MHET
product of hydrolysis of Polyethylene-terephthalate or HEMT model substrate. Polyethylene terephthalate is the most common thermoplastic polymer resin of the polyester family and is used in fibers for clothing, containers for liquids and foods. Degradation of PET using hydrolytic enzymes leads to the release of hydrolysis products such as BHET (bis(2-hydroxyethyl) terephthalate), MHET (mono-(2-hydroxyethyl) terephthalic acid), TPA (terephthalic acid) and EG (ethylene glycol)
General
Type : Terephthalate, Phthalate, Benzoate, Polyester fragment
Chemical_Nomenclature : 4-(2-hydroxyethoxycarbonyl)benzoic acid
Canonical SMILES : C1=CC(=CC=C1C(=O)O)C(=O)OCCO
InChI : InChI=1S\/C10H10O5\/c11-5-6-15-10(14)8-3-1-7(2-4-8)9(12)13\/h1-4,11H,5-6H2,(H,12,13)
InChIKey : BCBHDSLDGBIFIX-UHFFFAOYSA-N
Other name(s) : 4-((2-Hydroxyethoxy)carbonyl)benzoic acid || Mono(ethylene terephthalate) || Ethylene glycol, cyclic ester with (C7-C11)dibasic acids || AC1L5ATF || ET || C9C || 4-[(2-hydroxyethoxy)carbonyl]benzoate || 1,4-Benzenedicarboxylic acid, mono(2-hydroxyethyl) ester || CTK0G1127 || CHEBI:131701 || CHEBI:131704
Target
Structures : 7XTT, 7XTV, 7XTW, 7VVE, 6JTT
Families : Polyesterase-lipase-cutinase, Tannase, Carb_B_Bacteria, FAE-Bacterial-promiscuous, CarbLipBact_2, ABHD6-Lip
References (23)
| Title : Biodegradation of PET by Deep-Sea Pseudomonas chengduensis BC1815 through Utilization of Ethylene Glycol Monomer for Growth - Guo_2025_Environ.Sci.Technol__ |
| Author(s) : Guo W , Shi Z , Yu X , Duan J |
| Ref : Environ Sci Technol , : , 2025 |
| Abstract : |
| PubMedSearch : Guo_2025_Environ.Sci.Technol__ |
| PubMedID: 40252025 |
| Gene_locus related to this paper: 9gamm-a0a1g6lje2 |
| Title : Fine tuning enzyme activity assays for monitoring the enzymatic hydrolysis of PET - Boros_2025_Sci.Rep_15_1877 |
| Author(s) : Boros K , Nagy BE , Tomoiaga RB , Totos R , Tosa MI , Paizs C , Bencze LC |
| Ref : Sci Rep , 15 :1877 , 2025 |
| Abstract : |
| PubMedSearch : Boros_2025_Sci.Rep_15_1877 |
| PubMedID: 39805935 |
| Gene_locus related to this paper: 9bact-g9by57 |
| Title : New combined absorption\/(1)H NMR method for qualitative and quantitative analysis of PET degradation products - Kornberger_2024_Environ.Sci.Pollut.Res.Int_31_20689 |
| Author(s) : Kornberger D , Paatsch T , Schmidt M , Salat U |
| Ref : Environ Sci Pollut Res Int , 31 :20689 , 2024 |
| Abstract : |
| PubMedSearch : Kornberger_2024_Environ.Sci.Pollut.Res.Int_31_20689 |
| PubMedID: 38393574 |
| Title : Characterization of Thermotoga maritima Esterase Capable of Hydrolyzing Bis(2-hydroxyethyl) Terephthalate - Feng_2024_J.Agric.Food.Chem__ |
| Author(s) : Feng S , Xue M , Xie F , Zhao H , Xue Y |
| Ref : Journal of Agricultural and Food Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Feng_2024_J.Agric.Food.Chem__ |
| PubMedID: 38753963 |
| Gene_locus related to this paper: 9bact-a0a2h5z9r5 , thema-ESTA |
| Title : Complete bio-degradation of poly(butylene adipate-co-terephthalate) via engineered cutinases - Yang_2023_Nat.Commun_14_1645 |
| Author(s) : Yang Y , Min J , Xue T , Jiang P , Liu X , Peng R , Huang JW , Qu Y , Li X , Ma N , Tsai FC , Dai L , Zhang Q , Liu Y , Chen CC , Guo RT |
| Ref : Nat Commun , 14 :1645 , 2023 |
| Abstract : |
| PubMedSearch : Yang_2023_Nat.Commun_14_1645 |
| PubMedID: 36964144 |
| Gene_locus related to this paper: idesa-peth , thefu-q6a0i4 |
| Title : An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate - Perez-Garcia_2023_Commun.Chem_6_193 |
| Author(s) : Perez-Garcia P , Chow J , Costanzi E , Gurschke M , Dittrich J , Dierkes RF , Molitor R , Applegate V , Feuerriegel G , Tete P , Danso D , Thies S , Schumacher J , Pfleger C , Jaeger KE , Gohlke H , Smits SHJ , Schmitz RA , Streit WR |
| Ref : Commun Chem , 6 :193 , 2023 |
| Abstract : |
| PubMedSearch : Perez-Garcia_2023_Commun.Chem_6_193 |
| PubMedID: 37697032 |
| Gene_locus related to this paper: 9arch-PETcan211 , 9cren-PETcan204 , 9arch-PET46 |
| Title : Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization - von Haugwitz_2022_ACS.Catal_12_15259 |
| Author(s) : von Haugwitz G , Han X , Pfaff L , Li Q , Wei H , Gao J , Methling K , Ao Y , Brack Y , Jan Mican J , Feiler CG , Weiss MS , Bednar D , Palm GJ , Lalk M , Lammers M , Damborsky J , Weber G , Liu W , Bornscheuer UT , Wei R |
| Ref : ACS Catal , 12 :15259 , 2022 |
| Abstract : |
| PubMedSearch : von Haugwitz_2022_ACS.Catal_12_15259 |
| PubMedID: 36570084 |
| Gene_locus related to this paper: thefu-1831 |
| Title : Novel efficient enzymatic synthesis of the key-reaction intermediate of PET depolymerization, mono(2-hydroxyethyl terephthalate) - MHET - de Queiros Eugenio_2022_J.Biotechnol__ |
| Author(s) : de Queiros Eugenio E , Campisano ISP , Dias AG , de Castro AM , Coelho MAZ , Langone MAP |
| Ref : J Biotechnol , : , 2022 |
| Abstract : |
| PubMedSearch : de Queiros Eugenio_2022_J.Biotechnol__ |
| PubMedID: 36063976 |
| Gene_locus related to this paper: humin-cut |
| Title : An NMR look at an engineered PET depolymerase - Charlier_2022_Biophys.J_121_2882 |
| Author(s) : Charlier C , Gavalda S , Borsenberger V , Duquesne S , Marty A , Tournier V , Lippens G |
| Ref : Biophysical Journal , 121 :2882 , 2022 |
| Abstract : |
| PubMedSearch : Charlier_2022_Biophys.J_121_2882 |
| PubMedID: 35794828 |
| Gene_locus related to this paper: 9bact-g9by57 |
| Title : Metabolic engineering of Yarrowia lipolytica for poly(ethylene terephthalate) degradation - Kosiorowska_2022_Sci.Total.Environ_831_154841 |
| Author(s) : Kosiorowska KE , Biniarz P , Dobrowolski A , Leluk K , Mironczuk AM |
| Ref : Sci Total Environ , 831 :154841 , 2022 |
| Abstract : |
| PubMedSearch : Kosiorowska_2022_Sci.Total.Environ_831_154841 |
| PubMedID: 35358523 |
| Gene_locus related to this paper: fusso-cutas |
| Title : Structure-function analysis of two closely related cutinases from Thermobifida cellulosilytica - Baath_2021_Biotechnol.Bioeng__ |
| Author(s) : Baath JA , Novy V , Carneiro LV , Guebitz GM , Olsson L , Westh P , Ribitsch D |
| Ref : Biotechnol Bioeng , : , 2021 |
| Abstract : |
| PubMedSearch : Baath_2021_Biotechnol.Bioeng__ |
| PubMedID: 34755331 |
| Gene_locus related to this paper: thefu-q6a0i4 , thefu-q6a0i3 |
| Title : Development of a targeted gene disruption system in the PET-degrading bacterium Ideonella sakaiensis and its applications to PETase and MHETase genes - Hachisuka_2021_Appl.Environ.Microbiol__AEM0002021 |
| Author(s) : Hachisuka SI , Nishii T , Yoshida S |
| Ref : Applied Environmental Microbiology , :AEM0002021 , 2021 |
| Abstract : |
| PubMedSearch : Hachisuka_2021_Appl.Environ.Microbiol__AEM0002021 |
| PubMedID: 34260304 |
| Gene_locus related to this paper: idesa-mheth , idesa-peth |
| Title : Decomposition of the PET Film by MHETase Using Exo-PETase Function - Sagong_2020_ACS.Catal_10_48050 |
| Author(s) : Sagong HY , Seo H , Kim T , Son H , Joo S , Lee S , Kim S , Woo JS , Hwang S , Kim KJ |
| Ref : ACS Catal , 10 :4805 , 2020 |
| Abstract : |
| PubMedSearch : Sagong_2020_ACS.Catal_10_48050 |
| PubMedID: |
| Gene_locus related to this paper: idesa-mheth |
| Title : Using a marine microalga as a chassis for polyethylene terephthalate (PET) degradation - Moog_2019_Microb.Cell.Fact_18_171 |
| Author(s) : Moog D , Schmitt J , Senger J , Zarzycki J , Rexer KH , Linne U , Erb T , Maier UG |
| Ref : Microb Cell Fact , 18 :171 , 2019 |
| Abstract : |
| PubMedSearch : Moog_2019_Microb.Cell.Fact_18_171 |
| PubMedID: 31601227 |
| Title : Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase - Fecker_2018_Biophys.J_114_1302 |
| Author(s) : Fecker T , Galaz-Davison P , Engelberger F , Narui Y , Sotomayor M , Parra LP , Ramirez-Sarmiento CA |
| Ref : Biophysical Journal , 114 :1302 , 2018 |
| Abstract : |
| PubMedSearch : Fecker_2018_Biophys.J_114_1302 |
| PubMedID: 29590588 |
| Gene_locus related to this paper: idesa-peth |
| Title : Characterization and engineering of a plastic-degrading aromatic polyesterase - Austin_2018_Proc.Natl.Acad.Sci.U.S.A_115_E4350 |
| Author(s) : Austin HP , Allen MD , Donohoe BS , Rorrer NA , Kearns FL , Silveira RL , Pollard BC , Dominick G , Duman R , El Omari K , Mykhaylyk V , Wagner A , Michener WE , Amore A , Skaf MS , Crowley MF , Thorne AW , Johnson CW , Woodcock HL , McGeehan JE , Beckham GT |
| Ref : Proc Natl Acad Sci U S A , 115 :E4350 , 2018 |
| Abstract : |
| PubMedSearch : Austin_2018_Proc.Natl.Acad.Sci.U.S.A_115_E4350 |
| PubMedID: 29666242 |
| Gene_locus related to this paper: idesa-peth |
| Title : New insights into the function and global distribution of polyethylene terephthalate (PET) degrading bacteria and enzymes in marine and terrestrial metagenomes - Danso_2018_Appl.Environ.Microbiol_84_e2773 |
| Author(s) : Danso D , Schmeisser C , Chow J , Zimmermann W , Wei R , Leggewie C , Li X , Hazen T , Streit WR |
| Ref : Applied Environmental Microbiology , 84 :e2773 , 2018 |
| Abstract : |
| PubMedSearch : Danso_2018_Appl.Environ.Microbiol_84_e2773 |
| PubMedID: 29427431 |
| Gene_locus related to this paper: 9burk-PET10 , 9burk-PET11 , 9gamm-a0a0d4l7e6 , 9alte-n6vy44 , 9zzzz-a0a0f9x315 , deiml-e8u721 , olean-r4ykl9 , vibga-a0a1z2siq1 , 9burk-a0a0g3bi90 , 9bact-c3ryl0 , 9actn-h6wx58 , idesa-peth , 9bact-g9by57 , acide-PBSA , morsp-lip1 |
| Title : Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation - Joo_2018_Nat.Commun_9_382 |
| Author(s) : Joo S , Cho IJ , Seo H , Son HF , Sagong HY , Shin TJ , Choi SY , Lee SY , Kim KJ |
| Ref : Nat Commun , 9 :382 , 2018 |
| Abstract : |
| PubMedSearch : Joo_2018_Nat.Commun_9_382 |
| PubMedID: 29374183 |
| Gene_locus related to this paper: idesa-peth |
| Title : Structural insight into catalytic mechanism of PET hydrolase - Han_2017_Nat.Commun_8_2106 |
| Author(s) : Han X , Liu W , Huang JW , Ma J , Zheng Y , Ko TP , Xu L , Cheng YS , Chen CC , Guo RT |
| Ref : Nat Commun , 8 :2106 , 2017 |
| Abstract : |
| PubMedSearch : Han_2017_Nat.Commun_8_2106 |
| PubMedID: 29235460 |
| Gene_locus related to this paper: idesa-peth |
| Title : A dual enzyme system composed of a polyester hydrolase and a carboxylesterase enhances the biocatalytic degradation of polyethylene terephthalate films - Barth_2016_Biotechnol.J_11_1082 |
| Author(s) : Barth M , Honak A , Oeser T , Wei R , Belisario-Ferrari MR , Then J , Schmidt J , Zimmermann W |
| Ref : Biotechnol J , 11 :1082 , 2016 |
| Abstract : |
| PubMedSearch : Barth_2016_Biotechnol.J_11_1082 |
| PubMedID: 27214855 |
| Gene_locus related to this paper: 9bact-g9by57 , thefu-1831 |
| Title : A bacterium that degrades and assimilates poly(ethylene terephthalate) - Yoshida_2016_Science_351_1196 |
| Author(s) : Yoshida S , Hiraga K , Takehana T , Taniguchi I , Yamaji H , Maeda Y , Toyohara K , Miyamoto K , Kimura Y , Oda K |
| Ref : Science , 351 :1196 , 2016 |
| Abstract : |
| PubMedSearch : Yoshida_2016_Science_351_1196 |
| PubMedID: 26965627 |
| Gene_locus related to this paper: idesa-mheth , idesa-peth |
| Title : Hydrolysis of polyethyleneterephthalate by p-nitrobenzylesterase from Bacillus subtilis - Ribitsch_2011_Biotechnol.Prog_27_951 |
| Author(s) : Ribitsch D , Heumann S , Trotscha E , Herrero Acero E , Greimel K , Leber R , Birner-Gruenberger R , Deller S , Eiteljoerg I , Remler P , Weber T , Siegert P , Maurer KH , Donelli I , Freddi G , Schwab H , Guebitz GM |
| Ref : Biotechnol Prog , 27 :951 , 2011 |
| Abstract : |
| PubMedSearch : Ribitsch_2011_Biotechnol.Prog_27_951 |
| PubMedID: 21574267 |
| Gene_locus related to this paper: bacsu-pnbae |
| Title : Tailoring cutinase activity towards polyethylene terephthalate and polyamide 6,6 fibers - Araujo_2007_J.Biotechnol_128_849 |
| Author(s) : Araujo R , Silva C , O'Neill A , Micaelo N , Guebitz G , Soares CMF , Casal M , Cavaco-Paulo A |
| Ref : J Biotechnol , 128 :849 , 2007 |
| Abstract : |
| PubMedSearch : Araujo_2007_J.Biotechnol_128_849 |
| PubMedID: 17306400 |
| Gene_locus related to this paper: fusso-cutas |