mouse-ACOT6

 
Mus musculus (Mouse)acyl-CoA thioesterase 6 (EC 3.1.2.2). Weakly similar to peroxisomal acyl-coenzyme A thioester hydrolase2

Comment
The mouse ACOT gene cluster comprises six genes with localizations in cytosol (ACOT1), mitochondria (ACOT2), and peroxisomes (ACOT3-6). The corresponding human gene cluster contains only three genes (ACOT1, ACOT2, and ACOT4) coding for full-length thioesterase proteins only ACOT4 is peroxisomal


Relationship
Block X
Mus musculus position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Glires: N E > Rodentia: N E > Myomorpha: N E > Muroidea: N E > Muridae: N E > Murinae: N E > Mus [genus]: N E > Mus [subgenus]: N E > Mus musculus: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic



2 Genbank : AK039518, AY999300
1 UniProt : Q32Q92
1 UniProtTrembl : Q32Q92
1 Interpro : Q32Q92
1 Prodom : Q32Q92
1 Pfam : Q32Q92
1 PIRSF : Q32Q92
1 SUPERFAM : Q32Q92
1 QuickSwissBlast : Q32Q92
1 MGD : 1921287
1 ENSEMBL : ENSMUSG00000043487
 
Sequence
Graphical view for this peptide sequence: mouse-ACOT6
Colored MSA for Acyl-CoA_Thioesterase (raw)
MAATLSVEPAGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGMLFRAHA
RYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQI
PFVVELEVLDGHEPDGGQRLARAVHERHFMAPGVRRVPVREGRVRATLFL
PPGKGQFPGIIDLYGSIGGLCEHRASLLAGHGFAVLALAYFQFEDLPENL
SDVRLEYFEEALALMLRHPQVKGPNIGLIGVSKGADLCLSMAAFLKDNIT
ATVLINACVANTLVPLYYKDLFVPELGCDQTKNKSGLMDLRDMWNNPLEE
PNHQSLIPLEKAQGPFLFLVGMDDHNWKSDVYARIACERLQAHGKDRPQI
IYYPETGHCIEPPYFPPPIATVHFVLGEAVFNGGKPRAQSRAQLDAWQRI
QTFFQKYLNGEKPARHSKL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MAATLSVEPAGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGMLFRAHA
RYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQI
PFVVELEVLDGHEPDGGQRLARAVHERHFMAPGVRRVPVREGRVRATLFL
PPGKGQFPGIIDLYGSIGGLCEHRASLLAGHGFAVLALAYFQFEDLPENL
SDVRLEYFEEALALMLRHPQVKGPNIGLIGVSKGADLCLSMAAFLKDNIT
ATVLINACVANTLVPLYYKDLFVPELGCDQTKNKSGLMDLRDMWNNPLEE
PNHQSLIPLEKAQGPFLFLVGMDDHNWKSDVYARIACERLQAHGKDRPQI
IYYPETGHCIEPPYFPPPIATVHFVLGEAVFNGGKPRAQSRAQLDAWQRI
QTFFQKYLNGEKPARHSKL

no DNA




References
    Title: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs
    Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE
    Ref: FASEB Journal, 20:1855, 2006 : PubMed

            

    Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
    Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R and Hayashizaki Y <127 more author(s)>
    Ref: Nature, 420:563, 2002 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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