t-AUCB

This entry comprise both the cis and the trans conformation CHEMBL244405 is the cis conformer and CHEMBL242459 is the trans on both extremities of the cyclohexyl. IC50 for soluble epoxide hydrolase slightly better for the cis isomer c-AUCB 0.89 +/- 0.04 than t-AUCB 1.3 +/- 0.05

General

Type : Adamantyl, Urea derivative

Chemical_Nomenclature : 4-[4-(1-adamantylcarbamoylamino)cyclohexyl]oxybenzoic acid

Canonical SMILES : C1CC(CCC1NC(=O)NC23CC4CC(C2)CC(C4)C3)OC5=CC=C(C=C5)C(=O)O

InChI : InChI=1S\/C24H32N2O4\/c27-22(28)18-1-5-20(6-2-18)30-21-7-3-19(4-8-21)25-23(29)26-24-12-15-9-16(13-24)11-17(10-15)14-24\/h1-2,5-6,15-17,19,21H,3-4,7-14H2,(H,27,28)(H2,25,26,29)

InChIKey : KNBWKJBQDAQARU-UHFFFAOYSA-N

Other name(s) : CHEMBL242459  ||  CHEMBL244405  ||  Urea-based compound, 21  ||  AUB  ||  3wke  ||  Trans-ACUB  ||  4-[(Trans-4-{[(3s,5s,7s)-Tricyclo[3.3.1.1~3,7~]dec-1-Ylcarbamoyl]amino}cyclohexyl)oxy]benzoic Acid  ||  c-AUCB  ||  cAUCB  ||  tAUCB


MW : 412.53

Formula : C24H32N2O4

CAS_number :

PubChem : 16038368

UniChem : KNBWKJBQDAQARU-UHFFFAOYSA-N

Target

Families : t-AUCB ligand of proteins in family
Epoxide_hydrolase

Structure :
6N5H 5AM3 3WKE

Protein :
human-EPHX2 hypjq-g0r7e2

References (67)

Title : Soluble Epoxide Hydrolase Inhibition Reverses Cognitive Dysfunction in a Mouse Model of Metabolic Syndrome by Modulating Inflammation - Bah_2024_Prostaglandins.Other.Lipid.Mediat__106850
Author(s) : Bah TM , Davis CM , Allen E , Borkar RN , Perez R , Grafe MR , Raber J , Pike MM , Alkayed NJ
Ref : Prostaglandins Other Lipid Mediat , :106850 , 2024
Abstract :
PubMedSearch : Bah_2024_Prostaglandins.Other.Lipid.Mediat__106850
PubMedID: 38735559
Gene_locus related to this paper: human-EPHX2

Title : Sex-Specific Response of the Brain Free Oxylipin Profile to Soluble Epoxide Hydrolase Inhibition - Norman_2023_Nutrients_15_
Author(s) : Norman JE , Nuthikattu S , Milenkovic D , Rutledge JC , Villablanca AC
Ref : Nutrients , 15 : , 2023
Abstract :
PubMedSearch : Norman_2023_Nutrients_15_
PubMedID: 36904213

Title : Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors - Tian_2022_Bioorg.Chem_127_105898
Author(s) : Tian Y , Li S , Dong K , Su X , Fu S , Lv X , Duan M , Yang T , Han Y , Hu G , Liu J , Sun Y , Yue H , Zhang H , Du Z , Miao Z , Tong M , Liu Y , Qin M , Gong P , Hou Y , Gao Z , Zhao Y
Ref : Bioorg Chem , 127 :105898 , 2022
Abstract :
PubMedSearch : Tian_2022_Bioorg.Chem_127_105898
PubMedID: 35792317

Title : Soluble epoxide hydrolase inhibitor, t-AUCB, improves salivary gland function by ameliorating endothelial injury - Han_2022_Life.Sci_308_120942
Author(s) : Han WW , Wang XR , He YF , Zhang HS , Cong X , Xiang RL , Wu LL , Yu GY , Liu LM , Zhang Y
Ref : Life Sciences , 308 :120942 , 2022
Abstract :
PubMedSearch : Han_2022_Life.Sci_308_120942
PubMedID: 36096247

Title : High Glycemia and Soluble Epoxide Hydrolase in Females: Differential Multiomics in Murine Brain Microvasculature - Nuthikattu_2022_Int.J.Mol.Sci_23_
Author(s) : Nuthikattu S , Milenkovic D , Norman JE , Rutledge J , Villablanca A
Ref : Int J Mol Sci , 23 : , 2022
Abstract :
PubMedSearch : Nuthikattu_2022_Int.J.Mol.Sci_23_
PubMedID: 36361847

Title : Synthesis and biological evaluation of new series of benzamide derivatives containing urea moiety as sEH inhibitors - Tian_2022_Bioorg.Med.Chem.Lett_70_128805
Author(s) : Tian Y , Li S , Yang P , Su X , Liu J , Lv X , Dong K , Yang T , Duan M , Hu G , Yue H , Sun Y , Zhang H , Du Z , Miao Z , Tong M , Hou Y , Gao Z , Zhao Y
Ref : Bioorganic & Medicinal Chemistry Lett , 70 :128805 , 2022
Abstract :
PubMedSearch : Tian_2022_Bioorg.Med.Chem.Lett_70_128805
PubMedID: 35598794

Title : Soluble Epoxide Hydrolase Inhibitor t-AUCB Ameliorates Vascular Endothelial Dysfunction by Influencing the NF-kB\/miR-155-5p\/eNOS\/NO\/IkB Cycle in Hypertensive Rats - Wang_2022_Antioxidants.(Basel)_11_
Author(s) : Wang X , Han W , Zhang Y , Zong Y , Tan N , Li L , Liu C , Liu L
Ref : Antioxidants (Basel) , 11 : , 2022
Abstract :
PubMedSearch : Wang_2022_Antioxidants.(Basel)_11_
PubMedID: 35883863

Title : Inhibition of Soluble Epoxide Hydrolase Is Protective against the Multiomic Effects of a High Glycemic Diet on Brain Microvascular Inflammation and Cognitive Dysfunction - Nuthikattu_2021_Nutrients_13_
Author(s) : Nuthikattu S , Milenkovic D , Norman JE , Rutledge J , Villablanca A
Ref : Nutrients , 13 : , 2021
Abstract :
PubMedSearch : Nuthikattu_2021_Nutrients_13_
PubMedID: 34836168

Title : Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1 - Chen_2021_Front.Physiol_12_717119
Author(s) : Chen Y , Liu Q , Yang T , Shen L , Xu D
Ref : Front Physiol , 12 :717119 , 2021
Abstract :
PubMedSearch : Chen_2021_Front.Physiol_12_717119
PubMedID: 34646152

Title : Soluble Epoxide Hydrolase Blockade after Stroke Onset Protects Normal but Not Diabetic Mice - Davis_2021_Int.J.Mol.Sci_22_
Author(s) : Davis CM , Zhang WH , Allen EM , Bah TM , Shangraw RE , Alkayed NJ
Ref : Int J Mol Sci , 22 : , 2021
Abstract :
PubMedSearch : Davis_2021_Int.J.Mol.Sci_22_
PubMedID: 34063817

Title : Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy - Jiang_2020_Cell.Death.Dis_11_385
Author(s) : Jiang XS , Xiang XY , Chen XM , He JL , Liu T , Gan H , Du XG
Ref : Cell Death Dis , 11 :385 , 2020
Abstract :
PubMedSearch : Jiang_2020_Cell.Death.Dis_11_385
PubMedID: 32439839

Title : Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects - Han_2020_Eur.J.Med.Chem__113028
Author(s) : Han Y , Huang D , Xu S , Li L , Tian Y , Li S , Chen C , Li Y , Sun Y , Hou Y , Qin M , Gong P , Gao Z , Zhao Y
Ref : Eur Journal of Medicinal Chemistry , :113028 , 2020
Abstract :
PubMedSearch : Han_2020_Eur.J.Med.Chem__113028
PubMedID: 33248848

Title : The Metabolism of Epoxyeicosatrienoic Acids by Soluble Epoxide Hydrolase Is Protective against the Development of Vascular Calcification - Varennes_2020_Int.J.Mol.Sci_21_
Author(s) : Varennes O , Mentaverri R , Duflot T , Kauffenstein G , Objois T , Lenglet G , Avondo C , Morisseau C , Brazier M , Kamel S , Six I , Bellien J
Ref : Int J Mol Sci , 21 : , 2020
Abstract :
PubMedSearch : Varennes_2020_Int.J.Mol.Sci_21_
PubMedID: 32560362

Title : Soluble epoxide hydrolase inhibitor protects against blood-brain barrier dysfunction in a mouse model of type 2 diabetes via the AMPK\/HO-1 pathway - Wu_2020_Biochem.Biophys.Res.Commun__
Author(s) : Wu J , Zhao Y , Fan Z , Chen Q , Chen J , Sun Y , Jiang X , Xiao Q
Ref : Biochemical & Biophysical Research Communications , : , 2020
Abstract :
PubMedSearch : Wu_2020_Biochem.Biophys.Res.Commun__
PubMedID: 32001002

Title : A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction - Zhang_2020_Heart.Surg.Forum_23_E579
Author(s) : Zhang X , Liao C , Sun K , Liu L , Xu D
Ref : Heart Surg Forum , 23 :E579 , 2020
Abstract :
PubMedSearch : Zhang_2020_Heart.Surg.Forum_23_E579
PubMedID: 32990585

Title : Soluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome - Hamzaoui_2020_Front.Mol.Biosci_7_604042
Author(s) : Hamzaoui M , Roche C , Coquerel D , Duflot T , Brunel V , Mulder P , Richard V , Bellien J , Guerrot D
Ref : Front Mol Biosci , 7 :604042 , 2020
Abstract :
PubMedSearch : Hamzaoui_2020_Front.Mol.Biosci_7_604042
PubMedID: 33777999

Title : Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia\/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation - Darwesh_2019_Int.J.Mol.Sci_20_
Author(s) : Darwesh AM , Keshavarz-Bahaghighat H , Jamieson KL , Seubert JM
Ref : Int J Mol Sci , 20 : , 2019
Abstract :
PubMedSearch : Darwesh_2019_Int.J.Mol.Sci_20_
PubMedID: 31319469

Title : Impact of the acute local inhibition of soluble epoxide hydrolase on diabetic skin microcirculatory dysfunction - Savina_2019_Diab.Vasc.Dis.Res__1479164119860215
Author(s) : Savina Y , Duflot T , Bounoure F , Kotzki S , Thiebaut PA , Serreau PA , Skiba M , Picquenot JM , Cornic M , Morisseau C , Hammock B , Imbert L , Cracowski JL , Richard V , Roustit M , Bellien J
Ref : Diab Vasc Dis Res , :1479164119860215 , 2019
Abstract :
PubMedSearch : Savina_2019_Diab.Vasc.Dis.Res__1479164119860215
PubMedID: 31267765

Title : Soluble Epoxide Hydrolase Inhibitor t-AUCB Promotes Murine Brown Adipogenesis: Role of PPAR Gamma and PPAR Alpha (P21-069-19) - Hildreth_2019_Curr.Dev.Nutr_3_
Author(s) : Hildreth K , Overby H , Kodani S , Morisseau C , Hammock B , Bettaieb A , Zhao L
Ref : Curr Dev Nutr , 3 : , 2019
Abstract :
PubMedSearch : Hildreth_2019_Curr.Dev.Nutr_3_
PubMedID: 31223951

Title : The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors - de Oliveira_2019_Int.J.Biol.Macromol_129_653
Author(s) : de Oliveira GS , Adriani PP , Ribeiro JA , Morisseau C , Hammock BD , Dias MVB , Chambergo FS
Ref : Int J Biol Macromol , 129 :653 , 2019
Abstract :
PubMedSearch : de Oliveira_2019_Int.J.Biol.Macromol_129_653
PubMedID: 30771398
Gene_locus related to this paper: hypjq-g0r7e2

Title : Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei - de Oliveira_2019_Mol.Biol.Rep_46_371
Author(s) : de Oliveira GS , Adriani PP , Wu H , Morisseau C , Hammock BD , Chambergo FS
Ref : Mol Biol Rep , 46 :371 , 2019
Abstract :
PubMedSearch : de Oliveira_2019_Mol.Biol.Rep_46_371
PubMedID: 30426381
Gene_locus related to this paper: hypjq-g0r7e2

Title : Sex-linked differences in the mortality in Ren-2 transgenic hypertensive rats with aorto-caval fistula: effects of treatment with angiotensin converting enzyme alone and combined with inhibitor of soluble epoxide hydrolase - Kala_2019_Physiol.Res_68_589
Author(s) : Kala P , Cervenka L , Skaroupkova P , Taborsky M , Kompanowska-Jezierska E , Sadowski J
Ref : Physiol Res , 68 :589 , 2019
Abstract :
PubMedSearch : Kala_2019_Physiol.Res_68_589
PubMedID: 31177795

Title : Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction - Gui_2018_Lipids.Health.Dis_17_129
Author(s) : Gui Y , Li D , Chen J , Wang Y , Hu J , Liao C , Deng L , Xiang Q , Yang T , Du X , Zhang S , Xu D
Ref : Lipids Health Dis , 17 :129 , 2018
Abstract :
PubMedSearch : Gui_2018_Lipids.Health.Dis_17_129
PubMedID: 29843720

Title : Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula - Kala_2018_Physiol.Res_67_401
Author(s) : Kala P , Sedlakova L , Skaroupkova P , Kopkan L , Vanourkova Z , Taborsky M , Nishiyama A , Hwang SH , Hammock BD , Sadowski J , Melenovsky V , Imig JD , Cervenka L
Ref : Physiol Res , 67 :401 , 2018
Abstract :
PubMedSearch : Kala_2018_Physiol.Res_67_401
PubMedID: 29527914

Title : Soluble epoxide hydrolase inhibitors might prevent ischemic arrhythmias via microRNA-1 repression in primary neonatal mouse ventricular myocytes - Liu_2017_Mol.Biosyst_13_556
Author(s) : Liu Q , Zhao X , Peng R , Wang M , Zhao W , Gui YJ , Liao CX , Xu DY
Ref : Mol Biosyst , 13 :556 , 2017
Abstract :
PubMedSearch : Liu_2017_Mol.Biosyst_13_556
PubMedID: 28112313

Title : Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and omega-Hydroxylases - Hanif_2017_PLoS.One_12_e0169584
Author(s) : Hanif A , Edin ML , Zeldin DC , Morisseau C , Falck JR , Nayeem MA
Ref : PLoS ONE , 12 :e0169584 , 2017
Abstract :
PubMedSearch : Hanif_2017_PLoS.One_12_e0169584
PubMedID: 28056085
Gene_locus related to this paper: human-EPHX2

Title : Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARgamma - Hanif_2016_PLoS.One_11_e0162147
Author(s) : Hanif A , Edin ML , Zeldin DC , Morisseau C , Nayeem MA
Ref : PLoS ONE , 11 :e0162147 , 2016
Abstract :
PubMedSearch : Hanif_2016_PLoS.One_11_e0162147
PubMedID: 27583776

Title : Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis - Shen_2015_Atherosclerosis_239_557
Author(s) : Shen L , Peng H , Peng R , Fan Q , Zhao S , Xu D , Morisseau C , Chiamvimonvat N , Hammock BD
Ref : Atherosclerosis , 239 :557 , 2015
Abstract :
PubMedSearch : Shen_2015_Atherosclerosis_239_557
PubMedID: 25733327

Title : Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice - Roche_2015_Am.J.Physiol.Heart.Circ.Physiol_308_H1020
Author(s) : Roche C , Besnier M , Cassel R , Harouki N , Coquerel D , Guerrot D , Nicol L , Loizon E , Remy-Jouet I , Morisseau C , Mulder P , Ouvrard-Pascaud A , Madec AM , Richard V , Bellien J
Ref : American Journal of Physiology Heart Circ Physiol , 308 :H1020 , 2015
Abstract :
PubMedSearch : Roche_2015_Am.J.Physiol.Heart.Circ.Physiol_308_H1020
PubMedID: 25724490

Title : Impact of soluble epoxide hydrolase inhibition on early kidney damage in hyperglycemic overweight mice - Roche_2015_Prostaglandins.Other.Lipid.Mediat_120_148
Author(s) : Roche C , Guerrot D , Harouki N , Duflot T , Besnier M , Remy-Jouet I , Renet S , Dumesnil A , Lejeune A , Morisseau C , Richard V , Bellien J
Ref : Prostaglandins Other Lipid Mediat , 120 :148 , 2015
Abstract :
PubMedSearch : Roche_2015_Prostaglandins.Other.Lipid.Mediat_120_148
PubMedID: 26022136

Title : Successful generation of structural information for fragment-based drug discovery - Oster_2015_Drug.Discov.Today_20_1104
Author(s) : Oster L , Tapani S , Xue Y , Kack H
Ref : Drug Discov Today , 20 :1104 , 2015
Abstract :
PubMedSearch : Oster_2015_Drug.Discov.Today_20_1104
PubMedID: 25931264
Gene_locus related to this paper: human-EPHX2

Title : Inhibition of soluble epoxide hydrolase counteracts the development of renal dysfunction and progression of congestive heart failure in Ren-2 transgenic hypertensive rats with aorto-caval fistula - Cervenka_2015_Clin.Exp.Pharmacol.Physiol_42_795
Author(s) : Cervenka L , Melenovsky V , Huskova Z , Skaroupkova P , Nishiyama A , Sadowski J
Ref : Clinical & Experimental Pharmacology & Physiology , 42 :795 , 2015
Abstract :
PubMedSearch : Cervenka_2015_Clin.Exp.Pharmacol.Physiol_42_795
PubMedID: 25969338

Title : Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula - Cervenka_2015_Physiol.Res_64_857
Author(s) : Cervenka L , Melenovsky V , Huskova Z , Sporkova A , Burgelova M , Skaroupkova P , Hwang SH , Hammock BD , Imig JD , Sadowski J
Ref : Physiol Res , 64 :857 , 2015
Abstract :
PubMedSearch : Cervenka_2015_Physiol.Res_64_857
PubMedID: 26047375

Title : Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography - Amano_2014_Bioorg.Med.Chem_22_2427
Author(s) : Amano Y , Yamaguchi T , Tanabe E
Ref : Bioorganic & Medicinal Chemistry , 22 :2427 , 2014
Abstract :
PubMedSearch : Amano_2014_Bioorg.Med.Chem_22_2427
PubMedID: 24656800
Gene_locus related to this paper: human-EPHX2

Title : Soluble epoxide hydrolase gene deletion improves blood flow and reduces infarct size after cerebral ischemia in reproductively senescent female mice - Zuloaga_2014_Front.Pharmacol_5_290
Author(s) : Zuloaga KL , Zhang W , Roese NE , Alkayed NJ
Ref : Front Pharmacol , 5 :290 , 2014
Abstract :
PubMedSearch : Zuloaga_2014_Front.Pharmacol_5_290
PubMedID: 25642188

Title : Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARgamma - Nayeem_2013_Am.J.Physiol.Regul.Integr.Comp.Physiol_304_R23
Author(s) : Nayeem MA , Pradhan I , Mustafa SJ , Morisseau C , Falck JR , Zeldin DC
Ref : American Journal of Physiology Regul Integr Comp Physiol , 304 :R23 , 2013
Abstract :
PubMedSearch : Nayeem_2013_Am.J.Physiol.Regul.Integr.Comp.Physiol_304_R23
PubMedID: 23152114

Title : Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke - Shaik_2013_Am.J.Physiol.Heart.Circ.Physiol_305_H1605
Author(s) : Shaik JS , Ahmad M , Li W , Rose ME , Foley LM , Hitchens TK , Graham SH , Hwang SH , Hammock BD , Poloyac SM
Ref : American Journal of Physiology Heart Circ Physiol , 305 :H1605 , 2013
Abstract :
PubMedSearch : Shaik_2013_Am.J.Physiol.Heart.Circ.Physiol_305_H1605
PubMedID: 24043255

Title : Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus - Jouihan_2013_J.Cereb.Blood.Flow.Metab_33_1650
Author(s) : Jouihan SA , Zuloaga KL , Zhang W , Shangraw RE , Krasnow SM , Marks DL , Alkayed NJ
Ref : Journal of Cerebral Blood Flow & Metabolism , 33 :1650 , 2013
Abstract :
PubMedSearch : Jouihan_2013_J.Cereb.Blood.Flow.Metab_33_1650
PubMedID: 23899929

Title : Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice - Chaudhary_2013_Prostaglandins.Other.Lipid.Mediat_104-105_8
Author(s) : Chaudhary KR , Zordoky BN , Edin ML , Alsaleh N , El-Kadi AO , Zeldin DC , Seubert JM
Ref : Prostaglandins Other Lipid Mediat , 104-105 :8 , 2013
Abstract :
PubMedSearch : Chaudhary_2013_Prostaglandins.Other.Lipid.Mediat_104-105_8
PubMedID: 22922020

Title : Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie - Poli_2013_Life.Sci_92_1145
Author(s) : Poli G , Corda E , Martino PA , Dall'ara P , Bareggi SR , Bondiolotti G , Iulini B , Mazza M , Casalone C , Hwang SH , Hammock BD , Inceoglu B
Ref : Life Sciences , 92 :1145 , 2013
Abstract :
PubMedSearch : Poli_2013_Life.Sci_92_1145
PubMedID: 23651659

Title : Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models - Liu_2013_Eur.J.Pharm.Sci_48_619
Author(s) : Liu JY , Lin YP , Qiu H , Morisseau C , Rose TE , Hwang SH , Chiamvimonvat N , Hammock BD
Ref : Eur J Pharm Sci , 48 :619 , 2013
Abstract :
PubMedSearch : Liu_2013_Eur.J.Pharm.Sci_48_619
PubMedID: 23291046

Title : Role of haem oxygenase in the renoprotective effects of soluble epoxide hydrolase inhibition in diabetic spontaneously hypertensive rats - Elmarakby_2013_Clin.Sci.(Lond)_125_349
Author(s) : Elmarakby AA , Faulkner J , Pye C , Rouch K , Alhashim A , Maddipati KR , Baban B
Ref : Clinical Science (Lond) , 125 :349 , 2013
Abstract :
PubMedSearch : Elmarakby_2013_Clin.Sci.(Lond)_125_349
PubMedID: 23611540

Title : A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARgamma to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction - Xu_2013_Int.J.Cardiol_167_1298
Author(s) : Xu DY , Davis BB , Wang ZH , Zhao SP , Wasti B , Liu ZL , Li N , Morisseau C , Chiamvimonvat N , Hammock BD
Ref : Int J Cardiol , 167 :1298 , 2013
Abstract :
PubMedSearch : Xu_2013_Int.J.Cardiol_167_1298
PubMedID: 22525341

Title : Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system - Varcabova_2013_Clin.Exp.Pharmacol.Physiol_40_273
Author(s) : Varcabova S , Huskova Z , Kramer HJ , Hwang SH , Hammock BD , Imig JD , Kitada K , Cervenka L
Ref : Clinical & Experimental Pharmacology & Physiology , 40 :273 , 2013
Abstract :
PubMedSearch : Varcabova_2013_Clin.Exp.Pharmacol.Physiol_40_273
PubMedID: 23039246

Title : Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome - Zhao_2013_Lipids.Health.Dis_12_3
Author(s) : Zhao X , Du JQ , Xu DY , Zhao SP
Ref : Lipids Health Dis , 12 :3 , 2013
Abstract :
PubMedSearch : Zhao_2013_Lipids.Health.Dis_12_3
PubMedID: 23305094

Title : Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice - Liu_2012_PLoS.One_7_e39165
Author(s) : Liu Y , Dang H , Li D , Pang W , Hammock BD , Zhu Y
Ref : PLoS ONE , 7 :e39165 , 2012
Abstract :
PubMedSearch : Liu_2012_PLoS.One_7_e39165
PubMedID: 22720061

Title : [Effects of soluble epoxide hydrolase inhibitors on the expression of fatty acid synthase in peripheral blood mononuclear cell of patients and inflammatory response with acute coronary syndrome] - Du_2012_Zhonghua.Yi.Xue.Za.Zhi_92_86
Author(s) : Du JQ , Peng R , Xu DY , Zhao TT , Shen L , Zhao SP
Ref : Zhonghua Yi Xue Za Zhi , 92 :86 , 2012
Abstract :
PubMedSearch : Du_2012_Zhonghua.Yi.Xue.Za.Zhi_92_86
PubMedID: 22490687

Title : t-AUCB, an improved sEH inhibitor, suppresses human glioblastoma cell growth by activating NF-kappaB-p65 - Li_2012_J.Neurooncol_108_385
Author(s) : Li J , Liu H , Xing B , Yu Y , Wang H , Chen G , Gu B , Zhang G , Wei D , Gu P , Li M , Hu W
Ref : J Neurooncol , 108 :385 , 2012
Abstract :
PubMedSearch : Li_2012_J.Neurooncol_108_385
PubMedID: 22382785

Title : The apoptosis-resistance in t-AUCB-treated glioblastoma cells depends on activation of Hsp27 - Li_2012_J.Neurooncol_110_187
Author(s) : Li J , Hu W , Lan Q
Ref : J Neurooncol , 110 :187 , 2012
Abstract :
PubMedSearch : Li_2012_J.Neurooncol_110_187
PubMedID: 22903412

Title : [Soluble epoxide hydrolase inhibitor t-AUCB ameliorates ox-LDL induced conversion of macrophages into foam cells through activating the PPARgamma-ABCA1 pathway] - Zhao_2012_Zhonghua.Xin.Xue.Guan.Bing.Za.Zhi_40_248
Author(s) : Zhao TT , Peng R , Shen L , Zhao X , Xu DY , Zhao SP
Ref : Zhonghua Xin Xue Guan Bing Za Zhi , 40 :248 , 2012
Abstract :
PubMedSearch : Zhao_2012_Zhonghua.Xin.Xue.Guan.Bing.Za.Zhi_40_248
PubMedID: 22801272

Title : Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension - Kopkan_2012_Kidney.Blood.Press.Res_35_595
Author(s) : Kopkan L , Huskova Z , Sporkova A , Varcabova S , Honetschlagerova Z , Hwang SH , Tsai HJ , Hammock BD , Imig JD , Kramer HJ , Burgelova M , Vojtiskova A , Kujal P , Vernerova Z , Cervenka L
Ref : Kidney Blood Press Res , 35 :595 , 2012
Abstract :
PubMedSearch : Kopkan_2012_Kidney.Blood.Press.Res_35_595
PubMedID: 22948718

Title : Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension - Neckar_2012_Clin.Sci.(Lond)_122_513
Author(s) : Neckar J , Kopkan L , Huskova Z , Kolar F , Papousek F , Kramer HJ , Hwang SH , Hammock BD , Imig JD , Maly J , Netuka I , Ostadal B , Cervenka L
Ref : Clinical Science (Lond) , 122 :513 , 2012
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PubMedSearch : Neckar_2012_Clin.Sci.(Lond)_122_513
PubMedID: 22324471

Title : Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-\/-) mice - Zhang_2012_Dig.Dis.Sci_57_2580
Author(s) : Zhang W , Yang AL , Liao J , Li H , Dong H , Chung YT , Bai H , Matkowskyj KA , Hammock BD , Yang GY
Ref : Digestive Diseases & Sciences , 57 :2580 , 2012
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PubMedSearch : Zhang_2012_Dig.Dis.Sci_57_2580
PubMedID: 22588244

Title : Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats - Iyer_2012_Exp.Diabetes.Res_2012_758614
Author(s) : Iyer A , Kauter K , Alam MA , Hwang SH , Morisseau C , Hammock BD , Brown L
Ref : Exp Diabetes Res , 2012 :758614 , 2012
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PubMedSearch : Iyer_2012_Exp.Diabetes.Res_2012_758614
PubMedID: 22007192

Title : Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels - Hasenau_2011_Acta.Physiol.(Oxf)_203_117
Author(s) : Hasenau AL , Nielsen G , Morisseau C , Hammock BD , Wulff H , Kohler R
Ref : Acta Physiol (Oxf) , 203 :117 , 2011
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PubMedSearch : Hasenau_2011_Acta.Physiol.(Oxf)_203_117
PubMedID: 21362152

Title : Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase - Hwang_2011_J.Med.Chem_54_3037
Author(s) : Hwang SH , Wagner KM , Morisseau C , Liu JY , Dong H , Wecksler AT , Hammock BD
Ref : Journal of Medicinal Chemistry , 54 :3037 , 2011
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PubMedSearch : Hwang_2011_J.Med.Chem_54_3037
PubMedID: 21434686

Title : Cytochrome P450-derived epoxyeicosatrienoic acids accelerate wound epithelialization and neovascularization in the hairless mouse ear wound model - Sander_2011_Langenbecks.Arch.Surg_396_1245
Author(s) : Sander AL , Jakob H , Sommer K , Sadler C , Fleming I , Marzi I , Frank J
Ref : Langenbecks Arch Surg , 396 :1245 , 2011
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PubMedSearch : Sander_2011_Langenbecks.Arch.Surg_396_1245
PubMedID: 21887579

Title : Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy - Inoue_2011_Cancer.Biol.Ther_12_827
Author(s) : Inoue H , Hwang SH , Wecksler AT , Hammock BD , Weiss RH
Ref : Cancer Biol Ther , 12 :827 , 2011
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PubMedSearch : Inoue_2011_Cancer.Biol.Ther_12_827
PubMedID: 21878748

Title : Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension - Honetschlagerova_2011_J.Physiol_589_207
Author(s) : Honetschlagerova Z , Z ZH , Vanourkova Z , Sporkova A , Kramer HJ , Hwang SH , Tsai HJ , Hammock BD , Imig JD , Cervenka L , Kopkan L
Ref : The Journal of Physiology , 589 :207 , 2011
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PubMedSearch : Honetschlagerova_2011_J.Physiol_589_207
PubMedID: 21078594

Title : Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi - Senouvo_2011_Am.J.Physiol.Lung.Cell.Mol.Physiol_301_L675
Author(s) : Senouvo FY , Tabet Y , Morin C , Albadine R , Sirois C , Rousseau E
Ref : American Journal of Physiology Lung Cell Mol Physiol , 301 :L675 , 2011
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PubMedSearch : Senouvo_2011_Am.J.Physiol.Lung.Cell.Mol.Physiol_301_L675
PubMedID: 21821730

Title : Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury - Chaudhary_2010_J.Cardiovasc.Pharmacol_55_67
Author(s) : Chaudhary KR , Abukhashim M , Hwang SH , Hammock BD , Seubert JM
Ref : J Cardiovasc Pharmacol , 55 :67 , 2010
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PubMedSearch : Chaudhary_2010_J.Cardiovasc.Pharmacol_55_67
PubMedID: 19834332

Title : Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model - Liu_2010_Biochem.Pharmacol_79_880
Author(s) : Liu JY , Yang J , Inceoglu B , Qiu H , Ulu A , Hwang SH , Chiamvimonvat N , Hammock BD
Ref : Biochemical Pharmacology , 79 :880 , 2010
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PubMedSearch : Liu_2010_Biochem.Pharmacol_79_880
PubMedID: 19896470

Title : Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs - Tsai_2010_Eur.J.Pharm.Sci_40_222
Author(s) : Tsai HJ , Hwang SH , Morisseau C , Yang J , Jones PD , Kasagami T , Kim IH , Hammock BD
Ref : Eur J Pharm Sci , 40 :222 , 2010
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PubMedSearch : Tsai_2010_Eur.J.Pharm.Sci_40_222
PubMedID: 20359531

Title : Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease - Jung_2010_PLoS.One_5_e11979
Author(s) : Jung O , Jansen F , Mieth A , Barbosa-Sicard E , Pliquett RU , Babelova A , Morisseau C , Hwang SH , Tsai C , Hammock BD , Schaefer L , Geisslinger G , Amann K , Brandes RP
Ref : PLoS ONE , 5 :e11979 , 2010
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PubMedSearch : Jung_2010_PLoS.One_5_e11979
PubMedID: 20694143

Title : Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis - Luo_2010_J.Pharmacol.Exp.Ther_334_430
Author(s) : Luo P , Chang HH , Zhou Y , Zhang S , Hwang SH , Morisseau C , Wang CY , Inscho EW , Hammock BD , Wang MH
Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :430 , 2010
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PubMedSearch : Luo_2010_J.Pharmacol.Exp.Ther_334_430
PubMedID: 20439437

Title : Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation - Liu_2009_Br.J.Pharmacol_156_284
Author(s) : Liu JY , Tsai HJ , Hwang SH , Jones PD , Morisseau C , Hammock BD
Ref : British Journal of Pharmacology , 156 :284 , 2009
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PubMedSearch : Liu_2009_Br.J.Pharmacol_156_284
PubMedID: 19154430

Title : Orally bioavailable potent soluble epoxide hydrolase inhibitors - Hwang_2007_J.Med.Chem_50_3825
Author(s) : Hwang SH , Tsai HJ , Liu JY , Morisseau C , Hammock BD
Ref : Journal of Medicinal Chemistry , 50 :3825 , 2007
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PubMedSearch : Hwang_2007_J.Med.Chem_50_3825
PubMedID: 17616115