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Author Report for: Hsu KL

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    Title: Diacylglycerol Lipase-beta Is Required for TNF-alpha Response but Not CD8(+) T Cell Priming Capacity of Dendritic Cells
    Shin M, Buckner A, Prince J, Bullock TNJ, Hsu KL
    Ref: Cell Chemical Biology, 26:1036, 2019 : PubMed

            

    Title: Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond
    Shin M, Ware TB, Lee HC, Hsu KL
    Ref: Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids, 1864:907, 2019 : PubMed

            

    Title: Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy
    Curry ZA, Wilkerson JL, Bagdas D, Kyte SL, Patel N, Donvito G, Mustafa MA, Poklis JL, Niphakis MJ and Lichtman AH <4 more author(s)>
    Ref: Journal of Pharmacology & Experimental Therapeutics, 366:169, 2018 : PubMed

            

    Title: Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis
    Manterola A, Bernal-Chico A, Cipriani R, Ruiz A, Perez-Samartin A, Moreno-Rodriguez M, Hsu KL, Cravatt BF, Brown JM and Mato S <2 more author(s)>
    Ref: Neuropharmacology, 141:181, 2018 : PubMed

            

    Title: Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination
    Manterola A, Bernal-Chico A, Cipriani R, Canedo-Antelo M, Moreno-Garcia A, Martin-Fontecha M, Perez-Cerda F, Sanchez-Gomez MV, Ortega-Gutierrez S and Mato S <4 more author(s)>
    Ref: Biochemical Pharmacology, 157:189, 2018 : PubMed

            

    Title: Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo
    Shin M, Snyder HW, Donvito G, Schurman LD, Fox TE, Lichtman AH, Kester M, Hsu KL
    Ref: Mol Pharm, 15:721, 2018 : PubMed

            

    Title: Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2
    Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC
    Ref: Biochemical & Biophysical Research Communications, 490:1226, 2017 : PubMed

            

    Title: Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure
    Buczynski MW, Herman MA, Hsu KL, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ and Parsons LH <2 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 113:1086, 2016 : PubMed

            

    Title: Diacylglycerol lipase beta inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain
    Wilkerson JL, Ghosh S, Bagdas D, Mason BL, Crowe MS, Hsu KL, Wise LE, Kinsey SG, Damaj MI and Lichtman AH <1 more author(s)>
    Ref: British Journal of Pharmacology, 173:1678, 2016 : PubMed

            

    Title: Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons
    Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H and van der Stelt M <10 more author(s)>
    Ref: Journal of the American Chemical Society, 137:8851, 2015 : PubMed

            

    Title: Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes
    Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D and Saez E <6 more author(s)>
    Ref: Nat Chemical Biology, 10:113, 2014 : PubMed

            

    Title: Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells
    Manna JD, Wepy JA, Hsu KL, Chang JW, Cravatt BF, Marnett LJ
    Ref: Journal of Biological Chemistry, 289:33741, 2014 : PubMed

            

    Title: ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice
    Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs WR, Blankman JL, Tu S and Stella N <8 more author(s)>
    Ref: Neuron, 83:361, 2014 : PubMed

            

    Title: Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation
    Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC
    Ref: Journal of Biological Chemistry, 289:1491, 2014 : PubMed

            

    Title: Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1)
    Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T and Rosen H <4 more author(s)>
    Ref: Probe Report, :, 2013 : PubMed

            

    Title: Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2)
    Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T and Rosen H <4 more author(s)>
    Ref: Probe Report, :, 2013 : PubMed

            

    Title: Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of alpha/beta-hydrolase domain containing 6 (ABHD6)
    Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF
    Ref: Journal of Medicinal Chemistry, 56:8270, 2013 : PubMed

            

    Title: Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis
    Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF
    Ref: Journal of Medicinal Chemistry, 56:8257, 2013 : PubMed

            

    Title: Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)
    Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J and Cravatt BF <5 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 23:839, 2013 : PubMed

            

    Title: Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes
    Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T and Cravatt BF <4 more author(s)>
    Ref: J Am Chem Soc, 134:10345, 2012 : PubMed

            

    Title: DAGLbeta inhibition perturbs a lipid network involved in macrophage inflammatory responses
    Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF
    Ref: Nat Chemical Biology, 8:999, 2012 : PubMed

            

    Title: Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta)
    Hsu KL, Tsuboi K, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H
    Ref: Probe Report, :, 2012 : PubMed

            

    Title: Competitive activity-based protein profiling identifies aza-beta-lactams as a versatile chemotype for serine hydrolase inhibition
    Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, Lopez-Alberca MP, Fu GC, Cravatt BF
    Ref: J Am Chem Soc, 134:5068, 2012 : PubMed

            

    Title: Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors
    Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF
    Ref: Nat Chemical Biology, 7:469, 2011 : PubMed

            

    Title: Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211
    Adibekian A, Hsu KL, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H
    Ref: Probe Report, :, 2011 : PubMed

            

    Title: Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2)
    Adibekian A, Hsu KL, Speers AE, Monillas ES, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Bahnson BJ and Rosen H <2 more author(s)>
    Ref: Probe Report, :, 2011 : PubMed

            


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