Interpro : IPR022742 Alpha\/beta hydrolase, N-terminal
PIRSF : PIRSF000869 monoglyceride lipase
Pdoc : No Pdoc
Pfam : PF12146 Hydrolase_4
Prints : No Print
EC Number : 3.1.1.23
Title : Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan - Chen_2019_Nat.Chem.Biol_15_453 |
Author(s) : Chen AL , Lum KM , Lara-Gonzalez P , Ogasawara D , Cognetta AB, 3rd , To A , Parsons WH , Simon GM , Desai A , Petrascheck M , Bar-Peled L , Cravatt BF |
Ref : Nat Chemical Biology , 15 :453 , 2019 |
Abstract : Chen_2019_Nat.Chem.Biol_15_453 |
ESTHER : Chen_2019_Nat.Chem.Biol_15_453 |
PubMedSearch : Chen_2019_Nat.Chem.Biol_15_453 |
PubMedID: 30911178 |
Title : Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase - Butler_2017_J.Med.Chem_60_9860 |
Author(s) : Butler CR , Beck EM , Harris A , Huang Z , McAllister LA , Am Ende CW , Fennell K , Foley TL , Fonseca K , Hawrylik SJ , Johnson DS , Knafels JD , Mente S , Noell GS , Pandit J , Phillips TB , Piro JR , Rogers BN , Samad TA , Wang J , Wan S , Brodney MA |
Ref : Journal of Medicinal Chemistry , 60 :9860 , 2017 |
Abstract : Butler_2017_J.Med.Chem_60_9860 |
ESTHER : Butler_2017_J.Med.Chem_60_9860 |
PubMedSearch : Butler_2017_J.Med.Chem_60_9860 |
PubMedID: 29148769 |
Gene_locus related to this paper: human-MGLL |
Title : Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice - Owens_2017_Neuropharmacol_125_80 |
Author(s) : Owens RA , Mustafa MA , Ignatowska-Jankowska BM , Damaj MI , Beardsley PM , Wiley JL , Niphakis MJ , Cravatt BF , Lichtman AH |
Ref : Neuropharmacology , 125 :80 , 2017 |
Abstract : Owens_2017_Neuropharmacol_125_80 |
ESTHER : Owens_2017_Neuropharmacol_125_80 |
PubMedSearch : Owens_2017_Neuropharmacol_125_80 |
PubMedID: 28673548 |
Title : Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p - Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
Author(s) : Aschauer P , Rengachari S , Lichtenegger J , Schittmayer M , Das KM , Mayer N , Breinbauer R , Birner-Gruenberger R , Gruber CC , Zimmermann R , Gruber K , Oberer M |
Ref : Biochimica & Biophysica Acta , 1861 :462 , 2016 |
Abstract : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
ESTHER : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
PubMedSearch : Aschauer_2016_Biochim.Biophys.Acta_1861_462 |
PubMedID: 26869448 |
Gene_locus related to this paper: yeast-mgll |
Title : Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents - Griebel_2015_Sci.Rep_5_7642 |
Author(s) : Griebel G , Pichat P , Beeske S , Leroy T , Redon N , Jacquet A , Francon D , Bert L , Even L , Lopez-Grancha M , Tolstykh T , Sun F , Yu Q , Brittain S , Arlt H , He T , Zhang B , Wiederschain D , Bertrand T , Houtmann J , Rak A , Vallee F , Michot N , Auge F , Menet V , Bergis OE , George P , Avenet P , Mikol V , Didier M , Escoubet J |
Ref : Sci Rep , 5 :7642 , 2015 |
Abstract : Griebel_2015_Sci.Rep_5_7642 |
ESTHER : Griebel_2015_Sci.Rep_5_7642 |
PubMedSearch : Griebel_2015_Sci.Rep_5_7642 |
PubMedID: 25560837 |
Gene_locus related to this paper: mouse-ABHD6 |
Title : Purification, crystallization and preliminary X-ray diffraction analysis of a soluble variant of the monoglyceride lipase Yju3p from the yeast Saccharomyces cerevisiae - Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
Author(s) : Rengachari S , Aschauer P , Sturm C , Oberer M |
Ref : Acta Crystallographica F Struct Biol Commun , 71 :243 , 2015 |
Abstract : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
ESTHER : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
PubMedSearch : Rengachari_2015_Acta.Crystallogr.F.Struct.Biol.Commun_71_243 |
PubMedID: 25664804 |
Gene_locus related to this paper: yeast-mgll |
Title : Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution - Schalk-Hihi_2011_Protein.Sci_20_670 |
Author(s) : Schalk-Hihi C , Schubert C , Alexander R , Bayoumy S , Clemente JC , Deckman I , Desjarlais RL , Dzordzorme KC , Flores CM , Grasberger B , Kranz JK , Lewandowski F , Liu L , Ma H , Maguire D , Macielag MJ , McDonnell ME , Mezzasalma Haarlander T , Miller R , Milligan C , Reynolds C , Kuo LC |
Ref : Protein Science , 20 :670 , 2011 |
Abstract : Schalk-Hihi_2011_Protein.Sci_20_670 |
ESTHER : Schalk-Hihi_2011_Protein.Sci_20_670 |
PubMedSearch : Schalk-Hihi_2011_Protein.Sci_20_670 |
PubMedID: 21308848 |
Gene_locus related to this paper: human-MGLL |
Title : Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice - Pan_2011_J.Neurosci_31_13420 |
Author(s) : Pan B , Wang W , Zhong P , Blankman JL , Cravatt BF , Liu QS |
Ref : Journal of Neuroscience , 31 :13420 , 2011 |
Abstract : Pan_2011_J.Neurosci_31_13420 |
ESTHER : Pan_2011_J.Neurosci_31_13420 |
PubMedSearch : Pan_2011_J.Neurosci_31_13420 |
PubMedID: 21940435 |
Gene_locus related to this paper: human-MGLL , mouse-MGLL |
Title : Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum - Zhong_2011_J.Physiol_589_4847 |
Author(s) : Zhong P , Pan B , Gao XP , Blankman JL , Cravatt BF , Liu QS |
Ref : Journal de Physiologie , 589 :4847 , 2011 |
Abstract : Zhong_2011_J.Physiol_589_4847 |
ESTHER : Zhong_2011_J.Physiol_589_4847 |
PubMedSearch : Zhong_2011_J.Physiol_589_4847 |
PubMedID: 21911610 |
Gene_locus related to this paper: human-MGLL , mouse-MGLL |
Title : Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling - Labar_2010_Chembiochem_11_218 |
Author(s) : Labar G , Bauvois C , Borel F , Ferrer JL , Wouters J , Lambert DM |
Ref : Chembiochem , 11 :218 , 2010 |
Abstract : Labar_2010_Chembiochem_11_218 |
ESTHER : Labar_2010_Chembiochem_11_218 |
PubMedSearch : Labar_2010_Chembiochem_11_218 |
PubMedID: 19957260 |
Gene_locus related to this paper: human-MGLL |
Title : Structural basis for human monoglyceride lipase inhibition - Bertrand_2010_J.Mol.Biol_396_663 |
Author(s) : Bertrand T , Auge F , Houtmann J , Rak A , Vallee F , Mikol V , Berne PF , Michot N , Cheuret D , Hoornaert C , Mathieu M |
Ref : Journal of Molecular Biology , 396 :663 , 2010 |
Abstract : Bertrand_2010_J.Mol.Biol_396_663 |
ESTHER : Bertrand_2010_J.Mol.Biol_396_663 |
PubMedSearch : Bertrand_2010_J.Mol.Biol_396_663 |
PubMedID: 19962385 |
Gene_locus related to this paper: human-MGLL |
Title : Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae - Heier_2010_Biochim.Biophys.Acta_1801_1063 |
Author(s) : Heier C , Taschler U , Rengachari S , Oberer M , Wolinski H , Natter K , Kohlwein SD , Leber R , Zimmermann R |
Ref : Biochimica & Biophysica Acta , 1801 :1063 , 2010 |
Abstract : Heier_2010_Biochim.Biophys.Acta_1801_1063 |
ESTHER : Heier_2010_Biochim.Biophys.Acta_1801_1063 |
PubMedSearch : Heier_2010_Biochim.Biophys.Acta_1801_1063 |
PubMedID: 20554061 |
Gene_locus related to this paper: human-MGLL , mouse-MGLL , yeast-mgll |
Title : Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis - Nomura_2010_Cell_140_49 |
Author(s) : Nomura DK , Long JZ , Niessen S , Hoover HS , Ng SW , Cravatt BF |
Ref : Cell , 140 :49 , 2010 |
Abstract : Nomura_2010_Cell_140_49 |
ESTHER : Nomura_2010_Cell_140_49 |
PubMedSearch : Nomura_2010_Cell_140_49 |
PubMedID: 20079333 |
Gene_locus related to this paper: human-MGLL , mouse-MGLL |
Title : Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase - Vila_2007_Biochemistry_46_9578 |
Author(s) : Vila A , Rosengarth A , Piomelli D , Cravatt B , Marnett LJ |
Ref : Biochemistry , 46 :9578 , 2007 |
Abstract : Vila_2007_Biochemistry_46_9578 |
ESTHER : Vila_2007_Biochemistry_46_9578 |
PubMedSearch : Vila_2007_Biochemistry_46_9578 |
PubMedID: 17649977 |
Gene_locus related to this paper: human-MGLL , mouse-MGLL |
Structures (30)
Genes Proteins in Monoglyceridelipase_lysophospholip family (1182)
Fragments of genes in Monoglyceridelipase_lysophospholip family (102)
Structures in Monoglyceridelipase_lysophospholip family (30)Substrates in Monoglyceridelipase_lysophospholip family (24)
Inhibitors in Monoglyceridelipase_lysophospholip family (77)