Author

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Author Report for: Pang YP

Contact information:

Pang Yuan-Ping
Mayo Clinic; 200 First Street SW; Rochester; MN 55905
USA
Phone : +15072847868
Fax : 507-284-9111
Send E-Mail to Pang Yuan-Ping





    Title: Tacrine-Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer's Disease
    Cheng XJ, Gu JX, Pang YP, Liu J, Xu T, Li XR, Hua YZ, Newell KA, Huang XF and Liu Y <1 more author(s)>
    Ref: ACS Chem Neurosci, 10:3500, 2019 : PubMed

            

    Title: On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity
    Darras FH, Pang YP
    Ref: Biochemical & Biophysical Research Communications, 489:451, 2017 : PubMed

            

    Title: Physiological Roles for Butyrylcholinesterase: A BChE-Ghrelin Axis
    Brimijoin S, Chen VP, Pang YP, Geng L, Gao Y
    Ref: Chemico-Biological Interactions, 259:271, 2016 : PubMed

            

    Title: Protection against beta-amyloid-induced synaptic and memory impairments via altering beta-amyloid assembly by bis(heptyl)-cognitin
    Chang L, Cui W, Yang Y, Xu S, Zhou WH, Fu HJ, Hu SQ, Mak SH, Hu JW and Han YF <8 more author(s)>
    Ref: Sci Rep, 5:10256, 2015 : PubMed

            

    Title: Plasma butyrylcholinesterase regulates ghrelin to control aggression
    Chen VP, Gao Y, Geng L, Parks RJ, Pang YP, Brimijoin S
    Ref: Proc Natl Acad Sci U S A, 112:2251, 2015 : PubMed

            

    Title: Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's beta-Amyloid Neurotoxicity Via the Inhibition of Abeta Fibrils Formation and Disaggregation of Preformed Fibrils
    Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF
    Ref: CNS Neurosci Ther, 21:953, 2015 : PubMed

            

    Title: Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases
    Dou D, Park JG, Rana S, Madden BJ, Jiang H, Pang YP
    Ref: Sci Rep, 3:1068, 2013 : PubMed

            

    Title: Substantial Neuroprotection Against K(+) Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway
    Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF
    Ref: CNS Neurosci Ther, 19:764, 2013 : PubMed

            

    Title: Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle
    Lu Y, Pang YP, Park Y, Gao X, Yao J, Zhang X, Zhu KY
    Ref: PLoS ONE, 7:e32288, 2012 : PubMed

            

    Title: Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum
    Lu Y, Park Y, Gao X, Zhang X, Yao J, Pang YP, Jiang H, Zhu KY
    Ref: Sci Rep, 2:288, 2012 : PubMed

            

    Title: Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides
    Pang YP, Brimijoin S, Ragsdale DW, Zhu KY, Suranyi R
    Ref: Curr Drug Targets, 13:471, 2012 : PubMed

            

    Title: Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad
    Hornberg A, Artursson E, Warme R, Pang YP, Ekstrom F
    Ref: Biochemical Pharmacology, 79:507, 2010 : PubMed

            

    Title: Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle
    Polsinelli GA, Singh SK, Mishra RK, Suranyi R, Ragsdale DW, Pang YP, Brimijoin S
    Ref: Chemico-Biological Interactions, 187:142, 2010 : PubMed

            

    Title: Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds
    Wille T, Ekstrom F, Lee JC, Pang YP, Thiermann H, Worek F
    Ref: Biochemical Pharmacology, 80:941, 2010 : PubMed

            

    Title: Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design
    Ekstrom F, Hornberg A, Artursson E, Hammarstrom LG, Schneider G, Pang YP
    Ref: PLoS ONE, 4:e5957, 2009 : PubMed

            

    Title: Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides
    Pang YP, Singh SK, Gao Y, Lassiter TL, Mishra RK, Zhu KY, Brimijoin S
    Ref: PLoS ONE, 4:e4349, 2009 : PubMed

            

    Title: Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases
    Pang YP, Ekstrom F, Polsinelli GA, Gao Y, Rana S, Hua DH, Andersson B, Andersson PO, Peng L and Brimijoin S <5 more author(s)>
    Ref: PLoS ONE, 4:e6851, 2009 : PubMed

            

    Title: Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons
    Zhou L, Liu YW, Peoples RW, Yang M, Tian X, Ai YX, Pang YP, Li ZW, Han YF, Li CY
    Ref: Neuropharmacology, 57:33, 2009 : PubMed

            

    Title: Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies
    Liu YW, Luo JL, Ren H, Peoples RW, Ai YX, Liu LJ, Pang YP, Li ZW, Han YF, Li CY
    Ref: Neuropharmacology, 54:1086, 2008 : PubMed

            

    Title: The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine
    Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K and Han YF <1 more author(s)>
    Ref: J Pharm Biomed Anal, 46:75, 2008 : PubMed

            

    Title: Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry
    Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Lin G, Wang YT, Zuo Z, Han YF
    Ref: Biomedical Chromatography, 22:414, 2008 : PubMed

            

    Title: Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes
    Ekstrom F, Astot C, Pang YP
    Ref: Clinical Pharmacology & Therapeutics, 82:282, 2007 : PubMed

            

    Title: East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A
    Li WM, Kan KK, Carlier PR, Pang YP, Han YF
    Ref: Curr Alzheimer Res, 4:386, 2007 : PubMed

            

    Title: Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates
    Ekstrom F, Pang YP, Boman M, Artursson E, Akfur C, Borjegren S
    Ref: Biochemical Pharmacology, 72:597, 2006 : PubMed

            

    Title: Novel acetylcholinesterase target site for malaria mosquito control
    Pang YP
    Ref: PLoS ONE, 1:e58, 2006 : PubMed

            

    Title: Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge
    Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL
    Ref: Journal of Medicinal Chemistry, 49:5491, 2006 : PubMed

            

    Title: Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase
    Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL
    Ref: Journal of the American Chemical Society, 127:11029, 2005 : PubMed

            

    Title: A potent and selective tacrine analog--biomembrane permeation and physicochemical characterization
    Patani GA, Pang YP, Chien YW
    Ref: Pharm Dev Technol, 10:525, 2005 : PubMed

            

    Title: Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design
    Hammond PI, Kern C, Hong F, Kollmeyer TM, Pang YP, Brimijoin S
    Ref: Journal of Pharmacology & Experimental Therapeutics, 307:190, 2003 : PubMed

            

    Title: Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators
    Pang YP, Kollmeyer TM, Hong F, Lee JC, Hammond PI, Haugabouk SP, Brimijoin S
    Ref: Chemical Biology, 10:491, 2003 : PubMed

            

    Title: Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
    Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL
    Ref: J Am Chem Soc, 125:363, 2003 : PubMed

            

    Title: Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase
    Sun H, Shen ML, Pang YP, Lockridge O, Brimijoin S
    Ref: Journal of Pharmacology & Experimental Therapeutics, 302:710, 2002 : PubMed

            

    Title: Re-engineering butyrylcholinesterase as a cocaine hydrolase
    Sun H, Pang YP, Lockridge O, Brimijoin S
    Ref: Molecular Pharmacology, 62:220, 2002 : PubMed

            

    Title: Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ
    Ros E, Aleu J, Gomez de Aranda I, Canti C, Pang YP, Marsal J, Solsona C
    Ref: Journal of Neurophysiology, 86:183, 2001 : PubMed

            

    Title: Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
    Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP
    Ref: Journal of Biological Chemistry, 276:9330, 2001 : PubMed

            

    Title: Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product
    Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP
    Ref: Angew Chem Int Ed Engl, 39:1775, 2000 : PubMed

            

    Title: Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]
    Wu DC, Xiao XQ, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang YP, Yu AC, Han YF
    Ref: Neuroscience Letters, 288:95, 2000 : PubMed

            

    Title: Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis
    Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP
    Ref: Bioorganic & Medicinal Chemistry, 7:351, 1999 : PubMed

            

    Title: Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions
    Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP
    Ref: Journal of Medicinal Chemistry, 42:4225, 1999 : PubMed

            

    Title: Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors
    Carlier PR, Du DM, Han Y, Liu J, Pang YP
    Ref: Bioorganic & Medicinal Chemistry Lett, 9:2335, 1999 : PubMed

            

    Title: Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities
    Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR
    Ref: Bioorganic & Medicinal Chemistry, 7:2569, 1999 : PubMed

            

    Title: Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist
    Li CY, Wang H, Xue H, Carlier PR, Hui KM, Pang YP, Li ZW, Han YF
    Ref: Neuroreport, 10:795, 1999 : PubMed

            

    Title: Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE
    Wang H, Carlier PR, Ho WL, Wu DC, Lee NT, Li CP, Pang YP, Han YF
    Ref: Neuroreport, 10:789, 1999 : PubMed

            

    Title: Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor
    Wang H, Carlier PR, Ho WL, Lee NT, Pang YP, Han YF
    Ref: Zhongguo Yao Li Xue Bao, 20:211, 1999 : PubMed

            

    Title: Improved Acetylcholinesterase Reactivation with Bis-Oximes Modeled on Crystal Structure
    Hammond P, Kern C, Pang YP, Brimijoin S
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:252, 1998 : PubMed

            

    Title: Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
    Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL
    Ref: Nat Struct Biol, 4:57, 1997 : PubMed

            

    Title: Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease
    Pang YP, Quiram P, Jelacic T, Hong F, Brimijoin S
    Ref: Journal of Biological Chemistry, 271:23646, 1996 : PubMed

            

    Title: Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies
    Pang YP, Kozikowski AP
    Ref: J Comput Aided Mol Des, 8:669, 1994 : PubMed

            

    Title: Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program
    Pang YP, Kozikowski AP
    Ref: J Comput Aided Mol Des, 8:683, 1994 : PubMed

            

    Title: Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases
    Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radic Z, Quinn DM, Taylor P, Doctor BP
    Ref: Protein Science, 3:1770, 1994 : PubMed

            


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer