ABHD16
Comment
This family consists of abhydrolase domain-containing protein 16 A (ABHD16A). Function of its members is unknown. However, ABHD16A contains transmembrane domain and is a potential multi-pass membrane protein. BAT5 (HLA-B-associated transcript 5). Savinainen et al. showed hydrolysis of medium-chain saturated (C14:0), long-chain unsaturated (C18:1, C18:2, C20:4) monoacylglycerols (MAGs) and 15-deoxy-12,14-prostaglandin J2-2-glycerol ester (15d-PGJ2-G). Only marginal diacylglycerol (DAG), triacylglycerol (TAG), or lysophospholipase activity PANTHER PTHR12277:SF54 
There are two genes ABHD16 A and B in amniotes. Shan et al. identified a nonsense mutation in the bovine ABHD16B associated with male subfertility in Holstein cattle. ABHD16B is involved in lipid biosynthesis in testis and is crucial for fertilization. ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies (Lemire et al. 2021; Yahia et al. 2021; Miyake et al. 2021). Substrates of ABHD include medium-chain saturated monoacylglycerols, 1-linoleylglycerol, 15-deoxy-delta12,14-prostaglandin J2-2-glycerol ester
Database
Interpro : IPR026604 Abhydrolase domain-containing protein 16A ABHD16A
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| anoga-AGCG53639 | Anopheles gambiae str. PEST agcp6346 (fragment) | Anopheles gambiae |
| bovin-ABHD16A | Bos taurus (Bovine) Phosphatidylserine lipase ABHD16A HLA-B-associated transcript 5 BAT5 | Bos taurus |
| bovin-ABHD16B | Bos taurus (Bovine)\; Bos mutus (wild yak) Abhydrolase domain containing 16B | Bos taurus |
| caebr-A8XPH6 | Caenorhabditis briggsae hypothetical protein cbg16566 | Caenorhabditis briggsae |
| caeel-ypt1 | Caenorhabditis elegans hypothetical 54.7 kda protein f37a4.1 in chromosome III | Caenorhabditis elegans |
| drome-CG1309 | Drosophila melanogaster (Fruit fly) cg1309 protein (gh07444p) | Drosophila melanogaster |
| drops-q29d59 | Drosophila pseudoobscura (Fruit fly) ga12040-pa (fragment) | Drosophila pseudoobscura |
| human-ABHD16A | Homo sapiens (Human) Abhydrolase domain-containing protein 16A BAT5 (HLA-B-associated transcript 5) (NG26 protein) (G5) (PP199) | Homo sapiens |
| human-ABHD16B | Homo sapiens (Human) ABHD16B PS-PLA1 lipase activity | Homo sapiens |
| macfa-q4r8p0 | Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) BAT5 (HLA-B-associated transcript 5) (NG26 protein) (G5) (PP199) | Macaca fascicularis |
| mouse-Abhd16a | Mus musculus (Mouse) Phosphatidylserine lipase ABHD16A, bat5 (hla-b-associated transcript 5) (ng26 protein) | Mus musculus |
| mouse-Abhd16b | Mus musculus (Mouse) similar to chromosome 20 open reading frame 135 | Mus musculus |
| ponpy-q5r6s0 | Pongo pygmaeus (Orangutan) hypothetical protein dkfzp459m071 | Pongo pygmaeus |
| ratno-q5xil6 | Rattus norvegicus (Rat) rgd1309726_predicted protein | Rattus norvegicus |
| ratno-q6mg55 | Rattus norvegicus (Rat) hla-b associated transcript 5, rat orthologue | Rattus norvegicus |
| xenla-q6dcw6 | Xenopus laevis (African clawed frog) bat5-prov protein | Xenopus laevis |
| xenla-Q860X9 | Xenopus laevis (African clawed frog) similar to hla-b associated transcript 5 | Xenopus laevis |
| xentr-q6dig9 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) hla-b associated transcript 5 | Xenopus tropicalis |
| fukda-a0a091de08 | Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). Abhydrolase domain-containing protein 16A | Fukomys damarensis |
| poefo-a0a096m8k0 | Poecilia formosa (Amazon molly) (Limia formosa)\; Poecilia latipinna (sailfin molly)\; Poecilia mexicana. Abhydrolase domain containing 16A | Poecilia formosa |
| 9tele-a0a0s7hbm2 | Poeciliopsis prolifica (blackstripe livebearer). ABHGA | Poeciliopsis prolifica |
| papan-a0a2i3lzc4 | Papio anubis (Olive baboon). Abhydrolase domain containing 16A | Papio anubis |
| chlsb-a0a0d9r8e3 | Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). Abhydrolase domain containing 16A | Chlorocebus sabaeus |
| crohd-a0a0k8s3n3 | Crotalus horridus (Timber rattlesnake). Protein BAT5 | Crotalus horridus |
| hetga-a0a0p6jud6 | Heterocephalus glaber (Naked mole rat). Abhydrolase domain-containing protein 16A isoform a | Heterocephalus glaber |
| 9tele-a0a0p7vty8 | Scleropages formosus (Asian bonytongue). Abhydrolase domain-containing protein 16A-like | Scleropages formosus |
| 9acar-a0a131xd17 | Hyalomma excavatum. Putative conserved plasma membrane protein | Hyalomma excavatum |
| rhiap-a0a131yft0 | Rhipicephalus appendiculatus (Brown ear tick)\; Rhipicephalus pulchellus. Abhydrolase domain-containing protein 16A | Rhipicephalus appendiculatus |
| funhe-a0a146nnz9 | Fundulus heteroclitus (Killifish) (Mummichog)\; Iconisemion striatum\; Nothobranchius furzeri (Turquoise killifish)\; N kadleci\; N. korthausae\; N. kuhntae (Beira killifish)\; N. pienaari\; N.rachovii (bluefin notho)\; Scleropages formosus (Asian bonytongue). Abhydrolase domain-containing protein 16A | Fundulus heteroclitus |
| allmi-a0a151nc84 | Alligator mississippiensis (American alligator)\; Alligator sinensis (Chinese alligator). Abhydrolase domain-containing protein 16A | Alligator mississippiensis |
| pig-a0a191tc51 | Sus scrofa (Pig). Abhydrolase domain-containing protein 16A | Sus scrofa |
| neole-a0a1a6g1s4 | Neotoma lepida (Desert woodrat). Uncharacterized protein | Neotoma lepida |
| erieu-a0a1s3ama4 | Erinaceus europaeus (Western European hedgehog). protein ABHD16A | Erinaceus europaeus |
| dipor-a0a1s3gfr8 | Dipodomys ordii (Ord's kangaroo rat). abhydrolase domain-containing protein 16A | Dipodomys ordii |
| salsa-a0a1s3rw38 | Salmo salar (Atlantic salmon). abhydrolase domain-containing protein 16A-like isoform X1 | Salmo salar |
| mesau-a0a1u7re48 | Mesocricetus auratus (Golden hamster). abhydrolase domain-containing protein 16A | Mesocricetus auratus |
| tarsy-a0a1u7u0w2 | Tarsius syrichta (Philippine tarsier). abhydrolase domain-containing protein 16A | Tarsius syrichta |
| cereh-a0a212d4w7 | Cervus elaphus hippelaphus (European red deer). ABHD16A | Cervus elaphus hippelaphus |
| 9acar-a0a224ygk6 | Rhipicephalus zambeziensis. Abhydrolase domain-containing protein 16A | Rhipicephalus zambeziensis |
| cascn-a0a250y2u8 | Castor canadensis (Beaver). Abhydrolase domain-containing protein 16A | Castor canadensis |
| orner-a0a293n2r4 | Ornithodoros erraticus (European soft tick) (Alectorobius erraticus). Abhydrolase domain-containing protein 16A | Ornithodoros erraticus |
| ictpu-a0a2d0r307 | Ictalurus punctatus (Channel catfish) (Silurus punctatus). protein ABHD16A | Ictalurus punctatus |
| gorgo-g3r3b4 | Gorilla gorilla gorilla (Western lowland gorilla). Abhydrolase domain containing 16A | Gorilla gorilla gorilla |
| nomle-g1r2z5 | Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys). Abhydrolase domain containing 16A | Nomascus leucogenys |
| pantr-g2hih9 | Pan troglodytes (Chimpanzee). Protein BAT5 | Pan troglodytes |
| 9tele-a0a2i4bma3 | Austrofundulus limnaeus. abhydrolase domain-containing protein 16A | Austrofundulus limnaeus |
| ponab-a0a2j8r4n1 | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). ABHD16A isoform 1 | Pongo abelii |
| aotna-a0a2k5cut2 | Aotus nancymaae (Ma's night monkey). Abhydrolase domain containing 16A | Aotus nancymaae |
| colap-a0a2k5jms4 | Colobus angolensis palliatus (Peters' Angolan colobus). Abhydrolase domain containing 16A | Colobus angolensis palliatus |
| cerat-a0a2k5nse9 | Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys). Abhydrolase domain containing 16A | Cercocebus atys |
| cebca-a0a2k5rcx9 | Cebus capucinus imitator. Abhydrolase domain containing 16A | Cebus capucinus imitator |
| manle-a0a2k5yle0 | Mandrillus leucophaeus (Drill) (Papio leucophaeus). Abhydrolase domain containing 16A | Mandrillus leucophaeus |
| macne-a0a2k6cfb3 | Macaca nemestrina (Pig-tailed macaque). Abhydrolase domain containing 16A | Macaca nemestrina |
| proco-a0a2k6gjv0 | Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli). Abhydrolase domain containing 16A | Propithecus coquereli |
| rhibe-a0a2k6jwp8 | Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Rhinopithecus roxellana. Abhydrolase domain containing 16A | Rhinopithecus bieti |
| saibb-a0a2k6tf19 | Saimiri boliviensis boliviensis (Bolivian squirrel monkey). Abhydrolase domain containing 16A | Saimiri boliviensis boliviensis |
| panpa-a0a2r9bxk5 | Pan paniscus (Pygmy chimpanzee) (Bonobo). Abhydrolase domain containing 16A | Pan paniscus |
| odoro-a0a2u3wzy6 | Odobenus rosmarus divergens (Pacific walrus)\; Leptonychotes weddellii (Weddell seal)\; Physeter catodon (Sperm whale) (Physeter macrocephalus)\; Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi)\; Delphinapterus leucas (Beluga whale). abhydrolase domain-containing protein 16A | Odobenus rosmarus divergens |
| scomx-a0a2u9axn1 | Scophthalmus maximus (Turbot) (Psetta maxima). Putative abhydrolase domain-containing protein 16A-like | Scophthalmus maximus |
| enhlu-a0a2y9k495 | Enhydra lutris kenyoni (northern sea otter). protein ABHD16A isoform X1 | Enhydra lutris kenyoni |
| gamaf-a0a315vp68 | Gambusia affinis (Western mosquitofish) (Heterandria affinis). Uncharacterized protein | Gambusia affinis |
| felca-m3w2b0 | Felis catus (Cat) (Felis silvestris catus). Abhydrolase domain containing 16A | Felis catus |
| astmx-a0a3b1il55 | Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Abhydrolase domain containing 16A | Astyanax mexicanus |
| oryme-a0a3b3c959 | Oryzias melastigma (Marine medaka). Abhydrolase domain containing 16A | Oryzias melastigma |
| 9tele-a0a3b3t8w4 | Paramormyrops kingsleyae. Abhydrolase domain containing 16A | Paramormyrops kingsleyae |
| 9gobi-a0a3b4bmj6 | Periophthalmus magnuspinnatus. Abhydrolase domain containing 16A | Periophthalmus magnuspinnatus |
| pygna-a0a3b4cu18 | Pygocentrus nattereri (Red-bellied piranha). Abhydrolase domain containing 16A | Pygocentrus nattereri |
| 9cich-a0a3b4h2e7 | Pundamilia nyererei. Abhydrolase domain containing 16A | Pundamilia nyererei |
| serdu-a0a3b4um39 | Seriola dumerili (Mediterranean greater amberjack) (Caranx dumerili). Abhydrolase domain containing 16A | Seriola dumerili |
| serll-a0a3b4zd46 | Seriola lalandi dorsalis. Abhydrolase domain containing 16A | Seriola lalandi dorsalis |
| 9tele-a0a3b5axl0 | Stegastes partitus (bicolor damselfish). Abhydrolase domain containing 16A | Stegastes partitus |
| xipma-a0a3b5r3p5 | Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)\; Xiphophorus couchianus (Monterrey platyfish). Abhydrolase domain containing 16A | Xiphophorus maculatus |
| danre-a9jr90 | Danio rerio (Zebrafish) (Brachydanio rerio). Bat5l protein | Danio rerio |
| canlf-e2rq56 | Canis lupus familiaris (Dog) (Canis familiaris). Abhydrolase domain containing 16A | Canis lupus familiaris |
| macmu-f6qwx1 | Macaca mulatta (Rhesus macaque). HLA-B-associated transcript 5 | Macaca mulatta |
| mondo-f6tlv9 | Monodelphis domestica (Gray short-tailed opossum). Abhydrolase domain containing 16A | Monodelphis domestica |
| horse-f7bm46 | Equus caballus (Horse). Abhydrolase domain containing 16A | Equus caballus |
| calja-f7ia46 | Callithrix jacchus (White-tufted-ear marmoset). Abhydrolase domain containing 16A | Callithrix jacchus |
| ailme-g1lrp4 | Ailuropoda melanoleuca (Giant panda). Abhydrolase domain containing 16A | Ailuropoda melanoleuca |
| myolu-g1pdp2 | Myotis lucifugus (Little brown bat)\; Myotis davidii (David's myotis). Abhydrolase domain containing 16A | Myotis lucifugus |
| rabit-g1tmm5 | Oryctolagus cuniculus (Rabbit). Abhydrolase domain containing 16A | Oryctolagus cuniculus |
| gasac-g3p4x2 | Gasterosteus aculeatus (Three-spined stickleback). Abhydrolase domain containing 16A | Gasterosteus aculeatus |
| loxaf-g3t3u4 | Loxodonta africana (African elephant). Abhydrolase domain containing 16A | Loxodonta africana |
| sarha-g3vik5 | Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). Abhydrolase domain containing 16A | Sarcophilus harrisii |
| cavpo-h0vhq3 | Cavia porcellus (Guinea pig). Abhydrolase domain containing 16A | Cavia porcellus |
| otoga-h0x2c4 | Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). Abhydrolase domain containing 16A | Otolemur garnettii |
| oryla-h2mcz6 | Oryzias latipes (Japanese rice fish) (Japanese killifish). Abhydrolase domain containing 16A | Oryzias latipes |
| takru-h2rzs7 | Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). Abhydrolase domain containing 16A | Takifugu rubripes |
| latch-h3b704 | Latimeria chalumnae (West Indian ocean coelacanth). Abhydrolase domain containing 16A | Latimeria chalumnae |
| tetng-h3cre8 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis). Abhydrolase domain containing 16A | Tetraodon nigroviridis |
| anoca-h9gpa2 | Anolis carolinensis (Green anole) (American chameleon). Abhydrolase domain containing 16A | Anolis carolinensis |
| oreni-i3k5p0 | Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). G6f-like | Oreochromis niloticus |
| icttr-i3mk87 | Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus). Abhydrolase domain containing 16A | Ictidomys tridecemlineatus |
| pteal-l5l5n3 | Pteropus alecto (Black flying fox). Protein BAT5 | Pteropus alecto |
| muspf-m3yi69 | Mustela putorius furo (European domestic ferret) (Mustela furo). Abhydrolase domain containing 16A | Mustela putorius furo |
| myobr-s7mju4 | Myotis brandtii (Brandt's bat). Abhydrolase domain-containing protein 16A | Myotis brandtii |
| camfr-s9xcr2 | Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). Abhydrolase domain-containing protein 16A isoform a | Camelus ferus |
| neovi-u6d3c0 | Neovison vison (American mink) (Mustela vison). Abhydrolase domain-containing protein 16A | Neovison vison |
| calmi-v9kre8 | Callorhinchus milii (Ghost shark). Abhydrolase domain-containing protein 16A | Callorhinchus milii |
| sheep-w5p871 | Ovis aries (Sheep). Abhydrolase domain containing 16A | Ovis aries |
| pantr-h2rfv2 | Pan troglodytes (Chimpanzee). Abhydrolase domain containing 16B | Pan troglodytes |
| panpa-a0a2r8zr38 | Pan paniscus (Pygmy chimpanzee) (Bonobo). Abhydrolase domain containing 16B | Pan paniscus |
| gorgo-g3qe70 | Gorilla gorilla gorilla (Western lowland gorilla). Abhydrolase domain containing 16B | Gorilla gorilla gorilla |
| ponab-h2p2n2 | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). Abhydrolase domain containing 16B | Pongo abelii |
| nomle-g1sbw8 | Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys). Abhydrolase domain containing 16B | Nomascus leucogenys |
| macne-a0a2k6amf7 | Macaca nemestrina (Pig-tailed macaque). Abhydrolase domain containing 16B | Macaca nemestrina |
| papan-a0a096nfv4 | Papio anubis (Olive baboon). Abhydrolase domain containing 16B | Papio anubis |
| cerat-a0a2k5l3t9 | Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys). Abhydrolase domain containing 16B | Cercocebus atys |
| chlsb-a0a0d9sbl6 | Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). Abhydrolase domain containing 16B | Chlorocebus sabaeus |
| macmu-f7h4t2 | Macaca mulatta (Rhesus macaque). Uncharacterized protein | Macaca mulatta |
| macfa-a0a2k5vu07 | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Abhydrolase domain containing 16B | Macaca fascicularis |
| rhibe-a0a2k6kea5 | Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti). Abhydrolase domain containing 16B | Rhinopithecus bieti |
| odoro-a0a2u3wme5 | Odobenus rosmarus divergens (Pacific walrus)\; Delphinapterus leucas (Beluga whale)\; Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)\; Lipotes vexillifer (Yangtze river dolphin)\; Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)\; Leptonychotes weddellii (Weddell seal)\; Eschrichtius robustus (California gray whale) (Eschrichtius gibbosus)\; Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni). abhydrolase domain-containing protein 16B | Odobenus rosmarus divergens |
| enhlu-a0a2y9ivk3 | Enhydra lutris kenyoni (northern sea otter). protein ABHD16B | Enhydra lutris kenyoni |
| pteal-l5k1s7 | Pteropus alecto (Black flying fox). Uncharacterized protein | Pteropus alecto |
| muspf-m3z8y0 | Mustela putorius furo (European domestic ferret) (Mustela furo). Abhydrolase domain containing 16B | Mustela putorius furo |
| trima-a0a2y9d9p3 | Trichechus manatus latirostris (Florida manatee). protein ABHD16B | Trichechus manatus latirostris |
| neosc-a0a2y9g5j5 | Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi). protein ABHD16B | Neomonachus schauinslandi |
| calja-f7gmu7 | Callithrix jacchus (White-tufted-ear marmoset). Abhydrolase domain containing 16B | Callithrix jacchus |
| otoga-h0xsf3 | Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). Abhydrolase domain containing 16B | Otolemur garnettii |
| icttr-i3mxu3 | Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus). Abhydrolase domain containing 16B | Ictidomys tridecemlineatus |
| dipor-a0a1s3gag4 | Dipodomys ordii (Ord's kangaroo rat). abhydrolase domain-containing protein 16B | Dipodomys ordii |
| loxaf-g3u1y1 | Loxodonta africana (African elephant). Abhydrolase domain containing 16B | Loxodonta africana |
| pig-a0a286zt91 | Sus scrofa (Pig). Abhydrolase domain containing 16B | Sus scrofa |
| erieu-a0a1s2ztw6 | Erinaceus europaeus (Western European hedgehog). protein ABHD16B | Erinaceus europaeus |
| mesau-a0a1u7qif4 | Mesocricetus auratus (Golden hamster). abhydrolase domain-containing protein 16B | Mesocricetus auratus |
| myolu-g1nth4 | Myotis lucifugus (Little brown bat)\; Myotis brandtii (Brandt's bat)\; Myotis davidii (David's myotis). Abhydrolase domain containing 16B | Myotis lucifugus |
| phycd-a0a2y9szq4 | Physeter catodon (Sperm whale) (Physeter macrocephalus). protein ABHD16B | Physeter catodon |
| cavpo-h0vqx6 | Cavia porcellus (Guinea pig). Abhydrolase domain containing 16B | Cavia porcellus |
| neole-a0a1a6hjy8 | Neotoma lepida (Desert woodrat). Uncharacterized protein | Neotoma lepida |
| fukda-a0a091dft6 | Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). Abhydrolase domain-containing protein 16B | Fukomys damarensis |
| tarsy-a0a1u7tjf4 | Tarsius syrichta (Philippine tarsier). abhydrolase domain-containing protein 16B | Tarsius syrichta |
| sheep-w5pji8 | Ovis aries (Sheep). Abhydrolase domain containing 16B | Ovis aries |
| crigr-g3hh02 | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). Uncharacterized protein C20orf135-like | Cricetulus griseus |
| rabit-g1tqr7 | Oryctolagus cuniculus (Rabbit). Abhydrolase domain containing 16B | Oryctolagus cuniculus |
| camfr-s9yuz0 | Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). Abhydrolase domain-containing protein 16B | Camelus ferus |
| manle-a0a2k5zdp5 | Mandrillus leucophaeus (Drill) (Papio leucophaeus). Abhydrolase domain containing 16B | Mandrillus leucophaeus |
| canlf-j9nwb1 | Canis lupus familiaris (Dog) (Canis familiaris). Abhydrolase domain containing 16B | Canis lupus familiaris |
| chemy-m7bci9 | Chelonia mydas (Green sea-turtle) (Chelonia agassizi). Abhydrolase domain-containing protein 16B | Chelonia mydas |
| pelsi-k7gc94 | Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). Abhydrolase domain containing 16B | Pelodiscus sinensis |
| allmi-a0a151n0a8 | Alligator mississippiensis (American alligator)\; Alligator sinensis (Chinese alligator). Abhydrolase domain-containing protein 16B | Alligator mississippiensis |
| mondo-f6tdm5 | Monodelphis domestica (Gray short-tailed opossum). Abhydrolase domain containing 16B | Monodelphis domestica |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| oncmy-a0a060wi81 | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Uncharacterized protein | Oncorhynchus mykiss |
| oncmy-a0a060xp93 | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Uncharacterized protein | Oncorhynchus mykiss |
| crigr-a0a061im10 | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). Abhydrolase domain-containing protein 16A | Cricetulus griseus |
| 9hemi-a0a1b6jfk4 | Homalodisca liturata. Uncharacterized protein | Homalodisca liturata |
| 9acar-a0a1e1xjg7 | Amblyomma sculptum. Putative alpha\/beta hydrolase bat5 | Amblyomma sculptum |
| linun-a0a1s3j8k7 | Lingula unguis. protein ABHD16A-like | Lingula unguis |
| ornmo-a0a1z5l3m1 | Ornithodoros moubata (Soft tick) (Argasid tick). 60S acidic ribosomal protein P0 | Ornithodoros moubata |
| 9pase-a0a218u7i3 | Lonchura striata domestica (Bengalese finch). Abhydrolase domain-containing protein 16A | Lonchura striata domestica |
| 9plat-a0a267dgc4 | Macrostomum lignano. Uncharacterized protein | Macrostomum lignano |
| escro-a0a2f0b500 | Eschrichtius robustus (California gray whale) (Eschrichtius gibbosus). Protein ABHD16A | Eschrichtius robustus |
| litct-a0a2g9s3q2 | Lithobates catesbeiana (American bullfrog) (Rana catesbeiana). Uncharacterized protein | Lithobates catesbeiana |
| 9zzzz-a0a2s2n392 | bird metagenome. Protein ABHD16A | bird metagenome |
| 9zzzz-a0a2s2n5z7 | bird metagenome. Protein ABHD16A | bird metagenome |
| ursma-a0a384dsy3 | Ursus maritimus (Polar bear) (Thalarctos maritimus). LOW QUALITY PROTEIN: abhydrolase domain-containing protein 16A | Ursus maritimus |
| cioin-f6wnx6 | Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis). Uncharacterized protein | Ciona intestinalis |
| ornan-f7a5e5 | Ornithorhynchus anatinus (Duckbill platypus). Uncharacterized protein | Ornithorhynchus anatinus |
| 9acar-g3mfa4 | Amblyomma maculatum (Gulf Coast tick). Uncharacterized protein | Amblyomma maculatum |
| 9pipi-g5dz89 | Hymenochirus curtipes (western dwarf clawed frog). Putative hla-b associated transcript 5 | Hymenochirus curtipes |
| ciosa-h2ybh9 | Ciona savignyi (Pacific transparent sea squirt). Uncharacterized protein | Ciona savignyi |
| tupch-l9kgq0 | Tupaia chinensis (Chinese tree shrew). Abhydrolase domain-containing protein 16A | Tupaia chinensis |
| chemy-m7aml2 | Chelonia mydas (Green sea-turtle) (Chelonia agassizi). Abhydrolase domain-containing protein 16A | Chelonia mydas |
| denpd-n6u285 | Dendroctonus ponderosae (Mountain pine beetle). Uncharacterized protein | Dendroctonus ponderosae |
| ophha-v8n892 | Ophiophagus hannah (King cobra) (Naja hannah). Abhydrolase domain-containing protein 16A | Ophiophagus hannah |
| saibb-a0a2k6utv8 | Saimiri boliviensis boliviensis (Bolivian squirrel monkey). Abhydrolase domain containing 16B | Saimiri boliviensis boliviensis |
| ursma-a0a384bv14 | Ursus maritimus (Polar bear) (Thalarctos maritimus). abhydrolase domain-containing protein 16B | Ursus maritimus |
| hetga-g5c8b6 | Heterocephalus glaber (Naked mole rat). Uncharacterized protein | Heterocephalus glaber |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| NBD-Phosphatidylserine | human-ABHD16B | |
| 15d-PGJ2-G | 1,3-dihydroxypropan-2-yl (Z)-7-[(1S,5E)-5-[(Z)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoate | human-ABHD16A |
| Glyceryl-monolinoleate | 2,3-dihydroxypropyl (9Z,12Z)-octadeca-9,12-dienoate | human-ABHD16A |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| Thiazol-abietane-Cpd18 | methyl (1R,4aS,10aR)-1,4a-dimethyl-6-(2-methyl-1,3-thiazol-4-yl)-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylate | human-ABHD16A |
| KC01 | (6Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide | human-ABHD16A human-ABHD12 mouse-Abhd16a |
| Palmostatin-B | (3S,4S)-3-decyl-4-[2-(3,4-dimethoxyphenyl)ethyl]oxetan-2-one | human-ABHD16A human-ABHD6 human-FASN human-ABHD17A human-ABHD17B human-ABHD17C human-LYPLA1 human-LYPLA2 human-PREPL |
| MmPPOX | 5-methoxy-3-(3-phenoxyphenyl)-1,3,4-oxadiazol-2-one | human-LIPE human-ABHD16A |
| Orlistat | [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate | human-DAGLA human-DAGLB human-PNLIP human-FASN mycs2-a0r619 human-PNLIPRP2 human-ABHD16A myctu-a85c myctu-Rv3822 plafa-PF10.0379 staau-lipas human-CES2 |
References (11)
| Title : Elucidating the Functional Role of Human ABHD16B Lipase in Regulating Triacylglycerol Mobilization and Membrane Lipid Synthesis in Saccharomyces cerevisiae - Narayanasamy_2023_Chem.Phys.Lipids__105353 |
| Author(s) : Narayanasamy R , Usharani D , Rajasekharan R |
| Ref : Chemistry & Physic of Lipids , :105353 , 2023 |
| Abstract : |
| PubMedSearch : Narayanasamy_2023_Chem.Phys.Lipids__105353 |
| PubMedID: 37944658 |
| Gene_locus related to this paper: human-ABHD16B |
| Title : alpha\/beta-Hydrolase D16B Truncation Results in Premature Sperm Capacitation in Cattle - Shan_2022_Int.J.Mol.Sci_23_ |
| Author(s) : Shan S , Xu F , Hirschfeld M , Herrmann C , Schulze M , Sharifi AR , Hoelker M , Brenig B |
| Ref : Int J Mol Sci , 23 : , 2022 |
| Abstract : |
| PubMedSearch : Shan_2022_Int.J.Mol.Sci_23_ |
| PubMedID: 35887122 |
| Gene_locus related to this paper: bovin-ABHD16B , human-ABHD16B |
| Title : ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies - Lemire_2021_Am.J.Hum.Genet__ |
| Author(s) : Lemire G , Ito YA , Marshall AE , Chrestian N , Stanley V , Brady L , Tarnopolsky M , Curry CJ , Hartley T , Mears W , Derksen A , Rioux N , Laflamme N , Hutchison HT , Pais LS , Zaki MS , Sultan T , Dane AD , Gleeson JG , Vaz FM , Kernohan KD , Bernard G , Boycott KM |
| Ref : American Journal of Human Genetics , : , 2021 |
| Abstract : |
| PubMedSearch : Lemire_2021_Am.J.Hum.Genet__ |
| PubMedID: 34587489 |
| Gene_locus related to this paper: human-ABHD16A |
| Title : Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia - Yahia_2021_Front.Neurol_12_720201 |
| Author(s) : Yahia A , Elsayed LEO , Valter R , Hamed AAA , Mohammed IN , Elseed MA , Salih MA , Esteves T , Auger N , Abubaker R , Koko M , Abozar F , Malik H , Adil R , Emad S , Musallam MA , Idris R , Eltazi IZM , Babai A , Ahmed EAA , Abd Allah ASI , Mairey M , Ahmed A , Elbashir MI , Brice A , Ibrahim ME , Ahmed AE , Lamari F , Stevanin G |
| Ref : Front Neurol , 12 :720201 , 2021 |
| Abstract : |
| PubMedSearch : Yahia_2021_Front.Neurol_12_720201 |
| PubMedID: 34489854 |
| Gene_locus related to this paper: human-ABHD16A |
| Title : A homozygous ABHD16A variant causes a complex hereditary spastic paraplegia with developmental delay, absent speech, and characteristic face - Miyake_2021_Clin.Genet__ |
| Author(s) : Miyake N , Silva S , Troncoso M , Okamoto N , Andachi Y , Kato M , Iwabuchi C , Hirose M , Fujita A , Uchiyama Y , Matsumoto N |
| Ref : Clin Genet , : , 2021 |
| Abstract : |
| PubMedSearch : Miyake_2021_Clin.Genet__ |
| PubMedID: 34866177 |
| Gene_locus related to this paper: human-ABHD16A |
| Title : Association of alpha\/beta-Hydrolase D16B with Bovine Conception Rate and Sperm Plasma Membrane Lipid Composition - Shan_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Shan S , Xu F , Bleyer M , Becker S , Melbaum T , Wemheuer W , Hirschfeld M , Wacker C , Zhao S , Schutz E , Brenig B |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : Shan_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 31963602 |
| Gene_locus related to this paper: bovin-ABHD16B , human-ABHD16B , mouse-Abhd16b |
| Title : Mapping the neuroanatomy of ABHD16A-ABHD12 & lysophosphatidylserines provides new insights into the pathophysiology of the human neurological disorder PHARC - Singh_2020_Biochemistry_59_2299 |
| Author(s) : Singh S , Joshi A , Kamat SS |
| Ref : Biochemistry , 59 :2299 , 2020 |
| Abstract : |
| PubMedSearch : Singh_2020_Biochemistry_59_2299 |
| PubMedID: 32462874 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A |
| Title : The Lysophosphatidylserines-An Emerging Class of Signalling Lysophospholipids - Shanbhag_2020_J.Membr.Biol_253_381 |
| Author(s) : Shanbhag K , Mhetre A , Khandelwal N , Kamat SS |
| Ref : J Membr Biol , 253 :381 , 2020 |
| Abstract : |
| PubMedSearch : Shanbhag_2020_J.Membr.Biol_253_381 |
| PubMedID: 32767057 |
| Title : Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease - Xu_2018_Open.Biol_8_ |
| Author(s) : Xu J , Gu W , Ji K , Xu Z , Zhu H , Zheng W |
| Ref : Open Biol , 8 : , 2018 |
| Abstract : |
| PubMedSearch : Xu_2018_Open.Biol_8_ |
| PubMedID: 29794032 |
| Gene_locus related to this paper: human-ABHD16A , human-ABHD16B |
| Title : Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay - Kamat_2015_Nat.Chem.Biol_11_164 |
| Author(s) : Kamat SS , Camara K , Parsons WH , Chen DH , Dix MM , Bird TD , Howell AR , Cravatt BF |
| Ref : Nat Chemical Biology , 11 :164 , 2015 |
| Abstract : |
| PubMedSearch : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedID: 25580854 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A , mouse-abd12 , mouse-Abhd16a |
| Title : Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5\/ABHD16A) - Savinainen_2014_PLoS.One_9_e109869 |
| Author(s) : Savinainen JR , Patel JZ , Parkkari T , Navia-Paldanius D , Marjamaa JJ , Laitinen T , Nevalainen T , Laitinen JT |
| Ref : PLoS ONE , 9 :e109869 , 2014 |
| Abstract : |
| PubMedSearch : Savinainen_2014_PLoS.One_9_e109869 |
| PubMedID: 25290914 |
| Gene_locus related to this paper: human-ABHD16A , mouse-Abhd16a |