ABHD16

Relationship

Family: ABHD16

Block: X

Parent Family: No family

Comment

This family consists of abhydrolase domain-containing protein 16 A (ABHD16A). Function of its members is unknown. However, ABHD16A contains transmembrane domain and is a potential multi-pass membrane protein. BAT5 (HLA-B-associated transcript 5). Savinainen et al. showed hydrolysis of medium-chain saturated (C14:0), long-chain unsaturated (C18:1, C18:2, C20:4) monoacylglycerols (MAGs) and 15-deoxy-12,14-prostaglandin J2-2-glycerol ester (15d-PGJ2-G). Only marginal diacylglycerol (DAG), triacylglycerol (TAG), or lysophospholipase activity PANTHER PTHR12277:SF54 There are two genes ABHD16 A and B in amniotes. Shan et al. identified a nonsense mutation in the bovine ABHD16B associated with male subfertility in Holstein cattle. ABHD16B is involved in lipid biosynthesis in testis and is crucial for fertilization. ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies (Lemire et al. 2021; Yahia et al. 2021; Miyake 2021). Substrates of ABHD include medium-chain saturated monoacylglycerols, 1-linoleylglycerol, 15-deoxy-delta12,14-prostaglandin J2-2-glycerol ester

Database

Interpro : IPR026604 Abhydrolase domain-containing protein 16A ABHD16A

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in ABHD16 family (142)

Fragments of genes in ABHD16 family (26)

No fragment of genes

Substrates in ABHD16 family (3)

Inhibitors in ABHD16 family (5)

References (11)

Title : Elucidating the Functional Role of Human ABHD16B Lipase in Regulating Triacylglycerol Mobilization and Membrane Lipid Synthesis in Saccharomyces cerevisiae - Narayanasamy_2023_Chem.Phys.Lipids__105353
Author(s) : Narayanasamy R , Usharani D , Rajasekharan R
Ref : Chemistry & Physic of Lipids , :105353 , 2023
PubMedID: 37944658
Gene_locus related to this paper: human-ABHD16B

Title : alpha\/beta-Hydrolase D16B Truncation Results in Premature Sperm Capacitation in Cattle - Shan_2022_Int.J.Mol.Sci_23_
Author(s) : Shan S , Xu F , Hirschfeld M , Herrmann C , Schulze M , Sharifi AR , Hoelker M , Brenig B
Ref : Int J Mol Sci , 23 : , 2022
PubMedID: 35887122
Gene_locus related to this paper: bovin-ABHD16B , human-ABHD16B

Title : A homozygous ABHD16A variant causes a complex hereditary spastic paraplegia with developmental delay, absent speech, and characteristic face - Miyake_2021_Clin.Genet__
Author(s) : Miyake N , Silva S , Troncoso M , Okamoto N , Andachi Y , Kato M , Iwabuchi C , Hirose M , Fujita A , Uchiyama Y , Matsumoto N
Ref : Clin Genet , : , 2021
PubMedID: 34866177
Gene_locus related to this paper: human-ABHD16A

Title : ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies - Lemire_2021_Am.J.Hum.Genet__
Author(s) : Lemire G , Ito YA , Marshall AE , Chrestian N , Stanley V , Brady L , Tarnopolsky M , Curry CJ , Hartley T , Mears W , Derksen A , Rioux N , Laflamme N , Hutchison HT , Pais LS , Zaki MS , Sultan T , Dane AD , Gleeson JG , Vaz FM , Kernohan KD , Bernard G , Boycott KM
Ref : American Journal of Human Genetics , : , 2021
PubMedID: 34587489
Gene_locus related to this paper: human-ABHD16A

Title : Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia - Yahia_2021_Front.Neurol_12_720201
Author(s) : Yahia A , Elsayed LEO , Valter R , Hamed AAA , Mohammed IN , Elseed MA , Salih MA , Esteves T , Auger N , Abubaker R , Koko M , Abozar F , Malik H , Adil R , Emad S , Musallam MA , Idris R , Eltazi IZM , Babai A , Ahmed EAA , Abd Allah ASI , Mairey M , Ahmed A , Elbashir MI , Brice A , Ibrahim ME , Ahmed AE , Lamari F , Stevanin G
Ref : Front Neurol , 12 :720201 , 2021
PubMedID: 34489854
Gene_locus related to this paper: human-ABHD16A

Title : Association of alpha\/beta-Hydrolase D16B with Bovine Conception Rate and Sperm Plasma Membrane Lipid Composition - Shan_2020_Int.J.Mol.Sci_21_
Author(s) : Shan S , Xu F , Bleyer M , Becker S , Melbaum T , Wemheuer W , Hirschfeld M , Wacker C , Zhao S , Schutz E , Brenig B
Ref : Int J Mol Sci , 21 : , 2020
PubMedID: 31963602
Gene_locus related to this paper: bovin-ABHD16B , human-ABHD16B , mouse-Abhd16b

Title : Mapping the neuroanatomy of ABHD16A-ABHD12 & lysophosphatidylserines provides new insights into the pathophysiology of the human neurological disorder PHARC - Singh_2020_Biochemistry_59_2299
Author(s) : Singh S , Joshi A , Kamat SS
Ref : Biochemistry , 59 :2299 , 2020
PubMedID: 32462874
Gene_locus related to this paper: human-ABHD12 , human-ABHD16A

Title : The Lysophosphatidylserines-An Emerging Class of Signalling Lysophospholipids - Shanbhag_2020_J.Membr.Biol_253_381
Author(s) : Shanbhag K , Mhetre A , Khandelwal N , Kamat SS
Ref : J Membr Biol , 253 :381 , 2020
PubMedID: 32767057

Title : Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease - Xu_2018_Open.Biol_8_
Author(s) : Xu J , Gu W , Ji K , Xu Z , Zhu H , Zheng W
Ref : Open Biol , 8 : , 2018
PubMedID: 29794032
Gene_locus related to this paper: human-ABHD16A , human-ABHD16B

Title : Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay - Kamat_2015_Nat.Chem.Biol_11_164
Author(s) : Kamat SS , Camara K , Parsons WH , Chen DH , Dix MM , Bird TD , Howell AR , Cravatt BF
Ref : Nat Chemical Biology , 11 :164 , 2015
PubMedID: 25580854
Gene_locus related to this paper: human-ABHD12 , human-ABHD16A , mouse-abd12 , mouse-Abhd16a

Title : Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5\/ABHD16A) - Savinainen_2014_PLoS.One_9_e109869
Author(s) : Savinainen JR , Patel JZ , Parkkari T , Navia-Paldanius D , Marjamaa JJ , Laitinen T , Nevalainen T , Laitinen JT
Ref : PLoS ONE , 9 :e109869 , 2014
PubMedID: 25290914
Gene_locus related to this paper: human-ABHD16A , mouse-Abhd16a