll_2009_Purinergic.Signal_5_63
PubMedID: 18568426

Title : Poster: Radioligand binding characterization of [3H]-A-998679: A novel positive allosteric modulator of alpha4\/beta2 nAChRs -
Author(s) : Anderson DJ , Vaidyanathan S , Namovic M , Donnelly-Roberts D , Lee L , Gopalakrishnan M
Ref : Biochemical Pharmacology , 78 :903 , 2009
PubMedID:

Title : Poster: Profile of A-716096, a novel thiazolylidine positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor -
Author(s) : Donnelly-Roberts D , Malysz J , Faghih R , Gronlien H , Haakerud M , Thorin-Hagne K , Ween H , Gopalakrishnan SM , Hu M , Li J , Anderson DJ , Kohlhaas KL , Namovic M , Radek R , Robb H , Briggs CA , Bitner RS , Bunnelle WH , Gopalakrishnan M
Ref : Biochemical Pharmacology , 78 :912 , 2009
PubMedID:

Title : Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors - Donnelly-Roberts_2009_Br.J.Pharmacol_157_1203
Author(s) : Donnelly-Roberts D , Namovic MT , Han P , Jarvis MF
Ref : British Journal of Pharmacology , 157 :1203 , 2009
Abstract :
PubMedSearch : Donnelly-Roberts_2009_Br.J.Pharmacol_157_1203
PubMedID: 19558545

Title : [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors - Donnelly-Roberts_2009_Neuropharmacol_56_223
Author(s) : Donnelly-Roberts D , Namovic MT , Surber B , Vaidyanathan SX , Perez-Medrano A , Wang Y , Carroll WA , Jarvis MF
Ref : Neuropharmacology , 56 :223 , 2009
Abstract :
PubMedSearch : Donnelly-Roberts_2009_Neuropharmacol_56_223
PubMedID: 18602931

Title : Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain - Perez-Medrano_2009_J.Med.Chem_52_3366
Author(s) : Perez-Medrano A , Donnelly-Roberts D , Honore P , Hsieh GC , Namovic MT , Peddi S , Shuai Q , Wang Y , Faltynek CR , Jarvis MF , Carroll WA
Ref : Journal of Medicinal Chemistry , 52 :3366 , 2009
Abstract :
PubMedSearch : Perez-Medrano_2009_J.Med.Chem_52_3366
PubMedID: 19397270

Title : Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists - Betschmann_2008_Bioorg.Med.Chem.Lett_18_3848
Author(s) : Betschmann P , Bettencourt B , Donnelly-Roberts D , Friedman M , George J , Hirst G , Josephsohn N , Konopacki D , Li B , Maull J , Morytko MJ , Moore NS , Namovic M , Rafferty P , Salmeron-Garcia JA , Tarcsa E , Wang L , Woller K
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :3848 , 2008
Abstract :
PubMedSearch : Betschmann_2008_Bioorg.Med.Chem.Lett_18_3848
PubMedID: 18595695

Title : Painful purinergic receptors - Donnelly-Roberts_2008_J.Pharmacol.Exp.Ther_324_409
Author(s) : Donnelly-Roberts D , McGaraughty S , Shieh CC , Honore P , Jarvis MF
Ref : Journal of Pharmacology & Experimental Therapeutics , 324 :409 , 2008
Abstract :
PubMedSearch : Donnelly-Roberts_2008_J.Pharmacol.Exp.Ther_324_409
PubMedID: 18042830

Title : Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists - Morytko_2008_Bioorg.Med.Chem.Lett_18_2093
Author(s) : Morytko MJ , Betschmann P , Woller K , Ericsson A , Chen H , Donnelly-Roberts D , Namovic MT , Jarvis MF , Carroll WA , Rafferty P
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2093 , 2008
Abstract :
PubMedSearch : Morytko_2008_Bioorg.Med.Chem.Lett_18_2093
PubMedID: 18272365

Title : Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists - Nelson_2008_J.Med.Chem_51_3030
Author(s) : Nelson DW , Sarris K , Kalvin DM , Namovic MT , Grayson G , Donnelly-Roberts D , Harris R , Honore P , Jarvis MF , Faltynek CR , Carroll WA
Ref : Journal of Medicinal Chemistry , 51 :3030 , 2008
Abstract :
PubMedSearch : Nelson_2008_J.Med.Chem_51_3030
PubMedID: 18438986

Title : Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists - Florjancic_2008_Bioorg.Med.Chem.Lett_18_2089
Author(s) : Florjancic AS , Peddi S , Perez-Medrano A , Li B , Namovic MT , Grayson G , Donnelly-Roberts D , Jarvis MF , Carroll WA
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2089 , 2008
Abstract :
PubMedSearch : Florjancic_2008_Bioorg.Med.Chem.Lett_18_2089
PubMedID: 18272366

Title : Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists - Carroll_2007_Bioorg.Med.Chem.Lett_17_4044
Author(s) : Carroll WA , Kalvin DM , Perez Medrano A , Florjancic AS , Wang Y , Donnelly-Roberts D , Namovic MT , Grayson G , Honore P , Jarvis MF
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :4044 , 2007
Abstract :
PubMedSearch : Carroll_2007_Bioorg.Med.Chem.Lett_17_4044
PubMedID: 17482819

Title : P2X7-related modulation of pathological nociception in rats - McGaraughty_2007_Neurosci_146_1817
Author(s) : McGaraughty S , Chu KL , Namovic MT , Donnelly-Roberts D , Harris RR , Zhang XF , Shieh CC , Wismer CT , Zhu CZ , Gauvin DM , Fabiyi AC , Honore P , Gregg RJ , Kort ME , Nelson DW , Carroll WA , Marsh K , Faltynek CR , Jarvis MF
Ref : Neuroscience , 146 :1817 , 2007
Abstract :
PubMedSearch : McGaraughty_2007_Neurosci_146_1817
PubMedID: 17478048

Title : Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states - Donnelly-Roberts_2007_Br.J.Pharmacol_151_571
Author(s) : Donnelly-Roberts D , Jarvis MF
Ref : British Journal of Pharmacology , 151 :571 , 2007
Abstract :
PubMedSearch : Donnelly-Roberts_2007_Br.J.Pharmacol_151_571
PubMedID: 17471177

Title : A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat - Honore_2006_J.Pharmacol.Exp.Ther_319_1376
Author(s) : Honore P , Donnelly-Roberts D , Namovic MT , Hsieh G , Zhu CZ , Mikusa JP , Hernandez G , Zhong C , Gauvin DM , Chandran P , Harris R , Medrano AP , Carroll W , Marsh K , Sullivan JP , Faltynek CR , Jarvis MF
Ref : Journal of Pharmacology & Experimental Therapeutics , 319 :1376 , 2006
Abstract :
PubMedSearch : Honore_2006_J.Pharmacol.Exp.Ther_319_1376
PubMedID: 16982702

Title : 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction - Kolasa_2006_J.Med.Chem_49_5093
Author(s) : Kolasa T , Matulenko MA , Hakeem AA , Patel MV , Mortell K , Bhatia P , Henry R , Nakane M , Hsieh GC , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino B , El Kouhen O , Marsh KC , Wetter JM , Moreland RB , Brioni JD , Stewart AO
Ref : Journal of Medicinal Chemistry , 49 :5093 , 2006
Abstract :
PubMedSearch : Kolasa_2006_J.Med.Chem_49_5093
PubMedID: 16913699

Title : Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists - Nelson_2006_J.Med.Chem_49_3659
Author(s) : Nelson DW , Gregg RJ , Kort ME , Perez-Medrano A , Voight EA , Wang Y , Grayson G , Namovic MT , Donnelly-Roberts D , Niforatos W , Honore P , Jarvis MF , Faltynek CR , Carroll WA
Ref : Journal of Medicinal Chemistry , 49 :3659 , 2006
Abstract :
PubMedSearch : Nelson_2006_J.Med.Chem_49_3659
PubMedID: 16759108

Title : Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzam ide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction - Patel_2006_J.Med.Chem_49_7450
Author(s) : Patel MV , Kolasa T , Mortell K , Matulenko MA , Hakeem AA , Rohde JJ , Nelson SL , Cowart MD , Nakane M , Miller LN , Uchic ME , Terranova MA , El-Kouhen OF , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Chang R , Martino BR , Wetter JM , Marsh KC , Martin R , Darbyshire JF , Gintant G , Hsieh GC , Moreland RB , Sullivan JP , Brioni JD , Stewart AO
Ref : Journal of Medicinal Chemistry , 49 :7450 , 2006
Abstract :
PubMedSearch : Patel_2006_J.Med.Chem_49_7450
PubMedID: 17149874

Title : A-85380: a pharmacological probe for the preclinical and clinical investigation of the alphabeta neuronal nicotinic acetylcholine receptor - Rueter_2006_CNS.Drug.Rev_12_100
Author(s) : Rueter LE , Donnelly-Roberts D , Curzon P , Briggs CA , Anderson DJ , Bitner RS
Ref : CNS Drug Rev , 12 :100 , 2006
Abstract :
PubMedSearch : Rueter_2006_CNS.Drug.Rev_12_100
PubMedID: 16958984

Title : Pharmacological characterization of P2X7 receptors in rat peritoneal cells - Chen_2005_Inflamm.Res_54_119
Author(s) : Chen YW , Donnelly-Roberts D , Namovic MT , Gintant GA , Cox BF , Jarvis MF , Harris RR
Ref : Inflamm Res , 54 :119 , 2005
Abstract :
PubMedSearch : Chen_2005_Inflamm.Res_54_119
PubMedID: 15883745

Title : 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist - Nakane_2005_Neuropharmacol_49_112
Author(s) : Nakane M , Cowart MD , Hsieh GC , Miller L , Uchic ME , Chang R , Terranova MA , Donnelly-Roberts D , Namovic MT , Miller TR , Wetter JM , Marsh K , Stewart AO , Brioni JD , Moreland RB
Ref : Neuropharmacology , 49 :112 , 2005
Abstract :
PubMedSearch : Nakane_2005_Neuropharmacol_49_112
PubMedID: 15992586

Title : In vitro and in vivo effects of an alpha3 neuronal nicotinic acetylcholine receptor antisense oligonucleotide - Adams_2004_Brain.Res.Mol.Brain.Res_129_67
Author(s) : Adams MR , Nikkel AL , Donnelly-Roberts D , Watt AT , Johnston JF , Cowsert LM , Butler M , Kroeger PE , Frost L , Curzon P , Decker MW , Bitner RS
Ref : Brain Research Mol Brain Res , 129 :67 , 2004
Abstract :
PubMedSearch : Adams_2004_Brain.Res.Mol.Brain.Res_129_67
PubMedID: 15469883

Title : Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning - Stewart_2004_J.Med.Chem_47_2348
Author(s) : Stewart AO , Cowart MD , Moreland RB , Latshaw SP , Matulenko MA , Bhatia PA , Wang X , Daanen JF , Nelson SL , Terranova MA , Namovic MT , Donnelly-Roberts D , Miller LN , Nakane M , Sullivan JP , Brioni JD
Ref : Journal of Medicinal Chemistry , 47 :2348 , 2004
Abstract :
PubMedSearch : Stewart_2004_J.Med.Chem_47_2348
PubMedID: 15084133

Title : Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine - Hsieh_2004_J.Pharmacol.Exp.Ther_308_330
Author(s) : Hsieh GC , Hollingsworth PR , Martino B , Chang R , Terranova MA , O'Neill AB , Lynch JJ , Moreland RB , Donnelly-Roberts D , Kolasa T , Mikusa JP , McVey JM , Marsh KC , Sullivan JP , Brioni JD
Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :330 , 2004
Abstract :
PubMedSearch : Hsieh_2004_J.Pharmacol.Exp.Ther_308_330
PubMedID: 14569075

Title : Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats - Brioni_2004_Proc.Natl.Acad.Sci.U.S.A_101_6758
Author(s) : Brioni JD , Moreland RB , Cowart M , Hsieh GC , Stewart AO , Hedlund P , Donnelly-Roberts D , Nakane M , Lynch JJ, 3rd , Kolasa T , Polakowski JS , Osinski MA , Marsh K , Andersson KE , Sullivan JP
Ref : Proc Natl Acad Sci U S A , 101 :6758 , 2004
Abstract :
PubMedSearch : Brioni_2004_Proc.Natl.Acad.Sci.U.S.A_101_6758
PubMedID: 15087502

Title : Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists - Matulenko_2004_Bioorg.Med.Chem_12_3471
Author(s) : Matulenko MA , Hakeem AA , Kolasa T , Nakane M , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Moreland RB , Brioni JD , Stewart AO
Ref : Bioorganic & Medicinal Chemistry , 12 :3471 , 2004
Abstract :
PubMedSearch : Matulenko_2004_Bioorg.Med.Chem_12_3471
PubMedID: 15186832

Title : Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction - Cowart_2004_J.Med.Chem_47_3853
Author(s) : Cowart M , Latshaw SP , Bhatia P , Daanen JF , Rohde J , Nelson SL , Patel M , Kolasa T , Nakane M , Uchic ME , Miller LN , Terranova MA , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino BR , Lynch JJ, 3rd , Sullivan JP , Hsieh GC , Moreland RB , Brioni JD , Stewart AO
Ref : Journal of Medicinal Chemistry , 47 :3853 , 2004
Abstract :
PubMedSearch : Cowart_2004_J.Med.Chem_47_3853
PubMedID: 15239663

Title : Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand - Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095
Author(s) : Matulenko MA , Surber B , Fan L , Kolasa T , Nakane M , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Moreland RB , Brioni JD , Stewart AO
Ref : Bioorganic & Medicinal Chemistry Lett , 14 :5095 , 2004
Abstract :
PubMedSearch : Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095
PubMedID: 15380206

Title : Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5) - Moreland_2004_Biochem.Pharmacol_68_761
Author(s) : Moreland RB , Nakane M , Donnelly-Roberts D , Miller LN , Chang R , Uchic ME , Terranova MA , Gubbins EJ , Helfrich RJ , Namovic MT , El-Kouhen OF , Masters JN , Brioni JD
Ref : Biochemical Pharmacology , 68 :761 , 2004
Abstract :
PubMedSearch : Moreland_2004_Biochem.Pharmacol_68_761
PubMedID: 15276084

Title : Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells - Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053
Author(s) : Donnelly-Roberts D , Namovic MT , Faltynek CR , Jarvis MF
Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :1053 , 2004
Abstract :
PubMedSearch : Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053
PubMedID: 14634045

Title : ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders - Rueter_2004_CNS.Drug.Rev_10_167
Author(s) : Rueter LE , Anderson DJ , Briggs CA , Donnelly-Roberts D , Gintant GA , Gopalakrishnan M , Lin NH , Osinski MA , Reinhart GA , Buckley MJ , Martin RL , McDermott JS , Preusser LC , Seifert TR , Su Z , Cox BF , Decker MW , Sullivan JP
Ref : CNS Drug Rev , 10 :167 , 2004
Abstract :
PubMedSearch : Rueter_2004_CNS.Drug.Rev_10_167
PubMedID: 15179445

Title : A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors - Gopalakrishnan_2003_Anal.Biochem_321_192
Author(s) : Gopalakrishnan SM , Moreland RB , Kofron JL , Helfrich RJ , Gubbins E , McGowen J , Masters JN , Donnelly-Roberts D , Brioni JD , Burns DJ , Warrior U
Ref : Analytical Biochemistry , 321 :192 , 2003
Abstract :
PubMedSearch : Gopalakrishnan_2003_Anal.Biochem_321_192
PubMedID: 14511684

Title : Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat - Bitner_2000_Brain.Res_871_66
Author(s) : Bitner RS , Nikkel AL , Curzon P , Donnelly-Roberts D , Puttfarcken PS , Namovic M , Jacobs IC , Meyer MD , Decker MW
Ref : Brain Research , 871 :66 , 2000
Abstract :
PubMedSearch : Bitner_2000_Brain.Res_871_66
PubMedID: 10882784

Title : Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice - Holladay_1998_Bioorg.Med.Chem.Lett_8_2797
Author(s) : Holladay MW , Bai H , Li Y , Lin NH , Daanen JF , Ryther KB , Wasicak JT , Kincaid JF , He Y , Hettinger AM , Huang P , Anderson DJ , Bannon AW , Buckley MJ , Campbell JE , Donnelly-Roberts D , Gunther KL , Kim DJ , Kuntzweiler TA , Sullivan JP , Decker MW , Arneric SP
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2797 , 1998
Abstract :
PubMedSearch : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797
PubMedID: 9873625

Title : Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors - Holladay_1998_J.Med.Chem_41_407
Author(s) : Holladay MW , Wasicak JT , Lin NH , He Y , Ryther KB , Bannon AW , Buckley MJ , Kim DJ , Decker MW , Anderson DJ , Campbell JE , Kuntzweiler TA , Donnelly-Roberts D , Piattoni-Kaplan M , Briggs CA , Williams M , Arneric SP
Ref : Journal of Medicinal Chemistry , 41 :407 , 1998
Abstract :
PubMedSearch : Holladay_1998_J.Med.Chem_41_407
PubMedID: 9484491

Title : Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors - Bannon_1998_Science_279_77
Author(s) : Bannon AW , Decker MW , Holladay MW , Curzon P , Donnelly-Roberts D , Puttfarcken PS , Bitner RS , Diaz A , Dickenson AH , Porsolt RD , Williams M , Arneric SP
Ref : Science , 279 :77 , 1998
Abstract :
PubMedSearch : Bannon_1998_Science_279_77
PubMedID: 9417028

Title : Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist - Lin_1998_Bioorg.Med.Chem.Lett_8_249
Author(s) : Lin NH , Gunn DE , Li Y , He Y , Bai H , Ryther KB , Kuntzweiler T , Donnelly-Roberts D , Anderson DJ , Campbell JE , Sullivan JP , Arneric SP , Holladay MW
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :249 , 1998
Abstract :
PubMedSearch : Lin_1998_Bioorg.Med.Chem.Lett_8_249
PubMedID: 9871663

Title : The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594 - Decker_1998_J.Physiol.Paris_92_221
Author(s) : Decker MW , Curzon P , Holladay MW , Nikkel AL , Bitner RS , Bannon AW , Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Williams M , Arneric SP
Ref : Journal de Physiologie (Paris) , 92 :221 , 1998
Abstract :
PubMedSearch : Decker_1998_J.Physiol.Paris_92_221
PubMedID: 9789812

Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization - Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777
Author(s) : Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Anderson DJ , Campbell JE , Piattoni-Kaplan M , McKenna DG , Wasicak JT , Holladay MW , Williams M , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 285 :777 , 1998
Abstract :
PubMedSearch : Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777
PubMedID: 9580626

Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties - Sullivan_1997_J.Pharmacol.Exp.Ther_283_235
Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Xue IC , Piattoni-Kaplan M , Molinari E , Campbell JE , McKenna DG , Gunn DE , Lin NH , Ryther KB , He Y , Holladay MW , Wonnacott S , Williams M , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :235 , 1997
Abstract :
PubMedSearch : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235
PubMedID: 9336329

Title : Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo - Briggs_1997_Pharmacol.Biochem.Behav_57_231
Author(s) : Briggs CA , Anderson DJ , Brioni JD , Buccafusco JJ , Buckley MJ , Campbell JE , Decker MW , Donnelly-Roberts D , Elliott RL , Gopalakrishnan M , Holladay MW , Hui YH , Jackson WJ , Kim DJ , Marsh KC , O'Neill A , Prendergast MA , Ryther KB , Sullivan JP , Arneric SP
Ref : Pharmacol Biochem Behav , 57 :231 , 1997
Abstract :
PubMedSearch : Briggs_1997_Pharmacol.Biochem.Behav_57_231
PubMedID: 9164577

Title : Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties - Lin_1997_J.Med.Chem_40_385
Author(s) : Lin NH , Gunn DE , Ryther KB , Garvey DS , Donnelly-Roberts D , Decker MW , Brioni JD , Buckley MJ , Rodrigues AD , Marsh KG , Anderson DJ , Buccafusco JJ , Prendergast MA , Sullivan JP , Williams M , Arneric SP , Holladay MW
Ref : Journal of Medicinal Chemistry , 40 :385 , 1997
Abstract :
PubMedSearch : Lin_1997_J.Med.Chem_40_385
PubMedID: 9022806

Title : Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells - Puttfarcken_1997_J.Neurochem_69_930
Author(s) : Puttfarcken PS , Manelli AM , Arneric SP , Donnelly-Roberts D
Ref : Journal of Neurochemistry , 69 :930 , 1997
Abstract :
PubMedSearch : Puttfarcken_1997_J.Neurochem_69_930
PubMedID: 9282914

Title : Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors - Abreo_1996_J.Med.Chem_39_817
Author(s) : Abreo MA , Lin NH , Garvey DS , Gunn DE , Hettinger AM , Wasicak JT , Pavlik PA , Martin YC , Donnelly-Roberts D , Anderson DJ , Sullivan JP , Williams M , Arneric SP , Holladay MW
Ref : Journal of Medicinal Chemistry , 39 :817 , 1996
Abstract :
PubMedSearch : Abreo_1996_J.Med.Chem_39_817
PubMedID: 8632405

Title : A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand - Sullivan_1996_Neuropharmacol_35_725
Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Piattoni-Kaplan M , Campbell JE , McKenna DG , Molinari E , Hettinger AM , Garvey DS , Wasicak JT , Holladay MW , Williams M , Arneric SP
Ref : Neuropharmacology , 35 :725 , 1996
Abstract :
PubMedSearch : Sullivan_1996_Neuropharmacol_35_725
PubMedID: 8887981

Title : In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418 - Donnelly-Roberts_1996_Brain.Res_719_36
Author(s) : Donnelly-Roberts D , Xue IC , Arneric SP , Sullivan JP
Ref : Brain Research , 719 :36 , 1996
Abstract :
PubMedSearch : Donnelly-Roberts_1996_Brain.Res_719_36
PubMedID: 8782861

Title : Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor - Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289
Author(s) : Gopalakrishnan M , Monteggia LM , Anderson DJ , Molinari EJ , Piattoni-Kaplan M , Donnelly-Roberts D , Arneric SP , Sullivan JP
Ref : Journal of Pharmacology & Experimental Therapeutics , 276 :289 , 1996
Abstract :
PubMedSearch : Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289
PubMedID: 8558445

Title : Cholinergic channel activators: novel opportunities for the treatment of CNS disorders - Sullivan_1995_Proc.West.Pharmacol.Soc_38_127
Author(s) : Sullivan JP , Decker MW , Donnelly-Roberts D , Brioni JD , Bannon AW , Holladay MW , Anderson DJ , Briggs CA , Williams M , Arneric SP
Ref : Proc West Pharmacol Soc , 38 :127 , 1995
Abstract :
PubMedSearch : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127
PubMedID: 7480004

Title : Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties - Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50
Author(s) : Arneric SP , Sullivan JP , Decker MW , Brioni JD , Bannon AW , Briggs CA , Donnelly-Roberts D , Radek RJ , Marsh KC , Kyncl J , Williams M , Buccafusco JJ
Ref : Alzheimer Disease & Associated Disorders , 9 Suppl 2 :50 , 1995
Abstract :
PubMedSearch : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50
PubMedID: 8534424

Title : Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors - Decker_1995_Eur.J.Pharmacol_280_79
Author(s) : Decker MW , Anderson DJ , Brioni JD , Donnelly-Roberts D , Kang CH , O'Neill AB , Piattoni-Kaplan M , Swanson S , Sullivan JP
Ref : European Journal of Pharmacology , 280 :79 , 1995
Abstract :
PubMedSearch : Decker_1995_Eur.J.Pharmacol_280_79
PubMedID: 7498257

Title : Functional modulation of human ganglionic-like neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists - Donnelly-Roberts_1995_Biochem.Biophys.Res.Commun_213_657
Author(s) : Donnelly-Roberts D , Arneric SP , Sullivan JP
Ref : Biochemical & Biophysical Research Communications , 213 :657 , 1995
Abstract :
PubMedSearch : Donnelly-Roberts_1995_Biochem.Biophys.Res.Commun_213_657
PubMedID: 7544126

Title : Stable expression and pharmacological properties of the human alpha 7 nicotinic acetylcholine receptor - Gopalakrishnan_1995_Eur.J.Pharmacol_290_237
Author(s) : Gopalakrishnan M , Buisson B , Touma E , Giordano T , Campbell JE , Hu IC , Donnelly-Roberts D , Arneric SP , Bertrand D , Sullivan JP
Ref : European Journal of Pharmacology , 290 :237 , 1995
Abstract :
PubMedSearch : Gopalakrishnan_1995_Eur.J.Pharmacol_290_237
PubMedID: 7589218

Title : (+\/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors - Sullivan_1994_J.Pharmacol.Exp.Ther_271_624
Author(s) : Sullivan JP , Decker MW , Brioni JD , Donnelly-Roberts D , Anderson DJ , Bannon AW , Kang CH , Adams P , Piattoni-Kaplan M , Buckley MJ
Ref : Journal of Pharmacology & Experimental Therapeutics , 271 :624 , 1994
Abstract :
PubMedSearch : Sullivan_1994_J.Pharmacol.Exp.Ther_271_624
PubMedID: 7965777

Title : (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization - Arneric_1994_J.Pharmacol.Exp.Ther_270_310
Author(s) : Arneric SP , Sullivan JP , Briggs CA , Donnelly-Roberts D , Anderson DJ , Raszkiewicz JL , Hughes ML , Cadman ED , Adams P , Garvey DS
Ref : Journal of Pharmacology & Experimental Therapeutics , 270 :310 , 1994
Abstract :
PubMedSearch : Arneric_1994_J.Pharmacol.Exp.Ther_270_310
PubMedID: 7518514

Title : Pathogenesis of hyperacute experimental autoimmune myasthenia gravis. Acetylcholine receptor\/cholinergic site\/receptor function\/autoimmunity - Mihovilovic_1994_J.Immunol_152_5997
Author(s) : Mihovilovic M , Donnelly-Roberts D , Richman DP , Martinez-Carrion M
Ref : J Immunol , 152 :5997 , 1994
Abstract :
PubMedSearch : Mihovilovic_1994_J.Immunol_152_5997
PubMedID: 8207224

Title : Effects of mutations of Torpedo acetylcholine receptor alpha 1 subunit residues 184-200 on alpha-bungarotoxin binding in a recombinant fusion protein - Chaturvedi_1993_Biochemistry_32_9570
Author(s) : Chaturvedi V , Donnelly-Roberts D , Lentz TL
Ref : Biochemistry , 32 :9570 , 1993
Abstract :
PubMedSearch : Chaturvedi_1993_Biochemistry_32_9570
PubMedID: 8373764

Title : Sodium dodecyl sulfate- and carbamylcholine-induced changes in circular dichroism spectra of acetylcholine receptor synthetic peptides - Donnelly-Roberts_1993_Brain.Res.Mol.Brain.Res_19_55
Author(s) : Donnelly-Roberts D , Lentz TL
Ref : Brain Research Mol Brain Res , 19 :55 , 1993
Abstract :
PubMedSearch : Donnelly-Roberts_1993_Brain.Res.Mol.Brain.Res_19_55
PubMedID: 8361345

Title : Substitution of Torpedo acetylcholine receptor alpha 1-subunit residues with snake alpha 1- and rat nerve alpha 3-subunit residues in recombinant fusion proteins: effect on alpha-bungarotoxin binding - Chaturvedi_1992_Biochemistry_31_1370
Author(s) : Chaturvedi V , Donnelly-Roberts D , Lentz TL
Ref : Biochemistry , 31 :1370 , 1992
Abstract :
PubMedSearch : Chaturvedi_1992_Biochemistry_31_1370
PubMedID: 1736994

Title : Binding sites for alpha-bungarotoxin and the noncompetitive inhibitor phencyclidine on a synthetic peptide comprising residues 172-227 of the alpha-subunit of the nicotinic acetylcholine receptor - Donnelly-Roberts_1991_Biochemistry_30_7484
Author(s) : Donnelly-Roberts D , Lentz TL
Ref : Biochemistry , 30 :7484 , 1991
Abstract :
PubMedSearch : Donnelly-Roberts_1991_Biochemistry_30_7484
PubMedID: 1854749

Title : Structural and conformational similarity between synthetic peptides of curaremimetic neurotoxins and rabies virus glycoprotein - Donnelly-Roberts_1991_Brain.Res.Mol.Brain.Res_11_107
Author(s) : Donnelly-Roberts D , Lentz TL
Ref : Brain Research Mol Brain Res , 11 :107 , 1991
Abstract :
PubMedSearch : Donnelly-Roberts_1991_Brain.Res.Mol.Brain.Res_11_107
PubMedID: 1661807

Title : Antibodies against an alpha-bungarotoxin-binding peptide of the alpha-subunit of the acetylcholine receptor - Donnelly-Roberts_1989_Biochem.Biophys.Res.Commun_160_289
Author(s) : Donnelly-Roberts D , Lentz TL
Ref : Biochemical & Biophysical Research Communications , 160 :289 , 1989
Abstract :
PubMedSearch : Donnelly-Roberts_1989_Biochem.Biophys.Res.Commun_160_289
PubMedID: 2469418

Title : Synthetic peptides of neurotoxins and rabies virus glycoprotein behave as antagonists in a functional assay for the acetylcholine receptor - Donnelly-Roberts_1989_Pept.Res_2_221
Author(s) : Donnelly-Roberts D , Lentz TL
Ref : Pept Res , 2 :221 , 1989
Abstract :
PubMedSearch : Donnelly-Roberts_1989_Pept.Res_2_221
PubMedID: 2520759

Title : Synthetic peptides in the study of the interaction of rabies virus and the acetylcholine receptor - Lentz_1988_Adv.Biochem.Psychopharmacol_44_57
Author(s) : Lentz TL , Hawrot E , Donnelly-Roberts D , Wilson PT
Ref : Adv Biochem Psychopharmacol , 44 :57 , 1988
Abstract :
PubMedSearch : Lentz_1988_Adv.Biochem.Psychopharmacol_44_57
PubMedID: 3041753