Gene_Locus Report

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Gene_locus Report for: human-APEH

Homo sapiens (Human) acylamino acid-releasing enzyme APH APEH

Comment
Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. Preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser Belongs to peptidase family s9C, Fujino et al Q9P0Y2: P13798 2aa dif with Q9BQ33 old human-acph. DFP (IC(50) 11-17 nM), chlorpyrifos oxon (IC(50) 21-71 nM), dichlorvos (IC(50) 230-560 nM), naled (IC(50) 370-870 nM) (Quistad et al. 2005)


Relationship
Family|ACPH_Peptidase_S9
Block| X
Position in NCBI Life Tree|Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E


Molecular evidence
Database
3 Genbank : D38441, J03068, AC099668
2 UniProt : P13798, C9JIF9
1 Ncbi-nid : 556513
1 Ncbi-pid : 556514
2 UniProt : P13798, C9JIF9
2 Interpro : P13798, C9JIF9
2 Prodom : P13798, C9JIF9
2 Pfam : P13798, C9JIF9
2 PIRSF : P13798, C9JIF9
2 SUPERFAM : P13798, C9JIF9
1 EntrezGene : 327
1 SNP : 327
1 UniGene : 517969
1 HUGO HGNC : 586
1 IUPHAR : 2328
1 OMIM : 102645
1 Ensembl : ENSG00000164062
Sequence
Graphical view for this peptide sequence: human-APEH
Colored MSA for ACPH_Peptidase_S9 (raw)
MERQVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGQYRTVHTEW
TQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSG
SMKAVLRKAGGTGPGEEKQFLEVWEKNRKLKSFNLSVLEKHGPVYEDDCF
GCLSWSHSETHLLYVAERKRPKAESFFQTKALDVSASDDEIARLKKPDQP
IKGDQFVFYEDWGENMVSKSIPVLCVLDVESGNISVLEGVPENVSPGQAF
WAPGDAGVVFVGWWHEPFRLGIRFCTNRRSALYYVDLIGGKCELLSDDSL
AVSSPRLSPDQCRIVYLQYPSLIPHHQCSQLCLYDWYTKVTSVVVDVVPR
QLGENFSGIYCSLLPLGCWSADSQRVVFDSAQRSRQDLFAVDTQVGTVTS
LTAGGSGGSWKLLTIDQDLMVAQFSTPSLPPTLKVGFLPSAGKEQSVLWV
SLEEAEPIPDIHWGIRVLQPPPEQENVQYAGLDFEAILLQPGSPPDKTQV
PMVVMPHGGPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILS
LPGNVGHQDVKDVQFAVEQVLQEEHFDASHVALMGGSHGGFISCHLIGQY
PETYRACVARNPVINIASMLGSTDIPDWCVVEAGFPFSSDCLPDLSVWAE
MLDKSPIRYIPQVKTPLLLMLGQEDRRVPFKQGMEYYRALKTRNVPVRLL
LYPKSTHALSEVEVESDSFMNAVLWLRTHLGS
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MERQVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGQYRTVHTEW
TQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSG
SMKAVLRKAGGTGPGEEKQFLEVWEKNRKLKSFNLSVLEKHGPVYEDDCF
GCLSWSHSETHLLYVAERKRPKAESFFQTKALDVSASDDEIARLKKPDQP
IKGDQFVFYEDWGENMVSKSIPVLCVLDVESGNISVLEGVPENVSPGQAF
WAPGDAGVVFVGWWHEPFRLGIRFCTNRRSALYYVDLIGGKCELLSDDSL
AVSSPRLSPDQCRIVYLQYPSLIPHHQCSQLCLYDWYTKVTSVVVDVVPR
QLGENFSGIYCSLLPLGCWSADSQRVVFDSAQRSRQDLFAVDTQVGTVTS
LTAGGSGGSWKLLTIDQDLMVAQFSTPSLPPTLKVGFLPSAGKEQSVLWV
SLEEAEPIPDIHWGIRVLQPPPEQENVQYAGLDFEAILLQPGSPPDKTQV
PMVVMPHGGPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILS
LPGNVGHQDVKDVQFAVEQVLQEEHFDASHVALMGGSHGGFISCHLIGQY
PETYRACVARNPVINIASMLGSTDIPDWCVVEAGFPFSSDCLPDLSVWAE
MLDKSPIRYIPQVKTPLLLMLGQEDRRVPFKQGMEYYRALKTRNVPVRLL
LYPKSTHALSEVEVESDSFMNAVLWLRTHLGS


References
4 more
    Title: Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase
    Fujino T, Watanabe K, Beppu M, Kikugawa K, Yasuda H
    Ref: Biochimica & Biophysica Acta, 1478:102, 2000 : PubMed

            

    Title: The nucleotide sequence of human acylamino acid-releasing enzyme
    Mitta M, Ohnogi H, Mizutani S, Sakiyama F, Kato I and
    Ref: DNA Research, 3:31, 1996 : PubMed

            

    Title: The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer
    Naylor SL, Marshall A, Hensel C, Martinez PF, Holley B, Sakaguchi AY
    Ref: Genomics, 4:355, 1989 : PubMed

            


Other Papers


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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