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Edrophonium

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles

General

Type : Drug,Quaternary compound

Chemical_Nomenclature : ethyl-(3-hydroxyphenyl)-dimethylazanium

Canonical SMILES : CC[N+](C)(C)C1=CC(=CC=C1)O

InChI : InChI=1S\/C10H15NO\/c1-4-11(2,3)9-6-5-7-10(12)8-9\/h5-8H,4H2,1-3H3\/p+1

InChIKey : VWLHWLSRQJQWRG-UHFFFAOYSA-O

Other name(s) : Tensilon,R02-3198,Edrophonum,Reversol,Edroponium,Enlon,Ethyl (m-hydroxyphenyl) dimethylammonium bromide,(3-hydroxyphenyl) dimethylethylammonium bromide,dimethylethyl (3-hydroxyphenyl) ammonium bromide,3-hydroxy-N,N-dimethyl-N-ethylanilinium bromide,EDR

MW : 201.69

Formula : C10H16ClNO

CAS_number : 116-38-1

PubChem : 3202

UniChem : VWLHWLSRQJQWRG-UHFFFAOYSA-O

IUPHAR : 9073

Wikipedia : Edrophonium

Target

Families : Edrophonium ligand of proteins in family
ACHE BCHE

Protein :
torca-ACHE human-ACHE

References (35)

Title : beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies - Bartolini_2003_Biochem.Pharmacol_65_407
Author(s) : Bartolini M , Bertucci C , Cavrini V , Andrisano V
Ref : Biochemical Pharmacology , 65 :407 , 2003
Abstract : Bartolini_2003_Biochem.Pharmacol_65_407
ESTHER : Bartolini_2003_Biochem.Pharmacol_65_407
PubMedSearch : Bartolini_2003_Biochem.Pharmacol_65_407
PubMedID: 12527333

Title : Effect of tetramethylammonium, choline and edrophonium on insect acetylcholinesterase: test of a kinetic model - Stojan_1999_Chem.Biol.Interact_119-120_137
Author(s) : Stojan J , Marcel V , Fournier D
Ref : Chemico-Biological Interactions , 119-120 :137 , 1999
Abstract : Stojan_1999_Chem.Biol.Interact_119-120_137
ESTHER : Stojan_1999_Chem.Biol.Interact_119-120_137
PubMedSearch : Stojan_1999_Chem.Biol.Interact_119-120_137
PubMedID: 10421447

Title : Comparison of tilt angles and provocative agents (edrophonium and isoproterenol) to improve head-upright tilt-table testing - Voice_1998_Am.J.Cardiol_81_346
Author(s) : Voice RA , Lurie KG , Sakaguchi S , Rector TS , Benditt DG
Ref : American Journal of Cardiology , 81 :346 , 1998
Abstract : Voice_1998_Am.J.Cardiol_81_346
ESTHER : Voice_1998_Am.J.Cardiol_81_346
PubMedSearch : Voice_1998_Am.J.Cardiol_81_346
PubMedID: 9468082

Title : Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease - Costagli_1998_Biochem.Pharmacol_55_1733
Author(s) : Costagli C , Galli A
Ref : Biochemical Pharmacology , 55 :1733 , 1998
Abstract : Costagli_1998_Biochem.Pharmacol_55_1733
ESTHER : Costagli_1998_Biochem.Pharmacol_55_1733
PubMedSearch : Costagli_1998_Biochem.Pharmacol_55_1733
PubMedID: 9634011

Title : Static laue diffraction studies on acetylcholinesterase - Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359
Author(s) : Ravelli RB , Raves ML , Ren Z , Bourgeois D , Roth M , Kroon J , Silman I , Sussman JL
Ref : Acta Crystallographica D Biol Crystallogr , 54 :1359 , 1998
Abstract : Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359
ESTHER : Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359
PubMedSearch : Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359
PubMedID: 10089512
Gene_locus related to this paper: torca-ACHE

Title : Effects of four anticholinesterase-anticholinergic combinations and tracheal extubation on QTc interval of the ECG, heart rate and arterial pressure - Saarnivaara_1998_Acta.Anaesthesiol.Scand_42_460
Author(s) : Saarnivaara L , Simola M
Ref : Acta Anaesthesiologica Scandinavica , 42 :460 , 1998
Abstract : Saarnivaara_1998_Acta.Anaesthesiol.Scand_42_460
ESTHER : Saarnivaara_1998_Acta.Anaesthesiol.Scand_42_460
PubMedSearch : Saarnivaara_1998_Acta.Anaesthesiol.Scand_42_460
PubMedID: 9563867

Title : Neostigmine but not edrophonium prolongs the action of mivacurium - Symington_1996_Can.J.Anaesth_43_1220
Author(s) : Symington MJ , Mirakhur RK , Kumar N
Ref : Canadian Journal of Anaesthesia , 43 :1220 , 1996
Abstract : Symington_1996_Can.J.Anaesth_43_1220
ESTHER : Symington_1996_Can.J.Anaesth_43_1220
PubMedSearch : Symington_1996_Can.J.Anaesth_43_1220
PubMedID: 8955970

Title : Dose responses for neostigmine and edrophonium as antagonists of mivacurium in adults and children - Bevan_1996_Anesthesiology_84_354
Author(s) : Bevan JC , Tousignant C , Stephenson C , Blackman L , Reimer E , Smith MF , Bevan DR
Ref : Anesthesiology , 84 :354 , 1996
Abstract : Bevan_1996_Anesthesiology_84_354
ESTHER : Bevan_1996_Anesthesiology_84_354
PubMedSearch : Bevan_1996_Anesthesiology_84_354
PubMedID: 8602666

Title : Anticholinesterase drugs stimulate phosphatidylinositol response in rat tracheal slices - Shibata_1996_Anesth.Analg_82_1211
Author(s) : Shibata O , Kanairo M , Zhang S , Hasuo H , Morooka H , Fujie T , Sumikawa K
Ref : Anesthesia & Analgesia , 82 :1211 , 1996
Abstract : Shibata_1996_Anesth.Analg_82_1211
ESTHER : Shibata_1996_Anesth.Analg_82_1211
PubMedSearch : Shibata_1996_Anesth.Analg_82_1211
PubMedID: 8638793

Title : Different properties of the bradycardia produced by neostigmine and edrophonium in the cat - Backman_1996_Can.J.Anaesth_43_731
Author(s) : Backman SB , Stein RD , Blank DW , Collier B , Polosa C
Ref : Canadian Journal of Anaesthesia , 43 :731 , 1996
Abstract : Backman_1996_Can.J.Anaesth_43_731
ESTHER : Backman_1996_Can.J.Anaesth_43_731
PubMedSearch : Backman_1996_Can.J.Anaesth_43_731
PubMedID: 8807181

Title : Cloning and expression of acetylcholinesterase from Bungarus fasciatus venom. A new type of cooh-terminal domain\; involvement of a positively charged residue in the peripheral site - Cousin_1996_J.Biol.Chem_271_15099
Author(s) : Cousin X , Bon S , Duval N , Massoulie J , Bon C
Ref : Journal of Biological Chemistry , 271 :15099 , 1996
Abstract : Cousin_1996_J.Biol.Chem_271_15099
ESTHER : Cousin_1996_J.Biol.Chem_271_15099
PubMedSearch : Cousin_1996_J.Biol.Chem_271_15099
PubMedID: 8662867
Gene_locus related to this paper: bunfa-ACHE

Title : Acetylcholinesterase in Dendrobaena veneta (Oligochaeta: Opisthopora) is present with forms sensitive and insensitive to phosphatidylinositol phospholipase C. Biochemical characterization and histochemical localization in the nervous system - Talesa_1996_Eur.J.Biochem_238_538
Author(s) : Talesa V , Romani R , Rosi G , Giovannini E
Ref : European Journal of Biochemistry , 238 :538 , 1996
Abstract : Talesa_1996_Eur.J.Biochem_238_538
ESTHER : Talesa_1996_Eur.J.Biochem_238_538
PubMedSearch : Talesa_1996_Eur.J.Biochem_238_538
PubMedID: 8681969

Title : Solubilization, molecular forms, purification and substrate specificity of two acetylcholinesterases in the medicinal leech (Hirudo medicinalis) - Talesa_1995_Biochem.J_306_687
Author(s) : Talesa V , Grauso M , Giovannini E , Rosi G , Toutant JP
Ref : Biochemical Journal , 306 :687 , 1995
Abstract : Talesa_1995_Biochem.J_306_687
ESTHER : Talesa_1995_Biochem.J_306_687
PubMedSearch : Talesa_1995_Biochem.J_306_687
PubMedID: 7702560

Title : Fasciculin 2 binds to the peripheral site on acetylcholinesterase and inhibits substrate hydrolysis by slowing a step involving proton transfer during enzyme acylation - Eastman_1995_J.Biol.Chem_270_19694
Author(s) : Eastman J , Wilson EJ , Cervenansky C , Rosenberry TL
Ref : Journal of Biological Chemistry , 270 :19694 , 1995
Abstract : Eastman_1995_J.Biol.Chem_270_19694
ESTHER : Eastman_1995_J.Biol.Chem_270_19694
PubMedSearch : Eastman_1995_J.Biol.Chem_270_19694
PubMedID: 7649979

Title : Comparison of the effects of neostigmine and edrophonium on the duration of action of suxamethonium - McCoy_1995_Acta.Anaesthesiol.Scand_39_744
Author(s) : McCoy EP , Mirakhur RK
Ref : Acta Anaesthesiologica Scandinavica , 39 :744 , 1995
Abstract : McCoy_1995_Acta.Anaesthesiol.Scand_39_744
ESTHER : McCoy_1995_Acta.Anaesthesiol.Scand_39_744
PubMedSearch : McCoy_1995_Acta.Anaesthesiol.Scand_39_744
PubMedID: 7484027

Title : 6-Coumarin diazonium salt: a specific affinity label of the Torpedo acetylcholinesterase peripheral site - Schalk_1995_Mol.Pharmacol_48_1063
Author(s) : Schalk I , Ehret-Sabatier L , Le Feuvre Y , Bon S , Massoulie J , Goeldner M
Ref : Molecular Pharmacology , 48 :1063 , 1995
Abstract : Schalk_1995_Mol.Pharmacol_48_1063
ESTHER : Schalk_1995_Mol.Pharmacol_48_1063
PubMedSearch : Schalk_1995_Mol.Pharmacol_48_1063
PubMedID: 8848006

Title : Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase - Ordentlich_1995_J.Biol.Chem_270_2082
Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 270 :2082 , 1995
Abstract : Ordentlich_1995_J.Biol.Chem_270_2082
ESTHER : Ordentlich_1995_J.Biol.Chem_270_2082
PubMedSearch : Ordentlich_1995_J.Biol.Chem_270_2082
PubMedID: 7836436

Title : Edrophonium increases mivacurium concentrations during constant mivacurium infusion, and large doses minimally antagonize paralysis [see comments] - Hart_1995_Anesthesiology_82_912
Author(s) : Hart PS , Wright PM , Brown R , Lau M , Sharma ML , Miller RD , Gruenke L , Fisher DM
Ref : Anesthesiology , 82 :912 , 1995
Abstract : Hart_1995_Anesthesiology_82_912
ESTHER : Hart_1995_Anesthesiology_82_912
PubMedSearch : Hart_1995_Anesthesiology_82_912
PubMedID: 7717563

Title : Comparative pharmacokinetics of four cholinesterase inhibitors in rats - Yamamoto_1995_Biol.Pharm.Bull_18_1292
Author(s) : Yamamoto K , Sawada Y , Iga T
Ref : Biol Pharm Bull , 18 :1292 , 1995
Abstract : Yamamoto_1995_Biol.Pharm.Bull_18_1292
ESTHER : Yamamoto_1995_Biol.Pharm.Bull_18_1292
PubMedSearch : Yamamoto_1995_Biol.Pharm.Bull_18_1292
PubMedID: 8845827

Title : Differential effects of peripheral site ligands on Torpedo and chicken acetylcholinesterase - Eichler_1994_Mol.Pharmacol_45_335
Author(s) : Eichler J , Anselmet A , Sussman JL , Massoulie J , Silman I
Ref : Molecular Pharmacology , 45 :335 , 1994
Abstract : Eichler_1994_Mol.Pharmacol_45_335
ESTHER : Eichler_1994_Mol.Pharmacol_45_335
PubMedSearch : Eichler_1994_Mol.Pharmacol_45_335
PubMedID: 8114681

Title : Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core - Barak_1994_J.Biol.Chem_269_6296
Author(s) : Barak D , Kronman C , Ordentlich A , Ariel N , Bromberg A , Marcus D , Lazar A , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 269 :6296 , 1994
Abstract : Barak_1994_J.Biol.Chem_269_6296
ESTHER : Barak_1994_J.Biol.Chem_269_6296
PubMedSearch : Barak_1994_J.Biol.Chem_269_6296
PubMedID: 8119978

Title : The back door hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis - Kronman_1994_J.Biol.Chem_269_27819
Author(s) : Kronman C , Ordentlich A , Barak D , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 269 :27819 , 1994
Abstract : Kronman_1994_J.Biol.Chem_269_27819
ESTHER : Kronman_1994_J.Biol.Chem_269_27819
PubMedSearch : Kronman_1994_J.Biol.Chem_269_27819
PubMedID: 7961709

Title : The molecular forms of acetylcholinesterase from Necator americanus (Nematoda), a hookworm parasite of the human intestine - Pritchard_1994_Eur.J.Biochem_219_317
Author(s) : Pritchard DI , Brown A , Toutant JP
Ref : European Journal of Biochemistry , 219 :317 , 1994
Abstract : Pritchard_1994_Eur.J.Biochem_219_317
ESTHER : Pritchard_1994_Eur.J.Biochem_219_317
PubMedSearch : Pritchard_1994_Eur.J.Biochem_219_317
PubMedID: 8306998

Title : Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase - Shafferman_1994_EMBO.J_13_3448
Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B
Ref : EMBO Journal , 13 :3448 , 1994
Abstract : Shafferman_1994_EMBO.J_13_3448
ESTHER : Shafferman_1994_EMBO.J_13_3448
PubMedSearch : Shafferman_1994_EMBO.J_13_3448
PubMedID: 8062821

Title : Fresh frozen plasma and edrophonium in a patient with a plasma cholinesterase deficiency - Smith_1993_Anaesthesia_48_511
Author(s) : Smith DC , Ridley SA , Donaldson KF
Ref : Anaesthesia , 48 :511 , 1993
Abstract : Smith_1993_Anaesthesia_48_511
ESTHER : Smith_1993_Anaesthesia_48_511
PubMedSearch : Smith_1993_Anaesthesia_48_511
PubMedID: 8391759

Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074
Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P
Ref : Biochemistry , 32 :12074 , 1993
Abstract : Radic_1993_Biochemistry_32_12074
ESTHER : Radic_1993_Biochemistry_32_12074
PubMedSearch : Radic_1993_Biochemistry_32_12074
PubMedID: 8218285

Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083
Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 268 :17083 , 1993
Abstract : Ordentlich_1993_J.Biol.Chem_268_17083
ESTHER : Ordentlich_1993_J.Biol.Chem_268_17083
PubMedSearch : Ordentlich_1993_J.Biol.Chem_268_17083
PubMedID: 8349597
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase - Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031
Author(s) : Harel M , Schalk I , Ehret-Sabatier L , Bouet F , Goeldner M , Hirth C , Axelsen PH , Silman I , Sussman JL
Ref : Proceedings of the National Academy of Sciences of the United States of America , 90 :9031 , 1993
Abstract : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031
ESTHER : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031
PubMedSearch : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031
PubMedID: 8415649
Gene_locus related to this paper: torca-ACHE

Title : Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center - Shafferman_1992_EMBO.J_11_3561
Author(s) : Shafferman A , Velan B , Ordentlich A , Kronman C , Grosfeld H , Leitner M , Flashner Y , Cohen S , Barak D , Ariel N
Ref : EMBO Journal , 11 :3561 , 1992
Abstract : Shafferman_1992_EMBO.J_11_3561
ESTHER : Shafferman_1992_EMBO.J_11_3561
PubMedSearch : Shafferman_1992_EMBO.J_11_3561
PubMedID: 1396557

Title : Edrophonium and pralidoxime [letter] -
Author(s) : Alston TA
Ref : Anesthesia & Analgesia , 68 :826 , 1989
PubMedID: 2735555

Title : The effect of the organophosphate trichlorfon on the neuromuscular blocking activity of atracurium in halothane-anesthetized horses - Hildebrand_1989_J.Vet.Pharmacol.Ther_12_277
Author(s) : Hildebrand SV , Hill Td , Holland M
Ref : J Vet Pharmacol Ther , 12 :277 , 1989
Abstract : Hildebrand_1989_J.Vet.Pharmacol.Ther_12_277
ESTHER : Hildebrand_1989_J.Vet.Pharmacol.Ther_12_277
PubMedSearch : Hildebrand_1989_J.Vet.Pharmacol.Ther_12_277
PubMedID: 2810476

Title : Ligand stabilization of cholinesterases - Payne_1989_Biochim.Biophys.Acta_999_46
Author(s) : Payne CS , Saeed M , Wolfe AD
Ref : Biochimica & Biophysica Acta , 999 :46 , 1989
Abstract : Payne_1989_Biochim.Biophys.Acta_999_46
ESTHER : Payne_1989_Biochim.Biophys.Acta_999_46
PubMedSearch : Payne_1989_Biochim.Biophys.Acta_999_46
PubMedID: 2804138

Title : Structure-activity relationship of reversible cholinesterase inhibitors including paraquat - Seto_1988_Arch.Toxicol_62_37
Author(s) : Seto Y , Shinohara T
Ref : Archives of Toxicology , 62 :37 , 1988
Abstract : Seto_1988_Arch.Toxicol_62_37
ESTHER : Seto_1988_Arch.Toxicol_62_37
PubMedSearch : Seto_1988_Arch.Toxicol_62_37
PubMedID: 3190453

Title : Inhibition of human motor endplate cholinesterase by anticholinesterase compounds - Fujii_1982_Acta.Med.Okayama_36_229
Author(s) : Fujii M , Namba T
Ref : Acta Med Okayama , 36 :229 , 1982
Abstract : Fujii_1982_Acta.Med.Okayama_36_229
ESTHER : Fujii_1982_Acta.Med.Okayama_36_229
PubMedSearch : Fujii_1982_Acta.Med.Okayama_36_229
PubMedID: 7113748

Title : Interaction of fluorescence probes with acetylcholinesterase. The site and specificity of propidium binding - Taylor_1975_Biochemistry_14_1989
Author(s) : Taylor P , Lappi S
Ref : Biochemistry , 14 :1989 , 1975
Abstract : Taylor_1975_Biochemistry_14_1989
ESTHER : Taylor_1975_Biochemistry_14_1989
PubMedSearch : Taylor_1975_Biochemistry_14_1989
PubMedID: 1125207 
Array
(
    [id] => 135
    [inhibitor] => Edrophonium
    [type] => Array
        (
            [0] => Drug
            [1] => Quaternary compound
        )

    [other_name] => Array
        (
            [0] => Tensilon
            [1] => R02-3198
            [2] => Edrophonum
            [3] => Reversol
            [4] => Edroponium
            [5] => Enlon
            [6] => Ethyl (m-hydroxyphenyl) dimethylammonium bromide
            [7] => (3-hydroxyphenyl) dimethylethylammonium bromide
            [8] => dimethylethyl (3-hydroxyphenyl) ammonium bromide
            [9] => 3-hydroxy-N,N-dimethyl-N-ethylanilinium bromide
            [10] => EDR
        )

    [chemical_nomenclature] => ethyl-(3-hydroxyphenyl)-dimethylazanium
    [formula] => C10H16ClNO
    [cas_number] => 116-38-1
    [mw] => 201.69
    [pick_me_to_call] => display_script
    [kinetic_parameter] => Edrophonium_WT_bunfa-ACHE || Edrophonium_M70Y_bunfa-ACHE || Edrophonium_K285D_bunfa-ACHE || Edrophonium_M70Y\/K285D_bunfa-ACHE || Edrophonium_WT_torma-ACHE || Edrophonium_WT_human-ACHE || Edrophonium_W286A_human-ACHE || Edrophonium_Y337A_human-ACHE || Edrophonium_F338A_human-ACHE || Edrophonium_W86A_human-ACHE || Edrophonium_E84Q_human-ACHE || Edrophonium_E292A_human-ACHE || Edrophonium_E285A_human-ACHE || Edrophonium_D349N_human-ACHE || Edrophonium_E358Q_human-ACHE || Edrophonium_E389Q_human-ACHE || Edrophonium_D390N_human-ACHE || Edrophonium_E84Q\/E292A_human-ACHE || Edrophonium_D349N\/E358Q_human-ACHE || Edrophonium_E389Q\/D390N_human-ACHE || Edrophonium_E84Q\/D349N\/E358Q_human-ACHE || Edrophonium_E292A\/D349N\/E358Q_human-ACHE || Edrophonium_E292A\/E389Q\/D390N_human-ACHE || Edrophonium_E84Q\/E292A\/D349N\/E358Q_human-ACHE || Edrophonium_D349N\/E358Q\/E389Q\/D390N_human-ACHE || Edrophonium_E84Q\/E285A\/E292A\/D349N\/E358Q_human-ACHE || Edrophonium_E84Q\/D349N\/E358Q\/E389Q\/D390N_human-ACHE || Edrophonium_E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE || Edrophonium_E84Q\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE || Edrophonium_E84Q\/E285A\/E292A\/D349N\/E358Q\/E389Q\/D390N_human-ACHE || Edrophonium_Y72A_human-ACHE || Edrophonium_D74N_human-ACHE || Edrophonium_Y124A_human-ACHE || Edrophonium_Y341A_human-ACHE || Edrophonium_Y72A\/Y124A_human-ACHE || Edrophonium_Y72A\/E285A_human-ACHE || Edrophonium_Y72A\/W286A_human-ACHE || Edrophonium_E285A\/W286A_human-ACHE || Edrophonium_Y72A\/E285A\/W286A_human-ACHE || Edrophonium_Y124A\/E285A\/W286A_human-ACHE || Edrophonium_F295A_human-ACHE || Edrophonium_F297A_human-ACHE || Edrophonium_Y337F_human-ACHE || Edrophonium_D131N_human-ACHE || Edrophonium_V132A_human-ACHE || Edrophonium_V132K_human-ACHE || Edrophonium_WT_chick-ACHE || Edrophonium_W86F_human-ACHE || Edrophonium_W86E_human-ACHE || Edrophonium_Y133F_human-ACHE || Edrophonium_Y133A_human-ACHE || Edrophonium_E202Q_human-ACHE || Edrophonium_D74E_human-ACHE || Edrophonium_D74G_human-ACHE || Edrophonium_D74K_human-ACHE || Edrophonium_E202D_human-ACHE || Edrophonium_E202A_human-ACHE || Edrophonium_WT_mouse-ACHE || Edrophonium_WT_mouse-BCHE || Edrophonium_Y72N\/Y124Q\/W286R_mouse-ACHE || Edrophonium_Y72N\/Y124Q\/W286A_mouse-ACHE || Edrophonium_Y72N\/D74N\/Y124Q\/W286R_mouse-ACHE || Edrophonium_Y72N\/D74N\/Y124Q\/W286A_mouse-ACHE || Edrophonium_Y337A_mouse-ACHE || Edrophonium_Y337F_mouse-ACHE || Edrophonium_Y72N\/Y124Q_human-ACHE || Edrophonium_F295L\/F297V_human-ACHE || Edrophonium_Y72N\/Y124Q\/W286A_human-ACHE || Edrophonium_F295L\/F297V\/Y337A_human-ACHE || Edrophonium_Y72N\/Y124Q\/W286A\/F295L\/F297V\/Y337A_human-ACHE
    [paper] => Cousin_1996_J.Biol.Chem_271_15099 || Shafferman_1994_EMBO.J_13_3448 || Kronman_1994_J.Biol.Chem_269_27819 || Seto_1988_Arch.Toxicol_62_37 || Payne_1989_Biochim.Biophys.Acta_999_46 || Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 || Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359 || Hildebrand_1989_J.Vet.Pharmacol.Ther_12_277 || Symington_1996_Can.J.Anaesth_43_1220 || Fujii_1982_Acta.Med.Okayama_36_229 || Talesa_1995_Biochem.J_306_687 || Hart_1995_Anesthesiology_82_912 || Bartolini_2003_Biochem.Pharmacol_65_407 || Eastman_1995_J.Biol.Chem_270_19694 || McCoy_1995_Acta.Anaesthesiol.Scand_39_744 || Schalk_1995_Mol.Pharmacol_48_1063 || Talesa_1996_Eur.J.Biochem_238_538 || Smith_1993_Anaesthesia_48_511 || Pritchard_1994_Eur.J.Biochem_219_317 || Eichler_1994_Mol.Pharmacol_45_335 || Barak_1994_J.Biol.Chem_269_6296 || Taylor_1975_Biochemistry_14_1989 || Alston_1989_Anesth.Analg_68_826 || Yamamoto_1995_Biol.Pharm.Bull_18_1292 || Bevan_1996_Anesthesiology_84_354 || Shibata_1996_Anesth.Analg_82_1211 || Backman_1996_Can.J.Anaesth_43_731 || Voice_1998_Am.J.Cardiol_81_346 || Saarnivaara_1998_Acta.Anaesthesiol.Scand_42_460 || Costagli_1998_Biochem.Pharmacol_55_1733 || Stojan_1999_Chem.Biol.Interact_119-120_137 || Ordentlich_1993_J.Biol.Chem_268_17083 || Ordentlich_1995_J.Biol.Chem_270_2082 || Shafferman_1992_EMBO.J_11_3561 || Radic_1993_Biochemistry_32_12074
    [comment] => A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles
    [gene_locus] => torca-ACHE || human-ACHE
    [kin_inhibitor] => Edrophonium
    [cid] => 3202
    [family] => ACHE || BCHE
    [inchikey] => VWLHWLSRQJQWRG-UHFFFAOYSA-O
    [canonicalsmiles] => CC[N+](C)(C)C1=CC(=CC=C1)O
    [inchi] => InChI=1S\/C10H15NO\/c1-4-11(2,3)9-6-5-7-10(12)8-9\/h5-8H,4H2,1-3H3\/p+1
    [wikipedia] => Edrophonium
    [iupharlig] => 9073
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)