VX-Biotin
Serine Hydrolase probe consisting of a tag linked to a VX group, whichcovalently labels serine of enzymatically active serine hydrolases. ABPP-Probe (activity based protein profiling probe). Useful as ABPP probe but not specific: Labels lots of non serine hydrolases
General
Type : Organophosphate, ABPP-Probe, Imidazole, Sulfur Compound, Biotin derivative, Derivative of VX
Chemical_Nomenclature :
Canonical SMILES : [P](C)(SCC[N+](C(C)C)C(C)C)(=O)OCCCCCCCCCCCNC(CCCCC1C2C(CS1)NC(N2)=O)=O
InChI : InChI=1S\/C30H59N4O4PS2\/c1-24(2)34(25(3)4)20-22-41-39(5,37)38-21-16-12-10-8-6-7-9-11-15-19-31-28(35)18-14-13-17-27-29-26(23-40-27)32-30(36)33-29\/h24-27,29H,6-23H2,1-5H3,(H,31,35)(H2,32,33,36)\/p+1
InChIKey : IFUSBFMUVYCLLZ-UHFFFAOYSA-O
Other name(s) :
Target
Families : VX-Biotin ligand of proteins in family
Carboxypeptidase_S10
ACHE
BCHE
A85-EsteraseD-FGH
ACPH_Peptidase_S9
Carb_B_Chordata
Hormone-sensitive_lipase_like
LYsophospholipase_carboxylesterase
Lipase_3
Monoglyceridelipase_lysophospholip
Arylacetamide_deacetylase
Thioesterase
DPP4N_Peptidase_S9
PC-sterol_acyltransferase
ABHD6-Lip
PAF-Acetylhydrolase
S9N_PREPL_Peptidase_S9
PPase_methylesterase_euk
Kynurenine-formamidase
Protein :
human-CTSA
human-ACHE
human-BCHE
References (2)
| Title : Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A - Bouknight_2020_Biochem.Pharmacol__113980 |
| Author(s) : Bouknight KD , Jurkouich KM , Compton JR , Khavrutskii IV , Guelta MA , Harvey SP , Legler PM |
| Ref : Biochemical Pharmacology , :113980 , 2020 |
| Abstract : |
| PubMedSearch : Bouknight_2020_Biochem.Pharmacol__113980 |
| PubMedID: 32305437 |
| Gene_locus related to this paper: human-CTSA |
| Title : Activity Based Protein Profiling Leads to Identification of Novel Protein Targets for Nerve Agent VX - Carmany_2017_Chem.Res.Toxicol_30_1076 |
| Author(s) : Carmany D , Walz AJ , Hsu FL , Benton B , Burnett D , Gibbons J , Noort D , Glaros T , Sekowski JW |
| Ref : Chemical Research in Toxicology , 30 :1076 , 2017 |
| Abstract : |
| PubMedSearch : Carmany_2017_Chem.Res.Toxicol_30_1076 |
| PubMedID: 28267914 |