ratno-fas

Rattus norvegicus (Rat) fatty acid synthase FAS Thioesterase domain

Comment

Relationship

Family : Thioesterase

Block : X

Position in NCBI Life Tree : Rattus norvegicus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Rattus N E > Rattus norvegicus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

NDTSLKQAQL NLSILLVNPE GPTLTRLNSV QSSERPLFLV HPIEGSITVF HSLAAKLSVP TYGLQCTQAA PLDSIPNLAA YYIDCIKQVQ PEGPYRVAGY SFGACVAFEM CSQLQAQQGP APAHNNLFLF DGSHTYVLAY TQSYRAKLTP GCEAEAEAEA ICFFIKQFVD AEHSKVLEAL LPLKSLEDRV AAAVDLITRS HQSLDRRDLS FAAVSFYYKL RAADQYKPKA KYHGNVILLR AKTGGTYGED LGADYNLSQV CDGKVSVHII EGDHRTLLEG RGLESIINII HSSLAEPRVS VREG

References (17)

Title : Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues - Lundby_2012_Nat.Commun_3_876
Author(s) : Lundby A , Secher A , Lage K , Nordsborg NB , Dmytriyev A , Lundby C , Olsen JV
Ref : Nat Commun , 3 :876 , 2012
Abstract :
PubMedSearch : Lundby_2012_Nat.Commun_3_876
PubMedID: 22673903
Gene_locus related to this paper: ratno-2neur , ratno-fas

Title : Catalytic residues are shared between two pseudosubunits of the dehydratase domain of the animal fatty acid synthase - Pasta_2007_Chem.Biol_14_1377
Author(s) : Pasta S , Witkowski A , Joshi AK , Smith S
Ref : Chemical Biology , 14 :1377 , 2007
Abstract :
PubMedSearch : Pasta_2007_Chem.Biol_14_1377
PubMedID: 18096506
Gene_locus related to this paper: ratno-fas

Title : Fatty acid synthase: a novel target for antiglioma therapy - Zhao_2006_Br.J.Cancer_95_869
Author(s) : Zhao W , Kridel S , Thorburn A , Kooshki M , Little J , Hebbar S , Robbins M
Ref : Br J Cancer , 95 :869 , 2006
Abstract :
PubMedSearch : Zhao_2006_Br.J.Cancer_95_869
PubMedID: 16969344
Gene_locus related to this paper: ratno-fas

Title : Insulin acutely decreases hepatic fatty acid synthase activity - Najjar_2005_Cell.Metab_2_43
Author(s) : Najjar SM , Yang Y , Fernstrom MA , Lee SJ , Deangelis AM , Rjaily GA , Al-Share QY , Dai T , Miller TA , Ratnam S , Ruch RJ , Smith S , Lin SH , Beauchemin N , Oyarce AM
Ref : Cell Metab , 2 :43 , 2005
Abstract :
PubMedSearch : Najjar_2005_Cell.Metab_2_43
PubMedID: 16054098
Gene_locus related to this paper: ratno-fas

Title : Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates - Rendina_2005_Biochem.J_388_895
Author(s) : Rendina AR , Cheng D
Ref : Biochemical Journal , 388 :895 , 2005
Abstract :
PubMedSearch : Rendina_2005_Biochem.J_388_895
PubMedID: 15715522
Gene_locus related to this paper: ratno-fas

Title : Genome sequence of the Brown Norway rat yields insights into mammalian evolution - Gibbs_2004_Nature_428_493
Author(s) : Gibbs RA , Weinstock GM , Metzker ML , Muzny DM , Sodergren EJ , Scherer S , Scott G , Steffen D , Worley KC , Burch PE , Okwuonu G , Hines S , Lewis L , DeRamo C , Delgado O , Dugan-Rocha S , Miner G , Morgan M , Hawes A , Gill R , Celera , Holt RA , Adams MD , Amanatides PG , Baden-Tillson H , Barnstead M , Chin S , Evans CA , Ferriera S , Fosler C , Glodek A , Gu Z , Jennings D , Kraft CL , Nguyen T , Pfannkoch CM , Sitter C , Sutton GG , Venter JC , Woodage T , Smith D , Lee HM , Gustafson E , Cahill P , Kana A , Doucette-Stamm L , Weinstock K , Fechtel K , Weiss RB , Dunn DM , Green ED , Blakesley RW , Bouffard GG , de Jong PJ , Osoegawa K , Zhu B , Marra M , Schein J , Bosdet I , Fjell C , Jones S , Krzywinski M , Mathewson C , Siddiqui A , Wye N , McPherson J , Zhao S , Fraser CM , Shetty J , Shatsman S , Geer K , Chen Y , Abramzon S , Nierman WC , Havlak PH , Chen R , Durbin KJ , Egan A , Ren Y , Song XZ , Li B , Liu Y , Qin X , Cawley S , Cooney AJ , D'Souza LM , Martin K , Wu JQ , Gonzalez-Garay ML , Jackson AR , Kalafus KJ , McLeod MP , Milosavljevic A , Virk D , Volkov A , Wheeler DA , Zhang Z , Bailey JA , Eichler EE , Tuzun E , Birney E , Mongin E , Ureta-Vidal A , Woodwark C , Zdobnov E , Bork P , Suyama M , Torrents D , Alexandersson M , Trask BJ , Young JM , Huang H , Wang H , Xing H , Daniels S , Gietzen D , Schmidt J , Stevens K , Vitt U , Wingrove J , Camara F , Mar Alba M , Abril JF , Guigo R , Smit A , Dubchak I , Rubin EM , Couronne O , Poliakov A , Hubner N , Ganten D , Goesele C , Hummel O , Kreitler T , Lee YA , Monti J , Schulz H , Zimdahl H , Himmelbauer H , Lehrach H , Jacob HJ , Bromberg S , Gullings-Handley J , Jensen-Seaman MI , Kwitek AE , Lazar J , Pasko D , Tonellato PJ , Twigger S , Ponting CP , Duarte JM , Rice S , Goodstadt L , Beatson SA , Emes RD , Winter EE , Webber C , Brandt P , Nyakatura G , Adetobi M , Chiaromonte F , Elnitski L , Eswara P , Hardison RC , Hou M , Kolbe D , Makova K , Miller W , Nekrutenko A , Riemer C , Schwartz S , Taylor J , Yang S , Zhang Y , Lindpaintner K , Andrews TD , Caccamo M , Clamp M , Clarke L , Curwen V , Durbin R , Eyras E , Searle SM , Cooper GM , Batzoglou S , Brudno M , Sidow A , Stone EA , Payseur BA , Bourque G , Lopez-Otin C , Puente XS , Chakrabarti K , Chatterji S , Dewey C , Pachter L , Bray N , Yap VB , Caspi A , Tesler G , Pevzner PA , Haussler D , Roskin KM , Baertsch R , Clawson H , Furey TS , Hinrichs AS , Karolchik D , Kent WJ , Rosenbloom KR , Trumbower H , Weirauch M , Cooper DN , Stenson PD , Ma B , Brent M , Arumugam M , Shteynberg D , Copley RR , Taylor MS , Riethman H , Mudunuri U , Peterson J , Guyer M , Felsenfeld A , Old S , Mockrin S , Collins F
Ref : Nature , 428 :493 , 2004
Abstract :
PubMedSearch : Gibbs_2004_Nature_428_493
PubMedID: 15057822
Gene_locus related to this paper: rat-abhea , rat-abheb , rat-cd029 , rat-d3zaw4 , rat-dpp9 , rat-d3zhq1 , rat-d3zkp8 , rat-d3zuq1 , rat-d3zxw8 , rat-d4a4w4 , rat-d4a7w1 , rat-d4a9l7 , rat-d4a071 , rat-d4aa31 , rat-d4aa33 , rat-d4aa61 , rat-dglb , rat-f1lz91 , rat-Kansl3 , rat-nceh1 , rat-Tex30 , ratno-1hlip , ratno-1neur , ratno-1plip , ratno-2neur , ratno-3neur , ratno-3plip , ratno-ABH15 , ratno-ACHE , ratno-balip , ratno-BCHE , ratno-cauxin , ratno-Ces1d , ratno-Ces1e , ratno-Ces2f , ratno-m0r8j8 , ratno-d3ze31 , ratno-d3zp14 , ratno-d3zxi3 , ratno-d3zxq0 , ratno-d3zxq1 , ratno-d4a3d4 , ratno-d4aa05 , ratno-dpp4 , ratno-dpp6 , ratno-est8 , ratno-FAP , ratno-fas , ratno-hyep , ratno-hyes , ratno-kmcxe , ratno-lmcxe , ratno-LOC246252 , ratno-MGLL , ratno-pbcxe , ratno-phebest , ratno-Ppgb , ratno-q4qr68 , ratno-q6ayr2 , ratno-q6q629 , ratno-SPG21 , ratno-thyro , rat-m0rc77 , rat-a0a0g2k9y7 , rat-a0a0g2kb83 , rat-d3zba8 , rat-d3zbj1 , rat-d3zcr8 , rat-d3zxw5 , rat-d4a340 , rat-f1lvg7 , rat-m0r509 , rat-m0r5d4 , rat-b5den3 , rat-d3zxk4 , rat-d4a1b6 , rat-d3zmg4 , rat-ab17c , rat-g3v7a7

Title : The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs - Reed_2003_Org.Biomol.Chem_1_463
Author(s) : Reed MA , Schweizer M , Szafranska AE , Arthur C , Nicholson TP , Cox RJ , Crosby J , Crump MP , Simpson TJ
Ref : Org Biomol Chem , 1 :463 , 2003
Abstract :
PubMedSearch : Reed_2003_Org.Biomol.Chem_1_463
PubMedID: 12926246
Gene_locus related to this paper: ratno-fas

Title : Characterization of the interthiol acyltransferase reaction catalyzed by the beta-ketoacyl synthase domain of the animal fatty acid synthase - Witkowski_1997_Biochemistry_36_16338
Author(s) : Witkowski A , Joshi AK , Smith S
Ref : Biochemistry , 36 :16338 , 1997
Abstract :
PubMedSearch : Witkowski_1997_Biochemistry_36_16338
PubMedID: 9405069
Gene_locus related to this paper: ratno-fas

Title : Fatty acid synthase: in vitro complementation of inactive mutants - Witkowski_1996_Biochemistry_35_10569
Author(s) : Witkowski A , Joshi A , Smith S
Ref : Biochemistry , 35 :10569 , 1996
Abstract :
PubMedSearch : Witkowski_1996_Biochemistry_35_10569
PubMedID: 8756713
Gene_locus related to this paper: ratno-fas

Title : Construction of a cDNA encoding the multifunctional animal fatty acid synthase and expression in Spodoptera frugiperda cells using baculoviral vectors - Joshi_1993_Biochem.J_296 ( Pt 1)_143
Author(s) : Joshi AK , Smith S
Ref : Biochemical Journal , 296 ( Pt 1) :143 , 1993
Abstract :
PubMedSearch : Joshi_1993_Biochem.J_296 ( Pt 1)_143
PubMedID: 8250834
Gene_locus related to this paper: ratno-fas

Title : The fatty acid synthase (FAS) gene and its promoter in Rattus norvegicus. -
Author(s) : Beck KF , Schreglmann R , Stathopulos I , Klein H , Hoch J , Schweizer M
Ref : DNA Sequence , 2 :359 , 1992
PubMedID: 1339331
Gene_locus related to this paper: ratno-fas

Title : Intron-exon organization of the gene for the multifunctional animal fatty acid synthase - Amy_1992_Proc.Natl.Acad.Sci.U.S.A_89_1105
Author(s) : Amy CM , Williams-Ahlf B , Naggert J , Smith S
Ref : Proc Natl Acad Sci U S A , 89 :1105 , 1992
Abstract :
PubMedSearch : Amy_1992_Proc.Natl.Acad.Sci.U.S.A_89_1105
PubMedID: 1736293
Gene_locus related to this paper: ratno-fas

Title : Nutritional control of rat liver fatty acid synthase and S14 mRNA abundance - Clarke_1990_J.Nutr_120_218
Author(s) : Clarke SD , Armstrong MK , Jump DB
Ref : J Nutr , 120 :218 , 1990
Abstract :
PubMedSearch : Clarke_1990_J.Nutr_120_218
PubMedID: 2313386
Gene_locus related to this paper: ratno-fas

Title : Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase. -
Author(s) : Amy CM , Witkowski A , Naggert J , Williams B , Randhawa Z , Smith S , Randhawa ZI
Ref : Proceedings of the National Academy of Sciences of the United States of America , 86 :3114 , 1989
PubMedID: 2717611
Gene_locus related to this paper: ratno-fas

Title : Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation\/termination signals in the cDNA. -
Author(s) : Schweizer M , Takabeyashi K , Beck KF , Schreglmann R
Ref : Nucleic Acids Res , 17 :567 , 1989
PubMedID: 2915923
Gene_locus related to this paper: ratno-fas

Title : Molecular cloning and sequencing of a cDNA encoding the thioesterase domain of the rat fatty acid synthetase. -
Author(s) : Naggert J , Witkowski A , Mikkelsen J , Smith S
Ref : Journal of Biological Chemistry , 263 :1146 , 1988
PubMedID: 2891707
Gene_locus related to this paper: ratno-fas

Title : Molecular cloning and sequencing of a cDNA encoding the acyl carrier protein and its flanking domains in the mammalian fatty acid synthetase. -
Author(s) : Witlowski A , Naggert J , Mikkelsen J , Smith S
Ref : European Journal of Biochemistry , 165 :601 , 1987
PubMedID: 3109907
Gene_locus related to this paper: ratno-fas