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Inhibitor Report for: Palmostatin-B

Palmostatin B inhibits other protein thioesterases, such as APT2 (human-LYPLA2) (Ki = 34 nM)


General
Type Oxooxetan
Chemical_Nomenclature (3S,4S)-3-decyl-4-[2-(3,4-dimethoxyphenyl)ethyl]oxetan-2-one
Canonical SMILES CCCCCCCCCCC1C(OC1=O)CCC2=CC(=C(C=C2)OC)OC
InChI InChI=1S/C23H36O4/c1-4-5-6-7-8-9-10-11-12-19-20(27-23(19)24)15-13-18-14-16-21(25-2)22(17-18)26-3/h14,16-17,19-20H,4-13,15H2,1-3H3/t19-,20-/m0/s1
InChIKey ASVWFAVGLYUDFD-PMACEKPBSA-N
Other name(s) Palmostatin B ; PalmB ; Palm B ; CHEMBL1673415 ; PalmostatinB ; BDBM50336546
________________________________________________________________________________________________
MW|376.52
Formula|C23H36O4
CAS_number|
PubChem|45100481
UniChem|ASVWFAVGLYUDFD-PMACEKPBSA-N
IUPHAR|
Wikipedia|


References:
Search PubMed for references concerning: Palmostatin-B

6 more
    Title: Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways
    Turcotte C, Dumais E, Archambault AS, Martin C, Blanchet MR, Bissonnette E, Boulet LP, Laviolette M, Di Marzo V, Flamand N
    Ref: J Leukoc Biol, 106:1337, 2019 : PubMed

            

    Title: Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)
    Savinainen JR, Patel JZ, Parkkari T, Navia-Paldanius D, Marjamaa JJ, Laitinen T, Nevalainen T, Laitinen JT
    Ref: PLoS ONE, 9:e109869, 2014 : PubMed

            

    Title: Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M
    Rusch M, Zimmermann TJ, Burger M, Dekker FJ, Gormer K, Triola G, Brockmeyer A, Janning P, Bottcher T and Waldmann H <3 more author(s)>
    Ref: Angew Chem Int Ed Engl, 50:9838, 2011 : PubMed