The human lactating mammary gland and pancreas produce a lipolytic enzyme, carboxyl-ester lipase, earlier called bile salt-stimulated lipase. Carboxyl-ester lipase is a major component of pancreatic juice and is responsible for the hydrolysis of cholesterol esters as well as a variety of other dietary esters. The enzyme is activated when mixed with bile salts, and plays an important role in the digestion of milk fat in newborn infants. This enzyme combines properties of esterases (activity on esters soluble in water) and lipases (activity on insoluble long chain acylglycerols) Numerous repeats at the c-term excluded in ESTHER (only n-term Pfam A COesterase 1 544)
Interpro : IPR002018 Carboxylesterase, type B , IPR033560 Bile salt-activated lipase BAL
PIRSF : PIRSF005676 COesterase
Pdoc : PDOC00112
Pfam : PF00135 COesterase
Prints : No Print
EC Number : 3.1.1.13
Peptide in | Fasta |
Nucleotide in | Fasta |
Alignment with Multalin | Text only |
Seed alignment with MAFFT | No colour / coloured with Mview |
Alignment with MAFFT | No colour / coloured with Mview |
Dendrogram | The dnd file |
Structure | Name | Proteins |
---|---|---|
1AKN | Bovine bile-salt-activated lipase | bovin-balip |
1AQL | Bovine bile-salt-activated lipase + taurocholate | bovin-balip |
1F6W | Human bile-salt-activated lipase | human-CEL |
1JMY | Human bile-salt-activated lipase | human-CEL |
2BCE | Bovine cholesterol esterase | bovin-balip |
6H0T | Crystal structure of native recombinant human bile salt activated lipase | human-CEL |
6H0V | Crystal structure of tabun surrogate NEDPA inhibited recombinant human bile salt activated lipase | human-CEL |
6H18 | Crystal structure of sarin surrogate NIMP inhibited recombinant human bile salt activated lipase | human-CEL |
6H19 | Crystal structure of ethyl-paraoxon inhibited recombinant human bile salt activated lipase (aged form) | human-CEL |
6H1A | Crystal structure of VX surrogate NEMP inhibited recombinant human bile salt activated lipase | human-CEL |
Gene_locus | Name | Species |
---|---|---|
9aves-a0a091gme4 | Cuculus canorus (common cuckoo). Carboxylic ester hydrolase | Cuculus canorus |
9aves-a0a093bnc2 | Pterocles gutturalis (yellow-throated sandgrouse). Carboxylic ester hydrolase | Pterocles gutturalis |
9aves-a0a094mur0 | Podiceps cristatus (great crested grebe). Carboxylic ester hydrolase | Podiceps cristatus |
9eupu-a0a0b7a536 | Arion vulgaris (Spanish slug) Uncharacterized protein | Arion vulgaris |
9grui-a0a091le99 | Chlamydotis macqueenii (Macqueen's bustard). Carboxylic ester hydrolase | Chlamydotis macqueenii |
9grui-a0a091rpy7 | Mesitornis unicolor (brown roatelo). Carboxylic ester hydrolase | Mesitornis unicolor |
9pass-a0a093qi07 | Manacus vitellinus (golden-collared manakin). Carboxylic ester hydrolase | Manacus vitellinus |
9tele-a0a0n8jx05 | Scleropages formosus (Asian bonytongue) Uncharacterized protein | Scleropages formosus |
9tele-a0a0s7gz65 | Poeciliopsis prolifica (blackstripe livebearer). Carboxylic ester hydrolase | Poeciliopsis prolifica |
allmi-a0a151mg34 | Alligator mississippiensis (American alligator). Carboxylic ester hydrolase | Alligator mississippiensis |
amaae-a0a0q3tru3 | Amazona aestiva Uncharacterized protein | Amazona aestiva |
anapl-r0lw36 | Anas platyrhynchos (Domestic duck) (Anas boschas) Bile salt-activated lipase | Anas platyrhynchos |
anoca-g1kdb8 | Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein | Anolis carolinensis |
aotna-a0a2k5dan5 | Aotus nancymaae (Ma's night monkey). Carboxylic ester hydrolase | Aotus nancymaae |
aptfo-a0a087rh11 | Aptenodytes forsteri (Emperor penguin). Uncharacterized protein | Aptenodytes forsteri |
astmx-w5la73 | Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Uncharacterized protein | Astyanax mexicanus |
balre-a0a087v3l8 | Balearica regulorum gibbericeps. Uncharacterized protein | Balearica regulorum gibbericeps |
bovin-balip | ![]() |
Bos taurus |
bucrh-a0a091gvl2 | Buceros rhinoceros silvestris. Carboxylic ester hydrolase | Buceros rhinoceros silvestris |
calan-a0a091i7x7 | Calypte anna (Anna's hummingbird) (Archilochus anna). Carboxylic ester hydrolase | Calypte anna |
calja-f6u4n2 | Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein | Callithrix jacchus |
canfa-f1phd0 | Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein | Canis lupus familiaris |
capte-r7vcc3 | Capitella teleta (Polychaete worm) Uncharacterized protein | Capitella teleta |
capte-r7vgb9 | Capitella teleta (Polychaete worm) Uncharacterized protein | Capitella teleta |
cavpo-h0uyx7 | Cavia porcellus (Guinea pig) Uncharacterized protein | Cavia porcellus |
chavo-a0a0a0azw3 | Charadrius vociferus (Killdeer) (Aegialitis vocifera). Carboxylic ester hydrolase | Charadrius vociferus |
chemy-m7c2l1 | Chelonia mydas (Green sea-turtle) (Chelonia agassizi) Bile salt-activated lipase | Chelonia mydas |
chick-e1bvq6 | Gallus gallus (Chicken) Uncharacterized protein | Gallus gallus |
chlsb-a0a0d9rr87 | Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)\; Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys). Carboxylic ester hydrolase | Chlorocebus sabaeus |
colap-a0a2k5i2b4 | Colobus angolensis palliatus (Peters' Angolan colobus). Carboxylic ester hydrolase | Colobus angolensis palliatus |
corbr-a0a091fw75 | Corvus brachyrhynchos (American crow). Carboxylic ester hydrolase | Corvus brachyrhynchos |
crigr-g3iim8 | Cricetulus griseus (Chinese hamster) Bile salt-activated lipase | Cricetulus griseus |
danre-2balip | Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein | Danio rerio |
danre-Q6P004 | Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical cel.2 protein (fragment) (fragment) | Danio rerio |
danre-q4qrh4 | Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:112377 | Danio rerio |
dicla-a0a172eak8 | Dicentrarchus labrax (European seabass) (Morone labrax). Carboxylic ester hydrolase | Dicentrarchus labrax |
dipor-a0a1s3flf2 | Dipodomys ordii (Ord's kangaroo rat). Carboxylic ester hydrolase | Dipodomys ordii |
erieu-a0a1s3a1q9 | Erinaceus europaeus (Western European hedgehog). Carboxylic ester hydrolase | Erinaceus europaeus |
erieu-a0a1s3whb8 | Erinaceus europaeus (Western European hedgehog). Carboxylic ester hydrolase | Erinaceus europaeus |
eurhl-a0a093is34 | Eurypyga helias (Sunbittern). Carboxylic ester hydrolase | Eurypyga helias |
felca-m3x096 | Felis catus (Cat) (Felis silvestris catus) Uncharacterized protein | Felis catus |
fical-u3jfj5 | Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis) Uncharacterized protein | Ficedula albicollis |
fugru-2balip | Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) carboxylesterase | Fugu rubripes |
fugru-4cxest | Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) carboxylesterase | Fugu rubripes |
fugru-balip | Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) carboxylesterase | Fugu rubripes |
fukda-a0a091dlh8 | Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). Carboxylic ester hydrolase | Fukomys damarensis |
fukda-a0a091dn83 | Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). Carboxylic ester hydrolase | Fukomys damarensis |
funhe-a0a146mjy0 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a147a9c6 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a147arf1 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
gasac-balip | Gasterosteus aculeatus (Three-spined stickleback) Cholesterol_esterase | Gasterosteus aculeatus |
gasac-g3q258 | Gasterosteus aculeatus (Three-spined stickleback) Uncharacterized protein | Gasterosteus aculeatus |
gavst-a0a093fsb3 | Gavia stellata (Red-throated diver) (Red-throated loon). Carboxylic ester hydrolase | Gavia stellata |
gorgo-balip | Gorilla gorilla carboxyl-ester lipase (CEL) gene, complete cds | Gorilla gorilla gorilla |
halal-a0a091pas2 | Haliaeetus albicilla (White-tailed sea-eagle). Carboxylic ester hydrolase | Haliaeetus albicilla |
hetga-g5anw7 | Heterocephalus glaber (Naked mole rat) Bile salt-activated lipase | Heterocephalus glaber |
horse-f7agv7 | Equus caballus (Horse) Uncharacterized protein | Equus caballus |
human-CEL | ![]() |
Homo sapiens |
ictpu-w5utq3 | Ictalurus punctatus (Channel catfish) (Silurus punctatus). Bile salt-activated lipase | Ictalurus punctatus |
latch-h3b637 | Latimeria chalumnae (West Indian ocean coelacanth) Uncharacterized protein | Latimeria chalumnae |
lepoc-w5mf28 | Lepisosteus oculatus (Spotted gar). Uncharacterized protein | Lepisosteus oculatus |
loxaf-g3ss16 | Loxodonta africana (African elephant) Uncharacterized protein | Loxodonta africana |
macfa-a0a2k5vz29 | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)\; Macaca nemestrina (Pig-tailed macaque). Carboxyl ester lipase | Macaca fascicularis |
macmu-f7buk8 | Macaca mulatta (Rhesus macaque) Uncharacterized protein | Macaca mulatta |
manle-a0a2k6aer2 | Mandrillus leucophaeus (Drill) (Papio leucophaeus). Carboxyl ester lipase | Mandrillus leucophaeus |
melga-g1n3b6 | Meleagris gallopavo (Common turkey) Uncharacterized protein | Meleagris gallopavo |
mesau-a0a1u8cxs4 | Mesocricetus auratus (Golden hamster). Carboxylic ester hydrolase | Mesocricetus auratus |
mondo-f6wuf2 | Monodelphis domestica (Gray short-tailed opossum) Uncharacterized protein | Monodelphis domestica |
mouse-pches | Mus musculus pancreatic\/mammary gland cholesterol esterase | Mus musculus |
muspf-m3yly9 | Mustela putorius furo (European domestic ferret) (Mustela furo) Uncharacterized protein | Mustela putorius furo |
myobr-s7n4r2 | Myotis brandtii (Brandt's bat) Bile salt-activated lipase | Myotis brandtii |
myobr-s7ney7 | Myotis brandtii (Brandt's bat) Bile salt-activated lipase | Myotis brandtii |
myods-l5lvb4 | Myotis davidii (David's myotis) Bile salt-activated lipase | Myotis davidii |
myolu-g1p7m1 | Myotis lucifugus (Little brown bat) Uncharacterized protein | Myotis lucifugus |
myolu-g1q522 | Myotis lucifugus (Little brown bat) Uncharacterized protein | Myotis lucifugus |
myolu-g1q8x7 | Myotis lucifugus (Little brown bat) Uncharacterized protein | Myotis lucifugus |
myolu-g1qca1 | Myotis lucifugus (Little brown bat) Uncharacterized protein | Myotis lucifugus |
myolu-l7n1c2 | Myotis lucifugus (Little brown bat) Uncharacterized protein | Myotis lucifugus |
neole-a0a1a6ht56 | Neotoma lepida (Desert woodrat). Carboxylic ester hydrolase | Neotoma lepida |
nipni-a0a091urf7 | Nipponia nippon (Crested ibis) (Ibis nippon). Carboxylic ester hydrolase | Nipponia nippon |
nomle-g1rrc2 | Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Uncharacterized protein | Nomascus leucogenys |
oikdi-e4yp15 | Oikopleura dioica (Tunicate) Whole genome shotgun assembly, allelic scaffoldA_646 reference scaffold_150 | Oikopleura dioica |
oncmy-a0a060wwk2 | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Oncorhynchus mykiss genomic scaffold, scaffold_377 | Oncorhynchus mykiss |
oncmy-a0a060wxj2 | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Oncorhynchus mykiss genomic scaffold, scaffold_411 | Oncorhynchus mykiss |
opiho-a0a091va85 | Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). Carboxylic ester hydrolase | Opisthocomus hoazin |
oreni-i3k5f8 | Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) Uncharacterized protein | Oreochromis niloticus |
ornan-f7exu1 | Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein | Ornithorhynchus anatinus |
oryla-h2mhi0 | Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein | Oryzias latipes |
oryla-h2mhl7 | Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein | Oryzias latipes |
oryla-h2mpb5 | Oryzias latipes (Medaka fish) (Japanese ricefish) Uncharacterized protein | Oryzias latipes |
otoga-h0wze9 | Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Uncharacterized protein | Otolemur garnettii |
pantr-h2r646 | Pan troglodytes (Chimpanzee) Uncharacterized protein | Pan troglodytes |
papan-a0a2i3lqd9 | Papio anubis (Olive baboon) Carboxyl ester lipase | Papio anubis |
pelsi-k7g127 | Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) Uncharacterized protein | Pelodiscus sinensis |
picpb-a0a093g4t2 | Picoides pubescens (Downy woodpecker) (Dryobates pubescens). Carboxylic ester hydrolase | Picoides pubescens |
pig-i3ltk9 | Sus scrofa (Pig) Carboxylic ester hydrolase CEL | Sus scrofa |
poefo-a0a087x389 | Poecilia formosa (Amazon molly) (Limia formosa). Uncharacterized protein | Poecilia formosa |
poefo-a0a087xbd3 | Poecilia formosa (Amazon molly) (Limia formosa). Uncharacterized protein | Poecilia formosa |
poefo-a0a087xbz3 | Poecilia formosa (Amazon molly) (Limia formosa). Uncharacterized protein | Poecilia formosa |
ponab-h2pu85 | Pongo abelii (Sumatran orangutan) Uncharacterized protein | Pongo abelii |
pteal-l5k7h7 | Pteropus alecto (Black flying fox) Bile salt-activated lipase | Pteropus alecto |
pygad-a0a093nlw9 | Pygoscelis adeliae (Adelie penguin). Carboxylic ester hydrolase | Pygoscelis adeliae |
rabit-g1tfp2 | Oryctolagus cuniculus (Rabbit) Uncharacterized protein | Oryctolagus cuniculus |
ratno-balip | Rattus norvegicus (Rat) Cholesterol esterase | Rattus norvegicus |
rhibe-a0a2k6jtl7 | Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)\; Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana). Carboxylic ester hydrolase | Rhinopithecus bieti |
saibb-a0a2k6u7q3 | Saimiri boliviensis boliviensis (Bolivian squirrel monkey). Carboxylic ester hydrolase | Saimiri boliviensis boliviensis |
salsa-cxest | Salmo salar mRNA for carboxylesterase partial | Salmo salar |
sarha-g3vze3 | Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) Uncharacterized protein | Sarcophilus harrisii |
sheep-w5p5z7 | Ovis aries (Sheep). Uncharacterized protein | Ovis aries |
spaau-a0a023i9d7 | Sparus aurata (Gilthead sea bream). Bile salt-activated lipase | Sparus aurata |
spetr-i3n7y6 | Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) Uncharacterized protein | Spermophilus tridecemlineatus |
strca-a0a093h9u1 | Struthio camelus australis. Carboxylic ester hydrolase | Struthio camelus australis |
taegu-h0z4h9 | Taeniopygia guttata (Zebra finch) (Poephila guttata) Uncharacterized protein | Taeniopygia guttata |
tarsy-a0a1u7su80 | Tarsius syrichta (Philippine tarsier). Carboxylic ester hydrolase | Tarsius syrichta |
tetng-q4syn6 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf12000, whole genome shotgun sequence | Tetraodon nigroviridis |
thuor-u3u9m8 | Thunnus orientalis (North Pacific bluefin tuna) (Thunnus thynnum orientalis) Bile salt-activated lipase 1 | Thunnus orientalis |
thuor-u3ua79 | Thunnus orientalis (North Pacific bluefin tuna) (Thunnus thynnum orientalis) Bile salt-activated lipase 2 | Thunnus orientalis |
tingu-a0a099z263 | Tinamus guttatus (White-throated tinamou). Carboxylic ester hydrolase | Tinamus guttatus |
tytal-a0a093f655 | Tyto alba (Barn owl). Carboxylic ester hydrolase | Tyto alba |
xenla-Q7SYT6 | Xenopus laevis (African clawed frog) hypothetical protein | Xenopus laevis |
xenla-Q7SYX7 | Xenopus laevis (African clawed frog) hypothetical protein | Xenopus laevis |
xenla-a2bd54 | Xenopus laevis (African clawed frog) loc495520 protein | Xenopus laevis |
xenla-q6dci0 | Xenopus laevis (African clawed frog) cel-prov protein | Xenopus laevis |
xentr-b0bm89 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) LOC100144991 protein | Xenopus tropicalis |
xentr-f7e2e2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Uncharacterized protein | Xenopus tropicalis |
xipma-m4a8g0 | Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein | Xiphophorus maculatus |
xipma-m4ahq8 | Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein | Xiphophorus maculatus |
xipma-m4ahu4 | Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Uncharacterized protein | Xiphophorus maculatus |
Gene_locus_frgt | Name | Species |
---|---|---|
9ceta-t0nkw3 | Camelus ferus (Wild Bactrian camel) Bile-salt-activated lipase isoform 7-like protein | Camelus ferus |
9labr-w6b6c6 | Tautogolabrus adspersus (cunner). Bile salt-activated lipase | Tautogolabrus adspersus |
9pass-a0a093piy4 | Manacus vitellinus (golden-collared manakin). Carboxylic ester hydrolase | Manacus vitellinus |
9tele-a0a0s7ike0 | Poeciliopsis prolifica (blackstripe livebearer). Carboxylic ester hydrolase | Poeciliopsis prolifica |
9tele-a0a0s7iye2 | Poeciliopsis prolifica (blackstripe livebearer). CEL | Poeciliopsis prolifica |
9tele-a0a0s7m9x0 | Poeciliopsis prolifica (blackstripe livebearer). CEL | Poeciliopsis prolifica |
ailme-d2hpm8 | Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein | Ailuropoda melanoleuca |
capte-r7t6u1 | Capitella teleta (Polychaete worm) Uncharacterized protein | Capitella teleta |
capte-r7uqn8 | Capitella teleta (Polychaete worm) Uncharacterized protein | Capitella teleta |
capte-r7v4e2 | Capitella teleta (Polychaete worm) Uncharacterized protein | Capitella teleta |
capte-r7vfp4 | Capitella teleta (Polychaete worm) Uncharacterized protein | Capitella teleta |
cebca-a0a2k5qat0 | Cebus capucinus imitator. Carboxyl ester lipase | Cebus capucinus imitator |
cereh-a0a212cwf4 | Cervus elaphus hippelaphus (European red deer). Carboxylic ester hydrolase | Cervus elaphus hippelaphus |
cteid-d4hne5 | Ctenopharyngodon idella (Grass carp) (Leuciscus idella) Bile salt-activated lipase | Ctenopharyngodon idella |
dicla-b2ze90 | Dicentrarchus labrax (European sea bass) Bile-salt activated lipase | Dicentrarchus labrax |
epico-d3tjh1 | Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus) Bile salt-activated lipase | Epinephelus coioides |
escro-a0a2f0bla4 | Eschrichtius robustus (California gray whale) (Eschrichtius gibbosus). Carboxylic ester hydrolase | Eschrichtius robustus |
funhe-a0a146n2f3 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146n3c1 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146n4k7 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146n8l3 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxyl ester lipase (Bile salt-stimulated lipase), putative | Fundulus heteroclitus |
funhe-a0a146na58 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146nae6 | Fundulus heteroclitus (Killifish) (Mummichog). Bile salt-activated lipase | Fundulus heteroclitus |
funhe-a0a146nb91 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146nch4 | Fundulus heteroclitus (Killifish) (Mummichog). Bile salt-activated lipase | Fundulus heteroclitus |
funhe-a0a146nsn3 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxyl ester lipase (Bile salt-stimulated lipase), putative | Fundulus heteroclitus |
funhe-a0a146p7a4 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146qu90 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146qwa0 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146sep2 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146wyt3 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146wzh5 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
funhe-a0a146wzh7 | Fundulus heteroclitus (Killifish) (Mummichog). Carboxylic ester hydrolase | Fundulus heteroclitus |
gadmo-b0ze97 | Gadus morhua (Atlantic cod) Bile salt-activated lipase | Gadus morhua |
hetga-g5anw8 | Heterocephalus glaber (Naked mole rat) Bile salt-activated lipase | Heterocephalus glaber |
hetga-g5anw9 | Heterocephalus glaber (Naked mole rat) Bile salt-activated lipase | Heterocephalus glaber |
hiphi-q56p39 | Hippoglossus hippoglossus (Atlantic halibut) bile salt-activated lipase (fragment) | Hippoglossus hippoglossus |
larcr-w8ftr8 | Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea). Lipase | Larimichthys crocea |
latca-k9n0f7 | Lates calcarifer (Barramundi) (Holocentrus calcarifer) Bile-salt activated lipase | Lates calcarifer |
macmu-h9fcy0 | Macaca mulatta (Rhesus macaque) Bile salt-activated lipase | Macaca mulatta |
melae-q5ykh2 | Melanogrammus aeglefinus (Haddock) bile salt-activated lipase (fragment) | Melanogrammus aeglefinus |
muspu-q9trj4 | Mustela putorius (European polecat) bile salt stimulated lipase (fragment) | Mustela putorius |
myobr-s7nd25 | Myotis brandtii (Brandt's bat) Bile salt-activated lipase | Myotis brandtii |
myobr-s7njl0 | Myotis brandtii (Brandt's bat) Bile salt-activated lipase | Myotis brandtii |
myobr-s7pl14 | Myotis brandtii (Brandt's bat) Bile salt-activated lipase | Myotis brandtii |
myobr-s7q2d6 | Myotis brandtii (Brandt's bat) Bile salt-activated lipase | Myotis brandtii |
myods-l5lub5 | Myotis davidii (David's myotis) Bile salt-activated lipase | Myotis davidii |
myods-l5lvd9 | Myotis davidii (David's myotis) Bile salt-activated lipase | Myotis davidii |
myods-l5lx34 | Myotis davidii (David's myotis) Bile salt-activated lipase | Myotis davidii |
myods-l5m045 | Myotis davidii (David's myotis) Bile salt-activated lipase | Myotis davidii |
myods-l5m2t1 | Myotis davidii (David's myotis) Bile salt-activated lipase | Myotis davidii |
myods-l5m510 | Myotis davidii (David's myotis) Bile salt-activated lipase | Myotis davidii |
myods-l5mfe5 | Myotis davidii (David's myotis) Bile salt-activated lipase | Myotis davidii |
myolu-g1pef0 | Myotis lucifugus (Little brown bat) Uncharacterized protein | Myotis lucifugus |
myolu-g1q033 | Myotis lucifugus (Little brown bat) Uncharacterized protein | Myotis lucifugus |
neovi-u6ds90 | Neovison vison (American mink) (Mustela vison) Bile salt-activated lipase | Neovison vison |
ophha-v8nwe4 | Ophiophagus hannah (King cobra) (Naja hannah). Bile salt-activated lipase | Ophiophagus hannah |
pagpa-q1ak03 | Pagrus pagrus (Couch's sea bream) (Pagrus vulgaris) pancreatic bile salt-activated lipase (fragment) | Pagrus pagrus |
pseam-BAL | Pseudopleuronectes americanus (Winter flounder) (Pleuronecte bile salt-activated lipase (EC 3.1.1.13) (fragment) | Pseudopleuronectes americanus |
rabit-chest | Oryctolagus cuniculus mRNA for cholesterol esterase | Oryctolagus cuniculus |
takru-h2rzn7 | Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) Uncharacterized protein | Takifugu rubripes |
tetng-h3cck4 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Uncharacterized protein | Tetraodon nigroviridis |
tetng-q4syn5 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) | Tetraodon nigroviridis |
tetng-q4t8q3 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) | Tetraodon nigroviridis |
tupch-l8ych4 | Tupaia chinensis (Chinese tree shrew) Bile salt-activated lipase | Tupaia chinensis |
Substrate | Chemical Nomenclature | Proteins |
---|---|---|
C8-MGDG | [(2S)-2-octanoyloxy-3-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl] octanoate | human-PNLIPRP2 talth-f6lqk7 nech7-c7yuz1 cavpo-2plrp human-CEL bovin-balip canan-lipasA rhimi-lipas rhidl-lipas |
Cholesteryl-oleate | [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (Z)-octadec-9-enoate | human-NCEH1 |
Dipentyl-phthalate | dipentyl benzene-1,2-dicarboxylate | pig-i3ltk9 bovin-balip |
Dipropyl-phthalate | dipropyl benzene-1,2-dicarboxylate | malci-McLipB pig-i3ltk9 bovin-balip |
Monoacetylglycerol | [(2S)-2,3-dihydroxypropyl] acetate | human-CEL pig-EST1 canar-LipB |
Oryzanol | [7,7,12,16-tetramethyl-15-(6-methylhept-5-en-2-yl)-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate || [(1S,3R,6S,8R,11S,12S,15R,16R)-7,7,12,16-tetramethyl-15-[(2R)-6-methylhept-5-en-2-yl]-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] || [(3R,6S,12S,15R,16R)-7,7,12,16-tetramethyl-15-(6-methylhept-5-en-2-yl)-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate || [(3S,6S,12S,15R,16R)-7,7,12,16-tetramethyl-15-[(2S)-6-methylhept-5-en-2-yl]-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate || [(3R,12S,16R)-7,7,12,16-tetramethyl-15-(6-methylhept-5-en-2-yl)-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate || [(1R,3R,6S,8R,11S,12S,15R,16R)-7,7,12,16-tetramethyl-15-[(2R)-6-methylhept-5-en-2-yl]-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate || [(3R,6S,12S,15R,16R)-7,7,12,16-tetramethyl-15-[(2R)-6-methylhept-5-en-2-yl]-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate | muspf-m3yly9 |
Paranitrophenylbutyrate | (4-nitrophenyl) butanoate | bactc-lipas 9acto-f7ix06 artox-phhyd burgl-EstC bovin-balip rabit-1cxes psesp-OPH 9bact-H6BDX1 9bact-a0a2s1gux0 human-NOTUM 9delt-EstD11 9pezi-s4vch4 aspfu-q4x1n0 crysp-Q874E9 fusso-cutas pyrbr-Q9Y7G8 copci-b9u443 strsw-c9zcr8 humin-cut human-DAGLA 9baci-EstD9 9rhiz-g9i933 canar-LipB bacsu-pnbae thefu-q6a0i4 geost-est30 geost-est50 pyrab-PAB1050 sulad-g8tv28 |
Retinol-oleate | [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] (Z)-octadec-9-enoate | human-PNLIPRP2 |
Retinol-palmitate | [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] hexadecanoate | human-PNLIPRP2 human-PNLIP ratno-Ces1d mouse-Ces1d canru-1lipa pig-i3ltk9 human-LIPA |
Tributyrin | 2,3-di(butanoyloxy)propyl butanoate | bovin-balip rabit-1cxes pseae-llipa canar-LipB human-PNLIPRP2 talth-f6lqk7 nech7-c7yuz1 cavpo-2plrp human-CEL human-PNLIP canan-lipasA rhimi-lipas rhidl-lipas psesp-Q9RBY1 staha-Q9RGZ6 9bact-6EB3 pig-EST1 |
Tripropionin | 2,3-di(propanoyloxy)propyl propanoate | bovin-balip rabit-1cxes pseae-llipa staha-Q9RGZ6 |
Vinyl-acetate | ethenyl acetate | 9psed-q0mrg5 bovin-balip rabit-1cxes |
Vinyl-butyrate | ethenyl butanoate | bovin-balip rabit-1cxes |
Vinyl-laurate | ethenyl dodecanoate | bovin-balip rabit-1cxes |
Vinyl-propionate | ethenyl propanoate | bovin-balip rabit-1cxes |
Inhibitor | Chemical Nomenclature | Proteins |
---|---|---|
3-Cholesteryl-N-butylcarbamate | [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-butylcarbamate | pig-i3ltk9 |
3-Cholesteryl-N-octylcarbamate | [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-octylcarbamate | pig-i3ltk9 |
CHEMBL3125346 | 6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline | pig-i3ltk9 |
CHEMBL3125351 | 2-(1H-indol-3-yl)-6-nitro-4-phenylquinoline | pig-i3ltk9 |
DEUP | diethyl (2-oxochromen-7-yl) phosphate | human-NCEH1 luccu-E3aest7 |
IMP-pNP | 1-[methyl(propan-2-yloxy)phosphoryl]oxy-4-nitrobenzene | human-ACHE human-CEL |
KC01 | (6Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide | human-ABHD16A human-ABHD12 mouse-Abhd16a |
NEDPA | N-[ethoxy-(4-nitrophenoxy)phosphoryl]-N-methylmethanamine | torca-ACHE human-CEL |
NEMP | 1-[ethoxy(methyl)phosphoryl]oxy-4-nitrobenzene | human-ACHE human-CEL |
Piperidinyl-1,2,3-triazole-urea-inhibitor-2 | 4-[4-[2-[(2R)-2-phenylpiperidine-1-carbonyl]triazol-4-yl]phenyl]benzoic acid | human-LYPLAL1 |
SCHEMBL3761170 | 6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyrone | mesau-a0a1u8cxs4 |
WAY-121898 | (4-phenoxyphenyl) 4-methylpiperidine-1-carboxylate | pig-i3ltk9 |
p-nitrophenyl-N-butyl-N-methyl-carbamate | (4-nitrophenyl) N-butylmethylcarbamate | human-CEL |
p-nitrophenyl-N-butyl-carbamate | (4-nitrophenyl) N-butylcarbamate | pig-i3ltk9 |
p-nitrophenyl-N-octyl-carbamate | (4-nitrophenyl) N-octylcarbamate | pig-i3ltk9 |
Title : Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes - Tang_2022_Front.Genet_13_909091 |
Author(s) : Tang SL , Liang XF , He S , Li L , Alam MS , Wu J |
Ref : Front Genet , 13 :909091 , 2022 |
Abstract : |
PubMedSearch : Tang_2022_Front.Genet_13_909091 |
PubMedID: 35991544 |
Title : Comparative Structures and Evolution of Vertebrate Carboxyl Ester Lipase (CEL) Genes and Proteins with a Major Role in Reverse Cholesterol Transport - Holmes_2011_Cholesterol_2011_781643 |
Author(s) : Holmes RS , Cox LA |
Ref : Cholesterol , 2011 :781643 , 2011 |
Abstract : |
PubMedSearch : Holmes_2011_Cholesterol_2011_781643 |
PubMedID: 22162806 |
Title : The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding - Moore_2001_J.Mol.Biol_312_511 |
Author(s) : Moore SA , Kingston RL , Loomes KM , Hernell O , Blackberg L , Baker HM , Baker EN |
Ref : Journal of Molecular Biology , 312 :511 , 2001 |
Abstract : |
PubMedSearch : Moore_2001_J.Mol.Biol_312_511 |
PubMedID: 11563913 |
Gene_locus related to this paper: human-CEL |
Title : Crystal structure of the catalytic domain of human bile salt activated lipase - Terzyan_2000_Protein.Sci_9_1783 |
Author(s) : Terzyan S , Wang CS , Downs D , Hunter B , Zhang XC |
Ref : Protein Science , 9 :1783 , 2000 |
Abstract : |
PubMedSearch : Terzyan_2000_Protein.Sci_9_1783 |
PubMedID: 11045623 |
Gene_locus related to this paper: human-CEL |
Title : Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation - Chen_1998_Biochemistry_37_5107 |
Author(s) : Chen JC , Miercke LJ , Krucinski J , Starr JR , Saenz G , Wang X , Spilburg CA , Lange LG , Ellsworth JL , Stroud RM |
Ref : Biochemistry , 37 :5107 , 1998 |
Abstract : |
PubMedSearch : Chen_1998_Biochemistry_37_5107 |
PubMedID: 9548741 |
Gene_locus related to this paper: bovin-balip |
Title : The crystal structure of bovine bile salt activated lipase: insights into the bile salt activation mechanism - Wang_1997_Structure_5_1209 |
Author(s) : Wang X , Wang CS , Tang J , Dyda F , Zhang XC |
Ref : Structure , 5 :1209 , 1997 |
Abstract : |
PubMedSearch : Wang_1997_Structure_5_1209 |
PubMedID: 9331420 |
Gene_locus related to this paper: bovin-balip |