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human-ABHD4

Homo sapiens (Human) abhydrolase domain-containing protein 4 FLJ12816 similar to 2-hydroxymuconic semialdehyde hydrolase (EC 3.1.1.-)

Comment

selectively hydrolyzes N-acyl phosphatidylethanolamines NAPEs and lysoNAPE to N-Acyl ethanolamines (NAEs) Simon et al .2006>. Alternative splicing: ABHD4-1 localizes to lipid droplets, whereas ABHD4-2 selectively targets mitochondria and is enriched in oxidative tissues. ABHD4-2 localize to the cytosolic face of the OMM (outer mitochondrial membrane). ABHD4-2 selectively hydrolyzes Cardiolipin (CL) in vitro, producing monolysocardiolipin (MLCL) and dilysocardiolipin (DLCL) (Narayanasamy et al. 2026)

Relationship

Family : CGI-58_ABHD5_ABHD4

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

Database

Sequence

Peptide

MADDLEQQSQ GWLSSWLPTW RPTSMSQLKN VEARILQCLQ NKFLARYVSL PNQNKIWTVT VSPEQNDRTP LVMVHGFGGG VGLWILNMDS LSARRTLHTF DLLGFGRSSR PAFPRDPEGA EDEFVTSIET WRETMGIPSM ILLGHSLGGF LATSYSIKYP DRVKHLILVD PWGFPLRPTN PSGICAPPAW VKAVASVLGR SNPLAVLRVA GPWGPGLVQR FRPDFKRKFA DFFEDDTISE YIYHCNAQNP SGETAFKAMM ESFGWARRPM LERIHLIRKD VPITMIYGSD TWIDTSTGKK VKMQRPDSYV RDMEIKGASH HVYADQPHIF NAVVEEICDS VD

References (12)

Title : Bortezomib Induces Apoptosis via Upregulation of Abhd4 in Peripheral Nerve Cells - Konishi_2026_Biol.Pharm.Bull_49_496
Author(s) : Konishi Y , Omura T , Ijichi T , Nishiguchi H , Hayakawa R , Kitahiro Y , Itohara K , Yamamoto K , Yano I
Ref : Biol Pharm Bull , 49 :496 , 2026
Abstract :
PubMedSearch : Konishi_2026_Biol.Pharm.Bull_49_496
PubMedID: 41833403
Gene_locus related to this paper: human-ABHD4 , mouse-abhd4

Title : ABHD4-2: a cardiolipin-selective phospholipase of the outer mitochondrial membrane - Narayanasamy_2026_J.Lipid.Res__101119
Author(s) : Narayanasamy R , Sanders MA , Zhang H , Moreno-Torres M , Ramseyer VD , Wei HG , Faergeman NJ , Kelly CV , Granneman JG
Ref : J Lipid Res , :101119 , 2026
Abstract :
PubMedSearch : Narayanasamy_2026_J.Lipid.Res__101119
PubMedID: 42562323
Gene_locus related to this paper: drome-CG1882 , human-ABHD4

Title : ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice - Seramur_2023_J.Lipid.Res__100405
Author(s) : Seramur ME , Sink S , O'Brien Cox A , Furdui CM , Key CC
Ref : J Lipid Res , :100405 , 2023
Abstract :
PubMedSearch : Seramur_2023_J.Lipid.Res__100405
PubMedID: 37352974
Gene_locus related to this paper: human-ABHD4 , mouse-abhd4

Title : ABHD4-Regulating RNA Panel: Novel Biomarkers in Acute Coronary Syndrome Diagnosis - Agwa_2021_Cells_10_
Author(s) : Agwa SHA , Elzahwy SS , El Meteini MS , Elghazaly H , Saad M , Abd Elsamee AM , Shamekh R , Matboli M
Ref : Cells , 10 : , 2021
Abstract :
PubMedSearch : Agwa_2021_Cells_10_
PubMedID: 34208452
Gene_locus related to this paper: human-ABHD4

Title : ABHD4-dependent developmental anoikis safeguards the embryonic brain - Laszlo_2020_Nat.Commun_11_4363
Author(s) : Laszlo ZI , Lele Z , Zoldi M , Miczan V , Mogor F , Simon GM , Mackie K , Kacskovics I , Cravatt BF , Katona I
Ref : Nat Commun , 11 :4363 , 2020
Abstract :
PubMedSearch : Laszlo_2020_Nat.Commun_11_4363
PubMedID: 32868797
Gene_locus related to this paper: human-ABHD4 , mouse-abhd4

Title : Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases - Baggelaar_2017_ACS.Chem.Biol_12_852
Author(s) : Baggelaar MP , van Esbroeck AC , van Rooden EJ , Florea BI , Overkleeft HS , Marsicano G , Chaouloff F , van der Stelt M
Ref : ACS Chemical Biology , 12 :852 , 2017
Abstract :
PubMedSearch : Baggelaar_2017_ACS.Chem.Biol_12_852
PubMedID: 28106377
Gene_locus related to this paper: human-ABHD4 , human-ABHD6 , human-ABHD12 , human-DAGLA , human-MGLL

Title : Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines - Hussain_2017_Biochim.Biophys.Acta_1862_1546
Author(s) : Hussain Z , Uyama T , Tsuboi K , Ueda N
Ref : Biochimica & Biophysica Acta , 1862 :1546 , 2017
Abstract :
PubMedSearch : Hussain_2017_Biochim.Biophys.Acta_1862_1546
PubMedID: 28843504
Gene_locus related to this paper: human-ABHD4

Title : ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system - Lee_2015_Biochemistry_54_2539
Author(s) : Lee HC , Simon GM , Cravatt BF
Ref : Biochemistry , 54 :2539 , 2015
Abstract :
PubMedSearch : Lee_2015_Biochemistry_54_2539
PubMedID: 25853435
Gene_locus related to this paper: human-ABHD4

Title : A genome wide shRNA screen identifies alpha\/beta hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance - Simpson_2012_Apoptosis_17_666
Author(s) : Simpson CD , Hurren R , Kasimer D , MacLean N , Eberhard Y , Ketela T , Moffat J , Schimmer AD
Ref : Apoptosis , 17 :666 , 2012
Abstract :
PubMedSearch : Simpson_2012_Apoptosis_17_666
PubMedID: 22488300
Gene_locus related to this paper: human-ABHD4

Title : Multiple pathways involved in the biosynthesis of anandamide - Liu_2008_Neuropharmacol_54_1
Author(s) : Liu J , Wang L , Harvey-White J , Huang BX , Kim HY , Luquet S , Palmiter RD , Krystal G , Rai R , Mahadevan A , Razdan RK , Kunos G
Ref : Neuropharmacology , 54 :1 , 2008
Abstract :
PubMedSearch : Liu_2008_Neuropharmacol_54_1
PubMedID: 17631919
Gene_locus related to this paper: human-ABHD4

Title : Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha\/beta-hydrolase 4 in this pathway - Simon_2006_J.Biol.Chem_281_26465
Author(s) : Simon GM , Cravatt BF
Ref : Journal of Biological Chemistry , 281 :26465 , 2006
Abstract :
PubMedSearch : Simon_2006_J.Biol.Chem_281_26465
PubMedID: 16818490
Gene_locus related to this paper: human-ABHD4

Title : Complete sequencing and characterization of 21,243 full-length human cDNAs - Ota_2004_Nat.Genet_36_40
Author(s) : Ota T , Suzuki Y , Nishikawa T , Otsuki T , Sugiyama T , Irie R , Wakamatsu A , Hayashi K , Sato H , Nagai K , Kimura K , Makita H , Sekine M , Obayashi M , Nishi T , Shibahara T , Tanaka T , Ishii S , Yamamoto J , Saito K , Kawai Y , Isono Y , Nakamura Y , Nagahari K , Murakami K , Yasuda T , Iwayanagi T , Wagatsuma M , Shiratori A , Sudo H , Hosoiri T , Kaku Y , Kodaira H , Kondo H , Sugawara M , Takahashi M , Kanda K , Yokoi T , Furuya T , Kikkawa E , Omura Y , Abe K , Kamihara K , Katsuta N , Sato K , Tanikawa M , Yamazaki M , Ninomiya K , Ishibashi T , Yamashita H , Murakawa K , Fujimori K , Tanai H , Kimata M , Watanabe M , Hiraoka S , Chiba Y , Ishida S , Ono Y , Takiguchi S , Watanabe S , Yosida M , Hotuta T , Kusano J , Kanehori K , Takahashi-Fujii A , Hara H , Tanase TO , Nomura Y , Togiya S , Komai F , Hara R , Takeuchi K , Arita M , Imose N , Musashino K , Yuuki H , Oshima A , Sasaki N , Aotsuka S , Yoshikawa Y , Matsunawa H , Ichihara T , Shiohata N , Sano S , Moriya S , Momiyama H , Satoh N , Takami S , Terashima Y , Suzuki O , Nakagawa S , Senoh A , Mizoguchi H , Goto Y , Shimizu F , Wakebe H , Hishigaki H , Watanabe T , Sugiyama A , Takemoto M , Kawakami B , Watanabe K , Kumagai A , Itakura S , Fukuzumi Y , Fujimori Y , Komiyama M , Tashiro H , Tanigami A , Fujiwara T , Ono T , Yamada K , Fujii Y , Ozaki K , Hirao M , Ohmori Y , Kawabata A , Hikiji T , Kobatake N , Inagaki H , Ikema Y , Okamoto S , Okitani R , Kawakami T , Noguchi S , Itoh T , Shigeta K , Senba T , Matsumura K , Nakajima Y , Mizuno T , Morinaga M , Sasaki M , Togashi T , Oyama M , Hata H , Komatsu T , Mizushima-Sugano J , Satoh T , Shirai Y , Takahashi Y , Nakagawa K , Okumura K , Nagase T , Nomura N , Kikuchi H , Masuho Y , Yamashita R , Nakai K , Yada T , Ohara O , Isogai T , Sugano S
Ref : Nat Genet , 36 :40 , 2004
Abstract :
PubMedSearch : Ota_2004_Nat.Genet_36_40
PubMedID: 14702039
Gene_locus related to this paper: human-ABHD1 , human-ABHD4 , human-ABHD12 , human-ABHD16A , human-ACOT1 , human-LDAH , human-ABHD18 , human-CES1 , human-CES4A , human-CES5A , human-CPVL , human-DAGLB , human-EPHX2 , human-KANSL3 , human-LIPA , human-LPL , human-MEST , human-NDRG1 , human-NLGN1 , human-NLGN4X , human-PRCP , human-PRSS16 , human-SERAC1 , human-TMEM53 , human-cb069