mouse-Ces2e

 
Mus musculus Ces2e Ces5 carboxylesterase, Pyrethroid hydrolase

Comment
on Chromosome 8 Hydrolyse pyrethroids: Stok et al


Relationship
Block C
Mus musculus position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Glires: N E > Rodentia: N E > Myomorpha: N E > Muroidea: N E > Muridae: N E > Murinae: N E > Mus [genus]: N E > Mus [subgenus]: N E > Mus musculus: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic


Inhibitor: ABP-C6 ,
2 Genbank : XM_134366, BC022148
1 UniProt : Q8BK48
1 Ncbi-nid : 20886266
1 Ncbi-pid : 20886267
1 UniProtTrembl : Q8BK48
1 Interpro : Q8BK48
1 Prodom : Q8BK48
1 Pfam : Q8BK48
1 PIRSF : Q8BK48
1 SUPERFAM : Q8BK48
1 QuickSwissBlast : Q8BK48
1 MGD : 2443170
1 ENSEMBL : ENSMUSG00000031886
 
Sequence
Graphical view for this peptide sequence: mouse-Ces2e
Colored MSA for Carb_B_Chordata (raw)
MPLYKLLGWLNAVACGVLLLVLHVQGQDSASPIRNTHTGQVRGSLVHVKD
TDIAVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDN
LMGSEDLKMMNLILPPISMSEDCLYLNIYVPAHAHEGSNLPVMVWIHGGA
LTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFSTGDQHAKGNWGYLD
QVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGA
IMESGVAVLPDLISSSSEMVHRIVANLSGCAAVNSETLMCCLRGKNEAEM
LAINKVFKIIPGVVDGEFLPKHPQELMASKDFHPVPSIIGINNDEYGWIL
PTIMDPAQKIEEITRKTLPAVLKSTALKMMLPPECGDLLMEEYMGDTEDP
ETLQAQFREMKGDFMFVIPALQVAHFQRSHAPVYFYEFQHRPSFFKDFRP
PYVKADHGDEIFLVFGYQFGNIKLPYTEEEEQLSRRIMKYWANFARHGNP
NSEGLPYWPVMDHDEQYLQLDIQPSVGRALKARRLQFWTKTLPQKIQELK
GSQERHKEL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MPLYKLLGWLNAVACGVLLLVLHVQGQDSASPIRNTHTGQVRGSLVHVKD
TDIAVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDN
LMGSEDLKMMNLILPPISMSEDCLYLNIYVPAHAHEGSNLPVMVWIHGGA
LTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFSTGDQHAKGNWGYLD
QVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGA
IMESGVAVLPDLISSSSEMVHRIVANLSGCAAVNSETLMCCLRGKNEAEM
LAINKVFKIIPGVVDGEFLPKHPQELMASKDFHPVPSIIGINNDEYGWIL
PTIMDPAQKIEEITRKTLPAVLKSTALKMMLPPECGDLLMEEYMGDTEDP
ETLQAQFREMKGDFMFVIPALQVAHFQRSHAPVYFYEFQHRPSFFKDFRP
PYVKADHGDEIFLVFGYQFGNIKLPYTEEEEQLSRRIMKYWANFARHGNP
NSEGLPYWPVMDHDEQYLQLDIQPSVGRALKARRLQFWTKTLPQKIQELK
GSQERHKEL

Graphical view for this nucleotide DNA sequence (1727 bp): mouse-Ces2e



References
    Title: Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes
    Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD
    Ref: Journal of Biological Chemistry, 279:29863, 2004 : PubMed

            

    Title: Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes
    Wheelock CE, Wheelock AM, Zhang R, Stok JE, Morisseau C, Le Valley SE, Green CE, Hammock BD
    Ref: Analytical Biochemistry, 315:208, 2003 : PubMed

            

    Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
    Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R and Hayashizaki Y <127 more author(s)>
    Ref: Nature, 420:563, 2002 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer