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Author Report for: Hosokawa M

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    Title: Creating Pyrethrin Mimetic Phosphonates as Chemical Genetics Tools Targeting the GDSL Esterase/Lipase TcGLIP to Investigate Pyrethrin Biosynthesis
    Matsuo N, Sugisaka Y, Aoyama S, Ihara M, Shinoyama H, Hosokawa M, Kamakura Y, Tanaka D, Tanabe Y, Matsuda K
    Ref: Journal of Medicinal Chemistry, :, 2023 : PubMed

            

    Title: Functional roles and localization of hydrolases in the Japanese mitten crab Eriocheir japonica
    Takahashi M, Takahashi K, Yamaguchi T, Kohama T, Hosokawa M
    Ref: Comparative Biochemistry & Physiology B Biochem Mol Biol, 270:110932, 2023 : PubMed

            

    Title: Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases
    Takani D, Takahashi M, Hosokawa M
    Ref: Xenobiotica, :1, 2023 : PubMed

            

    Title: Identification of Lipolytic Enzymes Using High-Throughput Single-cell Screening and Sorting of a Metagenomic Library
    Alma'abadi A, Behzad H, Alarawi M, Conchouso D, Saito Y, Hosokawa M, Nishikawa Y, Kogawa M, Takeyama H and Gojobori T <1 more author(s)>
    Ref: N Biotechnol, :, 2022 : PubMed

            

    Title: Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase
    Takahashi M, Hirota I, Nakano T, Kotani T, Takani D, Shiratori K, Choi Y, Haba M, Hosokawa M
    Ref: Drug Metab Pharmacokinet, 38:100391, 2021 : PubMed

            

    Title: Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters
    Takahashi M, Takani D, Haba M, Hosokawa M
    Ref: Chirality, 32:73, 2020 : PubMed

            

    Title: Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1
    Takahashi M, Lee YJ, Kanayama T, Kondo Y, Nishio K, Mukai K, Haba M, Hosokawa M
    Ref: Eur J Pharm Sci, :105455, 2020 : PubMed

            

    Title: Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases
    Mizoi K, Takahashi M, Sakai S, Ogihara T, Haba M, Hosokawa M
    Ref: Xenobiotica, :1, 2019 : PubMed

            

    Title: Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase
    Takahashi M, Uehara T, Nonaka M, Minagawa Y, Yamazaki R, Haba M, Hosokawa M
    Ref: Eur J Pharm Sci, 132:125, 2019 : PubMed

            

    Title: Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies
    Ishizaki Y, Furihata T, Oyama Y, Ohura K, Imai T, Hosokawa M, Akita H, Chiba K
    Ref: Biol Pharm Bull, 41:697, 2018 : PubMed

            

    Title: Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1
    Takahashi M, Ogawa T, Kashiwagi H, Fukushima F, Yoshitsugu M, Haba M, Hosokawa M
    Ref: Bioorganic & Medicinal Chemistry Lett, 28:997, 2018 : PubMed

            

    Title: Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver
    Uno Y, Igawa Y, Tanaka M, Kayoko O, Hosokawa M, Imai T
    Ref: Xenobiotica, :1, 2018 : PubMed

            

    Title: Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques
    Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T
    Ref: J Med Primatol, 47:185, 2018 : PubMed

            

    Title: Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes
    Kabeya T, Matsumura W, Iwao T, Hosokawa M, Matsunaga T
    Ref: Biochemical & Biophysical Research Communications, 486:143, 2017 : PubMed

            

    Title: Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases
    Mizoi K, Takahashi M, Haba M, Hosokawa M
    Ref: Bioorganic & Medicinal Chemistry Lett, 26:921, 2016 : PubMed

            

    Title: Droplet-based microfluidics for high-throughput screening of a metagenomic library for isolation of microbial enzymes
    Hosokawa M, Hoshino Y, Nishikawa Y, Hirose T, Yoon DH, Mori T, Sekiguchi T, Shoji S, Takeyama H
    Ref: Biosensors & Bioelectronics, 67:379, 2015 : PubMed

            

    Title: Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques
    Uno Y, Hosokawa M, Imai T
    Ref: J Vet Med Sci, 77:721, 2015 : PubMed

            

    Title: Draft Genome Sequences of Marine Flavobacterium Algibacter lectus Strains SS8 and NR4
    Takatani N, Nakanishi M, Meirelles P, Mino S, Suda W, Oshima K, Hattori M, Ohkuma M, Hosokawa M and Sawabe T <3 more author(s)>
    Ref: Genome Announc, 2:, 2014 : PubMed

            

    Title: Systematic identification and characterization of carboxylesterases in cynomolgus macaques
    Uno Y, Uehara S, Hosokawa M, Imai T
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 42:2002, 2014 : PubMed

            

    Title: The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans
    Suzaki Y, Uemura N, Takada M, Ohyama T, Itohda A, Morimoto T, Imai H, Hamasaki H, Inano A and Ohashi K <2 more author(s)>
    Ref: European Journal of Clinical Pharmacology, 69:21, 2013 : PubMed

            

    Title: Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene
    Hori T, Jin L, Fujii A, Furihata T, Nagahara Y, Chiba K, Hosokawa M
    Ref: Xenobiotica, 42:614, 2012 : PubMed

            

    Title: Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
    Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M and Maltais LJ <9 more author(s)>
    Ref: Mamm Genome, 21:427, 2010 : PubMed

            

    Title: DNA methylation and its involvement in carboxylesterase 1A1 (CES1A1) gene expression
    Hori T, Hosokawa M
    Ref: Xenobiotica, 40:119, 2010 : PubMed

            

    Title: The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages
    Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y and Ishibashi S <11 more author(s)>
    Ref: Circulation Research, 107:1387, 2010 : PubMed

            

    Title: Prodrug approach using carboxylesterases activity: catalytic properties and gene regulation of carboxylesterase in mammalian tissue
    Imai T, Hosokawa M
    Ref: Journal of Pesticide Science, 35:229, 2010 : PubMed

            

    Title: Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients
    Sai K, Saito Y, Tatewaki N, Hosokawa M, Kaniwa N, Nishimaki-Mogami T, Naito M, Sawada J, Shirao K and Okuda H <11 more author(s)>
    Ref: British Journal of Clinical Pharmacology, 70:222, 2010 : PubMed

            

    Title: Carboxylesterases: structure, function and polymorphism in mammals
    Satoh T, Hosokawa M
    Ref: Journal of Pesticide Science, 35:218, 2010 : PubMed

            

    Title: Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs
    Hosokawa M
    Ref: Molecules, 13:412, 2008 : PubMed

            

    Title: Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes
    Hosokawa M, Furihata T, Yaginuma Y, Yamamoto N, Watanabe N, Tsukada E, Ohhata Y, Kobayashi K, Satoh T, Chiba K
    Ref: Drug Metab Pharmacokinet, 23:73, 2008 : PubMed

            

    Title: Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites
    Yoshimura M, Kimura T, Ishii M, Ishii K, Matsuura T, Geshi E, Hosokawa M, Muramatsu M
    Ref: Biochemical & Biophysical Research Communications, 369:939, 2008 : PubMed

            

    Title: Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes
    Hosokawa M, Furihata T, Yaginuma Y, Yamamoto N, Koyano N, Fujii A, Nagahara Y, Satoh T, Chiba K
    Ref: Drug Metabolism Reviews, 39:1, 2007 : PubMed

            

    Title: Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver
    Furihata T, Hosokawa M, Masuda M, Satoh T, Chiba K
    Ref: Archives of Biochemistry & Biophysics, 447:107, 2006 : PubMed

            

    Title: Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine
    Imai T, Taketani M, Shii M, Hosokawa M, Chiba K
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 34:1734, 2006 : PubMed

            

    Title: Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase
    Miyazaki M, Yamashita T, Hosokawa M, Taira H, Suzuki A
    Ref: Comparative Biochemistry & Physiology B Biochem Mol Biol, 145:270, 2006 : PubMed

            

    Title: Structure, function and regulation of carboxylesterases
    Satoh T, Hosokawa M
    Ref: Chemico-Biological Interactions, 162:195, 2006 : PubMed

            

    Title: Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma
    Furihata T, Hosokawa M, Fujii A, Derbel M, Satoh T, Chiba K
    Ref: Biochemical Pharmacology, 69:1287, 2005 : PubMed

            

    Title: Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA cloning, and baculovirus-mediated expression
    Furihata T, Hosokawa M, Koyano N, Nakamura T, Satoh T, Chiba K
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 32:1170, 2004 : PubMed

            

    Title: Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family
    Furihata T, Hosokawa M, Nakata F, Satoh T, Chiba K
    Ref: Archives of Biochemistry & Biophysics, 416:101, 2003 : PubMed

            

    Title: Current progress on esterases: from molecular structure to function
    Satoh T, Taylor P, Bosron WF, Sanghani SP, Hosokawa M, La Du BN
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 30:488, 2002 : PubMed

            

    Title: Purification, molecular cloning, and functional expression of dog liver microsomal acyl-CoA hydrolase: a member of the carboxylesterase multigene family
    Hosokawa M, Suzuki K, Takahashi D, Mori M, Satoh T, Chiba K
    Ref: Archives of Biochemistry & Biophysics, 389:245, 2001 : PubMed

            

    Title: Phenacetin deacetylase activity in human liver microsomes: distribution, kinetics, and chemical inhibition and stimulation
    Kudo S, Umehara K, Hosokawa M, Miyamoto G, Chiba K, Satoh T
    Ref: Journal of Pharmacology & Experimental Therapeutics, 294:80, 2000 : PubMed

            

    Title: Organophosphates and their impact on the global environment
    Satoh T, Hosokawa M
    Ref: Neurotoxicology, 21:223, 2000 : PubMed

            

    Title: cDNA cloning, characterization and stable expression of novel human brain carboxylesterase
    Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K
    Ref: FEBS Letters, 458:17, 1999 : PubMed

            

    Title: Toxicological significance in the cleavage of esterase-beta-glucuronidase complex in liver microsomes by organophosphorus compounds
    Satoh T, Suzuki S, Kawai N, Nakamura T, Hosokawa M
    Ref: Chemico-Biological Interactions, 119-120:471, 1999 : PubMed

            

    Title: The mammalian carboxylesterases: from molecules to functions
    Satoh T, Hosokawa M
    Ref: Annual Review of Pharmacology & Toxicology, 38:257, 1998 : PubMed

            

    Title: Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases
    Takayama H, Watanabe A, Hosokawa M, Chiba K, Satoh T, Aimi N
    Ref: Bioorganic & Medicinal Chemistry Lett, 8:415, 1998 : PubMed

            

    Title: cDNA cloning and genomic organization of peroxisome proliferator- inducible long-chain acyl-CoA hydrolase from rat liver cytosol.
    Yamada J, Suga K, Furihata T, Kitahara M, Watanabe T, Hosokawa M, Satoh T, Suga T
    Ref: Biochemical & Biophysical Research Communications, 248:608, 1998 : PubMed

            

    Title: Molecular cloning and expression of cDNAs encoding rat brain and liver cytosolic long-chain acyl-CoA hydrolases
    Yamada J, Furihata T, Iida N, Watanabe T, Hosokawa M, Satoh T, Someya A, Nagaoka I, Suga T
    Ref: Biochemical & Biophysical Research Communications, 232:198, 1997 : PubMed

            

    Title: Differences in the induction of carboxylesterase RL4 in rat liver microsomes by various perfluorinated fatty acids, metabolically inert derivatives of fatty acids
    Derbel M, Hosokawa M, Satoh T
    Ref: Biol Pharm Bull, 19:765, 1996 : PubMed

            

    Title: Interindividual variation in carboxylesterase levels in human liver microsomes
    Hosokawa M, Endo T, Fujisawa M, Hara S, Iwata N, Sato Y, Satoh T
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 23:1022, 1995 : PubMed

            

    Title: Molecular aspects of carboxylesterase isoforms in comparison with other esterases
    Satoh T, Hosokawa M
    Ref: Toxicol Lett, 82-83:439, 1995 : PubMed

            

    Title: Localization of an isoform of carboxylesterase in rat brain differs from that in human brain
    Yamada T, Kawaguchi N, Hosokawa M, Satoh T
    Ref: Brain Research, 674:175, 1995 : PubMed

            

    Title: Species differences in the induction of hepatic microsomal carboxylesterases caused by dietary exposure to di(2-ethylhexyl)phthalate, a peroxisome proliferator
    Hosokawa M, Hirata K, Nakata F, Suga T, Satoh T
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 22:889, 1994 : PubMed

            

    Title: Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase
    Satoh T, Hosokawa M, Atsumi R, Suzuki W, Hakusui H, Nagai E
    Ref: Biol Pharm Bull, 17:662, 1994 : PubMed

            

    Title: Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues
    Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, Yamamoto T
    Ref: Brain Research, 658:163, 1994 : PubMed

            

    Title: Differential responses of rat hepatic microsomal carboxylesterase isozymes to glucocorticoids and pregnenolone 16 alpha-carbonitrile
    Hosokawa M, Hattori K, Satoh T
    Ref: Biochemical Pharmacology, 45:2317, 1993 : PubMed

            

    Title: Differences in the induction of carboxylesterase isozymes in rat liver microsomes by perfluorinated fatty acids
    Hosokawa M, Satoh T
    Ref: Xenobiotica, 23:1125, 1993 : PubMed

            

    Title: Changes in carboxylesterase isoenzymes of rat liver microsomes during hepatocarcinogenesis
    Maki T, Hosokawa M, Satoh T, Sato K
    Ref: Jpn J Cancer Research, 82:800, 1991 : PubMed

            

    Title: Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans
    Hosokawa M, Maki T, Satoh T
    Ref: Archives of Biochemistry & Biophysics, 277:219, 1990 : PubMed

            

    Title: Differences in the induction of carboxylesterase isozymes in rat liver microsomes by xenobiotics
    Hosokawa M, Maki T, Satoh T
    Ref: Biochemical Pharmacology, 37:2708, 1988 : PubMed

            

    Title: Effects of hypophysectomy and pituitary hormones on hepatic microsomal carboxylesterase isozymes in male rats
    Hosokawa M, Satoh T
    Ref: Res Commun Chem Pathol Pharmacol, 62:279, 1988 : PubMed

            

    Title: Multiplicity and regulation of hepatic microsomal carboxylesterases in rats
    Hosokawa M, Maki T, Satoh T
    Ref: Molecular Pharmacology, 31:579, 1987 : PubMed

            

    Title: Effects of adrenalectomy on gonadal hormone-induced changes in hepatic microsomal carboxylesterase activities in rats
    Hosokawa M, Satoh T, Ohkawara S, Ohmori S, Igarashi T, Ueno K, Kitagawa H
    Ref: Res Commun Chem Pathol Pharmacol, 47:285, 1985 : PubMed

            

    Title: Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro
    Sugiyama S, Hosokawa M, Igarashi T, Ueno K, Satoh T, Kitagawa H
    Ref: Japanese Journal of Pharmacology, 37:39, 1985 : PubMed

            

    Title: Gonadal hormone-induced changes in hepatic microsomal carboxylesterase in rats
    Hosokawa M, Satoh T, Ohkawara S, Ohmori S, Igarashi T, Ueno K, Kitagawa H
    Ref: Res Commun Chem Pathol Pharmacol, 46:245, 1984 : PubMed

            


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