Cyclobutyl

General

A cyclobutyl group is defined as a four-membered carbon ring that serves as a pendent group in polymer structures

Inhibitor	Main targeted enzyme families	Type
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27	Monoglyceridelipase_lysophospholip	Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
Dimethyladamantan-ureido-cyclohexyl-dioxocyclobutenyl-methylbenzenesulfonamide-CpdA1	Epoxide_hydrolase	Urea derivative Piperidine Adamantyl Sulfur Compound Sulfonamide Cyclobutyl
KBR-2822		Sulfur Compound Organophosphate Trifluoro Cyclobutyl Not AlphaBeta Hydrolase target
J8-A34	ACHE	Piperidine Sulfur Compound Sulfonamide Quinoline Isoquinoline Cyclobutyl Benzylpiperidine Derivative of Donepezil Organochlorine
XB8-8CGO	BCHE	Alkaloid Natural_modified Cyclobutyl
ARUK3004877	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Indole Cyclobutyl
2-allyl-4-oxocyclobutyl-4-methylbenzenesulfonamide	LYsophospholipase_carboxylesterase	Sulfur Compound Sulfonamide Benzenesulfonamide Cyclobutyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27	Monoglyceridelipase_lysophospholip	Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
Dimethyladamantan-ureido-cyclohexyl-dioxocyclobutenyl-methylbenzenesulfonamide-CpdA1	Epoxide_hydrolase	Urea derivative Piperidine Adamantyl Sulfur compound Sulfonamide Cyclobutyl
KBR-2822		Sulfur compound Organophosphate Trifluoro Cyclobutyl Not AlphaBeta Hydrolase target
J8-A34	ACHE	Piperidine Sulfur compound Sulfonamide Quinoline Isoquinoline Cyclobutyl Benzylpiperidine Derivative of Donepezil Organochlorine
XB8-8CGO	BCHE	Alkaloid Natural_modified Cyclobutyl
ARUK3004877	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Indole Cyclobutyl
2-allyl-4-oxocyclobutyl-4-methylbenzenesulfonamide	LYsophospholipase_carboxylesterase	Sulfur compound Sulfonamide Benzenesulfonamide Cyclobutyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27	Monoglyceridelipase_lysophospholip	Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
Dimethyladamantan-ureido-cyclohexyl-dioxocyclobutenyl-methylbenzenesulfonamide-CpdA1	Epoxide_hydrolase	Urea derivative Piperidine Adamantyl Sulfur compound Sulfonamide Cyclobutyl
KBR-2822		Sulfur compound Organophosphate Trifluoro Cyclobutyl Not AlphaBeta Hydrolase target
J8-A34	ACHE	Piperidine Sulfur compound Sulfonamide Quinoline Isoquinoline Cyclobutyl Benzylpiperidine Derivative of Donepezil Organochlorine
XB8-8CGO	BCHE	Alkaloid Natural_modified Cyclobutyl
ARUK3004877	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Indole Cyclobutyl
2-allyl-4-oxocyclobutyl-4-methylbenzenesulfonamide	LYsophospholipase_carboxylesterase	Sulfur compound Sulfonamide Benzenesulfonamide Cyclobutyl