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Inhibitor Report for: Galanthamine

Alkaloid from caucasian snow-drop Galenthus woronowii, the common snowdrop Galanthus nivalis Ungernia genus, Amaryllidaceae, from Narcissus spp. Selectivity for AChE. The CAS number of Galanthamine Hydrobromide is 1953-04-4. Nivalin Reminyl trademark approved for treatment of Alzheimer disease in Austria. Galantamine is a specific competitive and reversible aceylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission at the ganglionic and the neuromuscular junctions.


General
Type Derivative of Galanthamine, Natural, Alkaloid, Drug
Chemical_Nomenclature 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2methylbenzofuro[4,3,2-efg][2]benzazocin-6-ol
Canonical SMILES CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O
InChI InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
InChIKey ASUTZQLVASHGKV-JDFRZJQESA-N
Other name(s) Galantamine ; Lycoremine ; Jilkon ; Nivalin ; Reminyl ; Razadyne
________________________________________________________________________________________________
MW|287.35
Formula|C17H21NO3
CAS_number|357-70-0
PubChem|9651
UniChem|ASUTZQLVASHGKV-JDFRZJQESA-N
IUPHAR|6693
Wikipedia|Galanthamine

Target
Families | Galanthamine ligand of proteins in family: ACHE
Stucture | 5 structures (e.g. : 1DX6, 1QTI, 1W6R... more)
Protein | torca-ACHE, human-ACHE

References:
Search PubMed for references concerning: Galanthamine

26 more
    Title: Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts
    Guillou C, Mary A, Renko DZ, Gras E, Thal C
    Ref: Bioorganic & Medicinal Chemistry Lett, 10:637, 2000 : PubMed

            

    Title: Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine
    Bores GM, Huger FP, Petko W, Mutlib AE, Camacho F, Rush DK, Selk DE, Wolf V, Kosley RW, Jr. and Vargas HM <1 more author(s)>
    Ref: Journal of Pharmacology & Experimental Therapeutics, 277:728, 1996 : PubMed

            

    Title: Galanthamine. [Review] [23 refs]
    Fulton B, Benfield P
    Ref: Drugs & Aging, 9:60, 1996 : PubMed