1. Home
  2. Family
  3. Cholesterol_esterase

Cholesterol_esterase

Relationship

Family: Cholesterol_esterase

Block: C

Parent Family: Carboxylesterase

Comment

The human lactating mammary gland and pancreas produce a lipolytic enzyme, carboxyl-ester lipase, earlier called bile salt-stimulated lipase. Carboxyl-ester lipase is a major component of pancreatic juice and is responsible for the hydrolysis of cholesterol esters as well as a variety of other dietary esters. The enzyme is activated when mixed with bile salts, and plays an important role in the digestion of milk fat in newborn infants. This enzyme combines properties of esterases (activity on esters soluble in water) and lipases (activity on insoluble long chain acylglycerols) Numerous repeats at the c-term excluded in ESTHER (only n-term Pfam A COesterase 1 544)

Database

Interpro : IPR002018 Carboxylesterase, type B , IPR033560 Bile salt-activated lipase BAL

PIRSF : PIRSF005676 COesterase

Pdoc : PDOC00112

Pfam : PF00135 COesterase

Prints : No Print

EC Number : 3.1.1.13

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
1AKN Bovine bile-salt-activated lipase bovin-balip
1AQL Bovine bile-salt-activated lipase + taurocholate bovin-balip
2BCE Bovine cholesterol esterase bovin-balip
1F6W Human bile-salt-activated lipase human-CEL
6H19 Crystal structure of ethyl-paraoxon inhibited recombinant human bile salt activated lipase (aged form) human-CEL
6H1A Crystal structure of VX surrogate NEMP inhibited recombinant human bile salt activated lipase human-CEL
6H18 Crystal structure of sarin surrogate NIMP inhibited recombinant human bile salt activated lipase human-CEL
6H0V Crystal structure of tabun surrogate NEDPA inhibited recombinant human bile salt activated lipase human-CEL
6H0T Crystal structure of native recombinant human bile salt activated lipase human-CEL
1JMY Human bile-salt-activated lipase human-CEL

Gene_locus Name Species
colap-a0a2k5i2b4 Colobus angolensis palliatus (Peters' Angolan colobus). Carboxylic ester hydrolase Colobus angolensis palliatus
manle-a0a2k6aer2 Mandrillus leucophaeus (Drill) (Papio leucophaeus). Carboxyl ester lipase Mandrillus leucophaeus
rhibe-a0a2k6jtl7 Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)\; Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana). Carboxylic ester hydrolase Rhinopithecus bieti
papan-a0a2i3lqd9 Papio anubis (Olive baboon) Carboxyl ester lipase Papio anubis
anapl-r0lw36 Anas platyrhynchos (Domestic duck) (Anas boschas) Bile salt-activated lipase Anas platyrhynchos
anoca-g1kdb8 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein Anolis carolinensis
bovin-balip Bos taurus (Bovine) Bos mutus (Yak) protein for bile-salt-activated lipase Bos taurus
calja-f6u4n2 Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein Callithrix jacchus
canfa-f1phd0 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
cavpo-h0uyx7 Cavia porcellus (Guinea pig) Uncharacterized protein Cavia porcellus
chick-e1bvq6 Gallus gallus (Chicken) Uncharacterized protein Gallus gallus
crigr-g3iim8 Cricetulus griseus (Chinese hamster) Bile salt-activated lipase Cricetulus griseus
danre-2balip Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein Danio rerio
danre-q4qrh4 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:112377 Danio rerio
danre-Q6P004 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical cel.2 protein (fragment) (fragment) Danio rerio
felca-m3x096 Felis catus (Cat) (Felis silvestris catus) Uncharacterized protein Felis catus
fugru-2balip Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) carboxylesterase Fugu rubripes
fugru-4cxest Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) carboxylesterase Fugu rubripes
fugru-balip Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) carboxylesterase Fugu rubripes
gasac-balip Gasterosteus aculeatus (Three-spined stickleback) Cholesterol_esterase Gasterosteus aculeatus
gasac-g3q258 Gasterosteus aculeatus (Three-spined stickleback) Uncharacterized protein Gasterosteus aculeatus
gorgo-balip Gorilla gorilla carboxyl-ester lipase (CEL) gene, complete cds Gorilla gorilla gorilla
hetga-g5anw7 Heterocephalus glaber (Naked mole rat) Bile salt-activated lipase Heterocephalus glaber
horse-f7agv7 Equus caballus (Horse) Uncharacterized protein Equus caballus
human-CEL Homo sapiens (Human) bile-salt-activated lipase, BSSL BAL CEL CEH carboxyl ester lipase chr 9 Homo sapiens
latch-h3b637 Latimeria chalumnae (West Indian ocean coelacanth) Uncharacterized protein Latimeria chalumnae
loxaf-g3ss16 Loxodonta africana (African elephant) Uncharacterized protein Loxodonta africana
macmu-f7buk8 Macaca mulatta (Rhesus macaque) Uncharacterized protein Macaca mulatta
melga-g1n3b6 Meleagris gallopavo (Common turkey) Uncharacterized protein Meleagris gallopavo
mondo-f6wuf2 Monodelphis domestica (Gray short-tailed opossum) Uncharacterized protein Monodelphis domestica
mouse-pches Mus musculus pancreatic\/mammary gland cholesterol esterase Mus musculus
muspf-m3yly9 Mustela putorius furo (European domestic ferret) (Mustela furo) Uncharacterized protein Mustela putorius furo
myolu-g1p7m1 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
myolu-g1q8x7 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
myolu-g1q522 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
myolu-g1qca1 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
nomle-g1rrc2 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Uncharacterized protein Nomascus leucogenys
oikdi-e4yp15 Oikopleura dioica (Tunicate) Whole genome shotgun assembly, allelic scaffoldA_646 reference scaffold_150 Oikopleura dioica
oreni-i3k5f8 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) Uncharacterized protein Oreochromis niloticus
ornan-f7exu1 Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein Ornithorhynchus anatinus
oryla-h2mhi0 Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein Oryzias latipes
oryla-h2mhl7 Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein Oryzias latipes
oryla-h2mpb5 Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein Oryzias latipes
otoga-h0wze9 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Uncharacterized protein Otolemur garnettii
pantr-h2r646 Pan troglodytes (Chimpanzee) Uncharacterized protein Pan troglodytes
pig-i3ltk9 Sus scrofa (Pig) Carboxylic ester hydrolase CEL Sus scrofa
ponab-h2pu85 Pongo abelii (Sumatran orangutan) Uncharacterized protein Pongo abelii
rabit-g1tfp2 Oryctolagus cuniculus (Rabbit) Uncharacterized protein Oryctolagus cuniculus
ratno-balip Rattus norvegicus (Rat) Cholesterol esterase Rattus norvegicus
salsa-cxest Salmo salar mRNA for carboxylesterase partial Salmo salar
sarha-g3vze3 Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) Uncharacterized protein Sarcophilus harrisii
spetr-i3n7y6 Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) Uncharacterized protein Spermophilus tridecemlineatus
taegu-h0z4h9 Taeniopygia guttata (Zebra finch) (Poephila guttata) Uncharacterized protein Taeniopygia guttata
tetng-q4syn6 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf12000, whole genome shotgun sequence Tetraodon nigroviridis
xenla-a2bd54 Xenopus laevis (African clawed frog) loc495520 protein Xenopus laevis
xenla-q6dci0 Xenopus laevis (African clawed frog) cel-prov protein Xenopus laevis
xenla-Q7SYT6 Xenopus laevis (African clawed frog) hypothetical protein Xenopus laevis
xenla-Q7SYX7 Xenopus laevis (African clawed frog) hypothetical protein Xenopus laevis
xentr-b0bm89 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) LOC100144991 protein Xenopus tropicalis
xentr-f7e2e2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Uncharacterized protein Xenopus tropicalis
pelsi-k7g127 Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) Uncharacterized protein Pelodiscus sinensis
myobr-s7n4r2 Myotis brandtii (Brandt's bat) Bile salt-activated lipase Myotis brandtii
myods-l5lvb4 Myotis davidii (David's myotis) Bile salt-activated lipase Myotis davidii
thuor-u3ua79 Thunnus orientalis (North Pacific bluefin tuna) (Thunnus thynnum orientalis) Bile salt-activated lipase 2 Thunnus orientalis
myobr-s7ney7 Myotis brandtii (Brandt's bat) Bile salt-activated lipase Myotis brandtii
pteal-l5k7h7 Pteropus alecto (Black flying fox) Bile salt-activated lipase Pteropus alecto
myolu-l7n1c2 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
thuor-u3u9m8 Thunnus orientalis (North Pacific bluefin tuna) (Thunnus thynnum orientalis) Bile salt-activated lipase 1 Thunnus orientalis
capte-r7vgb9 Capitella teleta (Polychaete worm) Uncharacterized protein Capitella teleta
fical-u3jfj5 Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis) Uncharacterized protein Ficedula albicollis
chemy-m7c2l1 Chelonia mydas (Green sea-turtle) (Chelonia agassizi) Bile salt-activated lipase Chelonia mydas
xipma-m4ahu4 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein Xiphophorus maculatus
xipma-m4ahq8 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein Xiphophorus maculatus
xipma-m4a8g0 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein Xiphophorus maculatus
capte-r7vcc3 Capitella teleta (Polychaete worm) Uncharacterized protein Capitella teleta
sheep-w5p5z7 Ovis aries (Sheep). Uncharacterized protein Ovis aries
poefo-a0a087xbd3 Poecilia formosa (Amazon molly) (Limia formosa). Uncharacterized protein Poecilia formosa
poefo-a0a087xbz3 Poecilia formosa (Amazon molly) (Limia formosa). Uncharacterized protein Poecilia formosa
lepoc-w5mf28 Lepisosteus oculatus (Spotted gar). Uncharacterized protein Lepisosteus oculatus
aptfo-a0a087rh11 Aptenodytes forsteri (Emperor penguin). Uncharacterized protein Aptenodytes forsteri
balre-a0a087v3l8 Balearica regulorum gibbericeps. Uncharacterized protein Balearica regulorum gibbericeps
spaau-a0a023i9d7 Sparus aurata (Gilthead sea bream). Bile salt-activated lipase Sparus aurata
oncmy-a0a060wwk2 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Oncorhynchus mykiss genomic scaffold, scaffold_377 Oncorhynchus mykiss
oncmy-a0a060wxj2 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Oncorhynchus mykiss genomic scaffold, scaffold_411 Oncorhynchus mykiss
ictpu-w5utq3 Ictalurus punctatus (Channel catfish) (Silurus punctatus). Bile salt-activated lipase Ictalurus punctatus
poefo-a0a087x389 Poecilia formosa (Amazon molly) (Limia formosa). Uncharacterized protein Poecilia formosa
astmx-w5la73 Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Uncharacterized protein Astyanax mexicanus
pygad-a0a093nlw9 Pygoscelis adeliae (Adelie penguin). Carboxylic ester hydrolase Pygoscelis adeliae
fukda-a0a091dlh8 Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). Carboxylic ester hydrolase Fukomys damarensis
fukda-a0a091dn83 Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). Carboxylic ester hydrolase Fukomys damarensis
corbr-a0a091fw75 Corvus brachyrhynchos (American crow). Carboxylic ester hydrolase Corvus brachyrhynchos
9aves-a0a091gme4 Cuculus canorus (common cuckoo). Carboxylic ester hydrolase Cuculus canorus
bucrh-a0a091gvl2 Buceros rhinoceros silvestris. Carboxylic ester hydrolase Buceros rhinoceros silvestris
calan-a0a091i7x7 Calypte anna (Anna's hummingbird) (Archilochus anna). Carboxylic ester hydrolase Calypte anna
9grui-a0a091le99 Chlamydotis macqueenii (Macqueen's bustard). Carboxylic ester hydrolase Chlamydotis macqueenii
halal-a0a091pas2 Haliaeetus albicilla (White-tailed sea-eagle). Carboxylic ester hydrolase Haliaeetus albicilla
9grui-a0a091rpy7 Mesitornis unicolor (brown roatelo). Carboxylic ester hydrolase Mesitornis unicolor
nipni-a0a091urf7 Nipponia nippon (Crested ibis) (Ibis nippon). Carboxylic ester hydrolase Nipponia nippon
opiho-a0a091va85 Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). Carboxylic ester hydrolase Opisthocomus hoazin
9aves-a0a093bnc2 Pterocles gutturalis (yellow-throated sandgrouse). Carboxylic ester hydrolase Pterocles gutturalis
tytal-a0a093f655 Tyto alba (Barn owl). Carboxylic ester hydrolase Tyto alba
gavst-a0a093fsb3 Gavia stellata (Red-throated diver) (Red-throated loon). Carboxylic ester hydrolase Gavia stellata
picpb-a0a093g4t2 Picoides pubescens (Downy woodpecker) (Dryobates pubescens). Carboxylic ester hydrolase Picoides pubescens
strca-a0a093h9u1 Struthio camelus australis. Carboxylic ester hydrolase Struthio camelus australis
eurhl-a0a093is34 Eurypyga helias (Sunbittern). Carboxylic ester hydrolase Eurypyga helias
9pass-a0a093qi07 Manacus vitellinus (golden-collared manakin). Carboxylic ester hydrolase Manacus vitellinus
9aves-a0a094mur0 Podiceps cristatus (great crested grebe). Carboxylic ester hydrolase Podiceps cristatus
tingu-a0a099z263 Tinamus guttatus (White-throated tinamou). Carboxylic ester hydrolase Tinamus guttatus
chavo-a0a0a0azw3 Charadrius vociferus (Killdeer) (Aegialitis vocifera). Carboxylic ester hydrolase Charadrius vociferus
9eupu-a0a0b7a536 Arion vulgaris (Spanish slug) Uncharacterized protein Arion vulgaris
chlsb-a0a0d9rr87 Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)\; Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys). Carboxylic ester hydrolase Chlorocebus sabaeus
9tele-a0a0n8jx05 Scleropages formosus (Asian bonytongue) Uncharacterized protein Scleropages formosus
amaae-a0a0q3tru3 Amazona aestiva Uncharacterized protein Amazona aestiva
9tele-a0a0s7gz65 Poeciliopsis prolifica (blackstripe livebearer). Carboxylic ester hydrolase Poeciliopsis prolifica
funhe-a0a146mjy0 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a147a9c6 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a147arf1 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
allmi-a0a151mg34 Alligator mississippiensis (American alligator). Carboxylic ester hydrolase Alligator mississippiensis
dicla-a0a172eak8 Dicentrarchus labrax (European seabass) (Morone labrax). Carboxylic ester hydrolase Dicentrarchus labrax
neole-a0a1a6ht56 Neotoma lepida (Desert woodrat). Carboxylic ester hydrolase Neotoma lepida
erieu-a0a1s3a1q9 Erinaceus europaeus (Western European hedgehog). Carboxylic ester hydrolase Erinaceus europaeus
dipor-a0a1s3flf2 Dipodomys ordii (Ord's kangaroo rat). Carboxylic ester hydrolase Dipodomys ordii
erieu-a0a1s3whb8 Erinaceus europaeus (Western European hedgehog). Carboxylic ester hydrolase Erinaceus europaeus
tarsy-a0a1u7su80 Tarsius syrichta (Philippine tarsier). Carboxylic ester hydrolase Tarsius syrichta
mesau-a0a1u8cxs4 Mesocricetus auratus (Golden hamster). Carboxylic ester hydrolase Mesocricetus auratus
aotna-a0a2k5dan5 Aotus nancymaae (Ma's night monkey). Carboxylic ester hydrolase Aotus nancymaae
macfa-a0a2k5vz29 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)\; Macaca nemestrina (Pig-tailed macaque). Carboxyl ester lipase Macaca fascicularis
saibb-a0a2k6u7q3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey). Carboxylic ester hydrolase Saimiri boliviensis boliviensis

Gene_locus_frgt Name Species
ailme-d2hpm8 Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein Ailuropoda melanoleuca
cteid-d4hne5 Ctenopharyngodon idella (Grass carp) (Leuciscus idella) Bile salt-activated lipase Ctenopharyngodon idella
dicla-b2ze90 Dicentrarchus labrax (European sea bass) Bile-salt activated lipase Dicentrarchus labrax
epico-d3tjh1 Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus) Bile salt-activated lipase Epinephelus coioides
gadmo-b0ze97 Gadus morhua (Atlantic cod) Bile salt-activated lipase Gadus morhua
hetga-g5anw9 Heterocephalus glaber (Naked mole rat) Bile salt-activated lipase Heterocephalus glaber
hiphi-q56p39 Hippoglossus hippoglossus (Atlantic halibut) bile salt-activated lipase (fragment) Hippoglossus hippoglossus
macmu-h9fcy0 Macaca mulatta (Rhesus macaque) Bile salt-activated lipase Macaca mulatta
melae-q5ykh2 Melanogrammus aeglefinus (Haddock) bile salt-activated lipase (fragment) Melanogrammus aeglefinus
muspu-q9trj4 Mustela putorius (European polecat) bile salt stimulated lipase (fragment) Mustela putorius
myolu-g1pef0 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
myolu-g1q033 Myotis lucifugus (Little brown bat) Uncharacterized protein Myotis lucifugus
pagpa-q1ak03 Pagrus pagrus (Couch's sea bream) (Pagrus vulgaris) pancreatic bile salt-activated lipase (fragment) Pagrus pagrus
pseam-BAL Pseudopleuronectes americanus (Winter flounder) (Pleuronecte bile salt-activated lipase (EC 3.1.1.13) (fragment) Pseudopleuronectes americanus
rabit-chest Oryctolagus cuniculus mRNA for cholesterol esterase Oryctolagus cuniculus
takru-h2rzn7 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) Uncharacterized protein Takifugu rubripes
tetng-h3cck4 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein Tetraodon nigroviridis
tetng-q4syn5 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetng-q4t8q3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
myods-l5m2t1 Myotis davidii (David's myotis) Bile salt-activated lipase Myotis davidii
hetga-g5anw8 Heterocephalus glaber (Naked mole rat) Bile salt-activated lipase Heterocephalus glaber
tupch-l8ych4 Tupaia chinensis (Chinese tree shrew) Bile salt-activated lipase Tupaia chinensis
myods-l5lub5 Myotis davidii (David's myotis) Bile salt-activated lipase Myotis davidii
9ceta-t0nkw3 Camelus ferus (Wild Bactrian camel) Bile-salt-activated lipase isoform 7-like protein Camelus ferus
neovi-u6ds90 Neovison vison (American mink) (Mustela vison) Bile salt-activated lipase Neovison vison
myods-l5lvd9 Myotis davidii (David's myotis) Bile salt-activated lipase Myotis davidii
myods-l5m510 Myotis davidii (David's myotis) Bile salt-activated lipase Myotis davidii
myods-l5lx34 Myotis davidii (David's myotis) Bile salt-activated lipase Myotis davidii
capte-r7vfp4 Capitella teleta (Polychaete worm) Uncharacterized protein Capitella teleta
capte-r7t6u1 Capitella teleta (Polychaete worm) Uncharacterized protein Capitella teleta
capte-r7uqn8 Capitella teleta (Polychaete worm) Uncharacterized protein Capitella teleta
myobr-s7pl14 Myotis brandtii (Brandt's bat) Bile salt-activated lipase Myotis brandtii
myobr-s7q2d6 Myotis brandtii (Brandt's bat) Bile salt-activated lipase Myotis brandtii
myods-l5m045 Myotis davidii (David's myotis) Bile salt-activated lipase Myotis davidii
latca-k9n0f7 Lates calcarifer (Barramundi) (Holocentrus calcarifer) Bile-salt activated lipase Lates calcarifer
capte-r7v4e2 Capitella teleta (Polychaete worm) Uncharacterized protein Capitella teleta
myobr-s7njl0 Myotis brandtii (Brandt's bat) Bile salt-activated lipase Myotis brandtii
myods-l5mfe5 Myotis davidii (David's myotis) Bile salt-activated lipase Myotis davidii
myobr-s7nd25 Myotis brandtii (Brandt's bat) Bile salt-activated lipase Myotis brandtii
larcr-w8ftr8 Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). Lipase Larimichthys crocea
ophha-v8nwe4 Ophiophagus hannah (King cobra) (Naja hannah). Bile salt-activated lipase Ophiophagus hannah
9labr-w6b6c6 Tautogolabrus adspersus (cunner). Bile salt-activated lipase Tautogolabrus adspersus
9pass-a0a093piy4 Manacus vitellinus (golden-collared manakin). Carboxylic ester hydrolase Manacus vitellinus
9tele-a0a0s7ike0 Poeciliopsis prolifica (blackstripe livebearer). Carboxylic ester hydrolase Poeciliopsis prolifica
9tele-a0a0s7iye2 Poeciliopsis prolifica (blackstripe livebearer). CEL Poeciliopsis prolifica
9tele-a0a0s7m9x0 Poeciliopsis prolifica (blackstripe livebearer). CEL Poeciliopsis prolifica
funhe-a0a146n2f3 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146n3c1 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146n4k7 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146n8l3 Fundulus heteroclitus (Killifish) (Mummichog). Carboxyl ester lipase (Bile salt-stimulated lipase), putative Fundulus heteroclitus
funhe-a0a146na58 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146nae6 Fundulus heteroclitus (Killifish) (Mummichog). Bile salt-activated lipase Fundulus heteroclitus
funhe-a0a146nb91 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146nch4 Fundulus heteroclitus (Killifish) (Mummichog). Bile salt-activated lipase Fundulus heteroclitus
funhe-a0a146nsn3 Fundulus heteroclitus (Killifish) (Mummichog). Carboxyl ester lipase (Bile salt-stimulated lipase), putative Fundulus heteroclitus
funhe-a0a146p7a4 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146qu90 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146qwa0 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146sep2 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146wyt3 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146wzh5 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
funhe-a0a146wzh7 Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase Fundulus heteroclitus
cereh-a0a212cwf4 Cervus elaphus hippelaphus (European red deer). Carboxylic ester hydrolase Cervus elaphus hippelaphus
escro-a0a2f0bla4 Eschrichtius robustus (California gray whale) (Eschrichtius gibbosus). Carboxylic ester hydrolase Eschrichtius robustus
cebca-a0a2k5qat0 Cebus capucinus imitator. Carboxyl ester lipase Cebus capucinus imitator

Substrate Chemical Nomenclature Proteins
Retinol-palmitate [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] hexadecanoate human-PNLIPRP2    human-PNLIP    ratno-Ces1d    mouse-Ces1d    canru-1lipa    pig-i3ltk9    human-LIPA
Retinol-oleate [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] (Z)-octadec-9-enoate human-PNLIPRP2
C8-MGDG [(2S)-2-octanoyloxy-3-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl] octanoate human-PNLIPRP2    talth-f6lqk7    nech7-c7yuz1    cavpo-2plrp    human-CEL    bovin-balip    canan-lipasA    rhimi-lipas    rhidl-lipas
Dipentyl-phthalate dipentyl benzene-1,2-dicarboxylate pig-i3ltk9    bovin-balip
Dipropyl-phthalate dipropyl benzene-1,2-dicarboxylate malci-McLipB    pig-i3ltk9    bovin-balip
Paranitrophenylbutyrate (4-nitrophenyl) butanoate bactc-lipas    9acto-f7ix06    artox-phhyd    burgl-EstC    bovin-balip    rabit-1cxes    psesp-OPH    9bact-H6BDX1    9bact-a0a2s1gux0    human-NOTUM    9delt-EstD11    9pezi-s4vch4    aspfu-q4x1n0    crysp-Q874E9    fusso-cutas    pyrbr-Q9Y7G8    copci-b9u443    strsw-c9zcr8    humin-cut    human-DAGLA    9baci-EstD9    9rhiz-g9i933    canar-LipB    bacsu-pnbae    thefu-q6a0i4    geost-est30    geost-est50    pyrab-PAB1050
Cholesteryl-oleate [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (Z)-octadec-9-enoate human-NCEH1
Tributyrin 2,3-di(butanoyloxy)propyl butanoate bovin-balip    rabit-1cxes    pseae-llipa    canar-LipB    human-PNLIPRP2    talth-f6lqk7    nech7-c7yuz1    cavpo-2plrp    human-CEL    human-PNLIP    canan-lipasA    rhimi-lipas    rhidl-lipas    psesp-Q9RBY1    staha-Q9RGZ6    9bact-6EB3
Tripropionin 2,3-di(propanoyloxy)propyl propanoate bovin-balip    rabit-1cxes    pseae-llipa    staha-Q9RGZ6
Vinyl-laurate ethenyl dodecanoate bovin-balip    rabit-1cxes
Vinyl-propionate ethenyl propanoate bovin-balip    rabit-1cxes
Vinyl-acetate ethenyl acetate 9psed-q0mrg5    bovin-balip    rabit-1cxes
Vinyl-butyrate ethenyl butanoate bovin-balip    rabit-1cxes

Inhibitor Chemical Nomenclature Proteins
KC01 (6Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide human-ABHD16A    human-ABHD12    mouse-Abhd16a
WAY-121898 (4-phenoxyphenyl) 4-methylpiperidine-1-carboxylate pig-i3ltk9
SCHEMBL3761170 6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyrone mesau-a0a1u8cxs4
Piperidinyl-1,2,3-triazole-urea-inhibitor-2 4-[4-[2-[(2R)-2-phenylpiperidine-1-carbonyl]triazol-4-yl]phenyl]benzoic acid human-LYPLAL1
p-nitrophenyl-N-butyl-carbamate (4-nitrophenyl) N-butylcarbamate pig-i3ltk9
3-Cholesteryl-N-butylcarbamate [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-butylcarbamate pig-i3ltk9
3-Cholesteryl-N-octylcarbamate [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-octylcarbamate pig-i3ltk9
p-nitrophenyl-N-butyl-N-methyl-carbamate (4-nitrophenyl) N-butylmethylcarbamate human-CEL
p-nitrophenyl-N-octyl-carbamate (4-nitrophenyl) N-octylcarbamate pig-i3ltk9
CHEMBL3125351 2-(1H-indol-3-yl)-6-nitro-4-phenylquinoline pig-i3ltk9
CHEMBL3125346 6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline pig-i3ltk9
DEUP diethyl (2-oxochromen-7-yl) phosphate human-NCEH1    luccu-E3aest7
IMP-pNP 1-[methyl(propan-2-yloxy)phosphoryl]oxy-4-nitrobenzene human-ACHE    human-CEL
NEMP 1-[ethoxy(methyl)phosphoryl]oxy-4-nitrobenzene human-ACHE    human-CEL
NEDPA N-[ethoxy-(4-nitrophenoxy)phosphoryl]-N-methylmethanamine torca-ACHE    human-CEL

References (6)

Title : Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes - Tang_2022_Front.Genet_13_909091
Author(s) : Tang SL , Liang XF , He S , Li L , Alam MS , Wu J
Ref : Front Genet , 13 :909091 , 2022
Abstract :
PubMedSearch : Tang_2022_Front.Genet_13_909091
PubMedID: 35991544

Title : Comparative Structures and Evolution of Vertebrate Carboxyl Ester Lipase (CEL) Genes and Proteins with a Major Role in Reverse Cholesterol Transport - Holmes_2011_Cholesterol_2011_781643
Author(s) : Holmes RS , Cox LA
Ref : Cholesterol , 2011 :781643 , 2011
Abstract :
PubMedSearch : Holmes_2011_Cholesterol_2011_781643
PubMedID: 22162806

Title : The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding - Moore_2001_J.Mol.Biol_312_511
Author(s) : Moore SA , Kingston RL , Loomes KM , Hernell O , Blackberg L , Baker HM , Baker EN
Ref : Journal of Molecular Biology , 312 :511 , 2001
Abstract :
PubMedSearch : Moore_2001_J.Mol.Biol_312_511
PubMedID: 11563913
Gene_locus related to this paper: human-CEL

Title : Crystal structure of the catalytic domain of human bile salt activated lipase - Terzyan_2000_Protein.Sci_9_1783
Author(s) : Terzyan S , Wang CS , Downs D , Hunter B , Zhang XC
Ref : Protein Science , 9 :1783 , 2000
Abstract :
PubMedSearch : Terzyan_2000_Protein.Sci_9_1783
PubMedID: 11045623
Gene_locus related to this paper: human-CEL

Title : Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation - Chen_1998_Biochemistry_37_5107
Author(s) : Chen JC , Miercke LJ , Krucinski J , Starr JR , Saenz G , Wang X , Spilburg CA , Lange LG , Ellsworth JL , Stroud RM
Ref : Biochemistry , 37 :5107 , 1998
Abstract :
PubMedSearch : Chen_1998_Biochemistry_37_5107
PubMedID: 9548741
Gene_locus related to this paper: bovin-balip

Title : The crystal structure of bovine bile salt activated lipase: insights into the bile salt activation mechanism - Wang_1997_Structure_5_1209
Author(s) : Wang X , Wang CS , Tang J , Dyda F , Zhang XC
Ref : Structure , 5 :1209 , 1997
Abstract :
PubMedSearch : Wang_1997_Structure_5_1209
PubMedID: 9331420
Gene_locus related to this paper: bovin-balip