Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: JZL184

Monoacylglycerol lipase (human-MGLL) selective inhibitor. Administration of JZL184 to mice was reported to cause dramatic elevation of brain 2-AG leading to several cannabinoid-related behavioral effects. Inhibits also FAAH and CES1 and a little ABHD6 Iglesias et al. Does not Inhibit Rv0183 from Mycobacterium tuberculosis (mtbMGL)


General
Type Piperidine, Benzodioxo, FAAH inhibitor, Multitarget, pNP
Chemical_Nomenclature (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
Canonical SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
InChI InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2
InChIKey SEGYOKHGGFKMCX-UHFFFAOYSA-N
Other name(s) JZL 184 ; JZL-184 ; UNII-7MZ1I2J68A ; CHEMBL576786
________________________________________________________________________________________________
MW|520.48
Formula|C27H24N2O9
CAS_number|1101854-58-3
PubChem|25021165
UniChem|SEGYOKHGGFKMCX-UHFFFAOYSA-N
IUPHAR|5207
Wikipedia|

Target
Families | JZL184 ligand of proteins in family: Monoglyceridelipase_lysophospholip, Carb_B_Chordata, ABHD6-Lip
Protein | human-MGLL

References:
Search PubMed for references concerning: JZL184

29 more
    Title: The protective effect of JZL184 on ovarian ischemia reperfusion injury and ovarian reserve in rats
    Demir Caltekin M, Ozkut MM, Caltekin I, Kaymak E, Cakir M, Kara M, Yalvac ES
    Ref: J Obstet Gynaecol Res, :, 2021 : PubMed

            

    Title: Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex
    Pavon FJ, Polis IY, Stouffer DG, Cravatt BF, Roberto M, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH, Serrano A
    Ref: Neurobiol Stress, 14:100293, 2021 : PubMed

            

    Title: Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress
    Alteba S, Mizrachi Zer-Aviv T, Tenenhaus A, Ben David G, Adelman J, Hillard CJ, Doron R, Akirav I
    Ref: European Neuropsychopharmacology, 39:70, 2020 : PubMed