Cocaine

General

Type : Natural, Drug, Alkaloid, Benzoate, Azabicyclo

Chemical_Nomenclature : methyl (1S,3S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

Canonical SMILES : CN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC

InChI : InChI=1S\/C17H21NO4\/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11\/h3-7,12-15H,8-10H2,1-2H3\/t12-,13+,14-,15+\/m0\/s1

InChIKey : ZPUCINDJVBIVPJ-LJISPDSOSA-N

Other name(s) : 2beta-carbomethoxy-3beta-benzoyloxytropane hydrochloride  ||  (-)-Cocaine  ||  3-beta-Hydroxy-, Methyl Ester, Benzoate  ||  Methylbenzoylepgonine  ||  Cocaine Free Base  ||  Benzoylmethylecgonine  ||  Crack  ||  L-Cocain  ||  beta-Cocain  ||  D-cocaine  ||  Cocain  ||  Kokain


MW : 303.35

Formula : C17H21NO4

CAS_number : 53-21-4

PubChem : 5760,    656832,    644017,    15558684,    644270,    5871,    21635054,    517282,    13006129,    122142,    2826,    11302220,    446220

UniChem : ZPUCINDJVBIVPJ-LJISPDSOSA-N

Wikipedia : Cocaine

Target

Structures : No structure

Families : BCHE, Carb_B_Chordata, Cocaine_esterase

References (64)

Title : In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase - Shang_2024_Sci.Rep_14_10952
Author(s) : Shang L , Wei H , Deng J , Stewart MJ , LeSaint JE , Kyomuhangi A , Park S , Maul EC , Zhan CG , Zheng F
Ref : Sci Rep , 14 :10952 , 2024
Abstract :
PubMedSearch : Shang_2024_Sci.Rep_14_10952
PubMedID: 38740850

Title : Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats - Wei_2024_Sci.Rep_14_927
Author(s) : Wei H , LeSaint JE , Jin Z , Zhan CG , Zheng F
Ref : Sci Rep , 14 :927 , 2024
Abstract :
PubMedSearch : Wei_2024_Sci.Rep_14_927
PubMedID: 38195724

Title : Human Butyrylcholinesterase Mutants for (-)-Cocaine Hydrolysis: A Correlation Relationship between Catalytic Efficiency and Total Hydrogen Bonding Energy with an Oxyanion Hole - Zheng_2023_J.Phys.Chem.B__
Author(s) : Zheng F , Hou S , Xue L , Yang W , Zhan CG
Ref : J Phys Chem B , : , 2023
Abstract :
PubMedSearch : Zheng_2023_J.Phys.Chem.B__
PubMedID: 38063500

Title : Recovery of dopaminergic system after cocaine exposure and impact of a long-acting cocaine hydrolase - Deng_2022_Addict.Biol_27_e13179
Author(s) : Deng J , Zhang T , Zheng X , Shang L , Zhan CG , Zheng F
Ref : Addict Biol , 27 :e13179 , 2022
Abstract :
PubMedSearch : Deng_2022_Addict.Biol_27_e13179
PubMedID: 35754103

Title : Development of a Highly Efficient Long-Acting Cocaine Hydrolase Entity to Accelerate Cocaine Metabolism - Zheng_2022_Bioconjug.Chem__
Author(s) : Zheng F , Jin Z , Deng J , Chen X , Zheng X , Wang G , Kim K , Shang L , Zhou Z , Zhan CG
Ref : Bioconjug Chem , : , 2022
Abstract :
PubMedSearch : Zheng_2022_Bioconjug.Chem__
PubMedID: 35767675

Title : Effects of alcohol on metabolism and toxicity of cocaine in rats - Shang_2022_Toxicol.Rep_9_1586
Author(s) : Shang L , Zheng X , Zhang T , Deng J , Zhan CG , Zheng F
Ref : Toxicol Rep , 9 :1586 , 2022
Abstract :
PubMedSearch : Shang_2022_Toxicol.Rep_9_1586
PubMedID: 36518391

Title : Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene - Zheng_2020_Org.Biomol.Chem__
Author(s) : Zheng X , Chen X , Zhang T , Zhan M , Zhan CG , Zheng F
Ref : Org Biomol Chem , : , 2020
Abstract :
PubMedSearch : Zheng_2020_Org.Biomol.Chem__
PubMedID: 32101217

Title : Efficient Cocaine Degradation by Cocaine Esterase-Loaded Red Blood Cells - Rossi_2020_Front.Physiol_11_573492
Author(s) : Rossi L , Pierige F , Agostini M , Bigini N , Termopoli V , Cai Y , Zheng F , Zhan CG , Landry DW , Magnani M
Ref : Front Physiol , 11 :573492 , 2020
Abstract :
PubMedSearch : Rossi_2020_Front.Physiol_11_573492
PubMedID: 33013487

Title : Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose - Li_2019_Nat.Biomed.Eng_3_105
Author(s) : Li Y , Kong Q , Yue J , Gou X , Xu M , Wu X
Ref : Nat Biomed Eng , 3 :105 , 2019
Abstract :
PubMedSearch : Li_2019_Nat.Biomed.Eng_3_105
PubMedID: 30899600

Title : Development of a long-acting Fc-fused cocaine hydrolase with improved yield of protein expression - Chen_2019_Chem.Biol.Interact_13ChEPon_306_89
Author(s) : Chen X , Deng J , Zheng X , Zhang J , Zhou Z , Wei H , Zhan CG , Zheng F
Ref : Chemico-Biological Interactions , 306 :89 , 2019
Abstract :
PubMedSearch : Chen_2019_Chem.Biol.Interact_13ChEPon_306_89
PubMedID: 30986387

Title : Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction - Yan_2019_Molecules_24_
Author(s) : Yan M , Zhang Z , Liu Z , Zhang C , Zhang J , Fan S , Yang Z
Ref : Molecules , 24 : , 2019
Abstract :
PubMedSearch : Yan_2019_Molecules_24_
PubMedID: 31717501
Gene_locus related to this paper: human-CES1

Title : Reengineering of Albumin-Fused Cocaine Hydrolase CocH1 (TV-1380) to Prolong Its Biological Half-Life - Cai_2019_AAPS.J_22_5
Author(s) : Cai Y , Zhou S , Jin Z , Wei H , Shang L , Deng J , Zhan CG , Zheng F
Ref : AAPS J , 22 :5 , 2019
Abstract :
PubMedSearch : Cai_2019_AAPS.J_22_5
PubMedID: 31754920

Title : Catalytic Reaction Mechanism for Drug Metabolism in Human Carboxylesterase-1: Cocaine Hydrolysis Pathway - Yao_2018_Mol.Pharm_15_3871
Author(s) : Yao J , Chen X , Zheng F , Zhan CG
Ref : Mol Pharm , 15 :3871 , 2018
Abstract :
PubMedSearch : Yao_2018_Mol.Pharm_15_3871
PubMedID: 30095924

Title : Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphine - Kim_2018_Chem.Biol.Interact_293_107
Author(s) : Kim K , Yao J , Jin Z , Zheng F , Zhan CG
Ref : Chemico-Biological Interactions , 293 :107 , 2018
Abstract :
PubMedSearch : Kim_2018_Chem.Biol.Interact_293_107
PubMedID: 30080993

Title : Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats - Chen_2016_Chem.Biol.Interact_259_104
Author(s) : Chen X , Zheng X , Zhou Z , Zhan CG , Zheng F
Ref : Chemico-Biological Interactions , 259 :104 , 2016
Abstract :
PubMedSearch : Chen_2016_Chem.Biol.Interact_259_104
PubMedID: 27154495

Title : Potential anti-obesity effects of a long-acting cocaine hydrolase - Zheng_2016_Chem.Biol.Interact_259_99
Author(s) : Zheng X , Deng J , Zhang T , Yao J , Zheng F , Zhan CG
Ref : Chemico-Biological Interactions , 259 :99 , 2016
Abstract :
PubMedSearch : Zheng_2016_Chem.Biol.Interact_259_99
PubMedID: 27163854

Title : Free energy profiles of cocaine esterase-cocaine binding process by molecular dynamics and potential of mean force simulations - Zhang_2016_Chem.Biol.Interact_259_142
Author(s) : Zhang Y , Huang X , Han K , Zheng F , Zhan CG
Ref : Chemico-Biological Interactions , 259 :142 , 2016
Abstract :
PubMedSearch : Zhang_2016_Chem.Biol.Interact_259_142
PubMedID: 27163853

Title : Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine - Chen_2016_ACS.Chem.Biol_11_2186
Author(s) : Chen X , Zheng X , Zhan M , Zhou Z , Zhan CG , Zheng F
Ref : ACS Chemical Biology , 11 :2186 , 2016
Abstract :
PubMedSearch : Chen_2016_ACS.Chem.Biol_11_2186
PubMedID: 27224254

Title : Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase - Chen_2015_Biochem.J_466_243
Author(s) : Chen X , Huang X , Geng L , Xue L , Hou S , Zheng X , Brimijoin S , Zheng F , Zhan CG
Ref : Biochemical Journal , 466 :243 , 2015
Abstract :
PubMedSearch : Chen_2015_Biochem.J_466_243
PubMedID: 25486543
Gene_locus related to this paper: human-BCHE

Title : Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase - Murthy_2015_Cell.Mol.Neurobiol_35_819
Author(s) : Murthy V , Geng L , Gao Y , Zhang B , Miller JD , Reyes S , Brimijoin S
Ref : Cellular Molecular Neurobiology , 35 :819 , 2015
Abstract :
PubMedSearch : Murthy_2015_Cell.Mol.Neurobiol_35_819
PubMedID: 25814464

Title : Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine - Zhan_2014_Biochem.J_457_197
Author(s) : Zhan M , Hou S , Zhan CG , Zheng F
Ref : Biochemical Journal , 457 :197 , 2014
Abstract :
PubMedSearch : Zhan_2014_Biochem.J_457_197
PubMedID: 24125115

Title : Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene - Hou_2014_Biochem.J_460_447
Author(s) : Hou S , Zhan M , Zheng X , Zhan CG , Zheng F
Ref : Biochemical Journal , 460 :447 , 2014
Abstract :
PubMedSearch : Hou_2014_Biochem.J_460_447
PubMedID: 24870023

Title : A highly efficient cocaine-detoxifying enzyme obtained by computational design - Zheng_2014_Nat.Commun_5_3457
Author(s) : Zheng F , Xue L , Hou S , Liu J , Zhan M , Yang W , Zhan CG
Ref : Nat Commun , 5 :3457 , 2014
Abstract :
PubMedSearch : Zheng_2014_Nat.Commun_5_3457
PubMedID: 24643289
Gene_locus related to this paper: human-BCHE

Title : Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase - Fang_2014_Chem.Biol.Interact_214C_18
Author(s) : Fang L , Hou S , Xue L , Zheng F , Zhan CG
Ref : Chemico-Biological Interactions , 214C :18 , 2014
Abstract :
PubMedSearch : Fang_2014_Chem.Biol.Interact_214C_18
PubMedID: 24582612
Gene_locus related to this paper: human-BCHE

Title : Contribution of human esterases to the metabolism of selected drugs of abuse - Meyer_2014_Toxicol.Lett_232_159
Author(s) : Meyer MR , Schutz A , Maurer HH
Ref : Toxicol Lett , 232 :159 , 2014
Abstract :
PubMedSearch : Meyer_2014_Toxicol.Lett_232_159
PubMedID: 25445008

Title : Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification - Fang_2014_ACS.Chem.Biol_9_1764
Author(s) : Fang L , Chow KM , Hou S , Xue L , Chen X , Rodgers DW , Zheng F , Zhan CG
Ref : ACS Chemical Biology , 9 :1764 , 2014
Abstract :
PubMedSearch : Fang_2014_ACS.Chem.Biol_9_1764
PubMedID: 24919140
Gene_locus related to this paper: rhosm-cocE

Title : Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice - Murthy_2014_J.Mol.Neurosci_53_409
Author(s) : Murthy V , Gao Y , Geng L , LeBrasseur NK , White TA , Brimijoin S
Ref : Journal of Molecular Neuroscience , 53 :409 , 2014
Abstract :
PubMedSearch : Murthy_2014_J.Mol.Neurosci_53_409
PubMedID: 24085526

Title : The future potential for cocaine vaccines - Orson_2014_Expert.Opin.Biol.Ther_14_1271
Author(s) : Orson FM , Wang R , Brimijoin S , Kinsey BM , Singh RA , Ramakrishnan M , Wang HY , Kosten TR
Ref : Expert Opin Biol Ther , 14 :1271 , 2014
Abstract :
PubMedSearch : Orson_2014_Expert.Opin.Biol.Ther_14_1271
PubMedID: 24835496

Title : Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine - Xue_2013_Biochem.J_453_447
Author(s) : Xue L , Hou S , Tong M , Fang L , Chen X , Jin Z , Tai HH , Zheng F , Zhan CG
Ref : Biochemical Journal , 453 :447 , 2013
Abstract :
PubMedSearch : Xue_2013_Biochem.J_453_447
PubMedID: 23849058

Title : Substrate selectivity of high-activity mutants of human butyrylcholinesterase - Hou_2013_Org.Biomol.Chem_11_7477
Author(s) : Hou S , Xue L , Yang W , Fang L , Zheng F , Zhan CG
Ref : Org Biomol Chem , 11 :7477 , 2013
Abstract :
PubMedSearch : Hou_2013_Org.Biomol.Chem_11_7477
PubMedID: 24077614

Title : Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity - Larrimore_2013_Chem.Biol.Interact_203_217
Author(s) : Larrimore KE , Barcus M , Kannan L , Gao Y , Zhan CG , Brimijoin S , Mor TS
Ref : Chemico-Biological Interactions , 203 :217 , 2013
Abstract :
PubMedSearch : Larrimore_2013_Chem.Biol.Interact_203_217
PubMedID: 23000451

Title : Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine - Xue_2013_Chem.Biol.Interact_203_57
Author(s) : Xue L , Hou S , Yang W , Fang L , Zheng F , Zhan CG
Ref : Chemico-Biological Interactions , 203 :57 , 2013
Abstract :
PubMedSearch : Xue_2013_Chem.Biol.Interact_203_57
PubMedID: 22917637

Title : Cocaine esterase-cocaine binding process and the free energy profiles by molecular dynamics and potential of mean force simulations - Huang_2012_J.Phys.Chem.B_116_3361
Author(s) : Huang X , Zhao X , Zheng F , Zhan CG
Ref : J Phys Chem B , 116 :3361 , 2012
Abstract :
PubMedSearch : Huang_2012_J.Phys.Chem.B_116_3361
PubMedID: 22385120

Title : Modeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuse - Zheng_2012_PLoS.Comput.Biol_8_e1002610
Author(s) : Zheng F , Zhan CG
Ref : PLoS Comput Biol , 8 :e1002610 , 2012
Abstract :
PubMedSearch : Zheng_2012_PLoS.Comput.Biol_8_e1002610
PubMedID: 22844238

Title : Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine - Xue_2011_Mol.Pharmacol_79_290
Author(s) : Xue L , Ko MC , Tong M , Yang W , Hou S , Fang L , Liu J , Zheng F , Woods JH , Tai HH , Zhan CG
Ref : Molecular Pharmacology , 79 :290 , 2011
Abstract :
PubMedSearch : Xue_2011_Mol.Pharmacol_79_290
PubMedID: 20971807

Title : Enzyme-therapy approaches for the treatment of drug overdose and addiction -
Author(s) : Zheng F , Zhan CG
Ref : Future Med Chem , 3 :9 , 2011
PubMedID: 21428822

Title : Human butyrylcholinesterase-cocaine binding pathway and free energy profiles by molecular dynamics and potential of mean force simulations - Huang_2011_J.Phys.Chem.B_115_11254
Author(s) : Huang X , Zheng F , Zhan CG
Ref : J Phys Chem B , 115 :11254 , 2011
Abstract :
PubMedSearch : Huang_2011_J.Phys.Chem.B_115_11254
PubMedID: 21902185

Title : Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency - Zheng_2010_Biochemistry_49_9113
Author(s) : Zheng F , Yang W , Xue L , Hou S , Liu J , Zhan CG
Ref : Biochemistry , 49 :9113 , 2010
Abstract :
PubMedSearch : Zheng_2010_Biochemistry_49_9113
PubMedID: 20886866

Title : Reaction pathway and free energy profile for prechemical reaction step of human butyrylcholinesterase-catalyzed hydrolysis of (-)-cocaine by combined targeted molecular dynamics and potential of mean force simulations - Huang_2010_J.Phys.Chem.B_114_13545
Author(s) : Huang X , Pan Y , Zheng F , Zhan CG
Ref : J Phys Chem B , 114 :13545 , 2010
Abstract :
PubMedSearch : Huang_2010_J.Phys.Chem.B_114_13545
PubMedID: 20883001

Title : Free energy perturbation simulation on transition states and high-activity mutants of human butyrylcholinesterase for (-)-cocaine hydrolysis - Yang_2010_J.Phys.Chem.B_114_10889
Author(s) : Yang W , Pan Y , Fang L , Gao D , Zheng F , Zhan CG
Ref : J Phys Chem B , 114 :10889 , 2010
Abstract :
PubMedSearch : Yang_2010_J.Phys.Chem.B_114_10889
PubMedID: 20677742

Title : Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin - Hatfield_2010_Br.J.Pharmacol_160_1916
Author(s) : Hatfield MJ , Tsurkan LG , Hyatt JL , Yu X , Edwards CC , Hicks LD , Wadkins RM , Potter PM
Ref : British Journal of Pharmacology , 160 :1916 , 2010
Abstract :
PubMedSearch : Hatfield_2010_Br.J.Pharmacol_160_1916
PubMedID: 20649590
Gene_locus related to this paper: human-CES1

Title : Recent progress in protein drug design and discovery with a focus on novel approaches to the development of anti-cocaine medications - Zheng_2009_Future.Med.Chem_1_515
Author(s) : Zheng F , Zhan CG
Ref : Future Med Chem , 1 :515 , 2009
Abstract :
PubMedSearch : Zheng_2009_Future.Med.Chem_1_515
PubMedID: 20161378

Title : Most efficient cocaine hydrolase designed by virtual screening of transition states - Zheng_2008_J.Am.Chem.Soc_130_12148
Author(s) : Zheng F , Yang W , Ko MC , Liu J , Cho H , Gao D , Tong M , Tai HH , Woods JH , Zhan CG
Ref : Journal of the American Chemical Society , 130 :12148 , 2008
Abstract :
PubMedSearch : Zheng_2008_J.Am.Chem.Soc_130_12148
PubMedID: 18710224

Title : Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction - Zheng_2008_Org.Biomol.Chem_6_836
Author(s) : Zheng F , Zhan CG
Ref : Org Biomol Chem , 6 :836 , 2008
Abstract :
PubMedSearch : Zheng_2008_Org.Biomol.Chem_6_836
PubMedID: 18292872

Title : Rational design of an enzyme mutant for anti-cocaine therapeutics - Zheng_2008_J.Comput.Aided.Mol.Des_22_661
Author(s) : Zheng F , Zhan CG
Ref : J Comput Aided Mol Des , 22 :661 , 2008
Abstract :
PubMedSearch : Zheng_2008_J.Comput.Aided.Mol.Des_22_661
PubMedID: 17989928

Title : Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase - Zhan_2003_J.Am.Chem.Soc_125_2462
Author(s) : Zhan CG , Zheng F , Landry DW
Ref : Journal of the American Chemical Society , 125 :2462 , 2003
Abstract :
PubMedSearch : Zhan_2003_J.Am.Chem.Soc_125_2462
PubMedID: 12603134

Title : Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase - Sun_2002_J.Pharmacol.Exp.Ther_302_710
Author(s) : Sun H , Shen ML , Pang YP , Lockridge O , Brimijoin S
Ref : Journal of Pharmacology & Experimental Therapeutics , 302 :710 , 2002
Abstract :
PubMedSearch : Sun_2002_J.Pharmacol.Exp.Ther_302_710
PubMedID: 12130735
Gene_locus related to this paper: human-BCHE

Title : Re-engineering butyrylcholinesterase as a cocaine hydrolase - Sun_2002_Mol.Pharmacol_62_220
Author(s) : Sun H , Pang YP , Lockridge O , Brimijoin S
Ref : Molecular Pharmacology , 62 :220 , 2002
Abstract :
PubMedSearch : Sun_2002_Mol.Pharmacol_62_220
PubMedID: 12130672
Gene_locus related to this paper: human-BCHE

Title : Crystal structure of a cocaine-binding antibody - Larsen_2001_J.Mol.Biol_311_9
Author(s) : Larsen NA , Zhou B , Heine A , Wirsching P , Janda KD , Wilson IA
Ref : Journal of Molecular Biology , 311 :9 , 2001
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PubMedSearch : Larsen_2001_J.Mol.Biol_311_9
PubMedID: 11469854

Title : Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication. - Sun_2001_J.Biol.Chem_276_9330
Author(s) : Sun H , El Yazal J , Lockridge O , Schopfer LM , Brimijoin S , Pang YP
Ref : Journal of Biological Chemistry , 276 :9330 , 2001
Abstract :
PubMedSearch : Sun_2001_J.Biol.Chem_276_9330
PubMedID: 11104759

Title : Role of cholinergic receptors and cholinesterase activity in hemodynamic responses to cocaine in conscious rats - Knuepfer_1999_Am.J.Physiol_276_R103
Author(s) : Knuepfer MM , Gan Q
Ref : American Journal of Physiology , 276 :R103 , 1999
Abstract :
PubMedSearch : Knuepfer_1999_Am.J.Physiol_276_R103
PubMedID: 9887183

Title : An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient - Xie_1999_Mol.Pharmacol_55_83
Author(s) : Xie W , Altamirano CV , Bartels CF , Speirs RJ , Cashman JR , Lockridge O
Ref : Molecular Pharmacology , 55 :83 , 1999
Abstract :
PubMedSearch : Xie_1999_Mol.Pharmacol_55_83
PubMedID: 9882701

Title : The influence of plasma butyrylcholinesterase concentration on the in vitro hydrolysis of cocaine in human plasma - Browne_1998_Biopharm.Drug.Dispos_19_309
Author(s) : Browne SP , Slaughter EA , Couch RA , Rudnic EM , McLean AM
Ref : Biopharmaceutics & Drug Disposition , 19 :309 , 1998
Abstract :
PubMedSearch : Browne_1998_Biopharm.Drug.Dispos_19_309
PubMedID: 9673783

Title : Cocaine benzoyl thioester: synthesis, kinetics of base hydrolysis, and application to the assay of cocaine esterases - Cashman_1998_Chem.Res.Toxicol_11_895
Author(s) : Cashman JR , Berkman CE , Underiner G , Kolly CA , Hunter AD
Ref : Chemical Research in Toxicology , 11 :895 , 1998
Abstract :
PubMedSearch : Cashman_1998_Chem.Res.Toxicol_11_895
PubMedID: 9705751

Title : Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy - Gorelick_1997_Drug.Alcohol.Depend_48_159
Author(s) : Gorelick DA
Ref : Drug Alcohol Depend , 48 :159 , 1997
Abstract :
PubMedSearch : Gorelick_1997_Drug.Alcohol.Depend_48_159
PubMedID: 9449014

Title : Cocaine detoxification by human plasma butyrylcholinesterase - Lynch_1997_Toxicol.Appl.Pharmacol_145_363
Author(s) : Lynch TJ , Mattes CE , Singh A , Bradley RM , Brady RO , Dretchen KL
Ref : Toxicol Appl Pharmacol , 145 :363 , 1997
Abstract :
PubMedSearch : Lynch_1997_Toxicol.Appl.Pharmacol_145_363
PubMedID: 9266810

Title : Therapeutic use of butyrylcholinesterase for cocaine intoxication - Mattes_1997_Toxicol.Appl.Pharmacol_145_372
Author(s) : Mattes CE , Lynch TJ , Singh A , Bradley RM , Kellaris PA , Brady RO , Dretchen KL
Ref : Toxicol Appl Pharmacol , 145 :372 , 1997
Abstract :
PubMedSearch : Mattes_1997_Toxicol.Appl.Pharmacol_145_372
PubMedID: 9266811

Title : Normal and atypical butyrylcholinesterases in placental development, function, and malfunction - Sternfeld_1997_Cell.Mol.Neurobiol_17_315
Author(s) : Sternfeld M , Rachmilewitz J , Loewenstein-Lichtenstein Y , Andres C , Timberg R , Ben-Ari S , Glick C , Soreq H , Zakut H
Ref : Cellular Molecular Neurobiology , 17 :315 , 1997
Abstract :
PubMedSearch : Sternfeld_1997_Cell.Mol.Neurobiol_17_315
PubMedID: 9187488

Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H
Ref : Molecular Pharmacology , 50 :1423 , 1996
Abstract :
PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
PubMedID: 8967962
Gene_locus related to this paper: human-BCHE

Title : Acetylcholinesterase and butyrylcholinesterase activity in the human term placenta: implications for fetal cocaine exposure - Simone_1994_J.Lab.Clin.Med_123_400
Author(s) : Simone C , Derewlany LO , Oskamp M , Johnson D , Knie B , Koren G
Ref : Journal of Laboratory & Clinical Medicine , 123 :400 , 1994
Abstract :
PubMedSearch : Simone_1994_J.Lab.Clin.Med_123_400
PubMedID: 8133152

Title : Differential toxicity of cocaine and its isomers, (+)-cocaine and (-)-psi-cocaine, is associated with stereoselective hydrolysis by hepatic carboxylesterases in cultured rat hepatocytes - Melchert_1992_Chem.Biol.Interact_84_243
Author(s) : Melchert RB , Goldlin C , Zweifel U , Welder AA , Boelsterli UA
Ref : Chemico-Biological Interactions , 84 :243 , 1992
Abstract :
PubMedSearch : Melchert_1992_Chem.Biol.Interact_84_243
PubMedID: 1423743

Title : Activities of the enantiomers of cocaine and some related compounds as substrates and inhibitors of plasma butyrylcholinesterase - Gatley_1991_Biochem.Pharmacol_41_1249
Author(s) : Gatley SJ
Ref : Biochemical Pharmacology , 41 :1249 , 1991
Abstract :
PubMedSearch : Gatley_1991_Biochem.Pharmacol_41_1249
PubMedID: 2009099

Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35
Author(s) : Lockridge O
Ref : Pharmacol Ther , 47 :35 , 1990
Abstract :
PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35
PubMedID: 2195556
Gene_locus related to this paper: human-BCHE

Title : Metabolism of cocaine in man - Inaba_1978_Clin.Pharmacol.Ther_23_547
Author(s) : Inaba T , Stewart DJ , Kalow W
Ref : Clinical Pharmacology & Therapeutics , 23 :547 , 1978
Abstract :
PubMedSearch : Inaba_1978_Clin.Pharmacol.Ther_23_547
PubMedID: 639429