BD-FAE

Relationship

Family: BD-FAE

Block: H

Parent Family: No family

Comment

Extracted from Hormone sensitive lipases. BD-FAE: The function of many members may differ from the one of the representavive used to describe the family in the PFAM database. (from PFAM): This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilisation loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates. In PFAM database it includes family Tannase_Bact and family Est9X which are separate families in ESTHER. Feruloyl esterases are distributed in different sub-classes type-A B C,D and E and fall respectively in the following families. Type-A in Lipase_3, Type-B in Esterase_phb (PHB depolymerase), Type-C in Tannase, Type-D in FaeC, Type-E in A85-Feruloyl-Esterase, Type-F in BD-FAE. This family also contains Sphingobium fuliginis meta-fission product hydrolase and Non-reducing polyketide synthase Lecanoric acid synthase thioesterase domain farther related to similar thioesterase domain.

Database

Interpro : IPR049492 BD-FAE-like domain

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF20434 BD-FAE

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (27)

Genes Proteins in BD-FAE family (794)

Fragments of genes in BD-FAE family (89)

Structures in BD-FAE family (27)

Substrates in BD-FAE family (13)

No Inhibitor

References (9)

Title : Cloning and Functional Characterization of the Polyketide Synthases Based on Genome Mining of Preussia isomera XL-1326 - Liu_2022_Front.Microbiol_13_819086
Author(s) : Liu Q , Zhang D , Xu Y , Gao S , Gong Y , Cai X , Yao M , Yang X
Ref : Front Microbiol , 13 :819086 , 2022
PubMedID: 35602042
Gene_locus related to this paper: preis-preu6

Title : A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study - Bzdrenga_2021_Molecules_26_657
Author(s) : Bzdrenga J , Trenet E , Chantegreil F , Bernal K , Nachon F , Brazzolotto X
Ref : Molecules , 26 :657 , 2021
PubMedID: 33513869
Gene_locus related to this paper: 9bact-TtEst2

Title : Polysaccharide utilization loci-driven enzyme discovery reveals BD-FAE: a bifunctional feruloyl and acetyl xylan esterase active on complex natural xylans - Hameleers_2021_Biotechnol.Biofuels_14_127
Author(s) : Hameleers L , Penttinen L , Ikonen M , Jaillot L , Faure R , Terrapon N , Deuss PJ , Hakulinen N , Master ER , Jurak E
Ref : Biotechnol Biofuels , 14 :127 , 2021
PubMedID: 34059129
Gene_locus related to this paper: 9zzzz-6XYC

Title : Structural Insights into the Dual-Substrate Recognition and Catalytic Mechanisms of a Bifunctional Acetyl Ester-Xyloside Hydrolase from Caldicellulosiruptor lactoaceticus - Cao_2019_ACS.Catal_9_1739
Author(s) : Cao H , Sun L , Huang Y , Liu X , Yang D , Liu T , Jia X , Wen B , Gu T , Wang F , Xin F
Ref : ACS Catal , 9 :1739 , 2019
PubMedID:
Gene_locus related to this paper: 9firm-g2pvg6

Title : Pressure adaptation is linked to thermal adaptation in salt-saturated marine habitats - Alcaide_2015_Environ.Microbiol_17_332
Author(s) : Alcaide M , Stogios PJ , Lafraya A , Tchigvintsev A , Flick R , Bargiela R , Chernikova TN , Reva ON , Hai T , Leggewie CC , Katzke N , La Cono V , Matesanz R , Jebbar M , Jaeger KE , Yakimov MM , Yakunin AF , Golyshin PN , Golyshina OV , Savchenko A , Ferrer M
Ref : Environ Microbiol , 17 :332 , 2015
PubMedID: 25330254
Gene_locus related to this paper: 9alte-MGS-MT1 , 9bact-MGS-M1 , 9bact-MGS-M2 , 9bact-a0a0b5kns5

Title : The Structure of a Novel Thermophilic Esterase from the Planctomycetes Species, Reveals an Open Active Site Due to a Minimal 'Cap' Domain - Sayer_2015_Front.Microbiol_6_1294
Author(s) : Sayer C , Szabo Z , Isupov MN , Ingham C , Littlechild JA
Ref : Front Microbiol , 6 :1294 , 2015
PubMedID: 26635762
Gene_locus related to this paper: 9bact-TtEst2

Title : A Lactobacillus plantarum Esterase Active on a Broad Range of Phenolic Esters - Esteban-Torres_2015_Appl.Environ.Microbiol_81_3235
Author(s) : Esteban-Torres M , Landete JM , Reveron I , Santamaria L , de Las Rivas B , Munoz R
Ref : Applied Environmental Microbiology , 81 :3235 , 2015
PubMedID: 25746986
Gene_locus related to this paper: lacpl-Est.1092

Title : Structure, biochemical characterization and analysis of the pleomorphism of carboxylesterase Cest-2923 from Lactobacillus plantarum WCFS1 - Benavente_2013_FEBS.J_280_6658
Author(s) : Benavente R , Esteban-Torres M , Acebron I , de Las Rivas B , Munoz R , Alvarez Y , Mancheno JM
Ref : Febs J , 280 :6658 , 2013
PubMedID: 24127688
Gene_locus related to this paper: lacpl-LP.2923

Title : A novel meta-cleavage product hydrolase from Flavobacterium sp. ATCC27551 - Khajamohiddin_2006_Biochem.Biophys.Res.Commun_351_675
Author(s) : Khajamohiddin S , Babu PS , Chakka D , Merrick M , Bhaduri A , Sowdhamini R , Siddavattam D
Ref : Biochemical & Biophysical Research Communications , 351 :675 , 2006
PubMedID: 17078928
Gene_locus related to this paper: sphsa-q8gc44