Gene_Locus Report

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Gene_locus Report for: ratno-LOC246252

Rattus norvegicus carboxylesterase isoenzyme gene (LOC246252) Ces1h EST2A Ces2a

Relationship
Family|Carb_B_Chordata
Block| C
Position in NCBI Life Tree|Rattus norvegicus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Glires: N E > Rodentia: N E > Myomorpha: N E > Muroidea: N E > Muridae: N E > Murinae: N E > Rattus: N E > Rattus norvegicus: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
>3 Genbank links 2 more: NM_144743, AY034877, AABR06096675
2 UniProt : Q8K3R0, F7F3M3
1 Ncbi-nid : 21426806
1 Ncbi-pid : 21426807
2 UniProt : Q8K3R0, F7F3M3
2 Interpro : Q8K3R0, F7F3M3
2 Pfam : Q8K3R0, F7F3M3
2 PIRSF : Q8K3R0, F7F3M3
2 SUPERFAM : Q8K3R0, F7F3M3
Sequence
Graphical view for this peptide sequence: ratno-LOC246252
Colored MSA for Carb_B_Chordata (raw)
MPLARLPGWLYVVACGLLLLLQHVHGQDSASPIRNTHTGQVRGSFVHVKD
TKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDI
MNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGL
VLGSASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLDQ
VAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAI
MQSGVALLPDLISDKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEIL
AINQVFKMIPGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIP
VFLGLDHIIKKITRETLPTVLKSTAAQMMLPPECIDLIMEEYMGDTENPE
TLQEQFRHMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLPSFIKQVRPS
HVKADHGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPN
GEDLPHWPVLDHDEQYLQLNTQPAVGRALKARRLQFWTKTLPQKIQELKG
SQSKHAEL
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MPLARLPGWLYVVACGLLLLLQHVHGQDSASPIRNTHTGQVRGSFVHVKD
TKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDI
MNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGL
VLGSASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLDQ
VAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAI
MQSGVALLPDLISDKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEIL
AINQVFKMIPGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIP
VFLGLDHIIKKITRETLPTVLKSTAAQMMLPPECIDLIMEEYMGDTENPE
TLQEQFRHMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLPSFIKQVRPS
HVKADHGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPN
GEDLPHWPVLDHDEQYLQLNTQPAVGRALKARRLQFWTKTLPQKIQELKG
SQSKHAEL


References
    Title: Construction and characterization of CRISPR/Cas9 knockout rat model of carboxylesterase 2a gene
    Liu J, Shang X, Huang S, Xu Y, Lu J, Zhang Y, Liu Z, Wang X
    Ref: Molecular Pharmacology, :, 2021 : PubMed

            

    Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution
    Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC and Collins F <218 more author(s)>
    Ref: Nature, 428:493, 2004 : PubMed

            

    Title: Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate
    Sanghani SP, Davis WI, Dumaual NG, Mahrenholz A, Bosron WF
    Ref: European Journal of Biochemistry, 269:4387, 2002 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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