Beanan M

References (4)

Title : Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain - Gill_2005_J.Bacteriol_187_2426
Author(s) : Gill SR , Fouts DE , Archer GL , Mongodin EF , DeBoy RT , Ravel J , Paulsen IT , Kolonay JF , Brinkac L , Beanan M , Dodson RJ , Daugherty SC , Madupu R , Angiuoli SV , Durkin AS , Haft DH , Vamathevan J , Khouri H , Utterback T , Lee C , Dimitrov G , Jiang L , Qin H , Weidman J , Tran K , Kang K , Hance IR , Nelson KE , Fraser CM
Ref : Journal of Bacteriology , 187 :2426 , 2005
Abstract : Staphylococcus aureus is an opportunistic pathogen and the major causative agent of numerous hospital- and community-acquired infections. Staphylococcus epidermidis has emerged as a causative agent of infections often associated with implanted medical devices. We have sequenced the approximately 2.8-Mb genome of S. aureus COL, an early methicillin-resistant isolate, and the approximately 2.6-Mb genome of S. epidermidis RP62a, a methicillin-resistant biofilm isolate. Comparative analysis of these and other staphylococcal genomes was used to explore the evolution of virulence and resistance between these two species. The S. aureus and S. epidermidis genomes are syntenic throughout their lengths and share a core set of 1,681 open reading frames. Genome islands in nonsyntenic regions are the primary source of variations in pathogenicity and resistance. Gene transfer between staphylococci and low-GC-content gram-positive bacteria appears to have shaped their virulence and resistance profiles. Integrated plasmids in S. epidermidis carry genes encoding resistance to cadmium and species-specific LPXTG surface proteins. A novel genome island encodes multiple phenol-soluble modulins, a potential S. epidermidis virulence factor. S. epidermidis contains the cap operon, encoding the polyglutamate capsule, a major virulence factor in Bacillus anthracis. Additional phenotypic differences are likely the result of single nucleotide polymorphisms, which are most numerous in cell envelope proteins. Overall differences in pathogenicity can be attributed to genome islands in S. aureus which encode enterotoxins, exotoxins, leukocidins, and leukotoxins not found in S. epidermidis.
ESTHER : Gill_2005_J.Bacteriol_187_2426
PubMedSearch : Gill_2005_J.Bacteriol_187_2426
PubMedID: 15774886
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594 , staep-lipas , staep-SE0011 , staep-SE0226 , staep-SE0386 , staep-SE0389 , staep-SE0424 , staep-SE0564 , staep-SE0714 , staep-SE0745 , staep-SE0980 , staep-SE1436 , staep-SE1460 , staep-SE1510 , staep-SE1780 , staep-SE1929 , staep-SERP2035 , staep-SE2050 , staep-SE2095 , staep-SE2213 , staep-SE2328

Title : Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis - Paulsen_2003_Science_299_2071
Author(s) : Paulsen IT , Banerjei L , Myers GS , Nelson KE , Seshadri R , Read TD , Fouts DE , Eisen JA , Gill SR , Heidelberg JF , Tettelin H , Dodson RJ , Umayam L , Brinkac L , Beanan M , Daugherty S , DeBoy RT , Durkin S , Kolonay J , Madupu R , Nelson W , Vamathevan J , Tran B , Upton J , Hansen T , Shetty J , Khouri H , Utterback T , Radune D , Ketchum KA , Dougherty BA , Fraser CM
Ref : Science , 299 :2071 , 2003
Abstract : The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
ESTHER : Paulsen_2003_Science_299_2071
PubMedSearch : Paulsen_2003_Science_299_2071
PubMedID: 12663927
Gene_locus related to this paper: entfa-EF0101 , entfa-EF0274 , entfa-EF0381 , entfa-EF0449 , entfa-EF0667 , entfa-EF0786 , entfa-EF1028 , entfa-EF1236 , entfa-EF1505 , entfa-EF1536 , entfa-EF1670 , entfa-EF2618 , entfa-EF2728 , entfa-EF2792 , entfa-EF2963 , entfa-EF3191

Title : Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis - Heidelberg_2002_Nat.Biotechnol_20_1118
Author(s) : Heidelberg JF , Paulsen IT , Nelson KE , Gaidos EJ , Nelson WC , Read TD , Eisen JA , Seshadri R , Ward N , Methe B , Clayton RA , Meyer T , Tsapin A , Scott J , Beanan M , Brinkac L , Daugherty S , DeBoy RT , Dodson RJ , Durkin AS , Haft DH , Kolonay JF , Madupu R , Peterson JD , Umayam LA , White O , Wolf AM , Vamathevan J , Weidman J , Impraim M , Lee K , Berry K , Lee C , Mueller J , Khouri H , Gill J , Utterback TR , McDonald LA , Feldblyum TV , Smith HO , Venter JC , Nealson KH , Fraser CM
Ref : Nat Biotechnol , 20 :1118 , 2002
Abstract : Shewanella oneidensis is an important model organism for bioremediation studies because of its diverse respiratory capabilities, conferred in part by multicomponent, branched electron transport systems. Here we report the sequencing of the S. oneidensis genome, which consists of a 4,969,803-base pair circular chromosome with 4,758 predicted protein-encoding open reading frames (CDS) and a 161,613-base pair plasmid with 173 CDSs. We identified the first Shewanella lambda-like phage, providing a potential tool for further genome engineering. Genome analysis revealed 39 c-type cytochromes, including 32 previously unidentified in S. oneidensis, and a novel periplasmic [Fe] hydrogenase, which are integral members of the electron transport system. This genome sequence represents a critical step in the elucidation of the pathways for reduction (and bioremediation) of pollutants such as uranium (U) and chromium (Cr), and offers a starting point for defining this organism's complex electron transport systems and metal ion-reducing capabilities.
ESTHER : Heidelberg_2002_Nat.Biotechnol_20_1118
PubMedSearch : Heidelberg_2002_Nat.Biotechnol_20_1118
PubMedID: 12368813
Gene_locus related to this paper: sheon-BIOH , sheon-LYPA , sheon-PIP , sheon-PTRB , sheon-q8ej95 , sheon-SO0071 , sheon-SO0614 , sheon-SO0616 , sheon-SO0801 , sheon-SO0880 , sheoe-SO0967 , sheon-SO1006 , sheon-SO1224 , sheon-SO1310 , sheon-SO1534 , sheon-SO1539 , sheon-SO1686 , sheon-SO1743 , sheon-SO1976 , sheon-SO1999 , sheon-SO2024 , sheon-SO2047 , sheon-SO2055 , sheon-SO2223 , sheon-SO2333 , sheon-SO2473 , sheon-SO2582 , sheon-SO2753 , sheon-SO2934 , sheon-SO3025 , sheon-SO3900 , sheon-SO3990 , sheon-SO4252 , sheon-SO4400 , sheon-SO4537 , sheon-SO4543 , sheon-SO4574 , sheon-SO4618 , sheon-SO4650 , sheon-SOA0048 , shefn-SfSFGH , sheon-ym51

Title : Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440 - Nelson_2002_Environ.Microbiol_4_799
Author(s) : Nelson KE , Weinel C , Paulsen IT , Dodson RJ , Hilbert H , Martins dos Santos VA , Fouts DE , Gill SR , Pop M , Holmes M , Brinkac L , Beanan M , DeBoy RT , Daugherty S , Kolonay J , Madupu R , Nelson W , White O , Peterson J , Khouri H , Hance I , Chris Lee P , Holtzapple E , Scanlan D , Tran K , Moazzez A , Utterback T , Rizzo M , Lee K , Kosack D , Moestl D , Wedler H , Lauber J , Stjepandic D , Hoheisel J , Straetz M , Heim S , Kiewitz C , Eisen JA , Timmis KN , Dusterhoft A , Tummler B , Fraser CM
Ref : Environ Microbiol , 4 :799 , 2002
Abstract : Pseudomonas putida is a metabolically versatile saprophytic soil bacterium that has been certified as a biosafety host for the cloning of foreign genes. The bacterium also has considerable potential for biotechnological applications. Sequence analysis of the 6.18 Mb genome of strain KT2440 reveals diverse transport and metabolic systems. Although there is a high level of genome conservation with the pathogenic Pseudomonad Pseudomonas aeruginosa (85% of the predicted coding regions are shared), key virulence factors including exotoxin A and type III secretion systems are absent. Analysis of the genome gives insight into the non-pathogenic nature of P. putida and points to potential new applications in agriculture, biocatalysis, bioremediation and bioplastic production.
ESTHER : Nelson_2002_Environ.Microbiol_4_799
PubMedSearch : Nelson_2002_Environ.Microbiol_4_799
PubMedID: 12534463
Gene_locus related to this paper: psep1-a5wa77 , psep1-a5wax1 , psepk-q88nk6 , psepk-q88qt0 , psepu-acoc , psepu-BIOH , psepu-bpest , psepu-ESTB , psepu-LIP , psepu-METX , psepu-PHAC1 , psepu-PHAC2 , psepu-PHAG , psepu-PHAZ , psepu-PIP , psepu-PP0375 , psepu-PP0498 , psepu-PP0532 , psepu-PP1064 , psepu-PP1184 , psepu-PP1310 , psepu-PP1500 , psepu-PP1617 , psepu-PP1829 , psepu-PP1979 , psepu-PP2083 , psepu-PP2201 , psepu-PP2236 , psepu-PP2567 , psepu-PP2804 , psepu-PP2934 , psepu-PP3195 , psepu-PP3367 , psepu-PP3404 , psepu-PP3645 , psepu-PP3807 , psepu-PP3812 , psepu-PP3943 , psepu-PP4164 , psepu-PP4165 , psepu-PP4178 , psepu-PP4249 , psepu-PP4540 , psepu-PP4551 , psepu-PP4583 , psepu-PP4624 , psepu-PP4634 , psepu-PP4916 , psepu-PP5117 , psepu-PP5161 , psepu-PP5167 , psepu-PPSD , psepu-Q8KQK1 , psepu-q9wwz4