Gene_locus Report for: bovin-2neur Bos taurus (Bovine), Bos mutus (Wild Yak) NLGN2 Neuroligin 2
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Laurasiatheria: N E > Cetartiodactyla: N E > Ruminantia: N E > Pecora: N E > Bovidae: N E > Bovinae: N E > Bos: N E > Bos taurus: N E A85-EsteraseD-FGH :
bovin-estd Bos taurus (Bovine) Esterase D .
ABHD6-Lip :
bovin-q1lz86 Bos taurus (Bovine) similar to abhydrolase domain containing 6 .
ABHD8 :
bovin-abhd8 Bos taurus (Bovine); Bos mutus (wild yak) abhydrolase domain-containing protein 8 (EC 3.-.-.-) .
ABHD10 :
bovin-ABHDA Bos taurus (Bovine); Bos mutus (wild yak) abhydrolase domain containing 10 .
ABHD11-Acetyl_transferase :
bovin-q3sz73 Bos taurus (Bovine) abhydrolase domain containing 11 .
ABHD12-PHARC :
bovin-f1mps6 Bos taurus (Bovine) Uncharacterized protein ,
bovin-q08dw9 Bos taurus (Bovine), Bos mutus (wild Yak) abhydrolase domain containing protein 12 .
ABHD13-BEM46 :
bovin-a7mb66 Bos taurus (Bovine). Abhydrolase domain containing 13 .
ABHD16 :
bovin-ABHD16A Bos taurus (Bovine) Phosphatidylserine lipase ABHD16A HLA-B-associated transcript 5 BAT5 ,
bovin-ABHD16B Bos taurus (Bovine); Bos mutus (wild yak) Abhydrolase domain containing 16B .
ABHD17-depalmitoylase :
bovin-AB17A Bos taurus (Bovine) Abhydrolase domain-containing protein FAM108A ,
bovin-AB17C Bos taurus (Bovine) Abhydrolase domain-containing protein FAM108C1 .
ABHD18 :
bovin-f1n673 Bos taurus (Bovine). Uncharacterized protein .
abh_upf0017 :
bovin-abhd1 Bos taurus (Bovine) lung alpha/beta hydrolase 1 (Labh1-pending) hypothetical protein mgc127615 ,
bovin-abhd2 Bos taurus (Bovine) alpha/beta hydrolase domain containing protein 2 ,
bovin-abhd3 Bos taurus (Bovine) Abhydrolase domain-containing protein 3 ,
bovin-e1bkm2 Bos taurus (Bovine) Abhydrolase domain containing 15 .
ACHE :
bovin-ACHE Bos taurus protein for acetylcholinesterase T subunit .
Acidic_Lipase :
bovin-1lipg Bos taurus (Bovine) Gastric triacylglycerol lipase ,
bovin-e1ba50 Bos taurus (Bovine) Lipase ,
bovin-e1bnt1 Bos taurus (Bovine) Lipase LIPJ ,
bovin-f1msa3 Bos taurus (Bovine) Lipase LIPK ,
bovin-f1n110 Bos taurus (Bovine) Lipase .
ACPH_Peptidase_S9 :
bovin-acph Bos taurus (Bovine) Acylaminoacyl-peptidase .
Arb2_FAM172A :
bovin-a0a3q1nm09 Bos taurus (Bovine); Bos mutus (wild yak). Uncharacterized protein .
Arylacetamide_deacetylase :
bovin-aaad Bos taurus (Bovine); Bos mutus (Bovine, wild yak) Arylacetamide deacetylase ,
bovin-nceh1 Bos taurus (Bovine); Bos mutus Arylacetamide deacetylase-like 1 ,
bovin-g5e5g5 Bos taurus (Bovine). Uncharacterized protein ,
bovin-g5e5i3 Bos taurus (Bovine). Uncharacterized protein .
BCHE :
bovin-BCHE Bos taurus (Bovine), Bos mutus (wild yak) butyrylcholinesterase .
Carboxypeptidase_S10 :
bovin-ppgb Bos taurus (Bovine) Lysosomal protective protein Cathepsin A Peptidase_S10 mgc128937 ,
bovin-q2nkz9 Bos taurus (Bovine) similar to serine carboxypeptidase 1 protein .
Carb_B_Chordata :
bovin-e1bn79 Bos taurus (Bovine) Bos mutus (Yak) cauxin ,
bovin-est8 Bos taurus (Bovine) Bos mutus (Yak) Carboxylesterase 4A (Carboxylesterase 8) UNQ440/PRO873 homolog ,
bovin-f1mi11 Bos taurus (Bovine) Bos mutus (Yak) Uncharacterized protein ,
bovin-q2kj30 Bos taurus (Bovine), Bos mutus (Yak) hypothetical protein ,
bovin-q3t0r6 Bos taurus (Bovine), Bos mutus (Yak) hypothetical protein mgc127393 ,
bovin-q5myb8 Bos taurus (Bovine) retinyl ester hydrolase type 1 breh1 .
CGI-58_ABHD5_ABHD4 :
bovin-abhd4 Bos taurus (Bovine) abhydrolase domain containing protein 4 Lyso-N-acylphosphatidylethanolamine lipase ,
bovin-q0vcc8 Bos taurus (Bovine) Abhydrolase domain containing 5 .
Cholesterol_esterase :
bovin-balip .
CIB-CCG1-interacting-factor-B :
bovin-abheb Bos taurus (Bovine) Abhydrolase domain-containing protein 14B ,
bovin-f1mr65 Bos taurus (Bovine) Uncharacterized protein .
CMBL :
bovin-f1n2i5 Bos taurus (Bovine); Bos indicus x Bos taurus (Hybrid cattle); Bos mutus (wild yak). Carboxymethylenebutenolidase homolog .
DPP4N_Peptidase_S9 :
bovin-a0jnh8 Bos taurus (Bovine) Dipeptidyl-peptidase 10 ,
bovin-a5d7b7 Bos taurus (Bovine) Uncharacterized protein ,
bovin-dpp4 Bos taurus (Bovine) dipeptidyl peptidase IV ,
bovin-dpp6 Bos taurus (Bovine) related protein) (dipeptidylpeptidase VI) (dppx) ,
bovin-e1bi31 Bos taurus (Bovine) Uncharacterized protein ,
bovin-f1n1l4 Bos taurus (Bovine) Uncharacterized protein .
Duf_676 :
bovin-e1bpw3 Bos taurus (Bovine) Uncharacterized protein ,
bovin-f1mcd9 Bos taurus (Bovine) Uncharacterized protein .
Duf_829 :
bovin-tmm53 Bos taurus (Bovine) Transmembrane protein 53 .
Epoxide_hydrolase :
bovin-q3zcj6 Bos taurus (Bovine) hypothetical protein mgc126963 .
FSH1 :
bovin-OVCA2 Bos taurus (Bovine); Bos mutus (wild yak) hypothetical protein mgc128661 .
Hepatic_Lipase :
bovin-q3sz79 Bos taurus (Bovine); Bos mutus grunniens (Wild yak) (Bos grunniens) lipase, hepatic .
Hormone-sensitive_lipase_like :
bovin-hslip Bos taurus (Bovine) 17.6 kda hormone-sensitive lipase (fragment) .
Kynurenine-formamidase :
bovin-e1bll5 Bos taurus (Bovine). N-formylkynurenine formamidase .
Lipase_3 :
bovin-e1bbv2 Bos taurus (Bovine); Bos mutus (wild yak) Uncharacterized protein .
Lipoprotein_Lipase :
bovin-lipli ,
bovin-LIPG Bos taurus; Bos mutus (wild yak) lipase G, endothelial type (LIPG) .
LYsophospholipase_carboxylesterase :
bovin-lypa1 Bos taurus (Bovine) lysophospholipase I .
Maspardin-ACP33-SPG21_like :
bovin-SPG21 Bos taurus (Bovine); Bos mutus (wild Yak) hypothetical protein acid cluster protein 33 ACP33 SPG21 maspardin .
MEST-like :
bovin-q2hjm9 Bos taurus (Bovine) mesoderm-specific transcript Paternally-expressed gene 1 peg1 (fragment) .
Ndr_family :
bovin-ndr1 Bos taurus (Bovine) hypothetical protein mgc127533 ,
bovin-ndrg2 Bos taurus (Bovine) mgc128884 Protein NDRG2 ,
bovin-ndrg3 Bos taurus (Bovine) Protein NDRG3 ,
bovin-q0vck8 Bos taurus (Bovine) Uncharacterized protein .
Neuroligin :
bovin-3neur Bos taurus (Bovine) similar to neuroligin 3 ,
bovin-g3mxp5 Bos taurus (Bovine) Bos mutus (Yak) Neuroligin-3 .
NLS3-Tex30 :
bovin-KANSL3 Bos taurus (Bovine) Bos Mutus (Yak) LOC618190 protein ,
bovin-TEX30 Bos taurus (Bovine), Bos mutus (Yak) Testis-expressed sequence 30 protein, C13orf27 homolog .
PAF-Acetylhydrolase :
bovin-paf2 Bos taurus (Bovine) (EC 3.1.1.47) (serine dependent phospholipase a2) ,
bovin-pafa Bovine plasma PAF acetylhydrolase .
Palmitoyl-protein_thioesterase :
bovin-ppt ,
bovin-ppt2 Bos taurus (Bovine) Lysosomal thioesterase PPT2 .
Pancreatic_lipase :
bovin-lipr2 Bos taurus (Bovine); Bos mutus (wild yak) Pancreatic lipase-related protein 2 Can hydrolyze both phospholipids and galactolipids ,
bovin-e1bjq9 Bos taurus (Bovine); Bos mutus (wild yak). Pancreatic lipase ,
bovin-f1mc21 Bos taurus (Bovine); Bos mutus (wild yak). Pancreatic lipase .
PC-sterol_acyltransferase :
bovin-lcat Bos taurus (Bovine) phosphatidylcholine-sterol acyltransferase ,
bovin-LPLA2 Bos taurus (Bovine) lysosomal phospholipase a2 ( lysophospholipase 3) .
Pectinacetylesterase-Notum :
bovin-f1mbd6 Bos taurus (Bovine) palmitoleoyl-protein carboxylesterase NOTUM .
PGAP1 :
bovin-e1bnq0 Bos taurus (Bovine) Uncharacterized protein ,
bovin-srac1 Bos taurus (Bovine) Protein SERAC1 .
Phospholipase :
bovin-q5e9h0 Bos taurus (Bovine) phospholipase a1 member a ,
bovin-f1mxa8 Bos taurus (Bovine). Lipase H .
PPase_methylesterase_euk :
bovin-ppme1 Bos taurus (Bovine) protein phosphatase methylesterase-1 .
Prolylcarboxypeptidase :
bovin-a6qnx2 Bos taurus (Bovine) DPP7 protein ,
bovin-q2ta14 Bos taurus (Bovine) hypothetical protein .
S9N_PPCE_Peptidase_S9 :
bovin-ppce Bos taurus (Bovine) (PE) .
SERHL :
bovin-f1n385 Bos taurus (Bovine); Bos mutus (wild yak) Uncharacterized protein .
Thioesterase :
bovin-fas Bos taurus (Bovine) oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14) .
Thyroglobulin :
bovin-thyro .
Valacyclovir-hydrolase :
bovin-q2kix6 Bos taurus (Bovine) Biphenyl hydrolase-like Serine hydrolase; breast epithelial mucin-associated antigen Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can
retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Bos grunniens mutus:
N ,
E .
Bos mutus:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: bovin-2neur Colored MSA for Neuroligin (raw)
EERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPP
EAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQ
SEDCLYLNLYVPTEDDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAY
GNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGG
DPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQP
LKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPV
VDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSAS
AFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLAL
FTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDEL
PYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQD
TKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLEL
VPHLHNLHTELFTTTTRLPPYATRWPPRPPPGAPGTRRPPPPATLPPEPE
PEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRR
QELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVG
ADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPP
SLHPFGPFPPPPPTATSHNNTLPHPHSTTRV
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
E E R F P V V N T A Y G R V R G V R R E L N N E I L G P V V Q F L G V P Y A T P P L G A R R F Q P P E A P A S W P G V R N A T T L P P A C P Q N L H G A L P A I M L P V W F T D N L E A A A T Y V Q N Q S E D C L Y L N L Y V P T E D D I R D S G K K P V M L F L H G G S Y M E G T G N M F D G S V L A A Y G N V I V A T L N Y R L G V L G F L S T G D Q A A K G N Y G L L D Q I Q A L R W L S E N I A H F G G D P E R I T I F G S G A G A S C V N L L I L S H H S E G L F Q K A I A Q S G T A I S S W S V N Y Q P L K Y T R L L A A K V G C D R E D S A E A V E C L R R K P S R E L V D Q D V Q P A R Y H I A F G P V V D G D V V P D D P E I L M Q Q G E F L N Y D M L I G V N Q G E G L K F V E D S A E S E D G V S A S A F D F T V S N F V D N L Y G Y P E G K D V L R E T I K F M Y T D W A D R D N G E M R R K T L L A L F T D H Q W V A P A V A T A K L H A D Y Q S P V Y F Y T F Y H H C Q A E G R P E W A D A A H G D E L P Y V F G V P M V G A T D L F P C N F S K N D V M L S A V V M T Y W T N F A K T G D P N Q P V P Q D T K F I H T K P N R F E E V V W S K F N S K E K Q Y L H I G L K P R V R D N Y R A N K V A F W L E L V P H L H N L H T E L F T T T T R L P P Y A T R W P P R P P P G A P G T R R P P P P A T L P P E P E P E P G P R A Y D R F P G D S R D Y S T E L S V T V A V G A S L L F L N I L A F A A L Y Y K R D R R Q E L R C R R L S P P G G S G S G V P G G G P L L P A A G R E L P P E E E L V S L Q L K R G G G V G A D P A E A L R P A C P P D Y T L A L R R A P D D V P L L A P G A L T L L P S G L G P P P P P P P P S L H P F G P F P P P P P T A T S H N N T L P H P H S T T R V
References
Title: The yak genome and adaptation to life at high altitudeQiu Q , Zhang G , Ma T , Qian W , Wang J , Ye Z , Cao C , Hu Q , Kim J and Liu J <35 more author(s)> Qiu Q , Zhang G , Ma T , Qian W , Wang J , Ye Z , Cao C , Hu Q , Kim J , Larkin DM , Auvil L , Capitanu B , Ma J , Lewin HA , Qian X , Lang Y , Zhou R , Wang L , Wang K , Xia J , Liao S , Pan S , Lu X , Hou H , Wang Y , Zang X , Yin Y , Ma H , Zhang J , Wang Z , Zhang Y , Zhang D , Yonezawa T , Hasegawa M , Zhong Y , Liu W , Huang Z , Zhang S , Long R , Yang H , Lenstra JA , Cooper DN , Wu Y , Shi P , Liu J (- 35) Ref: Nat Genet, 44 :946, 2012 : PubMed Abstract ESTHER: Qiu_2012_Nat.Genet_44_946 PubMedSearch: Qiu 2012 Nat.Genet 44 946 PubMedID: 22751099 Gene_locus related to this paper: bosmu-l8ic43 ,
bovin-2neur ,
bovin-balip ,
bovin-BCHE ,
bovin-e1bbv2 ,
bovin-e1bn79 ,
bovin-est8 ,
bovin-f1mi11 ,
bovin-f1n385 ,
bovin-g3mxp5 ,
bovin-lipli ,
bovin-lipr2 ,
bovin-q2kj30 ,
bovin-q3sz79 ,
bovin-q3t0r6 ,
bovin-ABHDA ,
bovin-q08dw9 ,
bovin-ABHD16B ,
bovin-SPG21 ,
bovin-TEX30 ,
9ceta-l8iwv2 ,
9ceta-l8idy3 ,
9ceta-l8hsi3 ,
bovin-e1bjq9 ,
bovin-f1mc21 ,
9ceta-l8hyl8 ,
bovin-LIPG ,
bovin-a0a3q1nm09 ,
bovin-f1n2i5 Abstract
Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.
Title: The genome sequence of taurine cattle: a window to ruminant biology and evolutionElsik CG , Tellam RL , Worley KC , Gibbs RA , Muzny DM , Weinstock GM , Adelson DL , Eichler EE , Elnitski L and Zhao FQ <297 more author(s)> Elsik CG , Tellam RL , Worley KC , Gibbs RA , Muzny DM , Weinstock GM , Adelson DL , Eichler EE , Elnitski L , Guigo R , Hamernik DL , Kappes SM , Lewin HA , Lynn DJ , Nicholas FW , Reymond A , Rijnkels M , Skow LC , Zdobnov EM , Schook L , Womack J , Alioto T , Antonarakis SE , Astashyn A , Chapple CE , Chen HC , Chrast J , Camara F , Ermolaeva O , Henrichsen CN , Hlavina W , Kapustin Y , Kiryutin B , Kitts P , Kokocinski F , Landrum M , Maglott D , Pruitt K , Sapojnikov V , Searle SM , Solovyev V , Souvorov A , Ucla C , Wyss C , Anzola JM , Gerlach D , Elhaik E , Graur D , Reese JT , Edgar RC , McEwan JC , Payne GM , Raison JM , Junier T , Kriventseva EV , Eyras E , Plass M , Donthu R , Larkin DM , Reecy J , Yang MQ , Chen L , Cheng Z , Chitko-McKown CG , Liu GE , Matukumalli LK , Song J , Zhu B , Bradley DG , Brinkman FS , Lau LP , Whiteside MD , Walker A , Wheeler TT , Casey T , German JB , Lemay DG , Maqbool NJ , Molenaar AJ , Seo S , Stothard P , Baldwin CL , Baxter R , Brinkmeyer-Langford CL , Brown WC , Childers CP , Connelley T , Ellis SA , Fritz K , Glass EJ , Herzig CT , Iivanainen A , Lahmers KK , Bennett AK , Dickens CM , Gilbert JG , Hagen DE , Salih H , Aerts J , Caetano AR , Dalrymple B , Garcia JF , Gill CA , Hiendleder SG , Memili E , Spurlock D , Williams JL , Alexander L , Brownstein MJ , Guan L , Holt RA , Jones SJ , Marra MA , Moore R , Moore SS , Roberts A , Taniguchi M , Waterman RC , Chacko J , Chandrabose MM , Cree A , Dao MD , Dinh HH , Gabisi RA , Hines S , Hume J , Jhangiani SN , Joshi V , Kovar CL , Lewis LR , Liu YS , Lopez J , Morgan MB , Nguyen NB , Okwuonu GO , Ruiz SJ , Santibanez J , Wright RA , Buhay C , Ding Y , Dugan-Rocha S , Herdandez J , Holder M , Sabo A , Egan A , Goodell J , Wilczek-Boney K , Fowler GR , Hitchens ME , Lozado RJ , Moen C , Steffen D , Warren JT , Zhang J , Chiu R , Schein JE , Durbin KJ , Havlak P , Jiang H , Liu Y , Qin X , Ren Y , Shen Y , Song H , Bell SN , Davis C , Johnson AJ , Lee S , Nazareth LV , Patel BM , Pu LL , Vattathil S , Williams RL, Jr. , Curry S , Hamilton C , Sodergren E , Wheeler DA , Barris W , Bennett GL , Eggen A , Green RD , Harhay GP , Hobbs M , Jann O , Keele JW , Kent MP , Lien S , McKay SD , McWilliam S , Ratnakumar A , Schnabel RD , Smith T , Snelling WM , Sonstegard TS , Stone RT , Sugimoto Y , Takasuga A , Taylor JF , Van Tassell CP , Macneil MD , Abatepaulo AR , Abbey CA , Ahola V , Almeida IG , Amadio AF , Anatriello E , Bahadue SM , Biase FH , Boldt CR , Carroll JA , Carvalho WA , Cervelatti EP , Chacko E , Chapin JE , Cheng Y , Choi J , Colley AJ , de Campos TA , De Donato M , Santos IK , de Oliveira CJ , Deobald H , Devinoy E , Donohue KE , Dovc P , Eberlein A , Fitzsimmons CJ , Franzin AM , Garcia GR , Genini S , Gladney CJ , Grant JR , Greaser ML , Green JA , Hadsell DL , Hakimov HA , Halgren R , Harrow JL , Hart EA , Hastings N , Hernandez M , Hu ZL , Ingham A , Iso-Touru T , Jamis C , Jensen K , Kapetis D , Kerr T , Khalil SS , Khatib H , Kolbehdari D , Kumar CG , Kumar D , Leach R , Lee JC , Li C , Logan KM , Malinverni R , Marques E , Martin WF , Martins NF , Maruyama SR , Mazza R , McLean KL , Medrano JF , Moreno BT , More DD , Muntean CT , Nandakumar HP , Nogueira MF , Olsaker I , Pant SD , Panzitta F , Pastor RC , Poli MA , Poslusny N , Rachagani S , Ranganathan S , Razpet A , Riggs PK , Rincon G , Rodriguez-Osorio N , Rodriguez-Zas SL , Romero NE , Rosenwald A , Sando L , Schmutz SM , Shen L , Sherman L , Southey BR , Lutzow YS , Sweedler JV , Tammen I , Telugu BP , Urbanski JM , Utsunomiya YT , Verschoor CP , Waardenberg AJ , Wang Z , Ward R , Weikard R , Welsh TH, Jr. , White SN , Wilming LG , Wunderlich KR , Yang J , Zhao FQ (- 297) Ref: Science, 324 :522, 2009 : PubMed Abstract ESTHER: Elsik_2009_Science_324_522 PubMedSearch: Elsik 2009 Science 324 522 PubMedID: 19390049 Gene_locus related to this paper: bovin-2neur ,
bovin-a0jnh8 ,
bovin-a5d7b7 ,
bovin-ACHE ,
bovin-balip ,
bovin-dpp4 ,
bovin-dpp6 ,
bovin-e1bi31 ,
bovin-e1bn79 ,
bovin-est8 ,
bovin-f1mbd6 ,
bovin-f1mi11 ,
bovin-f1mr65 ,
bovin-f1n1l4 ,
bovin-g3mxp5 ,
bovin-q0vcc8 ,
bovin-q2kj30 ,
bovin-q3t0r6 ,
bovin-thyro Abstract
To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Other Papers
Bos taurus (Bovine) Bos mutus (Yak) protein for bile-salt-activated lipase