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Inhibitor Report for: Paraoxon

Pesticide. Results from the metabolism in vivo of Parathion (oxygen replaces the sulfur atom), Often used in biochemical investigations of serine hydrolases (structures of not alpha/beta hydrolases includes SGNH 1J00)



General
Type: Organophosphate, Insecticide, Derivative of Paraoxon, pNP
Chemical_Nomenclature: diethyl (4-nitrophenyl) phosphate
Canonical SMILES: CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI: InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
InChIKey: WYMSBXTXOHUIGT-UHFFFAOYSA-N
Other name(s): phosphoric acid diethyl 4-nitrophenyl ester ; Diethyl 4-nitrophenyl phosphate ; diethyl p-nitrophenyl phosphate ; phosphacol ; E600 ; ester25 ; eticol ; phosphakol ; nintacol ; miotisal A ; solumlaucit ; Mintacol ; Fosfakol ; Ethyl paraoxon ; DNP ; Diethyl paraoxon ; paraoxon-ethyl ; paraoxon ethyl
MW: 275.21
Formula: C10H14NO6P
CAS_number: 311-45-5
PubChem: 9395
IUPHAR:
Wikipedia: Paraoxon

Target families

Stucture of targets
30 structures (e.g. : 7R1K, 8DT5, 8DT4... more)

Protein target

References
Search PubMed for references concerning: Paraoxon

45 more
    Title: Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects
    Blumenthal DK, Cheng X, Fajer M, Ho KY, Rohrer J, Gerlits O, Taylor P, Juneja P, Kovalevsky A, Radic Z
    Ref: Journal of Biological Chemistry, :101007, 2021 : PubMed

            

    Title: Toxicity of an acute dose of agent VX and other organophosphorus esters in the chicken
    Wilson BW, Henderson JD, Chow E, Schreider J, Goldman M, Culbertson R, Dacre JC
    Ref: J Toxicol Environ Health, 23:103, 1988 : PubMed

            

    Title: Evaluation of cytotoxic responses caused by selected organophosphorus esters in chick sympathetic ganglia cultures
    Obersteiner EJ, Sharma RP
    Ref: Can J Comp Med, 42:80, 1978 : PubMed