t-AUCB
This entry comprise both the cis and the trans conformation CHEMBL244405 is the cis conformer and CHEMBL242459 is the trans on both extremities of the cyclohexyl. IC50 for soluble epoxide hydrolase slightly better for the cis isomer c-AUCB 0.89 +/- 0.04 than t-AUCB 1.3 +/- 0.05
General
Type : Adamantyl, Urea derivative
Chemical_Nomenclature : 4-[4-(1-adamantylcarbamoylamino)cyclohexyl]oxybenzoic acid
Canonical SMILES : C1CC(CCC1NC(=O)NC23CC4CC(C2)CC(C4)C3)OC5=CC=C(C=C5)C(=O)O
InChI : InChI=1S\/C24H32N2O4\/c27-22(28)18-1-5-20(6-2-18)30-21-7-3-19(4-8-21)25-23(29)26-24-12-15-9-16(13-24)11-17(10-15)14-24\/h1-2,5-6,15-17,19,21H,3-4,7-14H2,(H,27,28)(H2,25,26,29)
InChIKey : KNBWKJBQDAQARU-UHFFFAOYSA-N
Other name(s) : CHEMBL242459, CHEMBL244405, Urea-based compound, 21, AUB, 3wke, Trans-ACUB, 4-[(Trans-4-{[(3s,5s,7s)-Tricyclo[3.3.1.1~3,7~]dec-1-Ylcarbamoyl]amino}cyclohexyl)oxy]benzoic Acid, c-AUCB, cAUCB, tAUCB
MW : 412.53
Formula : C24H32N2O4
CAS_number :
PubChem : 16038368
UniChem : KNBWKJBQDAQARU-UHFFFAOYSA-N
Target
Families : t-AUCB ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
hypjq-g0r7e2
References (67)
| Title : Soluble Epoxide Hydrolase Inhibition Reverses Cognitive Dysfunction in a Mouse Model of Metabolic Syndrome by Modulating Inflammation - Bah_2024_Prostaglandins.Other.Lipid.Mediat__106850 |
| Author(s) : Bah TM , Davis CM , Allen E , Borkar RN , Perez R , Grafe MR , Raber J , Pike MM , Alkayed NJ |
| Ref : Prostaglandins Other Lipid Mediat , :106850 , 2024 |
| PubMedID: 38735559 |
| Title : Sex-Specific Response of the Brain Free Oxylipin Profile to Soluble Epoxide Hydrolase Inhibition - Norman_2023_Nutrients_15_ |
| Author(s) : Norman JE , Nuthikattu S , Milenkovic D , Rutledge JC , Villablanca AC |
| Ref : Nutrients , 15 : , 2023 |
| PubMedID: 36904213 |
| Title : Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors - Tian_2022_Bioorg.Chem_127_105898 |
| Author(s) : Tian Y , Li S , Dong K , Su X , Fu S , Lv X , Duan M , Yang T , Han Y , Hu G , Liu J , Sun Y , Yue H , Zhang H , Du Z , Miao Z , Tong M , Liu Y , Qin M , Gong P , Hou Y , Gao Z , Zhao Y |
| Ref : Bioorg Chem , 127 :105898 , 2022 |
| PubMedID: 35792317 |
| Title : Soluble epoxide hydrolase inhibitor, t-AUCB, improves salivary gland function by ameliorating endothelial injury - Han_2022_Life.Sci_308_120942 |
| Author(s) : Han WW , Wang XR , He YF , Zhang HS , Cong X , Xiang RL , Wu LL , Yu GY , Liu LM , Zhang Y |
| Ref : Life Sciences , 308 :120942 , 2022 |
| PubMedID: 36096247 |
| Title : High Glycemia and Soluble Epoxide Hydrolase in Females: Differential Multiomics in Murine Brain Microvasculature - Nuthikattu_2022_Int.J.Mol.Sci_23_ |
| Author(s) : Nuthikattu S , Milenkovic D , Norman JE , Rutledge J , Villablanca A |
| Ref : Int J Mol Sci , 23 : , 2022 |
| PubMedID: 36361847 |
| Title : Synthesis and biological evaluation of new series of benzamide derivatives containing urea moiety as sEH inhibitors - Tian_2022_Bioorg.Med.Chem.Lett_70_128805 |
| Author(s) : Tian Y , Li S , Yang P , Su X , Liu J , Lv X , Dong K , Yang T , Duan M , Hu G , Yue H , Sun Y , Zhang H , Du Z , Miao Z , Tong M , Hou Y , Gao Z , Zhao Y |
| Ref : Bioorganic & Medicinal Chemistry Lett , 70 :128805 , 2022 |
| PubMedID: 35598794 |
| Title : Soluble Epoxide Hydrolase Inhibitor t-AUCB Ameliorates Vascular Endothelial Dysfunction by Influencing the NF-kB\/miR-155-5p\/eNOS\/NO\/IkB Cycle in Hypertensive Rats - Wang_2022_Antioxidants.(Basel)_11_ |
| Author(s) : Wang X , Han W , Zhang Y , Zong Y , Tan N , Li L , Liu C , Liu L |
| Ref : Antioxidants (Basel) , 11 : , 2022 |
| PubMedID: 35883863 |
| Title : Inhibition of Soluble Epoxide Hydrolase Is Protective against the Multiomic Effects of a High Glycemic Diet on Brain Microvascular Inflammation and Cognitive Dysfunction - Nuthikattu_2021_Nutrients_13_ |
| Author(s) : Nuthikattu S , Milenkovic D , Norman JE , Rutledge J , Villablanca A |
| Ref : Nutrients , 13 : , 2021 |
| PubMedID: 34836168 |
| Title : Soluble Epoxide Hydrolase Blockade after Stroke Onset Protects Normal but Not Diabetic Mice - Davis_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Davis CM , Zhang WH , Allen EM , Bah TM , Shangraw RE , Alkayed NJ |
| Ref : Int J Mol Sci , 22 : , 2021 |
| PubMedID: 34063817 |
| Title : Soluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome - Hamzaoui_2020_Front.Mol.Biosci_7_604042 |
| Author(s) : Hamzaoui M , Roche C , Coquerel D , Duflot T , Brunel V , Mulder P , Richard V , Bellien J , Guerrot D |
| Ref : Front Mol Biosci , 7 :604042 , 2020 |
| PubMedID: 33777999 |
| Title : Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy - Jiang_2020_Cell.Death.Dis_11_385 |
| Author(s) : Jiang XS , Xiang XY , Chen XM , He JL , Liu T , Gan H , Du XG |
| Ref : Cell Death Dis , 11 :385 , 2020 |
| PubMedID: 32439839 |
| Title : Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects - Han_2020_Eur.J.Med.Chem__113028 |
| Author(s) : Han Y , Huang D , Xu S , Li L , Tian Y , Li S , Chen C , Li Y , Sun Y , Hou Y , Qin M , Gong P , Gao Z , Zhao Y |
| Ref : Eur Journal of Medicinal Chemistry , :113028 , 2020 |
| PubMedID: 33248848 |
| Title : The Metabolism of Epoxyeicosatrienoic Acids by Soluble Epoxide Hydrolase Is Protective against the Development of Vascular Calcification - Varennes_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Varennes O , Mentaverri R , Duflot T , Kauffenstein G , Objois T , Lenglet G , Avondo C , Morisseau C , Brazier M , Kamel S , Six I , Bellien J |
| Ref : Int J Mol Sci , 21 : , 2020 |
| PubMedID: 32560362 |
| Title : Soluble epoxide hydrolase inhibitor protects against blood-brain barrier dysfunction in a mouse model of type 2 diabetes via the AMPK\/HO-1 pathway - Wu_2020_Biochem.Biophys.Res.Commun__ |
| Author(s) : Wu J , Zhao Y , Fan Z , Chen Q , Chen J , Sun Y , Jiang X , Xiao Q |
| Ref : Biochemical & Biophysical Research Communications , : , 2020 |
| PubMedID: 32001002 |
| Title : Soluble Epoxide Hydrolase Inhibitor t-AUCB Promotes Murine Brown Adipogenesis: Role of PPAR Gamma and PPAR Alpha (P21-069-19) - Hildreth_2019_Curr.Dev.Nutr_3_ |
| Author(s) : Hildreth K , Overby H , Kodani S , Morisseau C , Hammock B , Bettaieb A , Zhao L |
| Ref : Curr Dev Nutr , 3 : , 2019 |
| PubMedID: 31223951 |
| Title : Sex-linked differences in the mortality in Ren-2 transgenic hypertensive rats with aorto-caval fistula: effects of treatment with angiotensin converting enzyme alone and combined with inhibitor of soluble epoxide hydrolase - Kala_2019_Physiol.Res_68_589 |
| Author(s) : Kala P , Cervenka L , Skaroupkova P , Taborsky M , Kompanowska-Jezierska E , Sadowski J |
| Ref : Physiol Res , 68 :589 , 2019 |
| PubMedID: 31177795 |
| Title : Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia\/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation - Darwesh_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Darwesh AM , Keshavarz-Bahaghighat H , Jamieson KL , Seubert JM |
| Ref : Int J Mol Sci , 20 : , 2019 |
| PubMedID: 31319469 |
| Title : Impact of the acute local inhibition of soluble epoxide hydrolase on diabetic skin microcirculatory dysfunction - Savina_2019_Diab.Vasc.Dis.Res__1479164119860215 |
| Author(s) : Savina Y , Duflot T , Bounoure F , Kotzki S , Thiebaut PA , Serreau PA , Skiba M , Picquenot JM , Cornic M , Morisseau C , Hammock B , Imbert L , Cracowski JL , Richard V , Roustit M , Bellien J |
| Ref : Diab Vasc Dis Res , :1479164119860215 , 2019 |
| PubMedID: 31267765 |
| Title : The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors - de Oliveira_2019_Int.J.Biol.Macromol_129_653 |
| Author(s) : de Oliveira GS , Adriani PP , Ribeiro JA , Morisseau C , Hammock BD , Dias MVB , Chambergo FS |
| Ref : Int J Biol Macromol , 129 :653 , 2019 |
| PubMedID: 30771398 |
| Gene_locus related to this paper: hypjq-g0r7e2 |
| Title : Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei - de Oliveira_2019_Mol.Biol.Rep_46_371 |
| Author(s) : de Oliveira GS , Adriani PP , Wu H , Morisseau C , Hammock BD , Chambergo FS |
| Ref : Mol Biol Rep , 46 :371 , 2019 |
| PubMedID: 30426381 |
| Gene_locus related to this paper: hypjq-g0r7e2 |
| Title : Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction - Gui_2018_Lipids.Health.Dis_17_129 |
| Author(s) : Gui Y , Li D , Chen J , Wang Y , Hu J , Liao C , Deng L , Xiang Q , Yang T , Du X , Zhang S , Xu D |
| Ref : Lipids Health Dis , 17 :129 , 2018 |
| PubMedID: 29843720 |
| Title : Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula - Kala_2018_Physiol.Res_67_401 |
| Author(s) : Kala P , Sedlakova L , Skaroupkova P , Kopkan L , Vanourkova Z , Taborsky M , Nishiyama A , Hwang SH , Hammock BD , Sadowski J , Melenovsky V , Imig JD , Cervenka L |
| Ref : Physiol Res , 67 :401 , 2018 |
| PubMedID: 29527914 |
| Title : Soluble epoxide hydrolase inhibitors might prevent ischemic arrhythmias via microRNA-1 repression in primary neonatal mouse ventricular myocytes - Liu_2017_Mol.Biosyst_13_556 |
| Author(s) : Liu Q , Zhao X , Peng R , Wang M , Zhao W , Gui YJ , Liao CX , Xu DY |
| Ref : Mol Biosyst , 13 :556 , 2017 |
| PubMedID: 28112313 |
| Title : Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and omega-Hydroxylases - Hanif_2017_PLoS.One_12_e0169584 |
| Author(s) : Hanif A , Edin ML , Zeldin DC , Morisseau C , Falck JR , Nayeem MA |
| Ref : PLoS ONE , 12 :e0169584 , 2017 |
| PubMedID: 28056085 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARgamma - Hanif_2016_PLoS.One_11_e0162147 |
| Author(s) : Hanif A , Edin ML , Zeldin DC , Morisseau C , Nayeem MA |
| Ref : PLoS ONE , 11 :e0162147 , 2016 |
| PubMedID: 27583776 |
| Title : Successful generation of structural information for fragment-based drug discovery - Oster_2015_Drug.Discov.Today_20_1104 |
| Author(s) : Oster L , Tapani S , Xue Y , Kack H |
| Ref : Drug Discov Today , 20 :1104 , 2015 |
| PubMedID: 25931264 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Inhibition of soluble epoxide hydrolase counteracts the development of renal dysfunction and progression of congestive heart failure in Ren-2 transgenic hypertensive rats with aorto-caval fistula - Cervenka_2015_Clin.Exp.Pharmacol.Physiol_42_795 |
| Author(s) : Cervenka L , Melenovsky V , Huskova Z , Skaroupkova P , Nishiyama A , Sadowski J |
| Ref : Clinical & Experimental Pharmacology & Physiology , 42 :795 , 2015 |
| PubMedID: 25969338 |
| Title : Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula - Cervenka_2015_Physiol.Res_64_857 |
| Author(s) : Cervenka L , Melenovsky V , Huskova Z , Sporkova A , Burgelova M , Skaroupkova P , Hwang SH , Hammock BD , Imig JD , Sadowski J |
| Ref : Physiol Res , 64 :857 , 2015 |
| PubMedID: 26047375 |
| Title : Inhibition of soluble epoxide hydrolase in mice promotes reverse cholesterol transport and regression of atherosclerosis - Shen_2015_Atherosclerosis_239_557 |
| Author(s) : Shen L , Peng H , Peng R , Fan Q , Zhao S , Xu D , Morisseau C , Chiamvimonvat N , Hammock BD |
| Ref : Atherosclerosis , 239 :557 , 2015 |
| PubMedID: 25733327 |
| Title : Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice - Roche_2015_Am.J.Physiol.Heart.Circ.Physiol_308_H1020 |
| Author(s) : Roche C , Besnier M , Cassel R , Harouki N , Coquerel D , Guerrot D , Nicol L , Loizon E , Remy-Jouet I , Morisseau C , Mulder P , Ouvrard-Pascaud A , Madec AM , Richard V , Bellien J |
| Ref : American Journal of Physiology Heart Circ Physiol , 308 :H1020 , 2015 |
| PubMedID: 25724490 |
| Title : Impact of soluble epoxide hydrolase inhibition on early kidney damage in hyperglycemic overweight mice - Roche_2015_Prostaglandins.Other.Lipid.Mediat_120_148 |
| Author(s) : Roche C , Guerrot D , Harouki N , Duflot T , Besnier M , Remy-Jouet I , Renet S , Dumesnil A , Lejeune A , Morisseau C , Richard V , Bellien J |
| Ref : Prostaglandins Other Lipid Mediat , 120 :148 , 2015 |
| PubMedID: 26022136 |
| Title : Soluble epoxide hydrolase gene deletion improves blood flow and reduces infarct size after cerebral ischemia in reproductively senescent female mice - Zuloaga_2014_Front.Pharmacol_5_290 |
| Author(s) : Zuloaga KL , Zhang W , Roese NE , Alkayed NJ |
| Ref : Front Pharmacol , 5 :290 , 2014 |
| PubMedID: 25642188 |
| Title : Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography - Amano_2014_Bioorg.Med.Chem_22_2427 |
| Author(s) : Amano Y , Yamaguchi T , Tanabe E |
| Ref : Bioorganic & Medicinal Chemistry , 22 :2427 , 2014 |
| PubMedID: 24656800 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARgamma to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction - Xu_2013_Int.J.Cardiol_167_1298 |
| Author(s) : Xu DY , Davis BB , Wang ZH , Zhao SP , Wasti B , Liu ZL , Li N , Morisseau C , Chiamvimonvat N , Hammock BD |
| Ref : Int J Cardiol , 167 :1298 , 2013 |
| PubMedID: 22525341 |
| Title : Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system - Varcabova_2013_Clin.Exp.Pharmacol.Physiol_40_273 |
| Author(s) : Varcabova S , Huskova Z , Kramer HJ , Hwang SH , Hammock BD , Imig JD , Kitada K , Cervenka L |
| Ref : Clinical & Experimental Pharmacology & Physiology , 40 :273 , 2013 |
| PubMedID: 23039246 |
| Title : Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome - Zhao_2013_Lipids.Health.Dis_12_3 |
| Author(s) : Zhao X , Du JQ , Xu DY , Zhao SP |
| Ref : Lipids Health Dis , 12 :3 , 2013 |
| PubMedID: 23305094 |
| Title : Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARgamma - Nayeem_2013_Am.J.Physiol.Regul.Integr.Comp.Physiol_304_R23 |
| Author(s) : Nayeem MA , Pradhan I , Mustafa SJ , Morisseau C , Falck JR , Zeldin DC |
| Ref : American Journal of Physiology Regul Integr Comp Physiol , 304 :R23 , 2013 |
| PubMedID: 23152114 |
| Title : Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke - Shaik_2013_Am.J.Physiol.Heart.Circ.Physiol_305_H1605 |
| Author(s) : Shaik JS , Ahmad M , Li W , Rose ME , Foley LM , Hitchens TK , Graham SH , Hwang SH , Hammock BD , Poloyac SM |
| Ref : American Journal of Physiology Heart Circ Physiol , 305 :H1605 , 2013 |
| PubMedID: 24043255 |
| Title : Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus - Jouihan_2013_J.Cereb.Blood.Flow.Metab_33_1650 |
| Author(s) : Jouihan SA , Zuloaga KL , Zhang W , Shangraw RE , Krasnow SM , Marks DL , Alkayed NJ |
| Ref : Journal of Cerebral Blood Flow & Metabolism , 33 :1650 , 2013 |
| PubMedID: 23899929 |
| Title : Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice - Chaudhary_2013_Prostaglandins.Other.Lipid.Mediat_104-105_8 |
| Author(s) : Chaudhary KR , Zordoky BN , Edin ML , Alsaleh N , El-Kadi AO , Zeldin DC , Seubert JM |
| Ref : Prostaglandins Other Lipid Mediat , 104-105 :8 , 2013 |
| PubMedID: 22922020 |
| Title : Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie - Poli_2013_Life.Sci_92_1145 |
| Author(s) : Poli G , Corda E , Martino PA , Dall'ara P , Bareggi SR , Bondiolotti G , Iulini B , Mazza M , Casalone C , Hwang SH , Hammock BD , Inceoglu B |
| Ref : Life Sciences , 92 :1145 , 2013 |
| PubMedID: 23651659 |
| Title : Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models - Liu_2013_Eur.J.Pharm.Sci_48_619 |
| Author(s) : Liu JY , Lin YP , Qiu H , Morisseau C , Rose TE , Hwang SH , Chiamvimonvat N , Hammock BD |
| Ref : Eur J Pharm Sci , 48 :619 , 2013 |
| PubMedID: 23291046 |
| Title : Role of haem oxygenase in the renoprotective effects of soluble epoxide hydrolase inhibition in diabetic spontaneously hypertensive rats - Elmarakby_2013_Clin.Sci.(Lond)_125_349 |
| Author(s) : Elmarakby AA , Faulkner J , Pye C , Rouch K , Alhashim A , Maddipati KR , Baban B |
| Ref : Clinical Science (Lond) , 125 :349 , 2013 |
| PubMedID: 23611540 |
| Title : t-AUCB, an improved sEH inhibitor, suppresses human glioblastoma cell growth by activating NF-kappaB-p65 - Li_2012_J.Neurooncol_108_385 |
| Author(s) : Li J , Liu H , Xing B , Yu Y , Wang H , Chen G , Gu B , Zhang G , Wei D , Gu P , Li M , Hu W |
| Ref : J Neurooncol , 108 :385 , 2012 |
| PubMedID: 22382785 |
| Title : The apoptosis-resistance in t-AUCB-treated glioblastoma cells depends on activation of Hsp27 - Li_2012_J.Neurooncol_110_187 |
| Author(s) : Li J , Hu W , Lan Q |
| Ref : J Neurooncol , 110 :187 , 2012 |
| PubMedID: 22903412 |
| Title : [Soluble epoxide hydrolase inhibitor t-AUCB ameliorates ox-LDL induced conversion of macrophages into foam cells through activating the PPARgamma-ABCA1 pathway] - Zhao_2012_Zhonghua.Xin.Xue.Guan.Bing.Za.Zhi_40_248 |
| Author(s) : Zhao TT , Peng R , Shen L , Zhao X , Xu DY , Zhao SP |
| Ref : Zhonghua Xin Xue Guan Bing Za Zhi , 40 :248 , 2012 |
| PubMedID: 22801272 |
| Title : Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension - Kopkan_2012_Kidney.Blood.Press.Res_35_595 |
| Author(s) : Kopkan L , Huskova Z , Sporkova A , Varcabova S , Honetschlagerova Z , Hwang SH , Tsai HJ , Hammock BD , Imig JD , Kramer HJ , Burgelova M , Vojtiskova A , Kujal P , Vernerova Z , Cervenka L |
| Ref : Kidney Blood Press Res , 35 :595 , 2012 |
| PubMedID: 22948718 |
| Title : Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension - Neckar_2012_Clin.Sci.(Lond)_122_513 |
| Author(s) : Neckar J , Kopkan L , Huskova Z , Kolar F , Papousek F , Kramer HJ , Hwang SH , Hammock BD , Imig JD , Maly J , Netuka I , Ostadal B , Cervenka L |
| Ref : Clinical Science (Lond) , 122 :513 , 2012 |
| PubMedID: 22324471 |
| Title : Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-\/-) mice - Zhang_2012_Dig.Dis.Sci_57_2580 |
| Author(s) : Zhang W , Yang AL , Liao J , Li H , Dong H , Chung YT , Bai H , Matkowskyj KA , Hammock BD , Yang GY |
| Ref : Digestive Diseases & Sciences , 57 :2580 , 2012 |
| PubMedID: 22588244 |
| Title : Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats - Iyer_2012_Exp.Diabetes.Res_2012_758614 |
| Author(s) : Iyer A , Kauter K , Alam MA , Hwang SH , Morisseau C , Hammock BD , Brown L |
| Ref : Exp Diabetes Res , 2012 :758614 , 2012 |
| PubMedID: 22007192 |
| Title : Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice - Liu_2012_PLoS.One_7_e39165 |
| Author(s) : Liu Y , Dang H , Li D , Pang W , Hammock BD , Zhu Y |
| Ref : PLoS ONE , 7 :e39165 , 2012 |
| PubMedID: 22720061 |
| Title : [Effects of soluble epoxide hydrolase inhibitors on the expression of fatty acid synthase in peripheral blood mononuclear cell of patients and inflammatory response with acute coronary syndrome] - Du_2012_Zhonghua.Yi.Xue.Za.Zhi_92_86 |
| Author(s) : Du JQ , Peng R , Xu DY , Zhao TT , Shen L , Zhao SP |
| Ref : Zhonghua Yi Xue Za Zhi , 92 :86 , 2012 |
| PubMedID: 22490687 |
| Title : Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy - Inoue_2011_Cancer.Biol.Ther_12_827 |
| Author(s) : Inoue H , Hwang SH , Wecksler AT , Hammock BD , Weiss RH |
| Ref : Cancer Biol Ther , 12 :827 , 2011 |
| PubMedID: 21878748 |
| Title : Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension - Honetschlagerova_2011_J.Physiol_589_207 |
| Author(s) : Honetschlagerova Z , Z ZH , Vanourkova Z , Sporkova A , Kramer HJ , Hwang SH , Tsai HJ , Hammock BD , Imig JD , Cervenka L , Kopkan L |
| Ref : The Journal of Physiology , 589 :207 , 2011 |
| PubMedID: 21078594 |
| Title : Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi - Senouvo_2011_Am.J.Physiol.Lung.Cell.Mol.Physiol_301_L675 |
| Author(s) : Senouvo FY , Tabet Y , Morin C , Albadine R , Sirois C , Rousseau E |
| Ref : American Journal of Physiology Lung Cell Mol Physiol , 301 :L675 , 2011 |
| PubMedID: 21821730 |
| Title : Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels - Hasenau_2011_Acta.Physiol.(Oxf)_203_117 |
| Author(s) : Hasenau AL , Nielsen G , Morisseau C , Hammock BD , Wulff H , Kohler R |
| Ref : Acta Physiol (Oxf) , 203 :117 , 2011 |
| PubMedID: 21362152 |
| Title : Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase - Hwang_2011_J.Med.Chem_54_3037 |
| Author(s) : Hwang SH , Wagner KM , Morisseau C , Liu JY , Dong H , Wecksler AT , Hammock BD |
| Ref : Journal of Medicinal Chemistry , 54 :3037 , 2011 |
| PubMedID: 21434686 |
| Title : Cytochrome P450-derived epoxyeicosatrienoic acids accelerate wound epithelialization and neovascularization in the hairless mouse ear wound model - Sander_2011_Langenbecks.Arch.Surg_396_1245 |
| Author(s) : Sander AL , Jakob H , Sommer K , Sadler C , Fleming I , Marzi I , Frank J |
| Ref : Langenbecks Arch Surg , 396 :1245 , 2011 |
| PubMedID: 21887579 |
| Title : Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease - Jung_2010_PLoS.One_5_e11979 |
| Author(s) : Jung O , Jansen F , Mieth A , Barbosa-Sicard E , Pliquett RU , Babelova A , Morisseau C , Hwang SH , Tsai C , Hammock BD , Schaefer L , Geisslinger G , Amann K , Brandes RP |
| Ref : PLoS ONE , 5 :e11979 , 2010 |
| PubMedID: 20694143 |
| Title : Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis - Luo_2010_J.Pharmacol.Exp.Ther_334_430 |
| Author(s) : Luo P , Chang HH , Zhou Y , Zhang S , Hwang SH , Morisseau C , Wang CY , Inscho EW , Hammock BD , Wang MH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :430 , 2010 |
| PubMedID: 20439437 |
| Title : Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury - Chaudhary_2010_J.Cardiovasc.Pharmacol_55_67 |
| Author(s) : Chaudhary KR , Abukhashim M , Hwang SH , Hammock BD , Seubert JM |
| Ref : J Cardiovasc Pharmacol , 55 :67 , 2010 |
| PubMedID: 19834332 |
| Title : Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model - Liu_2010_Biochem.Pharmacol_79_880 |
| Author(s) : Liu JY , Yang J , Inceoglu B , Qiu H , Ulu A , Hwang SH , Chiamvimonvat N , Hammock BD |
| Ref : Biochemical Pharmacology , 79 :880 , 2010 |
| PubMedID: 19896470 |
| Title : Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs - Tsai_2010_Eur.J.Pharm.Sci_40_222 |
| Author(s) : Tsai HJ , Hwang SH , Morisseau C , Yang J , Jones PD , Kasagami T , Kim IH , Hammock BD |
| Ref : Eur J Pharm Sci , 40 :222 , 2010 |
| PubMedID: 20359531 |
| Title : Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation - Liu_2009_Br.J.Pharmacol_156_284 |
| Author(s) : Liu JY , Tsai HJ , Hwang SH , Jones PD , Morisseau C , Hammock BD |
| Ref : British Journal of Pharmacology , 156 :284 , 2009 |
| PubMedID: 19154430 |
| Title : Orally bioavailable potent soluble epoxide hydrolase inhibitors - Hwang_2007_J.Med.Chem_50_3825 |
| Author(s) : Hwang SH , Tsai HJ , Liu JY , Morisseau C , Hammock BD |
| Ref : Journal of Medicinal Chemistry , 50 :3825 , 2007 |
| PubMedID: 17616115 |