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Family Report for: PE-PPE


Family PE-PPE
Block X
The human pathogen Mycobacterium tuberculosis harbours a large number of genes that encode proteins whose N-termini contain the characteristic motifs Pro-Glu (PE) or Pro-Pro-Glu (PPE). A subgroup of the PE proteins contains polymorphic GC-rich sequences (PGRS), while a subgroup of the PPE proteins contains major polymorphic tandem repeats (MPTR). This domain is found C-terminal to the PE (IPR000084) and PPE (IPR000030) domains. Only a few of these domain are associated with alpha/beta hydrolases. The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands, and recently demonstrated to be alpha/beta hydrolase: see Sultana et al. This protein domain is close to cutinase. The membrane-associated acyltransferase Chp1 (myctu-Rv3822) accepts a synthetic diacyl sulfolipid and transfers an acyl group regioselectively from one donor substrate molecule to a second acceptor molecule in two successive reactions to yield a tetraacylated product. The rv1184c locus encodes Chp2, an acyltransferase in polyacyltrehalose lipid biosynthesis. In fact this domain is found in many unrelated folds only a few are alpha/beta hydrolases (Sultana 2016)

IPR013228 (PE-PPE, C-terminal), IPR000084 (PE-PGRS family, N-terminal)
PF08237 (PE-PPE)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

4 more
    Title: Ins and outs of Mycobacterium tuberculosis PPE family in pathogenesis and implications for novel measures against tuberculosis
    Deng W, Xie J
    Ref: Journal of Cellular Biochemistry, 113:1087, 2012 : PubMed


    Title: The PE-PPE domain in mycobacterium reveals a serine alpha/beta hydrolase fold and function: an in-silico analysis
    Sultana R, Tanneeru K, Guruprasad L
    Ref: PLoS ONE, 6:e16745, 2011 : PubMed


    Title: Sequence analysis corresponding to the PPE and PE proteins in Mycobacterium tuberculosis and other genomes
    Adindla S, Guruprasad L
    Ref: J Biosci, 28:169, 2003 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in PE-PPE family (92)

Fragments of genes in PE-PPE family (2)

Substrates of some enzymes in the PE-PPE family (1)

Inhibitors of some enzymes in the PE-PPE family (2)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
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AcePerl Lincoln Stein Home Page

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