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PE-PPE

Relationship

Family: PE-PPE

Block: X

Parent Family: No family

Comment

The human pathogen Mycobacterium tuberculosis harbours a large number of genes that encode proteins whose N-termini contain the characteristic motifs Pro-Glu (PE) or Pro-Pro-Glu (PPE). A subgroup of the PE proteins contains polymorphic GC-rich sequences (PGRS), while a subgroup of the PPE proteins contains major polymorphic tandem repeats (MPTR). This domain is found C-terminal to the PE (IPR000084) and PPE (IPR000030) domains. Only a few of these domain are associated with alpha/beta hydrolases. The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands, and recently demonstrated to be alpha/beta hydrolase: see Sultana et al. This protein domain is close to cutinase. The membrane-associated acyltransferase Chp1 (myctu-Rv3822) accepts a synthetic diacyl sulfolipid and transfers an acyl group regioselectively from one donor substrate molecule to a second acceptor molecule in two successive reactions to yield a tetraacylated product. The rv1184c locus encodes Chp2, an acyltransferase in polyacyltrehalose lipid biosynthesis. In fact this domain is found in many unrelated folds only a few are alpha/beta hydrolases (Sultana 2016)

Database

Interpro : IPR013228 PE-PPE, C-terminal , IPR000084 PE-PGRS family, N-terminal

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF08237 PE-PPE

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Gene_locus Name Species
9caud-b5lj44 Mycobacterium phage Myrna Gp33 Mycobacterium phage Myrna
myca9-b1mij3 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) PE\/PPE family protein Mycobacterium abscessus
mycab-a5a9u7 Mycobacterium abscessus PE protein(and strain ATCC19977\/DSM44196) Mycobacterium abscessus
mycch-a5a9r9 Mycobacterium chelonae PE protein Mycobacterium chelonae
mycgi-a4t1a6 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4t1g1 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4t3y0 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens(strain ATCC 700033 \/ PYR-GCK)) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4t6q4 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4tab0 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4tab4 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4tab9 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens(strain ATCC 700033 \/ PYR-GCK) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4tan3 Mycobacterium gilvum (Mycobacterium flavescens), Mycobacterium sp., PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4tc14 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4tcx5 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens(strain ATCC 700033 \/ PYR-GCK) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycgi-a4td78 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens(strain ATCC 700033 \/ PYR-GCK) PE-PPE, C-terminal domain protein Mycobacterium gilvum
mycle-q9cc62 Mycobacterium leprae (and strain Br4923 Lepb1170_F3_112) Putative uncharacterized protein ML1232 Mycobacterium leprae
mycmm-b2hgg2 Mycobacterium marinum (strain ATCC BAA-535 \/ M)Mycobacterium ulcerans (strain Agy99) PPE family protein, PPE28 Mycobacterium ulcerans
mycmm-b2hhu3 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE-PGRS family protein Mycobacterium marinum
mycmm-b2hiu5 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE family protein Mycobacterium marinum
mycmm-b2hiy0 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE family protein Mycobacterium marinum
mycmm-b2hlt7 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE family protein Mycobacterium marinum
mycmm-b2hlt8 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE family protein Mycobacterium marinum
mycmm-b2hlt9 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE family protein Mycobacterium marinum
mycmm-b2hlu0 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE family protein Mycobacterium marinum
mycmm-b2hlv0 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE-PGRS family protein Mycobacterium marinum
mycmm-b2hlv1 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE family protein Mycobacterium marinum
mycmm-b2hlv2 Mycobacterium marinum (strain ATCC BAA-535 \/ M) Mycobacterium ulcerans (strain Agy99) PE family protein, PE4 Mycobacterium ulcerans
mycmm-b2hp80 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE-PGRS family protein, PE16 Mycobacterium marinum
mycmm-b2hpp0 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PPE family protein Mycobacterium marinum
mycmm-b2hsm6 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PPE family protein Mycobacterium marinum
mycmm-b2ht06 Mycobacterium marinum (strain ATCC BAA-535 \/ M) PE family protein Mycobacterium marinum
mycpa-q73xs5 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) Putative uncharacterized protein Mycobacterium paratuberculosis
mycs2-a0qrn0 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Putative uncharacterized protein Mycobacterium smegmatis
mycs2-a0qvy2 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Ppe family protein Mycobacterium smegmatis
mycs2-a0r1f5 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Putative uncharacterized protein Mycobacterium smegmatis
mycs2-a0r356 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) PPE family protein, putative Mycobacterium smegmatis
mycs2-a0r3f6 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Pe family protein Mycobacterium smegmatis
mycs2-a0r3k1 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Putative uncharacterized protein Mycobacterium smegmatis
mycs2-a0r3k2 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Putative uncharacterized protein Mycobacterium smegmatis
mycs2-a0r4a0 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Pe family protein Mycobacterium smegmatis
mycs2-a0r5c7 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Pe family protein Mycobacterium smegmatis
mycs2-q2m5k2 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Putative uncharacterized protein Mycobacterium smegmatis
mycsj-a3ptj3 Mycobacterium sp. (strains MCS\; KMS\; JLS) Putative uncharacterized protein Mycobacterium sp.
mycss-q1b229 Mycobacterium sp. (strains MCS\; KMS\; JLS) PE-PPE-like protein, C-terminal domain protein Mycobacterium sp.
mycss-q1b382 Mycobacterium sp. (strain MCS\; KMS\; JLS) Putative uncharacterized protein Mycobacterium sp.
mycss-q1b3w7 Mycobacterium sp. (strains MCS\; KMS\; JLS) PE-PPE, C-terminal domain protein Mycobacterium sp.
mycss-q1b3w8 Mycobacterium sp. (strain MCS\; KMS\; JLS) PE-PPE-like protein, C-terminal domain protein Mycobacterium sp.
mycss-q1b3z8 Mycobacterium sp. (strains MCS\; KMS\; JLS) PE-PPE-like protein, C-terminal domain protein Mycobacterium sp.
mycss-q1b852 Mycobacterium sp. (strain MCS\; KMS\; JLS) PE-PPE-like protein C-terminal domain protein Mycobacterium sp.
mycss-q1bb90 Mycobacterium sp. (strain MCS\; KMS\; JLS) PE-PPE-like protein, C-terminal domain protein Mycobacterium sp.
mycss-q1bdh0 Mycobacterium sp. (strains MCS\; KMS\; JLS) PE-PPE-like protein Mycobacterium sp.
mycss-q1bez8 Mycobacterium sp. (strains MCS\; JLS\; KMS) PE-PPE, C-terminal domain protein Mycobacterium sp.
mycss-q1bfg5 Mycobacterium sp. (strains MCS\; KMS\; JLS) PE-PPE-like protein, C-terminal domain protein Mycobacterium sp.
mycss-q1bft3 Mycobacterium sp. (strains MCS\; KMS\; JLS) AAA ATPase containing von Willebrand factor type A (VWA) domain-like protein Mycobacterium sp.
myctu-Rv0151c Mycobacterium tuberculosis, Mycobacterium bovis, MT0160 Rv0151c PE family protein Mycobacterium tuberculosis
myctu-Rv0152c Mycobacterium tuberculosis, Mycobacterium bovis, Rv0152c MT0161 PE family protein Mycobacterium tuberculosis
myctu-Rv0159c Mycobacterium tuberculosis, Mycobacterium bovis, Rv0159c PE family protein Mycobacterium tuberculosis
myctu-Rv0160c Mycobacterium tuberculosis MT0169, Rv0160c Mycobacterium bovis, PE family protein Mycobacterium tuberculosis
myctu-Rv1184c Mycobacterium tuberculosis, Mycobacterium bovis, Rv1184c MT1221 Hypothetical exported protein Mycobacterium tuberculosis
myctu-Rv1430 Mycobacterium tuberculosis, Mycobacterium bovis, MT1474, Rv1430 PE family protein PE16 Mycobacterium tuberculosis
myctu-Rv1800 Mycobacterium tuberculosis, Mycobacterium bovis, PPE family protein Rv1800 PPE28 Mycobacterium tuberculosis
myctu-Rv3822 Mycobacterium tuberculosis Rv3822 MT3930 Chp1\; Mycobacterium bovis Mb3852 Mycobacterium tuberculosis
myctu-ppe42 Mycobacterium tuberculosis, Mycobacterium bovis, Rv2608, MT2683 PPE family protein PPE42 Mycobacterium tuberculosis
myctu-ppe63 Mycobacterium tuberculosis, Mycobacterium bovis, Rv3539, MT3643 ppe63 PPE family protein Mycobacterium tuberculosis
mycua-a0pml9 Mycobacterium ulcerans (strain Agy99) PE family protein Mycobacterium ulcerans
mycvp-a1t122 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t142 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t1s5 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t349 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t3u9 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t4h3 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t5h6 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t659 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t6t3 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t846 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t9c2 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t9q4 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t9q5 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t9q8 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1t9r2 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1tcf8 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1te97 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1tea0 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1tei8 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) PE-PPE, C-terminal domain protein Mycobacterium vanbaalenii
mycvp-a1tg45 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Transcriptional regulator, TetR family Mycobacterium vanbaalenii
nocfa-q5ysq0 Nocardia farcinica Putative uncharacterized protein Nocardia farcinica
nocfa-q5yzq7 Nocardia farcinica Putative uncharacterized protein Nocardia farcinica
rhoe4-c1a2u2 Rhodococcus erythropolis (strain PR4 \/ NBRC 100887) Putative uncharacterized protein Rhodococcus erythropolis
rhoer-c3jty5 Rhodococcus erythropolis SK121 Putative uncharacterized protein Rhodococcus erythropolis SK121
rhoob-c1ayj6 Rhodococcus opacus (strain B4) Putative uncharacterized protein Rhodococcus opacus
rhosr-q0s477 Rhodococcus sp. (strain RHA1) Putative uncharacterized protein Rhodococcus sp.
rhosr-q0s5m7 Rhodococcus sp. (strain RHA1) Putative uncharacterized protein Rhodococcus sp.

Gene_locus_frgt Name Species
9caud-d4p7q2 Rhodococcus phage LysB Rhodococcus phage ReqiPoco6
mycs2-a0r3c3 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Putative uncharacterized protein Mycobacterium smegmatis

Substrate Chemical Nomenclature Proteins
Paranitrophenyl-hexanoate (4-nitrophenyl) hexanoate erylo-E53    9bact-a0a2s1gux0    9flao-a0a330mq60    9flao-a0a0c1f4u8    myctu-Rv1430    geost-est30    geost-est50

Inhibitor Chemical Nomenclature Proteins
Orlistat [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate human-DAGLA    human-DAGLB    human-PNLIP    human-FASN    mycs2-a0r619    human-PNLIPRP2    human-ABHD16A    myctu-a85c    myctu-Rv3822    plafa-PF10.0379    staau-lipas    human-CES2    myctu-Rv3802c
PMSF Phenylmethylsulfonyl fluoride theet-q3ch51    emeni-q5avy9    human-ABHD10    human-PREPL    myctu-Rv1430    psefl-cxest    9bact-E40    thefu-q6a0i4    ecoli-Aes    orysj-Q10QA5    bac25-mglp    9bact-Q0GMU2    bacsu-FENB    psepu-clcd1    thema-TM0077    bacsu-RsbQ    ecoli-bioh    drome-CG9542    human-FAP    tubmm-TmEst2    human-NOTUM    cutac-e6dae5    9gamm-urc15994    9baci-EstD9    geost-est30    pholl-AntI

References (7)

Title : Mycobacterium tuberculosis PE1 and PE2 proteins carrying conserved alpha\/beta-serine hydrolase domain are esterases hydrolyzing short to medium chain p-nitrophenyl esters - Divya_2018_Prog.Biophys.Mol.Biol_140_90
Author(s) : Divya MB , Vemula M , Balakrishnan K , Banerjee S , Guruprasad L
Ref : Prog Biophys Mol Biol , 140 :90 , 2018
Abstract :
PubMedSearch : Divya_2018_Prog.Biophys.Mol.Biol_140_90
PubMedID: 29751012
Gene_locus related to this paper: myctu-Rv0151c , myctu-Rv0152c

Title : Prediction of Certain Well-Characterized Domains of Known Functions within the PE and PPE Proteins of Mycobacteria - Sultana_2016_PLoS.One_11_e0146786
Author(s) : Sultana R , Tanneeru K , Kumar AB , Guruprasad L
Ref : PLoS ONE , 11 :e0146786 , 2016
Abstract :
PubMedSearch : Sultana_2016_PLoS.One_11_e0146786
PubMedID: 26891364

Title : The rv1184c Locus Encodes Chp2, an Acyltransferase in Mycobacterium tuberculosis Polyacyltrehalose Lipid Biosynthesis - Touchette_2015_J.Bacteriol_197_201
Author(s) : Touchette MH , Holsclaw CM , Previti ML , Solomon VC , Leary JA , Bertozzi CR , Seeliger JC
Ref : Journal of Bacteriology , 197 :201 , 2015
Abstract :
PubMedSearch : Touchette_2015_J.Bacteriol_197_201
PubMedID: 25331437
Gene_locus related to this paper: myctu-Rv1184c

Title : Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis - Seeliger_2012_J.Biol.Chem_287_7990
Author(s) : Seeliger JC , Holsclaw CM , Schelle MW , Botyanszki Z , Gilmore SA , Tully SE , Niederweis M , Cravatt BF , Leary JA , Bertozzi CR
Ref : Journal of Biological Chemistry , 287 :7990 , 2012
Abstract :
PubMedSearch : Seeliger_2012_J.Biol.Chem_287_7990
PubMedID: 22194604
Gene_locus related to this paper: myctu-Rv3822

Title : Ins and outs of Mycobacterium tuberculosis PPE family in pathogenesis and implications for novel measures against tuberculosis - Deng_2012_J.Cell.Biochem_113_1087
Author(s) : Deng W , Xie J
Ref : Journal of Cellular Biochemistry , 113 :1087 , 2012
Abstract :
PubMedSearch : Deng_2012_J.Cell.Biochem_113_1087
PubMedID: 22275049

Title : The PE-PPE domain in mycobacterium reveals a serine alpha\/beta hydrolase fold and function: an in-silico analysis - Sultana_2011_PLoS.One_6_e16745
Author(s) : Sultana R , Tanneeru K , Guruprasad L
Ref : PLoS ONE , 6 :e16745 , 2011
Abstract :
PubMedSearch : Sultana_2011_PLoS.One_6_e16745
PubMedID: 21347309
Gene_locus related to this paper: myctu-Rv0151c , myctu-Rv0159c , myctu-Rv0160c , myctu-Rv1184c , myctu-Rv1800 , myctu-Rv3822

Title : Sequence analysis corresponding to the PPE and PE proteins in Mycobacterium tuberculosis and other genomes - Adindla_2003_J.Biosci_28_169
Author(s) : Adindla S , Guruprasad L
Ref : J Biosci , 28 :169 , 2003
Abstract :
PubMedSearch : Adindla_2003_J.Biosci_28_169
PubMedID: 12711809