(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Euglenozoa: NE > Kinetoplastida: NE > Trypanosomatidae: NE > Trypanosoma: NE > Trypanozoon: NE > Trypanosoma brucei: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Trypanosoma brucei TREU927: N, E.
Trypanosoma brucei gambiense: N, E.
Trypanosoma brucei brucei strain 927/4 GUTat10.1: N, E.
Trypanosoma brucei brucei: N, E.
Trypanosoma brucei gambiense DAL972: N, E.
Trypanosoma brucei brucei TREU927: N, E.
Trypanosoma brucei equiperdum: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MPLGPIVVAPHEEHNITLPSGDVFRLILFGGCDGDLVRRGEKPPPTLFCL HGAGMSSSNFHVLATHMTQHAKSSAHEESPYAVRVVTFDMRCHGDSTRRG GEGSLTLQVLVDDFRALLRTVKESLFSATPHFYFVGHSLGGSVLVHGLRG EADLLQLAAGVVLLDVVEGTARISLQHMDKFLENRPRQFHEVAEATQWFL RHGGMNSAASAAVTVPHLLRKEGDHFVWKSNLEAMAPVWPQWFDGLDECF VTLPCPKILCLASTERLDTALTIAQMQGKFQLEVLGNSCGHYVMDDQPSA VAAVLQRFIRRIETLTEKLKCSIRKPVK
African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei. The 26-megabase genome contains 9068 predicted genes, including approximately 900 pseudogenes and approximately 1700 T. brucei-specific genes. Large subtelomeric arrays contain an archive of 806 variant surface glycoprotein (VSG) genes used by the parasite to evade the mammalian immune system. Most VSG genes are pseudogenes, which may be used to generate expressed mosaic genes by ectopic recombination. Comparisons of the cytoskeleton and endocytic trafficking systems with those of humans and other eukaryotic organisms reveal major differences. A comparison of metabolic pathways encoded by the genomes of T. brucei, T. cruzi, and Leishmania major reveals the least overall metabolic capability in T. brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.
Trypanosoma brucei hypothetical protein