Family: A85-IroE-IroD-Fes-Yiel

Block: X

Parent Family: Antigen85c


This family contains enterobactin esterase IroD, enterochelin Esterase FES enterobactin and salmochelin esterase IroE; The proliferation of many pathogenic bacteria is limited by the scarcity of soluble iron in their environment Many of these bacteria scavenge iron by synthesizing and exporting small molecule siderophores that chelate iron Iron-bound siderophores are subsequently imported for metabolic processing. Three related serine hydrolases have been characterized biochemically in this pathway Fes IroD and IroE; This family corresponds to a subset ofthe Carbohydrate Esterase family CE1 in CAZy - Carbohydrate-Active enZYmes database (CE_1). Active site Ser His Asp or Glu or nothing


Interpro : IPR000801 Esterase_put


Pdoc : No Pdoc

Pfam : PF00756 Esterase

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (21)

Genes Proteins in A85-IroE-IroD-Fes-Yiel family (695)

Fragments of genes in A85-IroE-IroD-Fes-Yiel family (48)

Structures in A85-IroE-IroD-Fes-Yiel family (21)

Substrates in A85-IroE-IroD-Fes-Yiel family (5)

Inhibitors in A85-IroE-IroD-Fes-Yiel family (1)

References (3)

Title : Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases - Ecker_2018_Angew.Chem.Int.Ed.Engl_57_14624
Author(s) : Ecker F , Haas H , Groll M , Huber EM
Ref : Angew Chem Int Ed Engl , 57 :14624 , 2018
PubMedID: 30070018
Gene_locus related to this paper: aspfu-q4wf29 , emeni-AnEstB , emeni-q5av79 , aspfu-q4wf56

Title : A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition via the Siderophore Enterobactin in Pseudomonas aeruginosa - Perraud_2018_ACS.Chem.Biol_13_2603
Author(s) : Perraud Q , Moynie L , Gasser V , Munier M , Godet J , Hoegy F , Mely Y , Mislin GLA , Naismith JH , Schalk IJ
Ref : ACS Chemical Biology , 13 :2603 , 2018
PubMedID: 30086222
Gene_locus related to this paper: pseae-PA2689

Title : Structural characterization of enterobactin hydrolase IroE - Larsen_2006_Biochemistry_45_10184
Author(s) : Larsen NA , Lin H , Wei R , Fischbach MA , Walsh CT
Ref : Biochemistry , 45 :10184 , 2006
PubMedID: 16922493
Gene_locus related to this paper: ecoli-IROE