Gene_Locus Report

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Gene_locus Report for: anoga-ACHE2

Anopheles gambiae str. PEST (Anopheles funestus (African malaria mosquito); A merus; A arabiensis; A melas) acetylchlolinesterase 2

Comment
Other strains: Anopheles merus; Anopheles arabiensis; Anopheles melas


Relationship
Family|ACHE
Block| C
Position in NCBI Life Tree|Anopheles gambiae
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Nematocera: N E > Culicomorpha: N E > Culicoidea: N E > Culicidae: N E > Anophelinae: N E > Anopheles [genus]: N E > Cellia: N E > Pyretophorus: N E > gambiae species complex: N E > Anopheles gambiae: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
Sequence
Graphical view for this peptide sequence: anoga-ACHE2
Colored MSA for ACHE (raw)
MASAYYHQSAVGVGNVLVLLLGATVICPAYAIIDRLVVQTSSGPIRGRST
MVQGREVHVFNGVPFAKPPVDSLRFKKPVPAEPWHGVLDATRLPPSCIQE
RYEYFPGFAGEEMWNPNTNVSEDCLYLNIWVPTKTRLRHGRGLNFGSNDY
FQDDDDFQRQHQSKGGLAMLVWIYGGGFMSGTSTLDIYNAEILAAVGNVI
VASMQYRVGAFGFLYLAPYINGYEEDAPGNMGMWDQALAIRWLKENAKAF
GGDPDLITLFGESAGGSSVSLHLLSPVTRGLSKRGILQSGTLNAPWSHMT
AEKALQIAEGLIDDCNCNLTMLKESPSTVMQCMRNVDAKTISVQQWNSYS
GILGFPSAPTIDGVFMTADPMTMLREANLEGIDILVGSNRDEGTYFLLYD
FIDYFEKDAATSLPRDKFLEIMNTIFNKASEPEREAIIFQYTGWESGNDG
YQNQHQVGRAVGDHFFICPTNEFALGLTERGASVHYYYFTHRTSTSLWGE
WMGVLHGDEVEYIFGQPMNASLQYRQRERDLSRRMVLSVSEFARTGNPAL
EGEHWPLYTRENPIYFIFNAEGEDDLRGEKYGRGPMATSCAFWNDFLPRL
RAWSVPLKDPCKLDDHTSIASTARAAPTVALLIALSLAVARLVAA
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MASAYYHQSAVGVGNVLVLLLGATVICPAYAIIDRLVVQTSSGPIRGRST
MVQGREVHVFNGVPFAKPPVDSLRFKKPVPAEPWHGVLDATRLPPSCIQE
RYEYFPGFAGEEMWNPNTNVSEDCLYLNIWVPTKTRLRHGRGLNFGSNDY
FQDDDDFQRQHQSKGGLAMLVWIYGGGFMSGTSTLDIYNAEILAAVGNVI
VASMQYRVGAFGFLYLAPYINGYEEDAPGNMGMWDQALAIRWLKENAKAF
GGDPDLITLFGESAGGSSVSLHLLSPVTRGLSKRGILQSGTLNAPWSHMT
AEKALQIAEGLIDDCNCNLTMLKESPSTVMQCMRNVDAKTISVQQWNSYS
GILGFPSAPTIDGVFMTADPMTMLREANLEGIDILVGSNRDEGTYFLLYD
FIDYFEKDAATSLPRDKFLEIMNTIFNKASEPEREAIIFQYTGWESGNDG
YQNQHQVGRAVGDHFFICPTNEFALGLTERGASVHYYYFTHRTSTSLWGE
WMGVLHGDEVEYIFGQPMNASLQYRQRERDLSRRMVLSVSEFARTGNPAL
EGEHWPLYTRENPIYFIFNAEGEDDLRGEKYGRGPMATSCAFWNDFLPRL
RAWSVPLKDPCKLDDHTSIASTARAAPTVALLIALSLAVARLVAA


References
    Title: Biochemical properties, expression profiles, and tissue localization of orthologous acetylcholinesterase-2 in the mosquito, Anopheles gambiae
    Zhao P, Wang Y, Jiang H
    Ref: Insect Biochemistry & Molecular Biology, 43:260, 2013 : PubMed

            

    Title: The genome sequence of the malaria mosquito Anopheles gambiae
    Holt RA, Subramanian GM, Halpern A, Sutton GG, Charlab R, Nusskern DR, Wincker P, Clark AG, Ribeiro JM and Hoffman SL <113 more author(s)>
    Ref: Science, 298:129, 2002 : PubMed

            

    Title: A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non-homologous to the ace gene Drosophila
    Weill M, Fort P, Berthomieu A, Dubois MP, Pasteur N, Raymond M
    Ref: Proc R Soc Lond B Biol Sci, 269:2007, 2002 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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