Lactobacillus_peptidase
Relationship
Comment
Lactococcus X-Pro dipeptidyl-peptidase proteins (X-PDAP) belong to the S15 family of the carboxypeptidase (SC) clan. These proteins, which have similar pecificity to mammalian dipeptidyl-peptidase IV, cleave Xaa-Pro-releasing N-terminal dipeptides. The penultimate residue must be proline. In Lactococcus, the proteins exist as cytoplasmic homodimers. The closest relative is Cocaine_esterase
Database
Interpro : IPR000383 X-Pro dipeptidyl-peptidase-like domain Peptidase_S15
PIRSF : PIRSF009397 X-Pro dipeptidyl-peptidase
Pdoc : No Pdoc
Pfam : PF02129 Peptidase_S15
Prints : No Print
EC Number : 3.4.14.11
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Structure | Name | Proteins |
|---|---|---|
| 6NFF | Structure of X-prolyl dipeptidyl aminopeptidase from Lactobacillus helveticus | lache-pepx |
| 1LNS | Crystal Structure Analysis of the X-Prolyl Dipeptidyl Aminopeptidase From Lactococcus lactis | lacla-pepx |
| Gene_locus | Name | Species |
|---|---|---|
| 9acto-q2wfe0 | Streptomyces albulus putative x-pro dipeptidyl-peptidase | Streptomyces albulus |
| 9arch-d6pb23 | uncultured archaeon MedDCM-OCT-S04-C14 Putative X Pro dipeptidyl peptidase S15 family | uncultured archaeon MedDCM-OCT-S04-C14 |
| 9burk-q4lwx0 | Burkholderia cenocepacia HI2424 and AU 1054 xaa-pro dipeptidyl-peptidase precursor (EC 3.4.14.11) | Burkholderia cenocepacia HI2424 |
| baccr-pepx | Bacillus cereus, Bacillus thuringiensis, Bacillus anthracis, Bacillus mycoides, Bacillus weihenstephanensis, dipeptidyl-peptidase (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) | Bacillus cereus |
| burps-q63is4 | Burkholderia pseudomallei (Pseudomonas pseudomallei), Burkholderia thailandensis, family s15 non-peptidase homologue (EC 3.4.14.11) | Burkholderia pseudomallei |
| burps-q63mj8 | Burkholderia pseudomallei (Pseudomonas pseudomallei), Burkholderia mallei, family s15 non-peptidase homologue (EC 3.4.14.11) | Burkholderia pseudomallei |
| burs3-q39a92 | Burkholderia lata xaa-pro dipeptidyl-peptidase (EC 3.4.14.11) | Burkholderia sp. |
| burvi-q4bqq2 | Burkholderia vietnamiensis G4 Burkholderia ambifaria AMMD xaa-pro dipeptidyl-peptidase precursor (EC 3.4.14.11) | Burkholderia vietnamiensis |
| lacba-pepx | Lactobacillus brevis (strain ATCC 367 \/ JCM 1170) X-prolyl-dipeptidyl aminopeptidase | Lactobacillus brevis |
| lacc3-pepx | Lactobacillus casei (strains ATCC334\; BL23) X-prolyl-dipeptidyl aminopeptidase | Lactobacillus casei |
| lacdl-pepx | Lactobacillus lactis Lactobacillus delbrueckii (and subsp. bulgaricus (strains ATCC 11842 \/ DS20081\; ATCC BAA-365)) pepX gene encoding X-Prolyl-dipeptidyl-aminopeptidase | Lactobacillus delbrueckii |
| lache-pepx |  Lactobacillus helveticus (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) pepx (EC 3.4.14.5) |
Lactobacillus helveticus |
| lache-PEPX2 | Lactobacillus helveticus Strain IFO3809 x-prolyl dipeptidylaminopeptidase | Lactobacillus helveticus |
| lacjo-q74ii3 | Lactobacillus johnsonii, Lactobacillus gasseri, xaa-pro dipeptidyl-peptidase | Lactobacillus johnsonii |
| lacla-pepx | Lactococcus lactis and Lactococcus lactis (subsp.cremoris)(Streptococcus cremoris)(and strains MG1363\; SK11) X-prolyl dipeptidyl aminopeptidase (pepXP) |
Lactobacillus lactis |
| lacpl-pepx | Lactobacillus plantarum peptidase (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) | Lactobacillus plantarum |
| lacre-b3xl59 | Lactobacillus reuteri, xaa-pro dipeptidyl-peptidase (EC 3.4.14.11) | Lactobacillus reuteri |
| lacrh-pepx | Lactobacillus rhamnosus x-prolyl dipeptidyl aminopeptidase (x-pdap) | Lactobacillus rhamnosus |
| lacs1-PEPX | Lactobacillus salivarius, xaa-pro dipeptidyl-peptidase (EC 3.4.14.11) | Lactobacillus salivarius |
| lacss-q38xy2 | Lactobacillus sakei subsp. sakei (strain 23K) x-prolyl dipeptidyl-aminopeptidase (EC 3.4.14.11) | Lactobacillus sakei subsp. sakei |
| pedpa-pepx | Pediococcus pentosaceus (strain ATCC 25745 \/ 183-1w) X-prolyl-dipeptidyl aminopeptidase | Pediococcus pentosaceus |
| rhoba-pepx | Rhodopirellula baltica dipeptidyl-peptidase) (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) | Rhodopirellula baltica |
| strag-pepx | Streptococcus agalactiae (serotype III) H36B COH1 CJB111 515 18RS21 serotype Ia peptidase (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) (EC 3.4.14.11) | Streptococcus agalactiae |
| straw-pepx | Streptomyces avermitilis dipeptidyl-peptidase) (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) | Streptomyces avermitilis |
| strco-SCF34.20C | Streptomyces coelicolor hypothetical 69.9 kda protein | Streptomyces coelicolor |
| stre4-pepx | Streptococcus equi subsp. equi (strain 4047) subsp. zooepidemicus (strain MGCS10565) X-prolyl-dipeptidyl aminopeptidase | Streptococcus equi subsp. equi |
| strgo-Q93M42 | Streptococcus gordonii, Streptococcus sp., x-prolyl dipeptidyl-peptidase | Streptococcus gordonii |
| strma-PEPX | Streptococcus macedonicus x-prolyl-dipeptidyl aminopeptidase | Streptococcus macedonicus |
| strmu-pepx | Streptococcus mutans serotype c (strain ATCC 700610 \/ UA159) Xaa-Pro dipeptidyl-peptidase (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) pepX | Streptococcus mutans |
| strpi-pepx | Streptococcus pneumoniae (strain Hungary19A-6) (strain ATCC 700669 \/ Spain 23F-1) (strain CGSP14) X-prolyl-dipeptidyl aminopeptidase | Streptococcus pneumoniae |
| strpn-pepx | Streptococcus pneumoniae, x-pro dipeptidyl-peptidase | Streptococcus pneumoniae |
| strpy-PEPXP | Streptococcus pyogenes, putative x-pro dipeptidyl-peptidase IV (EC 3.4.14.11) | Streptococcus pyogenes |
| strs7-pepx | Streptococcus equi subsp. zooepidemicus (strain H70) X-prolyl-dipeptidyl aminopeptidase | Streptococcus equi subsp. zooepidemicus |
| strsu-q673u2 | Streptococcus suis, dipeptidyl aminopeptidase IV | Streptococcus suis |
| strsv-pepx | Streptococcus sanguinis, Streptococcus cristatus, X-prolyl-dipeptidyl aminopeptidase | Streptococcus sanguinis |
| strtr-pepx | Streptococcus thermophilus, Streptococcus salivarius, Streptococcus sp., Streptococcus vestibularis, Xaa-Pro dipeptidyl-peptidase (x-prolyl-dipeptidyl aminopeptidase) (x-pdap) | Streptococcus thermophilus |
| stru0-pepx | Streptococcus uberis (strain ATCC BAA-854 \/ 0140J) X-prolyl-dipeptidyl aminopeptidase | Streptococcus uberis |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Gly-Pro-pNA | (2S)-1-(2-aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide | aspfu-DPP4 lacla-pepx lache-pepx |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| DFP | Diisopropylphosphorofluoridate | arcfu-AF1763 human-DPP4 human-ACHE human-BCHE human-PLA2G7 bacce-BC3734 ecoli-IROE fusso-cutas human-FAP human-CTSA aspni-FAEA |
| PMSF | Phenylmethylsulfonyl fluoride | theet-q3ch51 emeni-q5avy9 human-ABHD10 human-PREPL myctu-Rv1430 psefl-cxest 9bact-E40 thefu-q6a0i4 ecoli-Aes orysj-Q10QA5 bac25-mglp 9bact-Q0GMU2 bacsu-FENB psepu-clcd1 thema-TM0077 bacsu-RsbQ ecoli-bioh drome-CG9542 human-FAP tubmm-TmEst2 human-NOTUM cutac-e6dae5 9gamm-urc15994 9baci-EstD9 geost-est30 pholl-AntI |
References (2)
| Title : Elucidating the Role of a Calcium-Binding Loop in an x-Prolyl Aminodipeptidase from Lb. helveticus - Ryder_2023_ACS.Omega_8_35410 |
| Author(s) : Ryder S , Pedigo J , Ojennus DD |
| Ref : ACS Omega , 8 :35410 , 2023 |
| Abstract : |
| PubMedSearch : Ryder_2023_ACS.Omega_8_35410 |
| PubMedID: 37779945 |
| Gene_locus related to this paper: lache-pepx |
| Title : The Structural Basis for Catalysis and Specificity of the X-Prolyl Dipeptidyl Aminopeptidase from Lactococcus lactis - Rigolet_2002_Structure.(Camb)_10_1383 |
| Author(s) : Rigolet P , Mechin I , Delage M , Chich J |
| Ref : Structure (Camb) , 10 :1383 , 2002 |
| Abstract : |
| PubMedSearch : Rigolet_2002_Structure.(Camb)_10_1383 |
| PubMedID: 12377124 |
| Gene_locus related to this paper: lacla-pepx |