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Author Report for: Wille T

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Wille Timo
Bundeswehr Institute of Pharmacology and Toxicology, Munich
Germany
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    Title: AChE reactivation in Precision-cut lung slices following organophosphorus compound poisoning
    Golitz F, Herbert J, Worek F, Wille T
    Ref: Toxicol Lett, :, 2023 : PubMed

            

    Title: Aminoalkoxy-substituted coumarins: Synthesis and evaluation for reactivation of inhibited human acetylcholinesterase
    Elsinghorst PW, Wille T, Baric D, Mertens MD, Baumann M, Kuppers J, Gutschow M
    Ref: Arch Pharm (Weinheim), :e2200208, 2022 : PubMed

            

    Title: Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro
    Horn G, Kranawetvogl T, John H, Weigel C, Rauen U, Worek F, Wille T
    Ref: Chemico-Biological Interactions, :110285, 2022 : PubMed

            

    Title: The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents
    Keuler T, Lemke C, Elsinghorst PW, Iriepa I, Chioua M, Martinez-Grau MA, Beadle CD, Vetman T, Lopez-Munoz F and Gutschow M <4 more author(s)>
    Ref: ACS Pharmacol Transl Sci, 5:1097, 2022 : PubMed

            

    Title: Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS/MS method development, validation, and application to a real-life denatured blood sample
    Koller M, Thiermann H, Worek F, Wille T
    Ref: Journal of Chromatography B Analyt Technol Biomed Life Sciences, 1179:122693, 2021 : PubMed

            

    Title: Post-VX exposure treatment of rats with engineered phosphotriesterases
    Stigler L, Kohler A, Koller M, Job L, Escher B, Potschka H, Thiermann H, Skerra A, Worek F, Wille T
    Ref: Archives of Toxicology, :, 2021 : PubMed

            

    Title: Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense
    Tigges J, Worek F, Thiermann H, Wille T
    Ref: Archives of Toxicology, :, 2021 : PubMed

            

    Title: Diagnostics and treatment of nerve agent poisoning-current status and future developments
    Amend N, Niessen KV, Seeger T, Wille T, Worek F, Thiermann H
    Ref: Annals of the New York Academy of Sciences, :, 2020 : PubMed

            

    Title: A case report of cholinesterase inhibitor poisoning: cholinesterase activities and analytical methods for diagnosis and clinical decision making
    Amend N, Langgartner J, Siegert M, Kranawetvogl T, Koller M, John H, Pflugler C, Mogele-Schmid C, Worek F and Wille T <1 more author(s)>
    Ref: Archives of Toxicology, :, 2020 : PubMed

            

    Title: Early diagnosis of nerve agent exposure with a mobile test kit and implications for medical countermeasures: a trigger to react
    Wille T, Djordjevic S, Worek F, Thiermann H, Vucinic S
    Ref: BMJ Mil Health, :, 2020 : PubMed

            

    Title: In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase
    Worek F, Thiermann H, Koller M, Wille T
    Ref: Molecules, 25:, 2020 : PubMed

            

    Title: Organophosphorus compounds and oximes: a critical review
    Worek F, Thiermann H, Wille T
    Ref: Archives of Toxicology, 94:2275, 2020 : PubMed

            

    Title: The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM)
    Amend N, Thiermann H, Worek F, Wille T
    Ref: Toxicol Lett, 308:1, 2019 : PubMed

            

    Title: COPD and asthma therapeutics for supportive treatment in organophosphate poisoning
    Herbert J, Thiermann H, Worek F, Wille T
    Ref: Clinical Toxicology (Phila), :1, 2019 : PubMed

            

    Title: Chromenones as Multineurotargeting Inhibitors of Human Enzymes
    Lemke C, Christmann J, Yin J, Alonso JM, Serrano E, Chioua M, Ismaili L, Martinez-Grau MA, Beadle CD and Gutschow M <9 more author(s)>
    Ref: ACS Omega, 4:22161, 2019 : PubMed

            

    Title: Human small bowel as model for poisoning with organophosphorus compounds
    Marquart K, Prokopchuk O, Wilhelm D, Worek F, Thiermann H, Martignoni ME, Wille T
    Ref: Toxicol In Vitro, 57:76, 2019 : PubMed

            

    Title: Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning
    Marquart K, Prokopchuk O, Worek F, Thiermann H, Martignoni ME, Wille T
    Ref: Toxicol Lett, 293:235, 2018 : PubMed

            

    Title: Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats
    Marquart K, Herbert J, Amend N, Thiermann H, Worek F, Wille T
    Ref: Clinical Toxicology (Phila), :1, 2018 : PubMed

            

    Title: The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study
    Worek F, Thiermann H, Wille T
    Ref: Toxicol Lett, 293:216, 2018 : PubMed

            

    Title: Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6
    Wille T, von der Wellen J, Thiermann H, Worek F
    Ref: Archives of Toxicology, 91:1309, 2017 : PubMed

            

    Title: Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase
    De Koning MC, Joosen MJ, Worek F, Nachon F, van Grol M, Klaassen SD, Alkema DPW, Wille T, de Bruijn HM
    Ref: Journal of Medicinal Chemistry, 60:9376, 2017 : PubMed

            

    Title: Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds
    Bierwisch A, Wille T, Thiermann H, Worek F
    Ref: Toxicol Lett, 246:49, 2016 : PubMed

            

    Title: A novel fluorogenic probe for the investigation of free thiols: Application to kinetic measurements of acetylcholinesterase activity
    Mertens MD, Bierwisch A, Li T, Gutschow M, Thiermann H, Wille T, Elsinghorst PW
    Ref: Toxicol Lett, 244:161, 2016 : PubMed

            

    Title: Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection
    Wille T, Neumaier K, Koller M, Ehinger C, Aggarwal N, Ashani Y, Goldsmith M, Sussman JL, Tawfik DS and Worek F <1 more author(s)>
    Ref: Toxicol Lett, 258:198, 2016 : PubMed

            

    Title: Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase
    Winter M, Wille T, Musilek K, Kuca K, Thiermann H, Worek F
    Ref: Toxicol Lett, 244:136, 2016 : PubMed

            

    Title: On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds
    Worek F, Schilha M, Neumaier K, Aurbek N, Wille T, Thiermann H, Kehe K
    Ref: Toxicol Lett, 249:22, 2016 : PubMed

            

    Title: Oximes in organophosphate poisoning: 60 years of hope and despair
    Worek F, Thiermann H, Wille T
    Ref: Chemico-Biological Interactions, 259:93, 2016 : PubMed

            

    Title: Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics
    Worek F, Koller M, Thiermann H, Wille T
    Ref: Toxicology, 350-352:25, 2016 : PubMed

            

    Title: Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study
    Worek F, Seeger T, Neumaier K, Wille T, Thiermann H
    Ref: Toxicol Lett, 262:12, 2016 : PubMed

            

    Title: Catalytic bioscavengers in nerve agent poisoning: A promising approach?
    Worek F, Thiermann H, Wille T
    Ref: Toxicol Lett, 244:143, 2016 : PubMed

            

    Title: Kinetics of pesticide degradation by human fresh frozen plasma (FFP) in vitro
    von der Wellen J, Bierwisch A, Worek F, Thiermann H, Wille T
    Ref: Toxicol Lett, 244:124, 2016 : PubMed

            

    Title: Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase
    Horn G, Wille T, Musilek K, Kuca K, Thiermann H, Worek F
    Ref: Archives of Toxicology, 89:405, 2015 : PubMed

            

    Title: Application of a dynamic in vitro model with real-time determination of acetylcholinesterase activity for the investigation of tabun analogues and oximes
    Worek F, Herkert NM, Koller M, Thiermann H, Wille T
    Ref: Toxicol In Vitro, 30:514, 2015 : PubMed

            

    Title: In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP)
    Wille T, Thiermann H, Worek F
    Ref: Archives of Toxicology, 88:301, 2014 : PubMed

            

    Title: Effectiveness of a substituted beta-cyclodextrin to prevent cyclosarin toxicity in vivo
    Worek F, Seeger T, Zengerle M, Kubik S, Thiermann H, Wille T
    Ref: Toxicol Lett, 226:222, 2014 : PubMed

            

    Title: Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro
    Worek F, Seeger T, Goldsmith M, Ashani Y, Leader H, Sussman JL, Tawfik DS, Thiermann H, Wille T
    Ref: Archives of Toxicology, 88:1257, 2014 : PubMed

            

    Title: Adaptation of a dynamic in vitro model with real-time determination of butyrylcholinesterase activity in the presence of cyclosarin and an oxime
    Worek F, Horn G, Wille T, Thiermann H
    Ref: Toxicol In Vitro, 29:162, 2014 : PubMed

            

    Title: Functionalized cyclodextrins bearing an alpha nucleophile - A promising way to degrade nerve agents
    Estour F, Letort S, Muller S, Kalakuntla RK, Le Provost R, Wille T, Reiter G, Worek F, Lafont O, Gouhier G
    Ref: Chemico-Biological Interactions, 203:202, 2013 : PubMed

            

    Title: New modified beta-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: Evaluation of the detoxification using a half-quantitative enzymatic assay
    Kalakuntla RK, Wille T, Le Provost R, Letort S, Reiter G, Muller S, Thiermann H, Worek F, Gouhier G and Estour F <1 more author(s)>
    Ref: Toxicol Lett, 216:200, 2013 : PubMed

            

    Title: Investigations of kinetic interactions between lipid emulsions, hydroxyethyl starch or dextran and organophosphorus compounds
    von der Wellen J, Worek F, Thiermann H, Wille T
    Ref: Clinical Toxicology (Phila), 51:918, 2013 : PubMed

            

    Title: Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates
    Wille T, Kaltenbach L, Thiermann H, Worek F
    Ref: Chemico-Biological Interactions, 206:569, 2013 : PubMed

            

    Title: Fourteenth International Medical Chemical Defence Conference 2013 Translation of experimental research for improved treatment of chemical warfare agents
    Wille T, Worek F, Thiermann H
    Ref: Chemico-Biological Interactions, 206:433, 2013 : PubMed

            

    Title: Structural requirements for effective oximes - Evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes
    Worek F, Wille T, Koller M, Thiermann H
    Ref: Chemico-Biological Interactions, 203:125, 2013 : PubMed

            

    Title: Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships
    Worek F, Wille T, Koller M, Thiermann H
    Ref: Biochemical Pharmacology, 83:1700, 2012 : PubMed

            

    Title: Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro
    Herkert NM, Schulz S, Wille T, Thiermann H, Hatz RA, Worek F
    Ref: Toxicol Appl Pharmacol, 253:7, 2011 : PubMed

            

    Title: Optimized strategies to synthesize beta-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers
    Le Provost R, Wille T, Louise L, Masurier N, Muller S, Reiter G, Renard PY, Lafont O, Worek F, Estour F
    Ref: Org Biomol Chem, 9:3026, 2011 : PubMed

            

    Title: In vitro detoxification of cyclosarin (GF) by modified cyclodextrins
    Muller S, Koller M, Le Provost R, Lafont O, Estour F, Wille T, Thiermann H, Worek F, Reiter G
    Ref: Toxicol Lett, 200:53, 2011 : PubMed

            

    Title: In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases
    Wille T, Thiermann H, Worek F
    Ref: Chemico-Biological Interactions, 190:79, 2011 : PubMed

            

    Title: In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases - Response to the letter to the editor
    Wille T, Thiermann H, Worek F
    Ref: Chemico-Biological Interactions, 193:108, 2011 : PubMed

            

    Title: Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species
    Wille T, Thiermann H, Worek F
    Ref: Toxicol Mech Methods, 21:533, 2011 : PubMed

            

    Title: Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase
    Worek F, Aurbek N, Wille T, Eyer P, Thiermann H
    Ref: Toxicol Lett, 200:19, 2011 : PubMed

            

    Title: Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach
    Worek F, Aurbek N, Wille T, Eyer P, Thiermann H
    Ref: J Enzyme Inhib Med Chem, 26:303, 2011 : PubMed

            

    Title: Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay
    Wille T, Thiermann H, Worek F
    Ref: Toxicol In Vitro, 24:1026, 2010 : PubMed

            

    Title: Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds
    Wille T, Ekstrom F, Lee JC, Pang YP, Thiermann H, Worek F
    Ref: Biochemical Pharmacology, 80:941, 2010 : PubMed

            

    Title: Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach
    Worek F, Wille T, Aurbek N, Eyer P, Thiermann H
    Ref: Toxicol Appl Pharmacol, 249:231, 2010 : PubMed

            

    Title: Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay
    Wille T, Tenberken O, Reiter G, Muller S, Le Provost R, Lafont O, Estour F, Thiermann H, Worek F
    Ref: Toxicology, 265:96, 2009 : PubMed

            


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